Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A(60% as Beta-Carotene and 40% from Fish Liver Oil)
7,500 mcg
833%
Vitamin D3(as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
Vitamin D derivatives enhance bone health
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
Read More
9
We explored how Nano Vitamin D3 influences osteoporosis, particularly in the context of treatments involving anastrozole, a medication often used in cancer therapy. In our study, we observed the effects of Nano Vitamin D3 compared to selenium nanoparticles in female albino rats.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
Read More
9
We investigated the effects of vitamin D3 supplementation during pregnancy on offspring's bone mineral density (BMD) as they grow. In the MAVIDOS study, pregnant women with low levels of vitamin D were given either a daily dose of 1000 IU of cholecalciferol (vitamin D3) or a placebo from their second trimester until delivery.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
Read More
Most Useful Reviews
9
Strengthens bones
We used it daily to protect against osteoporosis and strengthen bones.
Read More
7.5
Prevents osteoporosis
1 people found this helpful
I take one capsule daily for a month, with a month’s break before starting another course. I consider this drug essential for preventing osteoporosis, strengthening my nerves and boosting immunity. I recommend it in small doses for prevention.
Read More
7.5
Improves calcium absorption
Good quality and simple ingredients. The high dosage improves calcium and phosphorus absorption, essential for preventing osteoporosis. Vitamin D supports bone growth and maintains blood calcium balance. I found it easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
- All Researches
9.5
We looked into the effects of vitamin D3 on osteoporosis management, particularly in relation to glucocorticoid-induced complications. In a recent case involving an 85-year-old patient with IgG4-related disease, vitamin D3 was used alongside prednisone and azathioprine. The goal was to prevent bone density loss often seen with steroid treatments.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Read More
9
Vitamin D derivatives enhance bone health
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
Read More
9
We explored how Nano Vitamin D3 influences osteoporosis, particularly in the context of treatments involving anastrozole, a medication often used in cancer therapy. In our study, we observed the effects of Nano Vitamin D3 compared to selenium nanoparticles in female albino rats.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
Read More
9
We investigated the effects of vitamin D3 supplementation during pregnancy on offspring's bone mineral density (BMD) as they grow. In the MAVIDOS study, pregnant women with low levels of vitamin D were given either a daily dose of 1000 IU of cholecalciferol (vitamin D3) or a placebo from their second trimester until delivery.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
Read More
9
Calcium and Vitamin D3 boost bone health
We conducted a comprehensive study to assess the effectiveness and safety of a daily regimen of calcium 600 mg combined with cholecalciferol (vitamin D3) 2000 IU in treating vitamin D deficiency, particularly in the context of osteoporosis. Our research included 302 adults who took these orodispersible tablets for at least 24 weeks.
The results showed that this combination therapy successfully increased serum levels of 25-hydroxivitamin D, an essential marker of vitamin D status. Notably, patients suffering from vitamin D deficiency experienced significant improvement in their vitamin D levels, reaching an optimal range conducive to better bone health.
We also observed that while the treatment led to improved vitamin D status, there were no significant adverse events reported, making it a safe option for long-term management of vitamin D deficiency and osteoporosis. Additionally, we found that reducing secondary hyperparathyroidism, a condition often associated with low vitamin D, was another positive outcome of this treatment.
Overall, the magnitude of increase in vitamin D levels directly correlated with the severity of the deficiency, indicating that those most in need benefited the most. Our study emphasizes the importance of addressing vitamin D deficiency, especially for individuals at risk of osteoporosis, without any notable burden of side effects.
The results showed that this combination therapy successfully increased serum levels of 25-hydroxivitamin D, an essential marker of vitamin D status. Notably, patients suffering from vitamin D deficiency experienced significant improvement in their vitamin D levels, reaching an optimal range conducive to better bone health.
We also observed that while the treatment led to improved vitamin D status, there were no significant adverse events reported, making it a safe option for long-term management of vitamin D deficiency and osteoporosis. Additionally, we found that reducing secondary hyperparathyroidism, a condition often associated with low vitamin D, was another positive outcome of this treatment.
Overall, the magnitude of increase in vitamin D levels directly correlated with the severity of the deficiency, indicating that those most in need benefited the most. Our study emphasizes the importance of addressing vitamin D deficiency, especially for individuals at risk of osteoporosis, without any notable burden of side effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strengthens bones
We used it daily to protect against osteoporosis and strengthen bones.
Read More
7.5
Prevents osteoporosis
1 people found this helpful
I take one capsule daily for a month, with a month’s break before starting another course. I consider this drug essential for preventing osteoporosis, strengthening my nerves and boosting immunity. I recommend it in small doses for prevention.
Read More
7.5
Improves calcium absorption
Good quality and simple ingredients. The high dosage improves calcium and phosphorus absorption, essential for preventing osteoporosis. Vitamin D supports bone growth and maintains blood calcium balance. I found it easy to swallow.
Read More
Frequently Asked Questions
7.5
Prevents osteoporosis
1 people found this helpful
I take one capsule daily for a month, with a month’s break before starting another course. I consider this drug essential for preventing osteoporosis, strengthening my nerves and boosting immunity. I recommend it in small doses for prevention.
9
Strengthens bones
We used it daily to protect against osteoporosis and strengthen bones.
7.5
Improves calcium absorption
Good quality and simple ingredients. The high dosage improves calcium and phosphorus absorption, essential for preventing osteoporosis. Vitamin D supports bone growth and maintains blood calcium balance. I found it easy to swallow.
8
We conducted a study to assess the effects of combining raloxifene, a medication commonly used to treat osteoporosis, with cholecalciferol (vitamin D3) on bone mineral density in postmenopausal women with osteopenia. This randomized, open-label trial involved 112 participants who either received raloxifene along with vitamin D3 or vitamin D3 alone for 48 weeks.
Our findings revealed that those taking raloxifene with vitamin D3 experienced a significant increase in bone mineral density at the lumbar spine compared to those who received vitamin D3 alone. While both groups received vitamin D3, it was the addition of raloxifene that made a marked difference in enhancing bone density and reducing bone loss in the hip.
Importantly, we noted that the benefits of the combination treatment were even more pronounced among women with more severe osteopenia. However, it’s crucial to recognize that the study did not isolate the effects of vitamin D3 on its own, which limits our ability to draw conclusions about its effectiveness independently from raloxifene.
As we look at the broader implications, it seems combining these treatments could be an effective strategy for improving bone health, particularly in postmenopausal women at risk of osteoporosis.
Our findings revealed that those taking raloxifene with vitamin D3 experienced a significant increase in bone mineral density at the lumbar spine compared to those who received vitamin D3 alone. While both groups received vitamin D3, it was the addition of raloxifene that made a marked difference in enhancing bone density and reducing bone loss in the hip.
Importantly, we noted that the benefits of the combination treatment were even more pronounced among women with more severe osteopenia. However, it’s crucial to recognize that the study did not isolate the effects of vitamin D3 on its own, which limits our ability to draw conclusions about its effectiveness independently from raloxifene.
As we look at the broader implications, it seems combining these treatments could be an effective strategy for improving bone health, particularly in postmenopausal women at risk of osteoporosis.
8
We explored the mechanisms by which vitamin D3 might regulate bone metabolism and help combat osteoporosis, particularly in light of vitamin D insufficiency. By utilizing various mouse models, including those genetically modified to express certain genes related to vitamin D, we assessed how these factors contributed to bone health.
Our findings revealed that a deficiency in active vitamin D, or 1,25-dihydroxyvitamin D, led to decreased levels of an important protein called Sirt1, which is crucial for bone health. This drop in Sirt1 resulted in accelerated bone loss. Encouragingly, we discovered that overexpressing Sirt1 in mesenchymal stem cells could actually reverse this bone loss. It achieved this by reducing oxidative stress and promoting healthy bone formation while minimizing bone resorption.
Additionally, our study showed that vitamin D3 boosts Sirt1 levels through a direct interaction with its gene promoter. This means that adequate vitamin D not only supports Sirt1 levels but also plays a key role in regulating its activity in bone cells. We also examined the effects of resveratrol, a compound that activates Sirt1, and found it could mitigate the negative impact of vitamin D insufficiency on bone health.
Overall, we observed that the vitamin D-Sirt1/PGC1α axis is vital for maintaining bone health, especially when vitamin D levels are insufficient. These insights highlight the potential for targeting this pathway as a promising strategy for preventing and treating osteoporosis.
Our findings revealed that a deficiency in active vitamin D, or 1,25-dihydroxyvitamin D, led to decreased levels of an important protein called Sirt1, which is crucial for bone health. This drop in Sirt1 resulted in accelerated bone loss. Encouragingly, we discovered that overexpressing Sirt1 in mesenchymal stem cells could actually reverse this bone loss. It achieved this by reducing oxidative stress and promoting healthy bone formation while minimizing bone resorption.
Additionally, our study showed that vitamin D3 boosts Sirt1 levels through a direct interaction with its gene promoter. This means that adequate vitamin D not only supports Sirt1 levels but also plays a key role in regulating its activity in bone cells. We also examined the effects of resveratrol, a compound that activates Sirt1, and found it could mitigate the negative impact of vitamin D insufficiency on bone health.
Overall, we observed that the vitamin D-Sirt1/PGC1α axis is vital for maintaining bone health, especially when vitamin D levels are insufficient. These insights highlight the potential for targeting this pathway as a promising strategy for preventing and treating osteoporosis.
8
We conducted a multicenter, randomized, controlled clinical trial involving 226 patients with osteoporosis to assess the effectiveness of acupuncture alongside calcium and vitamin D3 supplementation. Participants were divided into two groups: one receiving standard treatment of calcium and vitamin D3, while the other group received the same treatment plus additional acupuncture.
Our findings showed that, after six months, while acupuncture led to improvements in bone density, balance, and muscle strength, the specific effects of vitamin D3 remained hard to isolate. This is because all participants received vitamin D3, and the concurrent acupuncture treatment makes it challenging to determine how much of the improvement can be attributed specifically to vitamin D3 on its own.
While vitamin D3 is a key player in bone health, it’s clear from our study that the additional acupuncture treatment offered unique benefits that may enhance overall patient outcomes. Therefore, although we can't pinpoint the exact effectiveness of vitamin D3 alone, it does play an essential role when combined with other therapies.
Our findings showed that, after six months, while acupuncture led to improvements in bone density, balance, and muscle strength, the specific effects of vitamin D3 remained hard to isolate. This is because all participants received vitamin D3, and the concurrent acupuncture treatment makes it challenging to determine how much of the improvement can be attributed specifically to vitamin D3 on its own.
While vitamin D3 is a key player in bone health, it’s clear from our study that the additional acupuncture treatment offered unique benefits that may enhance overall patient outcomes. Therefore, although we can't pinpoint the exact effectiveness of vitamin D3 alone, it does play an essential role when combined with other therapies.
References
- Mendoza-Vargas LÁ, Sevilla-Fuentes S, Bautista-Becerril B, Berthaúd-González B, Falfán-Valencia R, et al. IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report. J Clin Med. 2025;14. doi:10.3390/jcm14030958
- Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. doi:10.1016/j.jot.2024.10.011
- Paul T, Garg B, Kapoor N, Patil V, Kachnerkar N, et al. A Prospective, Active-controlled, Randomized, Double-blind, Multicenter, Phase III Study to Compare the Safety and Efficacy of Biosimilar Denosumab vs Reference Denosumab in the Treatment of Postmenopausal Osteoporosis. J Assoc Physicians India. 2025;73:e8. doi:10.59556/japi.73.0772
- Sawant D, Kamble N. Overcoming Recurrent Isolated Sleep Paralysis: A Case Report of Integrative Management With Yoga, Meditation, and Vitamin D3 Supplementation. Cureus. 2024;16:e76626. doi:10.7759/cureus.76626
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. doi:10.1248/cpb.c24-00598
- Elmalah SG, Mohsen ROM, Hassan R. Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats. J Stomatol Oral Maxillofac Surg. 2024. doi:10.1016/j.jormas.2024.102181
- Chang CH, Yang SJ, Young TH, Yao WC. Effect of co-loaded vitamin D3 on intravenous injectable raloxifene delivery system. Colloids Surf B Biointerfaces. 2025;246:114379. doi:10.1016/j.colsurfb.2024.114379
- Kluijver LG, Wagenmakers MAEM, Wilson JHP, Langendonk JG. The impact of minimal sunlight exposure on bone health: insights from a cohort study in erythropoietic protoporphyria. J Clin Endocrinol Metab. 2024. doi:10.1210/clinem/dgae729
- Chen Y, Qiu H, Xuan L, Jin Y, Chen R, et al. Acupuncture in Treating Osteopenia: A Multicenter, Randomized, Controlled Clinical Trial. Complement Med Res. 2024;31:516. doi:10.1159/000541440
- Moon RJ, D' Angelo S, Curtis EM, Ward KA, Crozier SR, et al. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. Am J Clin Nutr. 2024;120:1134. doi:10.1016/j.ajcnut.2024.09.014
- Pinto-Bonilla R, Baeza-Noci J, Blanco CC, Gumbau GJV, Fernández RJ, et al. Real-world effectiveness and safety of combined calcium 600 mg and cholecalciferol 2000 IU for treating vitamin d deficiency: Results from a nationwide study with focus in osteoporosis. Bone Rep. 2024;22:101796. doi:10.1016/j.bonr.2024.101796
- Xu D, Liu J, Zhang D, Zhang X, Huang C, et al. [Effects of thunder-fire moxibustion on balance function and musculoskeletal metabolism in female patients of primary osteoporosis with low muscle mass]. Zhongguo Zhen Jiu. 2024;44:859. doi:10.13703/j.0255-2930.20231229-0002
- Shin S, Hong N, Rhee Y. A randomized controlled trial of the effect of raloxifene plus cholecalciferol versus cholecalciferol alone on bone mineral density in postmenopausal women with osteopenia. JBMR Plus. 2024;8:ziae073. doi:10.1093/jbmrpl/ziae073
- Wu T, Lin Z, Wang C, Liu X. Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis. Front Med (Lausanne). 2024;11:1396254. doi:10.3389/fmed.2024.1396254
