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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A(60% as Beta-Carotene and 40% from Fish Liver Oil)
7,500 mcg
833%
Vitamin D3(as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Vitamin A and allergy management
Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.
Most Relevant Research
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
10
Zero allergy symptoms
Most Useful Review
I experience allergies unexpectedly throughout the year, manifesting as sneezing and a runny nose. During allergy season, I take one of these in the morning and one at night, resulting in complete symptom relief. I can’t be without it.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9.3
Significant relief
Most Useful Review
I ordered these vitamins for the first time as I have diabetes and suffer from numbness and aching legs at night. They have helped me considerably; I highly recommend them for diabetics.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 2 Reviews
8.6
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
9.5
Improved eye condition
Most Useful Review
I took vitamin A for prevention, and the dosage is excellent. I give it to everyone in the family, as vit A is essential. We took 2-3 capsules during the initial peak of illness, then 1 capsule thereafter. With other vitamins, we swiftly overcame the disease. I also noticed my dry eyes disappeared, which I often had while wearing lenses. With vit A, E, and D, these issues are resolved. I recommend taking vit A in courses, twice a year for a month as advised by my doctor.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Significant improvement
Most Useful Review
I ordered these vitamins for the first time as I have diabetes, and my legs often go numb and ache at night. They have helped me tremendously; I highly recommend them for treating leg cramps in diabetics.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Most Relevant Research
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
9.5
Effective for psoriasis
Most Useful Review
Good afternoon. I have very dry skin, so I purchased this dietary supplement with fat-soluble vitamins. It helped with my psoriasis without needing creams or hormones. I also recommend it for eye and bone health. The dosage is appropriate, and vitamin D supports immunity. The packaging is compact, and the taste is reminiscent of Aevit.
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 12 Reviews
8.5
8
Vitamin D3 improves cold symptoms
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Effective against colds
Most Useful Review
For common colds and flu, I take 4 (100,000 IU) with 50,000 IU of vitamin D-3 at the first sign of illness. It usually stops the cold immediately. I also include zinc lozenges every 3 hours if I experience a sore throat. I always bring it along when I travel.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.5
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Most Relevant Research
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
9.5
Strengthens bones
Most Useful Review
We used it daily to protect against osteoporosis and strengthen bones.
Blurred Vision details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.5
USERS' SCORE
Good
Based on 10 Reviews
8.4
9
Vitamin A treatment improves blurred vision
Case of persistent corneal epithelial damage after cataract surgery leading to diagnosis of vitamin A deficiency.
Most Relevant Research
We investigated a case of persistent blurred vision following cataract surgery, leading to the discovery of vitamin A deficiency in a 74-year-old man. Using advanced tests like full-field electroretinograms and optical coherence tomography, we noted significant retinal changes and low vitamin A levels.
After administering vitamin A supplements for three months, we saw remarkable improvement in his vision and retinal health. This highlights the importance of diagnosing vitamin A deficiency, especially in patients showing persistent vision problems post-surgery.
After administering vitamin A supplements for three months, we saw remarkable improvement in his vision and retinal health. This highlights the importance of diagnosing vitamin A deficiency, especially in patients showing persistent vision problems post-surgery.
9.5
Vision improvement noted
Most Useful Review
I take vitamin A and D-3 as per my doctor's advice, alongside lutein and vitamin E to enhance my vision. After two months, I've seen positive results; my vision has improved, and there have been no side effects. If my review was helpful, please put 👍.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.4
8.3
Bone and teeth health
Most Useful Review
This excellent complex strengthens my bones and teeth while maintaining eye health.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.4
8.8
Noticeable improvements
Most Useful Review
After two weeks of taking the small capsules for hyperkeratosis, the improvements are evident; there are fewer rashes.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.5
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.7
9.5
Vitamin A's effectiveness in acne
The role of vitamins and nutrients in rosacea.
Most Relevant Research
We explored how vitamin A can influence acne treatment, focusing on the effectiveness of its derivatives. According to the findings, oral isotretinoin, a form of vitamin A, showed remarkable efficacy. Patients experienced a significant reduction in lesions—up to 90%—with complete remission in one-quarter of those involved in the study.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
Moreover, more than half of the participants reported substantial improvement after treatment. This strong performance suggests that vitamin A plays a key role in managing acne symptoms effectively.
Overall, the evidence we examined indicates that incorporating vitamin A, particularly through isotretinoin, can lead to significant improvements for individuals struggling with acne.
9.5
Reduced acne
Most Useful Review
After taking this supplement, I found it harder to get acne. It seems to suit me well, so I will continue using it!
