Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Glutamine (Free-Form)
1 g (1,000 mg)
**
Top Medical Research Studies
9
Glutamine mouthwash reduces mucositis
We assessed how glutamine mouthwash stacks up against standard oral hygiene practices in kids with acute lymphoblastic leukemia undergoing high-dose methotrexate treatment.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
Read More
7
We examined how glutamine impacts cancer treatment and the immune system. Glutamine, the most abundant amino acid in our blood, is vital for cancer cell growth. It fuels immune cell functions that can help combat cancer.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Read More
8
We observed the effects of amino acids, particularly glutamine, glycine, and serine, on chemotherapy sensitivity in gastric cancer cells. By studying 20 amino acids, we found that higher concentrations of these nutrients can improve how well these cancer cells respond to cisplatin—a common chemotherapy agent. This happens because these amino acids can help break down a protein called KDM4A, which otherwise helps cancer cells survive chemotherapy. Although promising, more research is needed to fully understand how nutrition therapy can help gastric cancer patients during treatment.
Read More
Most Useful Reviews
9
Minimises mouth pain
1 people found this helpful
The doctor advises taking this during chemotherapy to prevent mouth injuries. The pills are quite large, requiring me to take ten at once, twice daily, but they are effective.
Read More
9
Effective for side effects
1 people found this helpful
This product is very effective in alleviating side effects after chemotherapy for family members. For friends who hesitate to take powder, capsules present a fine alternative.
Read More
6
Improves chemotherapy recovery
Excellent! Following chemotherapy, doctors recommend these ingredients to improve its aftereffects.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Glutamine mouthwash reduces mucositis
We assessed how glutamine mouthwash stacks up against standard oral hygiene practices in kids with acute lymphoblastic leukemia undergoing high-dose methotrexate treatment.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
Read More
8
We observed the effects of amino acids, particularly glutamine, glycine, and serine, on chemotherapy sensitivity in gastric cancer cells. By studying 20 amino acids, we found that higher concentrations of these nutrients can improve how well these cancer cells respond to cisplatin—a common chemotherapy agent. This happens because these amino acids can help break down a protein called KDM4A, which otherwise helps cancer cells survive chemotherapy. Although promising, more research is needed to fully understand how nutrition therapy can help gastric cancer patients during treatment.
Read More
7
Targeting glutamine in colorectal cancer
We explored a phase I/II trial investigating how targeting glutamine metabolism alongside EGFR inhibition could influence treatment outcomes for metastatic colorectal cancer (mCRC). Our findings indicated that while the combination treatment was tolerable and showed some promising responses, including two patients achieving partial response, the study was halted early due to the termination of one drug's development.
Interestingly, the B-cell activation signature "B-score" surfaced as a potential biomarker for treatment response, prompting further investigations into enhancing therapies for tumors reliant on glutamine metabolism.
Interestingly, the B-cell activation signature "B-score" surfaced as a potential biomarker for treatment response, prompting further investigations into enhancing therapies for tumors reliant on glutamine metabolism.
Read More
7
We examined how glutamine impacts cancer treatment and the immune system. Glutamine, the most abundant amino acid in our blood, is vital for cancer cell growth. It fuels immune cell functions that can help combat cancer.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Minimises mouth pain
1 people found this helpful
The doctor advises taking this during chemotherapy to prevent mouth injuries. The pills are quite large, requiring me to take ten at once, twice daily, but they are effective.
Read More
9
Effective for side effects
1 people found this helpful
This product is very effective in alleviating side effects after chemotherapy for family members. For friends who hesitate to take powder, capsules present a fine alternative.
Read More
6
Improves chemotherapy recovery
Excellent! Following chemotherapy, doctors recommend these ingredients to improve its aftereffects.
Read More
7.5
Reduces mouth ulcers
Very good! This can significantly aid friends undergoing chemotherapy by reducing the risk of developing mouth ulcers.
Read More
Frequently Asked Questions
9
Effective for side effects
1 people found this helpful
This product is very effective in alleviating side effects after chemotherapy for family members. For friends who hesitate to take powder, capsules present a fine alternative.
6
Improves chemotherapy recovery
Excellent! Following chemotherapy, doctors recommend these ingredients to improve its aftereffects.
9
Minimises mouth pain
1 people found this helpful
The doctor advises taking this during chemotherapy to prevent mouth injuries. The pills are quite large, requiring me to take ten at once, twice daily, but they are effective.
7.5
Reduces mouth ulcers
Very good! This can significantly aid friends undergoing chemotherapy by reducing the risk of developing mouth ulcers.
References
- Sankaran SS, Dewan P, Malhotra RK, Harit D, Kashyap B, et al. Glutamine Mouthwash for Preventing Methotrexate-Induced Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Cross-Over Trial. Indian Pediatr. 2025;62:269. doi:10.1007/s13312-025-00042-4
- Ciombor KK, Bae SW, Whisenant JG, Ayers GD, Sheng Q, et al. Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer. Clin Cancer Res. 2025;31:1437. doi:10.1158/1078-0432.CCR-24-3133
- Nan D, Yao W, Huang L, Liu R, Chen X, et al. Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets. Cell Commun Signal. 2025;23:45. doi:10.1186/s12964-024-02018-6
- Fu J, Ni Y, Hu Y, Tang W, Fu J, et al. Glutamine, Serine and Glycine at Increasing Concentrations Regulate Cisplatin Sensitivity in Gastric Cancer by Posttranslational Modifications of KDM4A. Mol Carcinog. 2025;64:703. doi:10.1002/mc.23881
