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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 9 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
High relevance to hypothyroidism
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Read More
8
Vitamin A's role in thyroid health
Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size.
Addresses vitamin A in hypothyroidism
We explored the impact of vitamin A supplementation on hypothyroidism in the context of concurrent vitamin A and iodine deficiencies. In our study, we used weanling rats, some of whom were fed diets lacking both vitamin A and iodine for 30 days before we administered treatments. This allowed us to set up a clear comparison between the effects of vitamin A alone, iodine alone, and combinations of both against a control group that received a nutrient-rich diet.
After we deprived the rats of these crucial nutrients, we repleted them with iodine and/or vitamin A for 10 days. What we found was quite interesting: while high doses of vitamin A restored serum retinol levels to normal, the key effects on thyroid function were observed mainly in the iodine-deficient rats. Here, vitamin A supplementation led to decreased production of thyroid-stimulating hormone (TSH) from the pituitary gland, effectively reducing thyroid stimulation and size without significantly altering circulating thyroid hormone levels.
Conversely, in rats that received sufficient iodine, vitamin A didn’t have any noticeable impact on the thyroid-pituitary function, indicating that the thyroid responses were largely dictated by iodine presence. Overall, our results suggest that vitamin A can modify thyroid hyperactivity caused by iodine deficiency, emphasizing its role in managing such deficiencies, even when iodine is not adequate. We observed that vitamin A’s influence might operate through its effects on pituitary TSHbeta gene expression—a point worthy of further exploration.
After we deprived the rats of these crucial nutrients, we repleted them with iodine and/or vitamin A for 10 days. What we found was quite interesting: while high doses of vitamin A restored serum retinol levels to normal, the key effects on thyroid function were observed mainly in the iodine-deficient rats. Here, vitamin A supplementation led to decreased production of thyroid-stimulating hormone (TSH) from the pituitary gland, effectively reducing thyroid stimulation and size without significantly altering circulating thyroid hormone levels.
Conversely, in rats that received sufficient iodine, vitamin A didn’t have any noticeable impact on the thyroid-pituitary function, indicating that the thyroid responses were largely dictated by iodine presence. Overall, our results suggest that vitamin A can modify thyroid hyperactivity caused by iodine deficiency, emphasizing its role in managing such deficiencies, even when iodine is not adequate. We observed that vitamin A’s influence might operate through its effects on pituitary TSHbeta gene expression—a point worthy of further exploration.
Read More
7
Vitamin A and thyroid health
[Relationship of vitamin A and thyroid function in Arctic residents].
Moderate relevance to treatment impact
We explored the link between vitamin A levels and thyroid health in residents of the Arctic region of Russia. Our study involved examining 304 healthy individuals, focusing on how gender influenced vitamin A serum levels and thyroid hormone profiles.
We found that the average vitamin A concentration was about 1.97 μmol/l, with women exhibiting significantly lower levels than men. In fact, women with vitamin A levels below 1.39 μmol/l faced a doubled risk of developing subclinical hypothyroidism—an early stage of thyroid dysfunction. Interestingly, higher vitamin A levels in men were associated with lower thyroxine levels, which suggests complex interactions between vitamin A and thyroid function.
While the vitamin A levels among Arctic inhabitants generally fell within normal limits, a notable 24.3% of men had higher-than-normal levels. This variability points to important differences in how vitamin A may influence thyroid health between genders. Our findings prompt a closer look at dietary vitamin A as a potential factor in thyroid disease management, particularly highlighting the need for further research to understand these dynamics.
We found that the average vitamin A concentration was about 1.97 μmol/l, with women exhibiting significantly lower levels than men. In fact, women with vitamin A levels below 1.39 μmol/l faced a doubled risk of developing subclinical hypothyroidism—an early stage of thyroid dysfunction. Interestingly, higher vitamin A levels in men were associated with lower thyroxine levels, which suggests complex interactions between vitamin A and thyroid function.
While the vitamin A levels among Arctic inhabitants generally fell within normal limits, a notable 24.3% of men had higher-than-normal levels. This variability points to important differences in how vitamin A may influence thyroid health between genders. Our findings prompt a closer look at dietary vitamin A as a potential factor in thyroid disease management, particularly highlighting the need for further research to understand these dynamics.
Read More
Most Useful Reviews
9.5
Improved vitamin levels
Working drug! My doctor said, "Vitamin A is essential for your mucous membranes." My vitamin A levels have significantly increased, which is crucial for someone with hypothyroidism. The capsules are small and easy to take; I also ensure to take them with fats for better absorption.
Read More
9.5
Remarkable symptom relief
A great product for both my son and I. After taking it for a month, my dry skin issues vanish, as do my son's acne and peeling skin. Many suffer for years without realising the cause may be a vitamin A deficiency.
Read More
9.5
Effective therapy aid
I'm very satisfied with this vitamin, which I purchased for my hypothyroidism therapy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
High relevance to hypothyroidism
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Read More
9
Keratoconjunctivitis and hypothyroidism in horses
Keratoconjunctivitis sicca attributable to parasympathetic facial nerve dysfunction associated with hypothyroidism in a horse.
Moderate relevance; treatment not isolated
We observed a case of a German Warmblood gelding exhibiting signs of keratoconjunctivitis sicca and other neurological symptoms, which were ultimately linked to hypothyroidism. As part of the treatment for this condition, vitamin A ointment was applied topically to the horse's eyes, alongside other therapies.
While vitamin A is traditionally known for its role in maintaining healthy eyes, the specific effectiveness of vitamin A in treating hypothyroidism remains unclear in this case. The primary treatment involved levothyroxine, which significantly improved the horse's thyroid function and correlated with the resolution of many clinical signs, including the eye issues.
Thus, while vitamin A was included in the treatment regimen, its distinct impact on the overall condition cannot be confidently isolated from the benefits observed with levothyroxine therapy. This underscores the need for more controlled studies to better understand the interplay between vitamin A and thyroid health.
While vitamin A is traditionally known for its role in maintaining healthy eyes, the specific effectiveness of vitamin A in treating hypothyroidism remains unclear in this case. The primary treatment involved levothyroxine, which significantly improved the horse's thyroid function and correlated with the resolution of many clinical signs, including the eye issues.
Thus, while vitamin A was included in the treatment regimen, its distinct impact on the overall condition cannot be confidently isolated from the benefits observed with levothyroxine therapy. This underscores the need for more controlled studies to better understand the interplay between vitamin A and thyroid health.
Read More
8
Vitamin A supports thyroid function
Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis.
Moderate relevance to hypothyroidism
We explored the relationship between vitamin A deficiency (VAD) and hypothyroidism, particularly how these deficiencies impact the pituitary-thyroid axis in the body. Our understanding comes from various studies, including those involving children in Africa, where VAD combined with iodine deficiency disorders (IDD) often leads to unique hormonal responses.
In children suffering from both VAD and IDD, we observed that higher levels of thyroid-stimulating hormone (TSH) may actually help in preventing hypothyroidism, despite existing conditions. Interestingly, research in rats showed that moderate VAD alone did not significantly affect the pituitary-thyroid axis. However, when VAD accompanies iodine deficiency, it can lead to more serious cases of primary hypothyroidism than iodine deficiency on its own.
When it comes to treatment, we noted that high doses of vitamin A could correct thyroid dysfunction caused by iodine deficiency. Therefore, while vitamin A does play a role, it doesn't diminish the effectiveness of iodine repletion. Our findings suggest that vitamin A supplementation can help manage thyroid stimulation, especially in individuals affected by both deficiencies.
Thus, we can conclude that while vitamin A isn’t a standalone solution for hypothyroidism, it certainly plays a supportive role in improving treatment outcomes when iodine levels are restored.
In children suffering from both VAD and IDD, we observed that higher levels of thyroid-stimulating hormone (TSH) may actually help in preventing hypothyroidism, despite existing conditions. Interestingly, research in rats showed that moderate VAD alone did not significantly affect the pituitary-thyroid axis. However, when VAD accompanies iodine deficiency, it can lead to more serious cases of primary hypothyroidism than iodine deficiency on its own.
When it comes to treatment, we noted that high doses of vitamin A could correct thyroid dysfunction caused by iodine deficiency. Therefore, while vitamin A does play a role, it doesn't diminish the effectiveness of iodine repletion. Our findings suggest that vitamin A supplementation can help manage thyroid stimulation, especially in individuals affected by both deficiencies.
Thus, we can conclude that while vitamin A isn’t a standalone solution for hypothyroidism, it certainly plays a supportive role in improving treatment outcomes when iodine levels are restored.
Read More
8
Vitamin A's role in thyroid health
Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size.
Addresses vitamin A in hypothyroidism
We explored the impact of vitamin A supplementation on hypothyroidism in the context of concurrent vitamin A and iodine deficiencies. In our study, we used weanling rats, some of whom were fed diets lacking both vitamin A and iodine for 30 days before we administered treatments. This allowed us to set up a clear comparison between the effects of vitamin A alone, iodine alone, and combinations of both against a control group that received a nutrient-rich diet.
After we deprived the rats of these crucial nutrients, we repleted them with iodine and/or vitamin A for 10 days. What we found was quite interesting: while high doses of vitamin A restored serum retinol levels to normal, the key effects on thyroid function were observed mainly in the iodine-deficient rats. Here, vitamin A supplementation led to decreased production of thyroid-stimulating hormone (TSH) from the pituitary gland, effectively reducing thyroid stimulation and size without significantly altering circulating thyroid hormone levels.
Conversely, in rats that received sufficient iodine, vitamin A didn’t have any noticeable impact on the thyroid-pituitary function, indicating that the thyroid responses were largely dictated by iodine presence. Overall, our results suggest that vitamin A can modify thyroid hyperactivity caused by iodine deficiency, emphasizing its role in managing such deficiencies, even when iodine is not adequate. We observed that vitamin A’s influence might operate through its effects on pituitary TSHbeta gene expression—a point worthy of further exploration.
After we deprived the rats of these crucial nutrients, we repleted them with iodine and/or vitamin A for 10 days. What we found was quite interesting: while high doses of vitamin A restored serum retinol levels to normal, the key effects on thyroid function were observed mainly in the iodine-deficient rats. Here, vitamin A supplementation led to decreased production of thyroid-stimulating hormone (TSH) from the pituitary gland, effectively reducing thyroid stimulation and size without significantly altering circulating thyroid hormone levels.
Conversely, in rats that received sufficient iodine, vitamin A didn’t have any noticeable impact on the thyroid-pituitary function, indicating that the thyroid responses were largely dictated by iodine presence. Overall, our results suggest that vitamin A can modify thyroid hyperactivity caused by iodine deficiency, emphasizing its role in managing such deficiencies, even when iodine is not adequate. We observed that vitamin A’s influence might operate through its effects on pituitary TSHbeta gene expression—a point worthy of further exploration.
Read More
8
Retinoic acid supports brain health
Retinoic acid reverses the PTU related decrease in neurogranin level in mice brain.
Moderate relevance to vitamin A effect
We explored the effects of retinoic acid (RA) on brain function in a model of mild hypothyroidism induced by propylthiouracil (PTU) in mice. This research sought to understand whether RA could counteract the decline in certain brain markers associated with thyroid hormone changes, specifically neurogranin, which is linked to brain plasticity and cognitive function.
In the study, we observed that the administration of RA helped restore the expression of several key receptors and neurogranin levels that had decreased due to PTU treatment. Specifically, both RA and the thyroid hormone triiodothyronine (T3) were effective in reversing reductions in receptor expression, suggesting that RA has a beneficial impact under conditions of mild hypothyroidism.
We were careful to note that while RA showed potential in normalizing some brain functions, the exact mechanisms and broader implications of this treatment warrant further exploration. These findings provide exciting insights into how retinoic acid may play a role in brain health, especially in the context of thyroid hormone related changes that can occur as we age.
In the study, we observed that the administration of RA helped restore the expression of several key receptors and neurogranin levels that had decreased due to PTU treatment. Specifically, both RA and the thyroid hormone triiodothyronine (T3) were effective in reversing reductions in receptor expression, suggesting that RA has a beneficial impact under conditions of mild hypothyroidism.
We were careful to note that while RA showed potential in normalizing some brain functions, the exact mechanisms and broader implications of this treatment warrant further exploration. These findings provide exciting insights into how retinoic acid may play a role in brain health, especially in the context of thyroid hormone related changes that can occur as we age.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.8
9.5
Improved vitamin levels
Working drug! My doctor said, "Vitamin A is essential for your mucous membranes." My vitamin A levels have significantly increased, which is crucial for someone with hypothyroidism. The capsules are small and easy to take; I also ensure to take them with fats for better absorption.
Read More
9.5
Remarkable symptom relief
A great product for both my son and I. After taking it for a month, my dry skin issues vanish, as do my son's acne and peeling skin. Many suffer for years without realising the cause may be a vitamin A deficiency.
9.5
Effective therapy aid
I'm very satisfied with this vitamin, which I purchased for my hypothyroidism therapy.
9.5
Strengthened immune system
A superb vitamin A at an excellent dosage, which aids my immune system while managing hypothyroidism effectively.
9.5
Essential vitamin intake
For those with hypothyroidism, regular intake of vitamin A is crucial due to poor absorption from food.
