Overview
Top Medical Research Studies
Over 8 and 12 weeks, we observed virtually no harmful cell changes in taurine-treated groups. Additionally, when retinal cells were exposed to high glucose conditions, taurine effectively reduced apoptosis across various concentrations. This suggests that taurine not only protects against cell death but also boosts the expression of a crucial taurine transporter in diabetic conditions.
PTER serves as a crucial hydrolase, breaking down N-acetyltaurine into taurine and acetate. We discovered that when PTER is genetically removed in mice, there's a noticeable increase in N-acetyltaurine levels. This change dramatically affects the creatures' dietary habits and weight management, as these knockout mice showed reduced food intake and resented gaining weight, even when offered a high-calorie diet.
Additionally, administering N-acetyltaurine to healthy mice led to a reduction in their food consumption and overall body weight. These findings tie PTER and N-acetyltaurine into the larger narrative of how taurine influences energy balance and weight control, making them significant to understanding our metabolism and the management of obesity.
Our analysis included both morphological and functional assessments, revealing that taurine not only ameliorated damage but also promoted neurite outgrowth in neurons exposed to high glucose levels. This suggests that taurine could play a beneficial role in repairing neural injuries associated with diabetes.
We also noted that taurine boosts the expression of nerve growth factor (NGF) and GAP-43, essential proteins for nerve growth and repair. The observed improvements seem linked to the activation of specific signaling pathways, namely the NGF-pAkt-mTOR axis. Interestingly, blocking this pathway with certain inhibitors dampened the positive effects of taurine, highlighting its crucial role in the protection and repair of neural tissues in diabetic conditions.
Overall, our findings indicate that taurine could be a promising therapeutic agent for enhancing spinal cord recovery from diabetic-induced injuries, providing hope for better management of diabetic neuropathy.
Most Useful Reviews
Medical Researches
- All Researches
In a study with ten participants, we noted that higher doses of taurocholate led to significant increases in GLP-1, PYY, and insulin levels.
Remarkably, plasma glucose levels dropped, and participants consumed up to 47% less food after treatment.
This suggests that therapies boosting bile salts might help manage diabetes and obesity effectively.
Over 8 and 12 weeks, we observed virtually no harmful cell changes in taurine-treated groups. Additionally, when retinal cells were exposed to high glucose conditions, taurine effectively reduced apoptosis across various concentrations. This suggests that taurine not only protects against cell death but also boosts the expression of a crucial taurine transporter in diabetic conditions.
By using microneedle technology, these patches ensure that the beneficial components penetrate deep into the wound tissue. This method enhances the effectiveness of taurine, allowing it to help reduce oxidative stress and low-level inflammation commonly associated with non-healing diabetic wounds.
Our findings revealed that these specially designed patches not only stimulate healing but also improve the overall immune environment, making it easier for the body to repair damaged tissue. Ultimately, the approach harnesses taurine's antioxidant and anti-inflammatory properties, showing promising results in facilitating wound closure in diabetic patients.
Overall, the study highlights the potential of combining taurine with advanced delivery methods in overcoming obstacles to effective diabetic wound healing.
PTER serves as a crucial hydrolase, breaking down N-acetyltaurine into taurine and acetate. We discovered that when PTER is genetically removed in mice, there's a noticeable increase in N-acetyltaurine levels. This change dramatically affects the creatures' dietary habits and weight management, as these knockout mice showed reduced food intake and resented gaining weight, even when offered a high-calorie diet.
Additionally, administering N-acetyltaurine to healthy mice led to a reduction in their food consumption and overall body weight. These findings tie PTER and N-acetyltaurine into the larger narrative of how taurine influences energy balance and weight control, making them significant to understanding our metabolism and the management of obesity.
Our findings showed that these special hydrogel dressings not only supported better biodegradation and biocompatibility, but they also encouraged healing processes like angiogenesis—the formation of new blood vessels. The inclusion of taurine appears to have anti-inflammatory properties and promotes the movement and growth of cells essential for healing.
Importantly, tests on mice demonstrated that these dressings significantly improved wound healing in both acute and chronic diabetic conditions. We observed that the sustained release of taurine from the hydrogels has great potential for clinical applications in treating various types of wounds, making our study an exciting step forward in wound care.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Diabetes is a chronic medical condition that occurs when the body either does not produce enough insulin or cannot effectively use the insulin it produces. Insulin is a hormone made by the pancreas that helps glucose from food enter the cells, providing them with energy. When diabetes is present, it leads to elevated levels of glucose in the blood, which can cause serious health complications if left unmanaged. There are primarily two types: Type 1 diabetes, which is an autoimmune condition where the body attacks insulin-producing cells, and Type 2 diabetes, which is often associated with lifestyle factors such as obesity and lack of physical activity, leading to insulin resistance.
Managing diabetes typically involves a combination of lifestyle changes, such as a balanced diet and regular exercise, along with monitoring blood sugar levels and, in many cases, medication or insulin therapy. Education is crucial for those with diabetes to understand how their condition works and how to manage it effectively. The goal of diabetes management is to keep blood sugar levels within a target range, helping to prevent complications such as heart disease, nerve damage, and kidney failure. Regular check-ups and consultations with healthcare professionals are essential to ensure optimal care.
L-Taurine is a sulfonic acid and an amino acid often categorized as a conditionally essential amino acid due to its important roles in various bodily functions. Unlike most amino acids, L-Taurine is not used to synthesize proteins but is critical for several physiological processes, including bile salt formation, osmoregulation, and antioxidant defense. It’s naturally found in high concentrations in the brain, muscles, heart, and blood, playing a vital role in cardiovascular health and the maintenance of neurological function.
L-Taurine is often included in dietary supplements and energy drinks due to its potential benefits, such as enhancing exercise performance, improving recovery, and supporting overall energy levels. While the body can produce taurine from other amino acids like cysteine, some people may choose to supplement with it, particularly athletes or those seeking additional health benefits. As always, it's important to consult with a healthcare provider before starting any new supplement regimen to ensure safety and appropriateness for your individual health needs.
There is some emerging evidence suggesting that L-Taurine may have beneficial effects for individuals with diabetes, though it is not a cure or primary treatment. L-Taurine, an amino acid found in various foods and produced naturally in the body, has shown properties that could potentially aid in glucose regulation and improve insulin sensitivity. Some studies suggest that it can help lower blood sugar levels, reduce oxidative stress, and impact lipid metabolism positively, which could be beneficial for people managing diabetes. However, while these findings are promising, more extensive clinical trials are needed to establish definitive conclusions about its effectiveness and dosage.
It's essential for anyone considering L-Taurine supplementation to consult their healthcare provider, particularly if they have existing medical conditions like diabetes. The interaction with diabetic medications or overall metabolic health should be carefully monitored. Remember, maintaining a balanced diet, regular physical activity, and adhering to prescribed medications remain the cornerstone of diabetes management.
Based on user reviews, the timeframe to see noticeable results from taurine supplementation for diabetes can vary. Many users suggest that positive effects can generally be observed within 1 to 2 months of consistent use. For example, one reviewer reported improvements after about 1-2 months, particularly beneficial for managing type 1 and type 2 diabetes (Read Review). Another user noted that significant improvements, including lower blood glucose levels, can be recognized after just two weeks of taking taurine (Read Review).
Additionally, some reviews indicate that individuals might experience stabilization of blood sugar levels relatively quickly, with one user mentioning that their parents saw results after just a week (Read Review). However, a longer treatment course of 3 to 6 months is also common, particularly for those seeking comprehensive management and stabilization of their diabetes (Read Review). Overall, while initial benefits might appear within weeks, users generally recommend consistent use for at least a few months to maximize taurine's effectiveness in managing diabetes.
The scientific research surrounding various supplements indicates a promising role for certain compounds in managing diabetes. For instance, cornel iridoid glycosides (CIG) have shown significant antidiabetic effects in diabetic rat models, suggesting potential clinical applications for controlling metabolic disorders linked to type 2 diabetes [1]. Similarly, studies on taurine have explored its implications in multiple contexts, including weight management, wound healing, and complications of diabetes, highlighting its potential role in enhancing the effectiveness of diabetes treatments, such as metformin [15] and improving kidney health [3].
Furthermore, specialized fermented milk products have been noted for their ability to improve body composition and metabolic markers in type 2 diabetes patients, offering a supportive addition to dietary therapies [2]. Other studies also indicate that taurine may mitigate diabetes-related oxidative stress and inflammation, aiding liver health and neural recovery [21], [19]. The cumulative evidence suggests that while more research is necessary to establish definitive guidelines and applications in human populations, certain supplements may present valuable options for diabetes management and complication mitigation.
Users have reported varying degrees of improvement in their diabetes symptoms after incorporating taurine into their daily regimen. Many reviewers noted significant reductions in blood glucose levels, with one user experiencing a noticeable stabilization after just a week of use, particularly for their parents who also had high blood pressure (Read Review). Others highlighted improvements over a slightly longer timeframe, such as two weeks, where marked decreases in blood sugar were observed without changing diet or diabetes medications (Read Review). Users consistently praised taurine for its efficacy in managing diabetes-related complications and emphasized its benefits in enhancing overall vitality and metabolic health (Read Review).
Moreover, taurine has been acknowledged for its role in stabilizing insulin levels, with long-term users reporting comprehensive management of diabetic symptoms alongside weight reduction and improved liver function (Read Review). It's important to note that while many users have derived positive benefits from taurine, individual experiences may vary, and it is advisable for users to consult with healthcare providers before starting any supplementation regimen.
Users report that combining taurine supplementation with other dietary enhancements can significantly aid in managing diabetes. Many reviewers noted that taking taurine alongside other supplements, particularly those targeting immunity and heart health, has been effective for individuals with type 2 diabetes. For instance, one user mentioned their mother effectively manages her diabetes with taurine in conjunction with other immune-supporting supplements (Read Review). Moreover, a couple of other users highlighted improvements in blood sugar levels when taurine was used together with a balanced diet (Read Review).
Several reviews also emphasized taurine's supportive role in stabilizing insulin and reducing blood glucose levels, creating a beneficial synergy when taken with other supplements or medications (Read Review). However, it's essential to approach this regimen cautiously as taurine can lower blood pressure, which is a consideration for users who may already be managing this symptom (Read Review). In summary, many users advocate for taurine as a complementary supplement within a broader diabetes management strategy, reflecting its versatility and effectiveness in enhancing metabolic health.
Based on user reviews, there appears to be a consensus that the right dose of L Taurine for managing diabetes ranges from 2 grams to higher amounts, taken on an empty stomach for optimal results. One user reported a positive experience using 2 grams in the morning, which contributed to stabilizing insulin levels and reducing weight over a course of 3 to 6 months (Read Review). Additionally, several users noted noticeable improvements in blood sugar levels after just a couple of weeks to a few months of consistent use, reinforcing the dosage's effectiveness (Read Review).
Moreover, users have appreciated the supplement's benefits beyond blood sugar management. Many have reported improvements in overall metabolic health, as taurine is said to enhance insulin sensitivity and support cardiovascular health (Read Review). However, some individuals mentioned the need for caution regarding blood pressure, as taurine may lower it further (Read Review). Overall, it seems the right dosing strategy involves starting with 2 grams and adjusting based on individual responses.
Our findings suggested that CIG has significant antidiabetic effects, helping to control metabolic disorders in these diabetic rats. This research paves the way for clinical applications of CIG and enhances our understanding of its metabolic mechanisms.
Observations revealed that diabetic rats had serious metabolic issues, including high glucose and fat levels, as well as low antioxidant enzyme activity. However, those treated with metformin combined with taurine and cholecalciferol showed significant improvements. Their metabolic parameters, including insulin levels and islet mass, responded positively to the combined supplements.
The findings suggest that the combination of taurine and metformin may help in controlling diabetes better by reducing inflammation and oxidative stress. This approach could lead to a more effective management strategy for patients struggling with diabetes-related complications.
Our findings highlight that the benefits might stem from changes in amino acid metabolism. Incorporating dietary anthocyanins could be an effective strategy for preventing or managing DKD effectively.
Good tolerability was noted, and both groups experienced significant weight loss and improvements in body composition. However, those who consumed the milk product showcased even greater benefits, such as increased vitamin levels and improved markers for fat and carbohydrate metabolism. Overall, this specialized product can be a helpful addition to diet therapy for those managing diabetes.
Our findings showed that administering taurine significantly reduced levels of liver enzymes, indicating better liver health. When we looked at liver cells under the microscope, they appeared much more normal, and we noticed fewer inflammatory cells in the liver.
Additionally, taurine boosted the liver's antioxidant defenses, increasing key indicators like SOD and CAT, which help combat oxidative stress. We also observed that taurine played a role in regulating inflammation, lowering the activity of certain inflammatory pathways linked to T2DM.
All of these results suggest that taurine can positively influence liver health by enhancing the liver's antioxidant capacity and reducing inflammation, offering hope for future diabetes treatments.
Our analysis included both morphological and functional assessments, revealing that taurine not only ameliorated damage but also promoted neurite outgrowth in neurons exposed to high glucose levels. This suggests that taurine could play a beneficial role in repairing neural injuries associated with diabetes.
We also noted that taurine boosts the expression of nerve growth factor (NGF) and GAP-43, essential proteins for nerve growth and repair. The observed improvements seem linked to the activation of specific signaling pathways, namely the NGF-pAkt-mTOR axis. Interestingly, blocking this pathway with certain inhibitors dampened the positive effects of taurine, highlighting its crucial role in the protection and repair of neural tissues in diabetic conditions.
Overall, our findings indicate that taurine could be a promising therapeutic agent for enhancing spinal cord recovery from diabetic-induced injuries, providing hope for better management of diabetic neuropathy.
References
- Hou Y, Huang Y, Shang Z, Ma S, Cui T, et al. Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats. J Ethnopharmacol. 2024;328:118065. doi:10.1016/j.jep.2024.118065
- Sharafetdinov KK, Novokshanova AL, Kochetkova AA, Plotnikova OA, Alekseeva RI, et al. [Assessment of the clinical effectiveness of a specialized fermented milk product for the dietary correction of carbohydrate and fat metabolism disorders]. Vopr Pitan. 2024;93:67. doi:10.33029/0042-8833-2024-93-6-67-75
- Li YX, Lu YP, Tang D, Hu B, Zhang ZY, et al. Anthocyanin improves kidney function in diabetic kidney disease by regulating amino acid metabolism. J Transl Med. 2022;20:510. doi:10.1186/s12967-022-03717-9
- Tian J, Dang H, O'Laco KA, Song M, Tiu BC, et al. Homotaurine Treatment Enhances CD4 and CD8 Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice. Immunohorizons. 2019;3:498. doi:10.4049/immunohorizons.1900019
- Zheng Y, Ceglarek U, Huang T, Wang T, Heianza Y, et al. Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets. J Clin Endocrinol Metab. 2016;101:3820.
- Abd El-Twab SM, Mohamed HM, Mahmoud AM. Taurine and pioglitazone attenuate diabetes-induced testicular damage by abrogation of oxidative stress and up-regulation of the pituitary-gonadal axis. Can J Physiol Pharmacol. 2016;94:651. doi:10.1139/cjpp-2015-0503
- Adrian TE, Gariballa S, Parekh KA, Thomas SA, Saadi H, et al. Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers. Diabetologia. 2012;55:2343. doi:10.1007/s00125-012-2593-2
- Song MK, Salam NK, Roufogalis BD, Huang TH. Lycium barbarum (Goji Berry) extracts and its taurine component inhibit PPAR-γ-dependent gene transcription in human retinal pigment epithelial cells: Possible implications for diabetic retinopathy treatment. Biochem Pharmacol. 2011;82:1209. doi:10.1016/j.bcp.2011.07.089
- Zeng K, Xu H, Chen K, Zhu J, Zhou Y, et al. Effects of taurine on glutamate uptake and degradation in Müller cells under diabetic conditions via antioxidant mechanism. Mol Cell Neurosci. 2010;45:192. doi:10.1016/j.mcn.2010.06.010
- Zeng K, Xu H, Mi M, Chen K, Zhu J, et al. Effects of taurine on glial cells apoptosis and taurine transporter expression in retina under diabetic conditions. Neurochem Res. 2010;35:1566. doi:10.1007/s11064-010-0216-1
- Gaamoussi F, Israili ZH, Lyoussi B. Hypoglycemic and hypolipidemic effects of an aqueous extract of Chamaerops humilis leaves in obese, hyperglycemic and hyperlipidemic Meriones shawi rats. Pak J Pharm Sci. 2010;23:212.
- Wang LJ, Yu YH, Zhang LG, Wang Y, Niu N, et al. Taurine rescues vascular endothelial dysfunction in streptozocin-induced diabetic rats: correlated with downregulation of LOX-1 and ICAM-1 expression on aortas. Eur J Pharmacol. 2008;597:75. doi:10.1016/j.ejphar.2008.08.031
- El-Akabawy G, Eid N. Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy: Potential and limitations. World J Diabetes. 2025;16:100066. doi:10.4239/wjd.v16.i1.100066
- Tian S, Mei J, Zhang L, Wang S, Yuan Y, et al. Multifunctional Hydrogel Microneedle Patches Modulating Oxi-inflamm-aging for Diabetic Wound Healing. Small. 2024;20:e2407340. doi:10.1002/smll.202407340
- Attia MS, Ayman F, Attia MS, Yahya G, Zahra MH, et al. Mitigating diabetes-related complications: Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats. World J Diabetes. 2024;15:1778. doi:10.4239/wjd.v15.i8.1778
- Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, et al. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Nature. 2024;633:182. doi:10.1038/s41586-024-07801-6
- Yuan J, Hou Q, He X, Zhong L, Li M, et al. Chitosan-taurine nanoparticles cross-linked carboxymethyl chitosan hydrogels facilitate both acute and chronic diabetic wound healing. Int J Biol Macromol. 2024;273:132762. doi:10.1016/j.ijbiomac.2024.132762
- Simões BES, Muniz MRR, Araujo TD, Magalhães Carneiro E, Simionato AVC. Evaluation of tauroursodeoxycholic acid in liver cells' cultures by MEKC: Initial hints to comprehend its role in diabetes mellitus of obese individuals. Electrophoresis. 2024;45:1252. doi:10.1002/elps.202300223
- Wang Y, Gao B, Chen X, Shi X, Li S, et al. Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway. Amino Acids. 2024;56:32. doi:10.1007/s00726-024-03392-8
- Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, et al. A PTER-dependent pathway of taurine metabolism linked to energy balance. bioRxiv. 2024. doi:10.1101/2024.03.21.586194
- Ouyang G, Wang N, Tong J, Sun W, Yang J, et al. Alleviation of taurine on liver injury of type 2 diabetic rats by improving antioxidant and anti-inflammatory capacity. Heliyon. 2024;10:e28400. doi:10.1016/j.heliyon.2024.e28400
