Glutamine reduces IBS-D symptomsRandomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.
Most Relevant Research
We examined the potential of l-glutamine as a treatment for postinfectious irritable bowel syndrome, specifically focusing on patients who experience diarrhea as a primary symptom. This study was a well-structured, randomized, double-blind, placebo-controlled trial that lasted for eight weeks.
Participants were divided into two groups, receiving either 5 grams of glutamine three times a day or a placebo. We aimed to track significant improvements in IBS symptoms, particularly looking for a reduction of at least 50 points on the Irritable Bowel Syndrome Severity Scoring System (IBS-SS).
Remarkably, we found that an impressive 79.6% of patients taking glutamine met this primary endpoint, compared to just 5.8% in the placebo group—which is a 14-fold difference! Alongside this, glutamine also positively impacted secondary outcomes like daily bowel movement frequency, stool consistency, and even normalized intestinal permeability.
The results suggest that oral dietary glutamine appears to be a safe and effective option for relieving IBS symptoms related to intestinal hyperpermeability following an infection. While the findings are promising, we recommend further large-scale trials to verify these benefits and explore underlying mechanisms.
Pain alleviation
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