Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 19 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
Read More
Most Useful Reviews
9
Significant mucous improvement
26 people found this helpful
Despite consuming greens, my mucous membranes remained problematic for years. Once I increased my vitamin A intake, all my issues, including angular cheilitis and nosebleeds, significantly improved. While some studies question the efficacy of supplements, I believe in their power and will continue to use them for my autoimmune disorder.
Read More
9
Skin condition improved
7 people found this helpful
For my rare skin disorder, I found a suitable vitamin A supplement. After starting this product, my skin has noticeably improved—no longer dry or acne-prone. This vitamin A has been the solution I needed for my autoimmune disorder, and I truly appreciate its effects.
Read More
9
Skin problem relief
3 people found this helpful
I ordered this vitamin for a colleague with chronic skin issues who had seen no improvement with treatments from her dermatologist. After taking these vitamins with vitamin C and zinc, her skin has cleared up significantly. She's thrilled with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant mucous improvement
26 people found this helpful
Despite consuming greens, my mucous membranes remained problematic for years. Once I increased my vitamin A intake, all my issues, including angular cheilitis and nosebleeds, significantly improved. While some studies question the efficacy of supplements, I believe in their power and will continue to use them for my autoimmune disorder.
Read More
9
Skin condition improved
7 people found this helpful
For my rare skin disorder, I found a suitable vitamin A supplement. After starting this product, my skin has noticeably improved—no longer dry or acne-prone. This vitamin A has been the solution I needed for my autoimmune disorder, and I truly appreciate its effects.
Read More
9
Skin problem relief
3 people found this helpful
I ordered this vitamin for a colleague with chronic skin issues who had seen no improvement with treatments from her dermatologist. After taking these vitamins with vitamin C and zinc, her skin has cleared up significantly. She's thrilled with the results.
Read More
7.5
Effective treatment noted
47 people found this helpful
I had persistent dryness in my nasal passages and throat, and eventually learned I had an autoimmune disorder. After taking vitamin A, I noticed significant improvements in my skin, mucous membranes, and overall well-being. My menstrual flow also decreased, and my symptoms lessened. It appears that having sufficient vitamin A is crucial for managing my condition.
Read More
8
Convenient skin treatment
26 people found this helpful
I was prescribed a therapeutic dose of vitamin A for my autoimmune disorder regarding skin post-acne and hyperkeratosis. This capsule form is much more convenient than liquid. Over time, my skin has dried less, appeared more even, and blemishes have become rare. I have noticed improvements in my skin as well as no side effects.
Read More
Frequently Asked Questions
7.5
Acne reduction
1 people found this helpful
I've been using this for four months and have noticed a benefit for my acne. The large bottle lasts a long time, and I appreciate that there's no taste. Just pure vitamin A and great quality.
7.5
Effective treatment noted
47 people found this helpful
I had persistent dryness in my nasal passages and throat, and eventually learned I had an autoimmune disorder. After taking vitamin A, I noticed significant improvements in my skin, mucous membranes, and overall well-being. My menstrual flow also decreased, and my symptoms lessened. It appears that having sufficient vitamin A is crucial for managing my condition.
8
Convenient skin treatment
26 people found this helpful
I was prescribed a therapeutic dose of vitamin A for my autoimmune disorder regarding skin post-acne and hyperkeratosis. This capsule form is much more convenient than liquid. Over time, my skin has dried less, appeared more even, and blemishes have become rare. I have noticed improvements in my skin as well as no side effects.
9
Significant mucous improvement
26 people found this helpful
Despite consuming greens, my mucous membranes remained problematic for years. Once I increased my vitamin A intake, all my issues, including angular cheilitis and nosebleeds, significantly improved. While some studies question the efficacy of supplements, I believe in their power and will continue to use them for my autoimmune disorder.
9
Skin condition improved
7 people found this helpful
For my rare skin disorder, I found a suitable vitamin A supplement. After starting this product, my skin has noticeably improved—no longer dry or acne-prone. This vitamin A has been the solution I needed for my autoimmune disorder, and I truly appreciate its effects.
9
Skin problem relief
3 people found this helpful
I ordered this vitamin for a colleague with chronic skin issues who had seen no improvement with treatments from her dermatologist. After taking these vitamins with vitamin C and zinc, her skin has cleared up significantly. She's thrilled with the results.
7.5
Cognitive function enhanced
3 people found this helpful
After taking this vitamin, I've observed a positive change in my cognitive function. To avoid overconsumption of vitamin A, I only take it every other day, which still seems effective in assisting my autoimmune disorder.
7.5
Effective for disease
1 people found this helpful
A high dosage of this vitamin A is suitable for individuals with gastrointestinal issues like Crohn's disease or other serious conditions related to autoimmune disorders. I use 25,000 IU during illness and 10,000 IU for prevention.
0
Dosage concerns
I ordered vitamin A at 25,000 IU, but I've learned that the recommended daily dose is 5,000 IU, with anything over 10,000 IU being possibly toxic. I'm curious why such high doses are available and who they’re intended for, especially regarding autoimmune disorders.
7.5
Eye health improvement
2 people found this helpful
Great! Both my eyes and skin benefit from this. I find it significantly helps with eye moisture, especially after yawning. My night vision has improved, and it helps delay the fundus damage caused by my autoimmune disorder. My skin also appears smoother, although high doses can cause itchiness. If unsure, I recommend a safer dose of 10,000 units.
7
This study evaluated whether adding formic acid could improve treatments for rheumatoid arthritis (RA) in children. We assessed 90 children with RA, splitting them into two groups—one receiving traditional medications and the other receiving those same medications plus all-trans retinoic acid.
After follow-ups at six months and one year, our analysis showed that the addition of all-trans retinoic acid seemed to enhance the overall effectiveness of the treatments the children received. It’s a promising prospect for improving RA management.
After follow-ups at six months and one year, our analysis showed that the addition of all-trans retinoic acid seemed to enhance the overall effectiveness of the treatments the children received. It’s a promising prospect for improving RA management.
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
8
We explored how vitamins A and D impact multiple sclerosis by examining their effects in a mouse model. By injecting these vitamins prior to inducing disease, we observed a notable reduction in disease severity.
The treatment led to fewer Th17 cells and decreased inflammation markers in the mice’s tissues. Additionally, levels of certain microRNAs were significantly increased, suggesting a mechanism through which these vitamins may act to suppress Th17 development.
Overall, vitamins A and D appear to have a promising role in reducing neuroinflammation linked to autoimmune disorders like multiple sclerosis.
The treatment led to fewer Th17 cells and decreased inflammation markers in the mice’s tissues. Additionally, levels of certain microRNAs were significantly increased, suggesting a mechanism through which these vitamins may act to suppress Th17 development.
Overall, vitamins A and D appear to have a promising role in reducing neuroinflammation linked to autoimmune disorders like multiple sclerosis.
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
References
- Cao TT, Ma JL, Zhang Y, Peng JW, Lin H. Efficacy of formic acid in combination with cDMARDs in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2024;28:4366. doi:10.26355/eurrev_202410_36831
- Ni Y, Cao Y, Qiu Y, Li Y. Association between dietary retinol intake and rheumatoid arthritis based on NHANES database. BMC Public Health. 2024;24:2167. doi:10.1186/s12889-024-19620-5
- Zhang Y, Shi J, Xie Y, Shao H, Ning Y, et al. Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy. Clin Exp Rheumatol. 2024;42:1387. doi:10.55563/clinexprheumatol/3pd9rp
- Banaeeyeh S, Afkhami-Goli A, Moosavi Z, Razavi BM, Hosseinzadeh H. Anti-inflammatory, antioxidant and anti-mitophagy effects of trans sodium crocetinate on experimental autoimmune encephalomyelitis in BALB/C57 mice. Metab Brain Dis. 2024;39:783. doi:10.1007/s11011-024-01349-0
- Asgari F, Nikzamir A, Baghaei K, Salami S, Masotti A, et al. Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients. Inflammation. 2024;47:1706. doi:10.1007/s10753-024-02004-7
- Wørzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, et al. Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype. J Autoimmun. 2024;144:103174. doi:10.1016/j.jaut.2024.103174
- Nehzat N, Browne RW, Ghazal D, Tamaño-Blanco M, Jakimovski D, et al. Exploratory 5-year follow-up study of retinol, tocopherols, and carotenoids in multiple sclerosis. Mult Scler Relat Disord. 2024;81:105143. doi:10.1016/j.msard.2023.105143
- Uozumi T, Serizawa N, Hagino T, Morita T, Mizuno M, et al. Dietary habits in Japanese patients with bullous pemphigoid: low intake of retinol. Eur J Dermatol. 2023;33:394. doi:10.1684/ejd.2023.4527
- Mohammadi-Kordkhayli M, Sahraian MA, Ghorbani S, Mansouri F, Talebi F, et al. Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2023;60:5853. doi:10.1007/s12035-023-03427-3
- Yang J, Zhao L, Wang W, Wu Y. All-trans retinoic acid added to treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Ann Hematol. 2023;102:1695. doi:10.1007/s00277-023-05263-w
- Moura RP, Carvalho ED, Martins C, des Rieux A, Pêgo AP, et al. Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders. J Control Release. 2023;358:43. doi:10.1016/j.jconrel.2023.04.034
- McBride DA, Kerr MD, Johnson WT, Nguyen A, Zoccheddu M, et al. Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis. Adv Sci (Weinh). 2023;10:e2202720. doi:10.1002/advs.202202720
- Sun R, Yang M, Lin C, Wu Y, Sun J, et al. A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome. BMC Ophthalmol. 2023;23:72. doi:10.1186/s12886-023-02805-8
- Abdelhamid L, Alajoleen R, Kingsmore KM, Cabana-Puig X, Lu R, et al. Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity. Immunohorizons. 2023;7:17. doi:10.4049/immunohorizons.2200015
- Nasl-Khameneh AM, Mirshafiey A, Moghadasi AN, Yekaninejad MS, Parastouei K, et al. The immunomodulatory effects of all-trans retinoic acid and docosahexaenoic acid combination treatment on the expression of IL-2, IL-4, T-bet, and GATA3 genes in PBMCs of multiple sclerosis patients. Neurol Res. 2023;45:510. doi:10.1080/01616412.2022.2162222
- Deng C, Zhao X, Chen Y, Ai K, Zhang Y, et al. Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis. ACS Nano. 2022;16:18430. doi:10.1021/acsnano.2c06584
