' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 131 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
High relevance for acne treatment
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Read More
9
Isotretinoin aids acne treatment
A review of isotretinoin in the treatment of frontal fibrosing alopecia.
Direct relationship to acne treatment
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
Read More
9
Viaminate significantly improves acne
Viaminate Inhibits Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade.
Direct focus on acne treatment
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Read More
Most Useful Reviews
9.5
Improved skin health
As a longtime acne sufferer, I've tried everything from Accutane to various skincare products without success. In just a week of using this supplement, I saw tremendous improvement; my skin appears clearer, my pores are smaller, and I'm even comfortable without makeup for the first time. The reduction in acne is phenomenal, with noticeable changes in texture and tone. For better absorption, I take it with a healthy fat like coconut oil, which I highly recommend.
Read More
10
Life-changing results
This purchase was life-changing for me! I've spent so much money on washes, scrubs, and masks to treat my acne, seeing dermatologists without success. This vitamin has provided real results and even helped ease some symptoms related to my menstrual cycle. I'm thrilled I've finally found something that works!
Read More
10
Rapid improvement
Hello clear skin! I've suffered from bad breakouts and acne for a long time. I've tried everything from creams to acids with little success. Then I read that apricots are good for skin due to vitamin A, which inspired me to try taking it directly. After just two days, my skin cleared up, and I haven't had a breakout in about two weeks! It's the greatest feeling, and I owe it all to this product. If you have skin issues like mine, it could be a vitamin A deficiency, so do give this a go.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
9.5
Impact of Isotretinoin on Liver Function
Laboratory investigations of liver function and lipid profiles tests before and after oral isotretinoin treatment among Acne valgaris clients at Ibri Polyclinic: A retrospective study.
Moderate relevance to vitamin A effects
We conducted a retrospective study to understand how vitamin A, particularly in the form of oral isotretinoin, impacts acne treatment. This powerful medication is often prescribed for severe cases of acne that don’t respond to other treatments.
Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.
Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.
While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
Our research reviewed medical records of 50 patients aged between 13 and 40 years who received isotretinoin at Ibri Polyclinic from 2012 to 2022. Over the treatment period, we observed notable changes in liver function and lipid profiles among the patients.
Specifically, after treatment, there were increases in liver enzymes indicating changes in liver function, as well as fluctuations in cholesterol and triglyceride levels. These findings suggest potential risks associated with isotretinoin, highlighting the need for careful monitoring.
While isotretinoin does show effectiveness in treating severe acne, there’s an evident impact on liver health and lipid metabolism that we must consider when prescribing this medication. More research is necessary to fully unravel these effects and guide future treatments.
Read More
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
High relevance for acne treatment
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Read More
9
Retinoic acid's enhanced acne treatment
Preparation and evaluation the effects of retinoic acid loaded proliposomal nanofibers on microbial biofilm inhibition.
Study shows promising delivery method
We explored the effectiveness of retinoic acid, commonly known as vitamin A, for acne treatment using a unique delivery method that combines proliposomes and nanofibers. The goal was to assess how these specially formulated nanofibers, loaded with retinoic acid, could inhibit microbial biofilm formation, a common contributor to acne.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
In our study, we created various formulations of blank and retinoic acid-loaded proliposomal nanofibers. By using different ratios of polyvinylpyrrolidone, phosphatidylcholine, and cholesterol, we aimed to optimize the delivery system. Our findings showed that these formulations were able to form liposomes rapidly after hydration and had appropriate characteristics such as vesicle size and stability.
Notably, the ATRA (all-trans retinoic acid) loaded nanofibers demonstrated greater bioadhesion than a commercial cream, suggesting they may adhere better to the skin. The results indicated these nanofibers offered superior antibacterial and anti-biofilm effects compared to retinoic acid alone. This suggests that this innovative delivery method could enhance the effectiveness of vitamin A in acne treatment.
Overall, the study highlights the promising potential of combining nanofibers and liposomes to improve acne treatment outcomes, showing that vitamin A can be more effective when delivered using this advanced method.
Read More
9
Isotretinoin aids acne treatment
A review of isotretinoin in the treatment of frontal fibrosing alopecia.
Direct relationship to acne treatment
We investigated the impact of vitamin A, specifically isotretinoin, on acne through its use in treating frontal fibrosing alopecia (FFA). Our exploration included a comprehensive review of the available research, focusing on its effectiveness in alleviating symptoms related to acne, especially in the context of hair loss and facial papules.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
The analysis covered 15 relevant studies involving 232 FFA patients. Remarkably, nearly 90% of these individuals reported a significant reduction in symptoms after daily doses of 10-40 mg of isotretinoin. This indicates that vitamin A, in the form of isotretinoin, effectively addresses not only the physical manifestations of acne but also helps improve overall skin health.
Our findings suggest that isotretinoin holds promise as a treatment option, particularly for those struggling with the dual challenges of FFA and acne. While further research is warranted, the current evidence strongly supports its role in mitigating acne symptoms.
Read More
9
Viaminate significantly improves acne
Viaminate Inhibits Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade.
Direct focus on acne treatment
We explored how viaminate, a vitamin A acid treatment commonly used in acne therapy, impacts the skin. To investigate this, acne was induced in rat ears using a combination of acne bacteria and sebum. After 30 days of treatment, we saw a remarkable improvement in the thickening and keratin overproduction associated with acne.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Our analysis indicated that viaminate effectively modifies certain pathways related to skin cell behavior. Specifically, we observed a significant reduction in the expression of the S100A8 and S100A9 proteins, which are known to play a role in inflammation and skin proliferation. Furthermore, viaminate suppressed the activity of the MAPK pathway, which is vital for managing skin cell growth and differentiation.
Importantly, when we administered S100A8 and S100A9 proteins alongside viaminate, we found that this reversed its beneficial effects, highlighting the importance of these proteins in viaminate’s mechanism of action. Overall, our findings suggest that viaminate could serve as an effective option for treating acne by regulating cellular processes that contribute to its development.
Read More
User Reviews
USERS' SCORE
Good
Based on 131 Reviews
8.8
10
Life-changing results
SAVED MY LIFE. As a 24-year-old suffering from mild acne, I found myself becoming increasingly depressed after dealing with severe acne in my youth. My skin worsened despite dieting and eliminating certain allergens. After witnessing my sister's success with NOW brand vitamin A, I decided to try it myself. Initially, it caused a purge, but shortly after, my skin began to clear and heal. The fading of my red marks has made treatment easier, and I have regained the freedom to enjoy various foods. Though I avoid peanuts and eggs, the improvement in my acne has been so significant that minor breakouts become inconsequential. This vitamin A has truly transformed my life.
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10
Flawless skin
Breakouts Eliminated Flawless Complexion. After about a year on this supplement, I absolutely love it. It’s helped me prevent breakouts related to hormonal and stress factors, ensuring I maintain a flawless complexion. I also combine this with gentle care routines for my sensitive skin. I strongly recommend skipping harsher treatments like Accutane and trying this supplement for any serious acne issues.
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10
Dramatic improvement
An absolute life changer! Despite having great success with Accutane in my 20s, I faced a resurgence of cystic acne at 42. My experience with this product has been phenomenal. I take four capsules daily, and after three months, I am entirely clear. My sunspots have improved dramatically, and I rarely experience breakouts. This product has surpassed my expectations; I can now confidently go without foundation.
Read More
10
Rapid improvement
Hello clear skin! I've suffered from bad breakouts and acne for a long time. I've tried everything from creams to acids with little success. Then I read that apricots are good for skin due to vitamin A, which inspired me to try taking it directly. After just two days, my skin cleared up, and I haven't had a breakout in about two weeks! It's the greatest feeling, and I owe it all to this product. If you have skin issues like mine, it could be a vitamin A deficiency, so do give this a go.
Read More
10
Miracle cure
Eye strain? Bad skin, chronic acne? This is the answer. My experience with vitamin A has been remarkable. Every time I face skin issues, I take a high dose for a week or two, and the problems vanish. In my early 20s, very high doses literally cured my acne. Although overdosing is easy and it's essential to monitor intake, vitamin A has genuinely worked wonders for me.
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