5/14/2025
Last update
5/14/2025
Infographics 
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 131 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9.5
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Read More
9
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
Read More
9
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Read More
Most Useful Reviews
9
Improved skin health
305 people found this helpful
As a longtime acne sufferer, I've tried everything from Accutane to various skincare products without success. In just a week of using this supplement, I saw tremendous improvement; my skin appears clearer, my pores are smaller, and I'm even comfortable without makeup for the first time. The reduction in acne is phenomenal, with noticeable changes in texture and tone. For better absorption, I take it with a healthy fat like coconut oil, which I highly recommend.
Read More
10
Life-changing results
211 people found this helpful
This purchase was life-changing for me! I've spent so much money on washes, scrubs, and masks to treat my acne, seeing dermatologists without success. This vitamin has provided real results and even helped ease some symptoms related to my menstrual cycle. I'm thrilled I've finally found something that works!
Read More
10
Rapid improvement
147 people found this helpful
Hello clear skin! I've suffered from bad breakouts and acne for a long time. I've tried everything from creams to acids with little success. Then I read that apricots are good for skin due to vitamin A, which inspired me to try taking it directly. After just two days, my skin cleared up, and I haven't had a breakout in about two weeks! It's the greatest feeling, and I owe it all to this product. If you have skin issues like mine, it could be a vitamin A deficiency, so do give this a go.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9.5
Impact of Isotretinoin on Liver Function
We conducted a retrospective study to understand how vitamin A, particularly in the form of oral isotretinoin, impacts acne treatment. This powerful medication is often prescribed for severe cases of acne that don’t respond to other treatments.
Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.
Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.
While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.
Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.
While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
Read More
9.5
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Read More
9
We explored the effectiveness of retinoic acid, commonly known as vitamin A, for acne treatment using a unique delivery method that combines proliposomes and nanofibers. The goal was to assess how these specially formulated nanofibers, loaded with retinoic acid, could inhibit microbial biofilm formation, a common contributor to acne.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
Read More
9
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
Read More
9
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Read More
User Reviews
USERS' SCORE
Good
Based on 131 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved skin health
305 people found this helpful
As a longtime acne sufferer, I've tried everything from Accutane to various skincare products without success. In just a week of using this supplement, I saw tremendous improvement; my skin appears clearer, my pores are smaller, and I'm even comfortable without makeup for the first time. The reduction in acne is phenomenal, with noticeable changes in texture and tone. For better absorption, I take it with a healthy fat like coconut oil, which I highly recommend.
Read More
10
Life-changing results
211 people found this helpful
This purchase was life-changing for me! I've spent so much money on washes, scrubs, and masks to treat my acne, seeing dermatologists without success. This vitamin has provided real results and even helped ease some symptoms related to my menstrual cycle. I'm thrilled I've finally found something that works!
Read More
10
Rapid improvement
147 people found this helpful
Hello clear skin! I've suffered from bad breakouts and acne for a long time. I've tried everything from creams to acids with little success. Then I read that apricots are good for skin due to vitamin A, which inspired me to try taking it directly. After just two days, my skin cleared up, and I haven't had a breakout in about two weeks! It's the greatest feeling, and I owe it all to this product. If you have skin issues like mine, it could be a vitamin A deficiency, so do give this a go.
Read More
9
Near-miraculous results
69 people found this helpful
A near miracle with this for cystic acne. This product has almost entirely cleared my son's acne, who has struggled with severe outbreaks. Instead of proceeding with Accutane, we opted for high doses of vitamin A. After two months, his skin appears normal with very few breakouts. We've also integrated vitamin E to help reduce scarring. His cholesterol levels rose but have since normalised. Overall, we are incredibly pleased with the outcomes.
Read More
7.5
Effective hormonal acne solution
59 people found this helpful
I love this product and highly recommend it for ACNE. At 22, I’ve struggled with hormonal acne for years. This higher percentage of Vitamin A has shown results within weeks. While improvements are noteworthy and breakouts occur less frequently, I adhere to a skincare routine that doesn’t dry out my skin. Additionally, cutting back on dairy has helped. I encourage persistence in any acne treatment routine.
Read More
Frequently Asked Questions
9
Effective for acne
12 people found this helpful
I bought this for my back acne, having tried various cosmetics and medications unsuccessfully. Just two weeks after starting the supplement, my back acne vanished! I've stopped for a bit as recommended, but I'll repurchase it when the acne returns.
7.5
Redness reduction
7 people found this helpful
This vitamin, alongside a couple of others, helped me combat acne and redness. I couldn’t complete the course due to recovery from surgery, but even after two weeks, I noticed a significant reduction in acne and redness.
9
Reduces acne significantly
34 people found this helpful
I use this vitamin as an alternative to Roaccutane for treating acne. After two months on a high dose, my acne has reduced by 70%, though I experience dry lips as a side effect. I plan to continue taking it for another two months to fully address my acne issues.
7.5
Acne solution
8 people found this helpful
I've taken this for over six months to help my acne. While not as strong as roaccutane, it significantly reduces my breakouts. It's affordable, and now my skin glows—my sister even noticed and joined me in taking it.
9
Improves skin consistency
26 people found this helpful
My doctor prescribed a therapeutic dose of vitamin A, which I switched to from liquid retinol palmitate. The capsules are convenient and effective for my acne treatment. I have noticed improvements in my skin texture and reduced inflammation. However, I’m reminded of its toxicity in high doses, especially for pregnant women.
9
Highly recommended for acne
23 people found this helpful
I suggest taking vitamin A every other day paired with vitamin C and E to treat acne. This combination worked wonders for me in just two weeks, addressing a problem I'd struggled with for five years.
7.5
Targets acne effectively
16 people found this helpful
This high dosage of vitamin A is recommended for a 30-day acne treatment. When taken alongside vitamin E and other supplements, it significantly helps clear up the skin.
7.5
Helps with acne
8 people found this helpful
I've been taking this for over six months to address my acne. While it’s not as powerful as Roaccutane, my acne has significantly improved. It’s very affordable and I recommend it to everyone. I also take it with pantothenic acid, which gives my skin a lovely glow. My sister even noticed the difference and started taking it too.
9.5
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
8
We conducted a study looking into how vitamin A, particularly in the form of isotretinoin, affects severe acne vulgaris (AV). This inflammatory skin condition can lead to both physical and emotional distress, and we aimed to understand whether vitamin A could help alleviate these symptoms.
A total of 100 patients with severe acne participated in our research, taking 0.75 mg/kg of isotretinoin daily for a span of four months. Throughout this time, we closely monitored serum vitamin D levels at three key points: before, during, and after the treatment.
Our findings indicated that although severe acne may negatively affect vitamin D synthesis, the treatment with isotretinoin leads to an increase in vitamin D serum levels. This suggests a potential benefit of vitamin A treatment in improving vitamin D status in those suffering from severe AV. However, further studies are needed to clarify the relationship between the two.
A total of 100 patients with severe acne participated in our research, taking 0.75 mg/kg of isotretinoin daily for a span of four months. Throughout this time, we closely monitored serum vitamin D levels at three key points: before, during, and after the treatment.
Our findings indicated that although severe acne may negatively affect vitamin D synthesis, the treatment with isotretinoin leads to an increase in vitamin D serum levels. This suggests a potential benefit of vitamin A treatment in improving vitamin D status in those suffering from severe AV. However, further studies are needed to clarify the relationship between the two.
9
We explored the effectiveness of retinoic acid, commonly known as vitamin A, for acne treatment using a unique delivery method that combines proliposomes and nanofibers. The goal was to assess how these specially formulated nanofibers, loaded with retinoic acid, could inhibit microbial biofilm formation, a common contributor to acne.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
9
We assessed how vitamin A, specifically in the form of tretinoin, impacts the treatment of acne when combined with benzoyl peroxide. In two clinical trials, which lasted 12 weeks and included a control group, we found that the combination cream significantly reduced both inflammatory and noninflammatory acne lesions on the face. This led to improvements in overall acne ratings from both the patients and the investigators involved in the studies.
The safety profile of tretinoin 0.1%-benzoyl peroxide 3% cream also stood out to us. The most common side effects were mild and included moments of pain and dryness at the application site, which we found to be manageable for many users. This is great news for anyone dealing with acne who might be concerned about the potential downsides of treatment.
When we compared the results of this combination treatment to other standard therapies, it showed similar effectiveness. The benefit of combining both tretinoin and benzoyl peroxide lies in the simplicity it offers. Instead of using two separate products, patients can streamline their skincare routine with a single application. However, we noted that the cost might be a barrier for some, despite the convenience.
Overall, it seems that tretinoin in combination with benzoyl peroxide presents a safe and effective option for treating moderate to severe acne. Yet, we're still waiting for long-term data on how well patients tolerate this combination over extended periods.
The safety profile of tretinoin 0.1%-benzoyl peroxide 3% cream also stood out to us. The most common side effects were mild and included moments of pain and dryness at the application site, which we found to be manageable for many users. This is great news for anyone dealing with acne who might be concerned about the potential downsides of treatment.
When we compared the results of this combination treatment to other standard therapies, it showed similar effectiveness. The benefit of combining both tretinoin and benzoyl peroxide lies in the simplicity it offers. Instead of using two separate products, patients can streamline their skincare routine with a single application. However, we noted that the cost might be a barrier for some, despite the convenience.
Overall, it seems that tretinoin in combination with benzoyl peroxide presents a safe and effective option for treating moderate to severe acne. Yet, we're still waiting for long-term data on how well patients tolerate this combination over extended periods.
7
In our exploration of the effects of isotretinoin, a high-dose vitamin A treatment for acne vulgaris, we focused on how it might influence anger levels in patients. We analyzed a group of 100 individuals, half receiving isotretinoin for their acne and half acting as a control group without any medication. This structure allowed us to assess the emotional responses more effectively.
Our findings revealed an interesting connection: patients taking isotretinoin showed increased levels of anger compared to those who weren’t. We particularly noted a correlation between certain temperament traits—like being cyclothymic or hyperthymic—and different anger responses. For instance, individuals with a cyclothymic temperament exhibited anxiety-related behaviors, while those with a hyperthymic temperament had a greater tendency towards certain anger-related thoughts.
Although we delved into how acne treatment can be linked with emotional well-being, it’s important to clarify that while isotretinoin addresses acne effectively, it can also create emotional fluctuations for some individuals. Our study adds a unique perspective by highlighting the psychological dimensions associated with acne treatment, which haven’t been deeply explored in previous research.
Our findings revealed an interesting connection: patients taking isotretinoin showed increased levels of anger compared to those who weren’t. We particularly noted a correlation between certain temperament traits—like being cyclothymic or hyperthymic—and different anger responses. For instance, individuals with a cyclothymic temperament exhibited anxiety-related behaviors, while those with a hyperthymic temperament had a greater tendency towards certain anger-related thoughts.
Although we delved into how acne treatment can be linked with emotional well-being, it’s important to clarify that while isotretinoin addresses acne effectively, it can also create emotional fluctuations for some individuals. Our study adds a unique perspective by highlighting the psychological dimensions associated with acne treatment, which haven’t been deeply explored in previous research.
9
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
7
We analyzed how oral isotretinoin, a vitamin A derivative, impacts acne treatment and ocular health. This study included 489 participants from the Jazan region, where we used an online questionnaire to gather data on symptoms experienced during isotretinoin therapy.
As we learned, many participants faced issues such as dry eyes and blurry vision, which are known side effects of the treatment. Over half of current users reported severe ocular symptoms, highlighting the importance of monitoring eye health for those undergoing this acne treatment.
Notably, individuals who used contact lenses or were on higher doses of isotretinoin experienced worse symptoms. These findings remind us of the necessity to assess individual risk factors before starting treatment. Overall, while vitamin A in isotretinoin effectively addresses acne, it also brings potential ocular concerns that should not be overlooked.
As we learned, many participants faced issues such as dry eyes and blurry vision, which are known side effects of the treatment. Over half of current users reported severe ocular symptoms, highlighting the importance of monitoring eye health for those undergoing this acne treatment.
Notably, individuals who used contact lenses or were on higher doses of isotretinoin experienced worse symptoms. These findings remind us of the necessity to assess individual risk factors before starting treatment. Overall, while vitamin A in isotretinoin effectively addresses acne, it also brings potential ocular concerns that should not be overlooked.
References
- Abuallut II, Dibaji MQ, Assiri A, Mawkili W, Najmi AY, et al. Oral Isotretinoin-Associated Ocular Effects and Risk Factors: A Cross-Sectional Study. Clin Ophthalmol. 2024;18:4041. 10.2147/OPTH.S491757
- Yaqoubi WSAA, Touby SSJA, Hossain MA. Laboratory investigations of liver function and lipid profiles tests before and after oral isotretinoin treatment among Acne valgaris clients at Ibri Polyclinic: A retrospective study. Toxicol Rep. 2024;13:101799. 10.1016/j.toxrep.2024.101799
- Tort S, Öztürk ZC, Kaynak-Onurdağ F, Mutlu-Ağardan NB. Preparation and evaluation the effects of retinoic acid loaded proliposomal nanofibers on microbial biofilm inhibition. Pharm Dev Technol. 2024;29:955. 10.1080/10837450.2024.2411034
- Kulaklı S, Elmas Telli AC, Sarı İF, Oğuz ID, Kulaklı F. Increased femoral cartilage thickness in acne patients using isotretinoin: could it be a sign of early osteoarthritis?. Arch Dermatol Res. 2024;316:512. 10.1007/s00403-024-03264-x
- Powała K, Żołek T, Brown G, Kutner A. Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ. Int J Mol Sci. 2024;25. 10.3390/ijms25126568
- Hussein RS, Dayel SB, Abahussein O. Prospective study of the effects of isotretinoin and vitamin D levels on severe acne vulgaris. Turk J Med Sci. 2023;53:1732. 10.55730/1300-0144.5742
- Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. 10.1007/s00403-024-02895-4
- Shahpar A, Nezhad NZ, Sahaf AS, Ahramiyanpour N. A review of isotretinoin in the treatment of frontal fibrosing alopecia. J Cosmet Dermatol. 2024;23:1956. 10.1111/jocd.16245
- Demir EY, Köse ÖK. Effects of oral isotretinoin treatment for acne vulgaris patients on anger responses and the relationship with temperament. Rev Assoc Med Bras (1992). 2023;70:e20230592. 10.1590/1806-9282.20230592
- Cao J, Xu M, Zhu L, Xiao S. Viaminate Inhibits Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade. Curr Drug Targets. 2023;24:1055. 10.2174/0113894501243867230928115205
- Tsai MJ, Lin CY, Trousil J, Sung CT, Lee MH, et al. Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation. Int J Nanomedicine. 2023;18:3879. 10.2147/IJN.S416966
- Gurel A, Gurel G, Fırat F, Ozgul E, Turkoglu IND, et al. Effect of systemic isotretinoin therapy on semen parameters. Ann Med. 2023;55:2207038. 10.1080/07853890.2023.2207038
- Cook MK, Perche PO, Feldman SR. The use of oral vitamin A in acne management: a review. Dermatol Online J. 2022;28. 10.5070/D328559239
- Cao J, Xu M, Zhu L, Xiao S. Viaminate ameliorates Propionibacterium acnes-induced acne via inhibition of the TLR2/NF-κB and MAPK pathways in rats. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:1487. 10.1007/s00210-022-02379-0
- Kontzias C, Zaino M, Feldman SR. Tretinoin 0.1% and Benzoyl Peroxide 3% Cream for the Treatment of Facial Acne Vulgaris. Ann Pharmacother. 2023;57:1088. 10.1177/10600280221147338
- Kosmoski G, Miller D, Coret C, Atillasoy E. A Topical Combination Regimen of Benzoyl Peroxide and Retinol Moisturizer for Mild to Moderate Acne. J Drugs Dermatol. 2022;21:1340. 10.36849/JDD.6845
