Overview
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
8
We examined the effects of vitamin E on atherosclerosis in the cerebellum of rabbits. In this study, forty rabbits were split into four groups, where specific groups received vitamin E alongside regular diets or added cholesterol.
The results revealed that cholesterol-treated rabbits experienced significant damage, evident through decreased fiber density and changes in brain cell structure. Surprisingly, while vitamin E showed some protective traits by reducing these changes, its overall impact on atherosclerosis was inconclusive.
The results revealed that cholesterol-treated rabbits experienced significant damage, evident through decreased fiber density and changes in brain cell structure. Surprisingly, while vitamin E showed some protective traits by reducing these changes, its overall impact on atherosclerosis was inconclusive.
Read More
9
We investigated a new compound called NATOH, which combines vitamin E with properties of natural anti-inflammatory agents.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
Read More
9
We investigated how a form of vitamin E, tocopheryl phosphate (TPM), impacts the development of atherosclerosis using apolipoprotein-E deficient mice. By comparing TPM with traditional vitamin E, we found that TPM significantly reduced atherosclerotic lesions and inflammation indicators.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Read More
Most Useful Reviews
9
Essential supplement
2 people found this helpful
Vitamin E is a fat-soluble vitamin with powerful antioxidant properties, preventing lipid oxidation and helping to avert arteriosclerosis and blood clots. It may lower blood pressure and reduce LDL (bad) cholesterol. Moreover, it keeps cell membranes healthy, potentially warding off age-related diseases, hence its title as the "rejuvenating vitamin." It is an essential supplement for my health.
Read More
9
Heart disease risk
Vitamin E, known for its excellent antioxidant properties, may lower the risk of heart disease by improving arteriosclerosis. I consider it essential for the elderly, and I take it daily.
Read More
9
Essential antioxidant
Vitamin E is a fat-soluble vitamin with strong antioxidant properties, preventing lipid oxidation in the body while also helping to prevent arteriosclerosis and blood clots. It lowers blood pressure and LDL (bad) cholesterol, promoting cellular health and vitality, making it an essential supplement for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
- All Researches
9
We investigated a new compound called NATOH, which combines vitamin E with properties of natural anti-inflammatory agents.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
Read More
9
We explored the potential benefits of combining vitamins C and E on heart health in mice with arteriosclerosis. By monitoring mice on an atherogenic diet, we found that this combination significantly lowered unhealthy cholesterol and triglyceride levels.
The vitamins supported better function in high-density lipoprotein (HDL), reducing inflammation markers and helping to remodel HDL particles. This suggests a cardioprotective effect and improved overall health in the studied mice. However, the implications for human health remain unclear.
The vitamins supported better function in high-density lipoprotein (HDL), reducing inflammation markers and helping to remodel HDL particles. This suggests a cardioprotective effect and improved overall health in the studied mice. However, the implications for human health remain unclear.
Read More
9
We investigated how a form of vitamin E, tocopheryl phosphate (TPM), impacts the development of atherosclerosis using apolipoprotein-E deficient mice. By comparing TPM with traditional vitamin E, we found that TPM significantly reduced atherosclerotic lesions and inflammation indicators.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
Read More
8
We examined the effectiveness of tocotrienol and tocopherol, two forms of vitamin E, in treating atherosclerotic cardiovascular diseases. Our systematic review analyzed studies published between 2002 and early 2023 to evaluate their safety and health benefits.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
Read More
8
We examined the impact of vitamin E on patients with severe lower limb atherosclerosis after reconstructive surgery.
Sixty patients were divided into two groups: one received vitamin E daily for a month, while the other followed standard therapy.
After treatment, we found that vitamin E significantly reduced the level of the harmful Bax protein and raised the protective Bcl-2 protein.
This suggests that vitamin E could enhance recovery by balancing apoptosis markers in these patients.
Sixty patients were divided into two groups: one received vitamin E daily for a month, while the other followed standard therapy.
After treatment, we found that vitamin E significantly reduced the level of the harmful Bax protein and raised the protective Bcl-2 protein.
This suggests that vitamin E could enhance recovery by balancing apoptosis markers in these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential supplement
2 people found this helpful
Vitamin E is a fat-soluble vitamin with powerful antioxidant properties, preventing lipid oxidation and helping to avert arteriosclerosis and blood clots. It may lower blood pressure and reduce LDL (bad) cholesterol. Moreover, it keeps cell membranes healthy, potentially warding off age-related diseases, hence its title as the "rejuvenating vitamin." It is an essential supplement for my health.
Read More
9
Heart disease risk
Vitamin E, known for its excellent antioxidant properties, may lower the risk of heart disease by improving arteriosclerosis. I consider it essential for the elderly, and I take it daily.
Read More
9
Essential antioxidant
Vitamin E is a fat-soluble vitamin with strong antioxidant properties, preventing lipid oxidation in the body while also helping to prevent arteriosclerosis and blood clots. It lowers blood pressure and LDL (bad) cholesterol, promoting cellular health and vitality, making it an essential supplement for me.
Read More
7.5
Staying healthy
1 people found this helpful
I am using Vitamin E due to its strong antioxidant properties that prevent lipid oxidation. It can help prevent arteriosclerosis and blood clots, lower blood pressure, and reduce LDL (bad) cholesterol. This supplement plays a significant role in my health maintenance!
Read More
7.5
Improves circulation
I take E-400 with mixed tocopherols, rich in Vitamin E, which can enhance blood flow and dilate blood vessels. By using this megavitamin therapy, I aim to reduce the risk of arteriosclerosis and heart disease.
Read More
Frequently Asked Questions
6
Coping with insomnia
I've been taking 1200U of Vitamin E nightly for three years to help with insomnia. It enhances my blood flow and regulates my autonomic nervous system, which I believe aids in preventing arteriosclerosis. Natural vitamins are essential for health.
7.5
Staying healthy
1 people found this helpful
I am using Vitamin E due to its strong antioxidant properties that prevent lipid oxidation. It can help prevent arteriosclerosis and blood clots, lower blood pressure, and reduce LDL (bad) cholesterol. This supplement plays a significant role in my health maintenance!
7.5
Improves circulation
I take E-400 with mixed tocopherols, rich in Vitamin E, which can enhance blood flow and dilate blood vessels. By using this megavitamin therapy, I aim to reduce the risk of arteriosclerosis and heart disease.
7.5
Cholesterol reduction
I take Vitamin E to prevent arteriosclerosis and blood clots, lower my blood pressure, and reduce LDL (bad) cholesterol.
9
Essential supplement
2 people found this helpful
Vitamin E is a fat-soluble vitamin with powerful antioxidant properties, preventing lipid oxidation and helping to avert arteriosclerosis and blood clots. It may lower blood pressure and reduce LDL (bad) cholesterol. Moreover, it keeps cell membranes healthy, potentially warding off age-related diseases, hence its title as the "rejuvenating vitamin." It is an essential supplement for my health.
9
Heart disease risk
Vitamin E, known for its excellent antioxidant properties, may lower the risk of heart disease by improving arteriosclerosis. I consider it essential for the elderly, and I take it daily.
8
We examined the effectiveness of tocotrienol and tocopherol, two forms of vitamin E, in treating atherosclerotic cardiovascular diseases. Our systematic review analyzed studies published between 2002 and early 2023 to evaluate their safety and health benefits.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
4
We examined how serum vitamin E levels connect with arteriosclerosis risk factors in Japanese postmenopausal women. The study involved 107 participants whose vitamin E status was measured through serum α- and γ-tocopherol levels.
Although we did not find significant differences in vitamin E levels across groups with varying arteriosclerosis risks, there was a trend showing that higher serum α-tocopherol levels, adjusted by cholesterol and triglycerides, were linked to fewer arteriosclerotic risk factors.
This suggests that maintaining proper vitamin E levels might play a role in reducing risks associated with arteriosclerosis.
Although we did not find significant differences in vitamin E levels across groups with varying arteriosclerosis risks, there was a trend showing that higher serum α-tocopherol levels, adjusted by cholesterol and triglycerides, were linked to fewer arteriosclerotic risk factors.
This suggests that maintaining proper vitamin E levels might play a role in reducing risks associated with arteriosclerosis.
9
We investigated a new compound called NATOH, which combines vitamin E with properties of natural anti-inflammatory agents.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
7
Vitamin E's limited effect on atherosclerosis
We explored how vitamin E influences atherosclerosis, particularly focusing on its effects on endoplasmic reticulum (ER) stress caused by a high-cholesterol diet. The study analyzed aortic tissue from animals to examine protein levels related to ER stress.
Surprisingly, despite vitamin E showing potential in modulating ER stress markers, the overall effects on atherosclerosis didn’t seem significantly beneficial. While it did improve certain protein responses and pathways, this does not guarantee a substantial impact on plaque formation.
Altogether, while vitamin E might help with ER stress, it doesn't dramatically change atherosclerosis outcomes.
Surprisingly, despite vitamin E showing potential in modulating ER stress markers, the overall effects on atherosclerosis didn’t seem significantly beneficial. While it did improve certain protein responses and pathways, this does not guarantee a substantial impact on plaque formation.
Altogether, while vitamin E might help with ER stress, it doesn't dramatically change atherosclerosis outcomes.
5
We explored how vitamin E and aspirin affect arteriosclerosis in aged rats. The study involved a control group of sham-operates and several groups of orchidectomized rats that were given vitamin E, aspirin, or a combination for 90 days.
Our findings showed that vitamin E reduced atherosclerotic lesions, but aspirin was significantly more effective, completely reversing the fatty streak areas. Unfortunately, neither vitamin E nor aspirin helped in reversing bone loss related to hormonal changes.
Overall, while vitamin E offers some benefits against atherosclerosis, aspirin is the clearer winner in this treatment comparison.
Our findings showed that vitamin E reduced atherosclerotic lesions, but aspirin was significantly more effective, completely reversing the fatty streak areas. Unfortunately, neither vitamin E nor aspirin helped in reversing bone loss related to hormonal changes.
Overall, while vitamin E offers some benefits against atherosclerosis, aspirin is the clearer winner in this treatment comparison.
7
We examined the relationship between dietary vitamin E intake and the risk of developing peripheral arterial disease (PAD) using data from 6,588 participants in the National Health and Nutrition Examination Survey from 1999 to 2004.
Our analysis revealed a negative association between vitamin E intake and the incidence of PAD. Specifically, individuals who consumed more vitamin E appeared to have a lower likelihood of developing this condition.
This suggests that increasing dietary vitamin E might be beneficial, particularly for those at risk. Therefore, considering these findings for dietary guidance can help in the prevention of PAD.
Our analysis revealed a negative association between vitamin E intake and the incidence of PAD. Specifically, individuals who consumed more vitamin E appeared to have a lower likelihood of developing this condition.
This suggests that increasing dietary vitamin E might be beneficial, particularly for those at risk. Therefore, considering these findings for dietary guidance can help in the prevention of PAD.
We explored how dietary antioxidants, especially vitamin E, affect atherosclerosis by looking at carotid intima media thickness (cIMT) in both men and women. Analyzing data from 894 people, we found that in women, increasing vitamin E intake led to lower cIMT. For each milligram of vitamin E consumed, the cIMT decreased by about 1.48 micrometers. Unfortunately, we did not see the same positive effect in men, suggesting that vitamin E's benefits might be limited to women.
References
- Liu Q, Wu X, Wang Y, Wang X, Zhao F, et al. Association of dietary vitamin E intake with peripheral arterial disease: A retrospective cross-sectional study. PLoS One. 2025;20:e0320356. doi:10.1371/journal.pone.0320356
- Rafique S, Khan DA, Farhat K, Khan MA, Noor M, et al. Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans. J Pak Med Assoc. 2024;74:1124. doi:10.47391/JPMA.9227
- Kalinin RA, Suchkov IA, Klimentova ÉA, Shchul'kin AV, Egorov AA. [Effect of an antioxidant on vascular wall cell apoptosis markers after reconstructive operations]. Angiol Sosud Khir. 2021;27:8. doi:10.33529/ANGIO2021301
- Wang Y, Zhang S, Zhang G, Yu B, Gao X, et al. Association between type D personality and in-stent restenosis in patients treated with percutaneous coronary intervention: A mediation analysis of dietary patterns. J Psychosom Res. 2020;138:110244. doi:10.1016/j.jpsychores.2020.110244
- Nakatsu Y, Niida S, Tanaka K, Takenaka S, Kuwabara A. The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women. J Nutr Sci Vitaminol (Tokyo). 2020;66:213. doi:10.3177/jnsv.66.213
- Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020;46:653. doi:10.1002/biof.1635
- Elbeltagy MAF, Elkholy WB, Salman AS. Effect of atherosclerosis and the protective effect of the antioxidant vitamin E on the rabbit cerebellum. Microscopy (Oxf). 2019;68:369. doi:10.1093/jmicro/dfz023
- Ranard KM, Kuchan MJ, Erdman JW. α-Tocopherol, but Not γ-Tocopherol, Attenuates the Expression of Selective Tumor Necrosis Factor-Alpha-Induced Genes in Primary Human Aortic Cell Lines. Lipids. 2019;54:289. doi:10.1002/lipd.12149
- Rodriguez-Duarte J, Galliussi G, Dapueto R, Rossello J, Malacrida L, et al. A novel nitroalkene-α-tocopherol analogue inhibits inflammation and ameliorates atherosclerosis in Apo E knockout mice. Br J Pharmacol. 2019;176:757. doi:10.1111/bph.14561
- Maugeri A, Hruskova J, Jakubik J, Kunzova S, Sochor O, et al. Dietary antioxidant intake decreases carotid intima media thickness in women but not in men: A cross-sectional assessment in the Kardiovize study. Free Radic Biol Med. 2019;131:274. doi:10.1016/j.freeradbiomed.2018.12.018
- Chai SC, Foley EM, Arjmandi BH. Anti-atherogenic properties of vitamin E, aspirin, and their combination. PLoS One. 2018;13:e0206315. doi:10.1371/journal.pone.0206315
- Contreras-Duarte S, Chen P, Andía M, Uribe S, Irarrázaval P, et al. Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice. Biol Res. 2018;51:34. doi:10.1186/s40659-018-0183-6
- Libinaki R, Vinh A, Tesanovic-Klajic S, Widdop R, Gaspari T. The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:107. doi:10.1111/1440-1681.12821
- Del Carmen Baez M, Taran M, de La Paz Scribano M, Balceda A, Buonanotte C, et al. Inflammatory and Oxidative Stress Markers as Indicator of Atherogenesis in Rats: Antioxidants as Preventive Pharmacological Methods. Antiinflamm Antiallergy Agents Med Chem. 2017;16:87. doi:10.2174/1871523016666170616121133
- Minotti GC, Cortese F, Corsonello A, Guadalupi G, D Arcangelo AP, et al. The Influence of Dietary Components on Early Signs of Atherosclerosis in Apparently Healthy Young-adult Males: An Observational Study of 615 Subjects. Curr Vasc Pharmacol. 2017;15:482. doi:10.2174/1570161115666170201111809
