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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
The product is found useful for the following medical conditions
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.2
USERS' SCORE
Good
Based on 23 Reviews
8.9
8
Retinoic acid enhances glioma treatment
Retinoic acid-induced alterations enhance eATP-mediated anti-cancer effects in glioma cells: Implications for P2X7 receptor variants as key players.
Most Relevant Research
We investigated how retinoic acid (RA), a derivative of vitamin A, could influence cancer treatment, particularly in glioma, a type of brain tumor. Previous attempts to use RA as a therapeutic option were inconclusive, so we aimed to explore its effects alongside extracellular ATP (eATP) to harness their combined potential.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
Our experiments examined two human glioma cell lines, M059K and M059J, to see how they responded to RA-based differentiation. Notably, this process led to changes in the expression of a receptor called P2X7 and reduced the activity of enzymes that break down nucleotides. These modifications contributed to a significant decrease in cell proliferation and migration abilities, as well as an increased sensitivity to the effects of eATP.
Specifically, we found that in the presence of eATP, cell viability decreased by up to 40% in RA-treated M059K cells and 20% in M059J cells. Migration capabilities of the cells were reduced by as much as 60% when exposed to a specific concentration of ATP, showing that the P2X7 receptor plays a major role in mediating these effects.
Our observations suggest that combining retinoic acid with eATP can have anti-cancer benefits by influencing purinergic signaling pathways in glioma cells. This points to the need for further exploration of P2X7 receptor variants as potential therapeutic targets for treating glioma.
9.5
Improved gastritis
Most Useful Review
The required amount of Vitamin A varies significantly depending on individual circumstances. Those with dry eye, asthma, gastrointestinal issues, or a family history of cancer may require more. I gradually increased my intake to 100,000 units for a year, which cleared my persistent red sore gastritis, eliminating the need for medication.
Ulcer details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.9
9.5
Improvement observed
Most Useful Review
The required dosage of vitamin A varies significantly between individuals, particularly for those with dry eyes, asthma, gastrointestinal issues, or a history of cancer. Due to my low protein intake, I've gradually increased my dosage to 100,000 units over a year. Remarkably, my persistent gastritis, unresolved for over ten years, has cleared, eliminating the need for medication.
Acne details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 131 Reviews
8.8
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
Most Relevant Research
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
9.5
Improved skin health
Most Useful Review
As a longtime acne sufferer, I've tried everything from Accutane to various skincare products without success. In just a week of using this supplement, I saw tremendous improvement; my skin appears clearer, my pores are smaller, and I'm even comfortable without makeup for the first time. The reduction in acne is phenomenal, with noticeable changes in texture and tone. For better absorption, I take it with a healthy fat like coconut oil, which I highly recommend.
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.8
9.5
Improved chronic cough
Most Useful Review
Respite Vitamin A is essential for mucous membranes, so I purchased it for my husband with severe asthma. I struggled to sleep due to suffocation, but after taking 100,000 IU daily, I noticed a significant improvement within a month. His daytime cough has also decreased dramatically. However, high doses of vitamin A can result in vitamin K deficiency, so I recommend consuming natto alongside it.
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 9 Reviews
8.8
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
Most Relevant Research
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
9.5
Improved vitamin levels
Most Useful Review
Working drug! My doctor said, "Vitamin A is essential for your mucous membranes." My vitamin A levels have significantly increased, which is crucial for someone with hypothyroidism. The capsules are small and easy to take; I also ensure to take them with fats for better absorption.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.8
9.5
Great eye relief
Most Useful Review
I take this Vitamin A for my blepharitis or dry eye syndrome, which I've suffered from for some time. It has significantly helped in the last few weeks. I've also begun using Organic Egyptian Carrot Seed Oil in my eyes with great results. We all require Vitamin A, as many vital nutrients are absent from our diets now. If you have eye problems, I recommend trying this.
Allergies details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 11 Reviews
8.7
9
Vitamin A and allergy management
Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.
Most Relevant Research
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
9.5
Skin improvement
Most Useful Review
25,000 IU is a high dose but suitable for my allergies and atrophoderma. Initially, I had skin breakouts, but after a day, my skin improved. Within two weeks, facial inflammation cleared up. The overall condition of my skin has significantly improved, a result I previously only achieved with injections.
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
Vitamin A's role in anemia
Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances.
Most Relevant Research
We examined the connection between vitamin A deficiency (VAD) and anemia, particularly how a lack of vitamin A can impact iron metabolism in our bodies. Through reviewing existing research, we discovered that VAD doesn't just lead to general anemia but may cause a specific type known as vitamin A deficiency anemia (VADA).
Our findings reveal that vitamin A plays an essential role in the production of red blood cells. When we lack vitamin A, our bodies struggle to utilize iron effectively. Instead of being available for red blood cell production, iron accumulates in our liver and spleen, leading to reduced levels of circulating iron.
We also saw that inflammation and systemic infections could further exacerbate this issue by triggering the liver to produce more hepcidin, a protein that regulates iron levels. The excess hepcidin can create a situation where there isn’t enough iron for the production of hemoglobin, ultimately causing anemia.
Interestingly, our review highlighted that VADA happens not because of a lack of iron, but due to how iron is managed within the body. By understanding these mechanisms, we can work towards creating better strategies to tackle anemia on a global scale.
Our findings reveal that vitamin A plays an essential role in the production of red blood cells. When we lack vitamin A, our bodies struggle to utilize iron effectively. Instead of being available for red blood cell production, iron accumulates in our liver and spleen, leading to reduced levels of circulating iron.
We also saw that inflammation and systemic infections could further exacerbate this issue by triggering the liver to produce more hepcidin, a protein that regulates iron levels. The excess hepcidin can create a situation where there isn’t enough iron for the production of hemoglobin, ultimately causing anemia.
Interestingly, our review highlighted that VADA happens not because of a lack of iron, but due to how iron is managed within the body. By understanding these mechanisms, we can work towards creating better strategies to tackle anemia on a global scale.
8.8
Remarkable improvement
Most Useful Review
Great product! For myself and my 13-year-old son, I prefer this Now Foods product at a dosage of 25,000 IU daily. We take it for a month, then rest for a month, from September to May. The results are remarkable; within a week, my dry skin and enamel sensitivity, as well as my son's acne and peeling fingers, significantly improved. Many endure these unpleasant symptoms for years without help, often due to vitamin A deficiency. It's advisable to use vitamin A in treating iron deficiency anemia, as there's a link between retinol levels and serum iron. Long-term vitamin A intake should also be paired with vitamin E for better absorption.
Blood Clot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
Replenished levels
Most Useful Review
Excellent! My blood test showed that my levels were replenished thanks to this product.
Brain Tumor details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Tumour markers normal
Most Useful Review
I've been taking Vitamin A for five years. My cancer tumour markers were positive earlier, and my doctor advised vitamins A and D. I was taking 225,000 IU daily for about six months, which helped reduce chickenpox zoster virus infections, with no side effects. After fasting, walking on organic juices, and maintaining an organic diet, my tumour markers returned to normal over two years. Now, I take 75,000 IU daily. In Japan, most people are vitamin D deficient due to limited sun exposure.
Common Cold details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 46 Reviews
8.7
9.5
Strengthened mucous membranes
Most Useful Review
I have been taking 75000 IU of vitamin A daily for six months, and my eyesight has improved! Even when I catch a common cold, my throat is less sore, and I feel my mucous membranes have strengthened significantly. I believe this is enhanced by my intake of protein and other vitamins and minerals alongside vitamin A.
Eczema details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Alitretinoin improves eczema treatment
The Endogenous Dual Retinoid Receptor Agonist Alitretinoin Exhibits Immunoregulatory Functions on Antigen-Presenting Cells.
Most Relevant Research
We explored the effects of alitretinoin, a form of vitamin A, on chronic hand eczema (CHE). This powerful drug is known to target specific receptors in the skin, offering insights into its method of action. Through our detailed study, we examined skin samples from patients who responded well to alitretinoin treatment.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
9.5
Eczema totally cleared
Most Useful Review
Be mindful of the dosage at 25,000 IU - it's high but manageable. I recommend this dosage for those with medical needs. I have reduced vision, allergies, and most importantly, atrophoderma. Initially, pimples appeared, but they cleared the next day, and within two weeks, all facial inflammation was gone. The effect was similar to previous injections of lidase. Eczema typically flares on my hands in August, but since starting vitamin A, it has disappeared. Combining it with vitamin E showed immediate results.
Knee Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
Moisturised skin
Most Useful Review
Since taking vitamin A supplements, I've noticed the dryness around my elbows and knees has vanished. I used to apply a lot of cream to my legs and elbows each night, but now I hardly need to. Having suffered from atopic dermatitis, I never thought my body could retain moisture like this.
Psoriasis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
8.8
Excellent absorption
Most Useful Review
Vitamin A in its retinol form has a 90% absorption rate, compared to 50% for beta-carotene, making it safer and suitable for thrice-weekly use. This has an excellent effect on epithelial and corneal cells, particularly beneficial for those with psoriasis. It is advisable to combine it with vitamin E at separate meals and to ensure adequate water intake.
Whooping Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.7
10
Chronic cough eliminated
Most Useful Review
This supplement significantly improved my immunity and, most importantly, cured my chronic cough that I struggled to eliminate for a long time. Now, I occasionally take these capsules to prevent respiratory illnesses and boost my immunity. I recommend it to anyone who frequently gets sick. Benefits include strengthened immune system and elimination of a chronic cough; I found no disadvantages.
Autoimmune Disorder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 19 Reviews
8.6
9.5
Significant mucous improvement
Most Useful Review
Despite consuming greens, my mucous membranes remained problematic for years. Once I increased my vitamin A intake, all my issues, including angular cheilitis and nosebleeds, significantly improved. While some studies question the efficacy of supplements, I believe in their power and will continue to use them for my autoimmune disorder.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 18 Reviews
8.6
9.5
Skin and vision
Most Useful Review
As a sufferer of keratosis and dry eyes, I've found vitamin A supplements transformative. They have significantly improved both my skin texture and vision, especially in low-light situations, reducing my chronic fatigue syndrome considerably.
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
8.8
Cold sore relief
Most Useful Review
I suffer from dry mucous membranes in my throat and nose, which often leads to cold sores and feeling unwell. Initially, I took a small dose, but found that 25,000 to 50,000 IU is effective, especially in winter. This supplement has significantly reduced my colds and improved my overall health.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
10
Effective for acne
Most Useful Review
I purchased this product for acne and keratinisation, and it has been very effective against back acne! After trying various cosmetics and medications without success, I noticed my back acne had completely disappeared just two weeks after taking one tablet daily. Now, I can confidently wear off-shoulder tops and swimwear. However, it's advisable to take breaks after finishing the supplement and only buy it again if the acne returns.
Menopause details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Excellent supplement
Most Useful Review
This supplement has been excellent for my mother, who was prescribed it as part of her menopause treatment. It’s a good addition to her needs.
Pneumonia details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Boosts immunity
Most Useful Review
Supplementing my diet with vitamin A offers numerous benefits. The right dose can enhance mucosal tissue and bolster immune cells. This supplement significantly aids in preventing symptoms associated with colds, coughs, and pneumonia. My family takes one pill each morning and evening to boost our immune system. The product is of high quality with excellent ingredients, moisture-proof packaging, no unusual taste, and it’s easy to swallow.
Reflux details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
No reflux experienced
Most Useful Review
Now Brand has demonstrated to me that their products are natural with no side effects, particularly the krill oil, which is tasteless and does not cause reflux or unpleasant odour.
Sinusitis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
10
Cured sinusitis
Most Useful Review
A single dose completely cured my sinusitis!
Bruise details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Bruise healing observed
Most Useful Review
The skin thanks you! I bought vitamin A and was very satisfied. I must mention that I took 2 capsules instead of one, but there were no adverse effects. My facial skin has an even tone, and I’ve noticed fewer rashes. I work in a hot kitchen, so I require good skincare. Interestingly, I've observed that my bruises started to fade in 3-4 days, even though they were painful a week ago.
Heart Attack details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9.5
No recurrence noted
Most Useful Review
A couple began using this supplement for vitamin health. Since then, I have not experienced a recurrence of my heart attack, my "arrhythmia" remains stable, and my wife's "trigger finger" is also under control.
Lung Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.5
9
Vitamin A mitigates lung cancer
Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA).
Most Relevant Research
We aimed to understand how all-trans retinoic acid (ATRA), a form of vitamin A, influences lung cancer development caused by benzo(a)pyrene (B(a)P) exposure in mice. The study involved a thorough examination of the overall health of the mice, including body and organ weights, blood tests, and tissue analysis for any signs of damage or inflammation.
In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.
The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.
Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.
In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.
The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.
Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.
9.5
Tumour markers normalised
Most Useful Review
I have taken Vitamin A for five years as advised by my doctor to lower lung cancer marker levels. Initially, I took high doses but now manage with 75,000 IU daily, supporting my recovery and normalising my tumour markers.
Cold details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Vitamin A's key role in thermogenesis
Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis.
Most Relevant Research
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
8.5
Essential for immunity
Most Useful Review
My go-to source for Vitamin A. It’s essential for boosting immunity and fighting infections. I always use the NOW 25,000 IU version, which provides an adequate dosage easily, and I can increase it quickly if I sense a cold coming on without needing numerous daily servings.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Vitamin A's potential in arthritis treatment
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.
Most Relevant Research
We explored the potential of all-trans retinoic acid (ATRA), a form of vitamin A, in treating autoimmune arthritis. The research focused on how ATRA can help improve the body's immune response while reducing inflammation associated with arthritis.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
Through innovative use of biodegradable microparticles, ATRA is released directly in the joints over a sustained period, enhancing the body's immune activity. This unique approach helped transform naïve T cells into protective regulatory T cells, which in turn helped to mitigate inflammatory responses.
Notably, the sustained release of ATRA not only improved joint health but also affected the entire body without leading to widespread immune suppression. In animal models of arthritis, those treated with ATRA showed less joint damage and inflammation compared to untreated counterparts, suggesting a promising avenue for managing this challenging condition.
Overall, these findings illuminate the role of vitamin A in potentially modifying the disease course for those battling autoimmune arthritis, indicating exciting new possibilities for treatment that could offer hope for improved patient outcomes.
8.8
Stable remission achieved
Most Useful Review
Great, I ordered it for my husband on the recommendation of a doctor during the Autoimmune Protocol. This new approach aids in the prevention and treatment of asthma, lupus, psoriasis, IBS, Hashimoto's thyroiditis, rheumatoid arthritis, and various other autoimmune conditions. Combined with other supplements, we reached a stable remission.
Bronchitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 2 Reviews
8.4
7
Vitamin A supports immune response
Effect of oral vitamin A supplementation on host immune response to infectious bronchitis virus infection in specific pathogen-free chicken.
Most Relevant Research
We conducted a study to investigate how vitamin A supplementation affects the immune response in chickens infected with the infectious bronchitis virus (IBV). In our approach, we used 40 one-day-old specific pathogen-free (SPF) chickens, dividing them into two groups. One group received an oral vitamin A treatment daily, while the other group was given a placebo until they were 21 days old.
Afterward, both groups were infected with a pathogenic strain of IBV. Our findings showed that while vitamin A supplementation didn't significantly alter the disease's clinical course or the chickens' overall growth, it had some notable effects on their immune response. Specifically, we observed increased levels of IBV-specific antibodies and a decrease in viral load in certain tissues among the vitamin A group.
Interestingly, vitamin A appeared to also suppress some immune responses, leading to lower expression levels of certain molecules related to inflammation and immune regulation. While vitamin A helped improve specific aspects of the immune response, it did not completely cure the chickens or prevent infection.
Overall, we can conclude that while vitamin A supplementation can offer some benefits in terms of boosting immunity and managing viral replication, it doesn't drastically change the outcome of IBV infections in chickens.
Afterward, both groups were infected with a pathogenic strain of IBV. Our findings showed that while vitamin A supplementation didn't significantly alter the disease's clinical course or the chickens' overall growth, it had some notable effects on their immune response. Specifically, we observed increased levels of IBV-specific antibodies and a decrease in viral load in certain tissues among the vitamin A group.
Interestingly, vitamin A appeared to also suppress some immune responses, leading to lower expression levels of certain molecules related to inflammation and immune regulation. While vitamin A helped improve specific aspects of the immune response, it did not completely cure the chickens or prevent infection.
Overall, we can conclude that while vitamin A supplementation can offer some benefits in terms of boosting immunity and managing viral replication, it doesn't drastically change the outcome of IBV infections in chickens.
9
Cough relief
Most Useful Review
This product resolved my chronic cough of 20 years within days. I bought it for my husband after his bronchitis, and it worked wonders for both of us. By the second dose, I stopped coughing entirely, which is something I hadn’t experienced before. This is now a staple in my home.
Chest Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.4
9.5
Reduced chest pain
Most Useful Review
No way did I expect this vitamin A to help with my vision and mucous membranes, but it remarkably relieved my chest pain from hernias. Within four days of taking it, my long-standing back pain also vanished. After a brief break, it worked immediately when I reintroduced it after a minor back injury. Although I’m not sure about my eyesight, my skin looks cleaner. I believe the combination with B vitamins is beneficial.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
8
Vitamin A's impact on OSA
The role of antioxidant vitamins and selenium in patients with obstructive sleep apnea.
Most Relevant Research
We conducted a case-control study to explore the levels of essential antioxidant nutrients, particularly vitamin A, in patients with obstructive sleep apnea (OSA) who did not have any other health issues. By categorizing our 146 subjects based on their apnea-hypopnea index (AHI) scores, we examined how these nutrient levels compared between those with mild to severe OSA and healthy individuals.
Our findings revealed that patients with OSA showed increased concentrations of vitamin A as part of their antioxidant response. This suggests that vitamin A and selenium may serve as important defenses against the harmful impacts of OSA. The implication of our research highlights that supplementing with antioxidant nutrients could be a beneficial approach to enhance overall health in individuals suffering from sleep apnea.
However, while there is a positive correlation between vitamin A levels and OSA, it is important to note that the isolated effects of vitamin A were not the primary focus of our study. Therefore, more research is needed to fully unravel its specific role in treating or managing sleep apnea.
Our findings revealed that patients with OSA showed increased concentrations of vitamin A as part of their antioxidant response. This suggests that vitamin A and selenium may serve as important defenses against the harmful impacts of OSA. The implication of our research highlights that supplementing with antioxidant nutrients could be a beneficial approach to enhance overall health in individuals suffering from sleep apnea.
However, while there is a positive correlation between vitamin A levels and OSA, it is important to note that the isolated effects of vitamin A were not the primary focus of our study. Therefore, more research is needed to fully unravel its specific role in treating or managing sleep apnea.
9.5
Enhanced motivation
Most Useful Review
Fabulous! I'm delighted with the results. The quality of the packaging is superb and delivery was swift. I consistently appreciate this brand's commitment to natural ingredients. The capsules are medium-sized and easy to swallow, with a neutral taste and no odour. I've felt the benefits from the second day. I feel better and more motivated. My sleep has improved, becoming more sound and restful. I highly recommend this product.
Back Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 11 Reviews
8.2
9.5
Tumour markers normalised
Most Useful Review
I've been taking Vitamin A for five years. Initially, my cancer tumour markers were positive, and my doctor advised me to take vitamins A and D. I was taking 225,000 IU daily to reduce chickenpox zoster virus infections. After about two years on this regimen, my tumour markers normalised. Now, I take 75,000 IU each day. Due to Japan's climate, many people here are vitamin D deficient.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 9 Reviews
8.2
9.5
Effective for bone pain
Most Useful Review
I purchased this hoping to enhance my vision and improve my mucous membranes. Surprisingly, it was remarkably effective against my bone pain associated with hernias. After starting it, my back pain resolved in just four days. When I resumed taking it after a minor back injury, it worked instantly. I feel the combination with B vitamins has a positive effect, and while I'm unsure about my eyesight, my skin appears clearer.
Headache details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.5
8
Vitamin A toxicity's impact on headaches
A Rare Case Report of Benign Intracranial Hypertension Caused by Hypervitaminosis A.
Most Relevant Research
We examined a rare case involving a 13-year-old girl who experienced symptoms of headache and visual disturbances due to benign intracranial hypertension (BIH) related to vitamin A toxicity. This condition was characterized by elevated pressure inside her skull, which led to her experiencing severe headaches, photophobia, and vomiting.
After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.
What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.
This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.
After conducting various tests, including magnetic resonance imaging and a lumbar puncture, we confirmed the diagnosis of BIH. Treatment was initiated with acetazolamide, a medication commonly used to reduce intracranial pressure. Although the study primarily focuses on the condition resulting from vitamin A excess, the use of acetazolamide makes it challenging to isolate the effect of vitamin A on headache relief specifically.
What's particularly noteworthy in this case is the significant elevation of serum vitamin A levels, which aligned with her symptoms. Following treatment, this patient showed a remarkable clinical improvement, including a reduction in papilledema during regular eye check-ups. Within just two weeks after starting treatment, she was discharged symptom-free, highlighting how important it is to consider vitamin A levels in children presenting with similar symptoms.
This case serves as a reminder for clinicians regarding the potential consequences of vitamin A toxicity, especially when evaluating children with headaches correlated to papilledema.
8.8
Quality vitamins noted
Most Useful Review
I started taking this product for chronic headaches related to low cerebrospinal fluid. I advise against using it without a doctor’s supervision, as Vitamin A can build up to toxic levels. The product quality is good, arriving in a sealed bottle. Despite being fish liver derived, it has no fishy aftertaste. I will order this again.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 5 Reviews
7
8
Vitamin A reduces pregnancy nausea
Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women.
Most Relevant Research
We conducted a double-masked, placebo-controlled trial involving 15,832 Nepali women to explore how vitamin A and beta-carotene supplementation affects pregnancy-related nausea and overall illness symptoms. Our observations showed that while there was no noticeable impact during the early stages of pregnancy, vitamin A supplementation made a significant difference in late pregnancy.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
Specifically, we found that women who received vitamin A experienced a reduction in nausea. Additionally, symptoms such as faintness and night blindness were also less prevalent in those women. Beta-carotene supplementation did not yield the same benefits for nausea, highlighting the unique role of vitamin A in managing these symptoms.
Moreover, supplementation with vitamin A contributed to a shorter labor duration, which is promising for expectant mothers. It also helped reduce the postpartum risks of conditions like night blindness and loose stools. Overall, our findings indicate that ensuring adequate vitamin A intake can be important for improving reproductive health in women, particularly in areas with limited healthcare access.
8.8
Improved energy levels
Most Useful Review
Good composition, fast delivery, high-quality and convenient packaging. The capsules are slightly large, but there's no issue swallowing them. They have a citrus taste which I enjoy. I take one capsule daily with meals alongside vitamin D3+K2, magnesium, and vitamin B6. I've noticed significant benefits; prior to starting, I often suffered from headaches, nausea, and fatigue. After ten days, I feel more energetic, my headaches have ceased, and my mood remains excellent. I highly recommend it, especially for those interested in sports, fitness, or specific diets, as omega-3 is energising and replenishes essential nutrients.
Asthma details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.5
9.5
Stops mild asthma
Most Useful Review
This is really helping with my unusual lung issues and constant infections, plus it has stopped my mild asthma. The high dosage is terrific; it truly works and keeps me warm as well.
Hair Loss details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.3
9
Vitamin A's role in hair recovery
Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia.
Most Relevant Research
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
6.8
Acne treatment success
Most Useful Review
Works well. I began taking these to address moderate acne and cystic bumps on my face. Adding one softgel daily has dried up sebum production. I introduced Vitamin E as a counterbalance to dryness. Both have worked well together, plus my hair is growing quickly as a side effect!
