Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
USERS' SCORE
Excellent
Based on 30 Reviews
9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Riboflavin (Vitamin B-2)
100 mg
7692%
Top Medical Research Studies
9.5
We evaluated the effectiveness of Vitamin B2 supplementation in preventing migraines through a comprehensive review of existing studies.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
Read More
9.5
We evaluated how effective riboflavin is for children and teens suffering from migraines by examining 42 patients over a year at Dell Children's Medical Center.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Read More
9
We explored the effects of naproxen sodium (NxS) as a short-term treatment for women with pure menstrual migraine. Involving 25 participants, we administered NxS daily around their menstrual cycle for three cycles.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Read More
Most Useful Reviews
10
Life-changing solution
142 people found this helpful
Vitamin B2 has changed my life, not an exaggeration. I’ve had chronic migraines for years and tried numerous medications without success. Initially sceptical, I tried B2 to reduce migraine frequency and severity. My daily migraines decreased to about one a week, with a record of 18 days without a migraine! I take 200 mg each morning and night, and I believe it's worth trying for anyone with frequent migraines.
Read More
9
Reduced migraine frequency
66 people found this helpful
Excellent quality and results. I struggled for over fifty years with migraine, anxiety, stress, and allergy headaches. I began researching supplements as I wanted to avoid Topamax due to side effects. I discovered that Vitamin B2, Butterbur, and Feverfew effectively prevent migraines without adverse effects, unlike Topamax. My hair's texture improved without Minoxidil, and I also take Turmeric Curcumin, Magnesium, Potassium, and Devil's Claw to alleviate chronic pain.
Read More
9
Increased quality of life
45 people found this helpful
I had severe migraine headaches and read about taking 400mg of B-2 daily to decrease the frequency of migraines. After three months, I’m pleased to report it works! I reduced my rescue medication use from twice a week to twice a month. The difference is incredible, leading to fewer headaches and an improved quality of life.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.9
- All Researches
9.5
We evaluated the effectiveness of Vitamin B2 supplementation in preventing migraines through a comprehensive review of existing studies.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
By analyzing data from nine studies involving 673 individuals, we found that taking 400 mg of Vitamin B2 daily for three months led to significant reductions in migraine days, duration, frequency, and pain intensity.
This promising result suggests that Vitamin B2 could be an effective preventive strategy for those struggling with migraines, complementing traditional pharmaceutical treatments.
Read More
9.5
We evaluated how effective riboflavin is for children and teens suffering from migraines by examining 42 patients over a year at Dell Children's Medical Center.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Our findings revealed that riboflavin significantly reduced headache frequency, intensity, and duration.
Patients missed fewer school days and required less acute medication after treatment. Overall, riboflavin stands out as a safe, cost-effective option to help manage pediatric migraines.
Read More
9
Peripheral cannabinoids may relieve migraines
We examined the effects of a new type of cannabinoid, designed to specifically target peripheral receptors without affecting the brain. Using mouse models, we observed that this treatment could effectively prevent certain symptoms of migraine and avoid complications often seen with traditional medications.
Notably, when we administered these peripherally restricted cannabinoids before migraine-triggering agents, we noted a significant reduction in pain sensitivity and biochemical responses typically associated with migraines. Interestingly, these cannabinoids did not seem to cause any negative side effects linked to tolerance development.
This study supports the idea that targeting peripheral cannabinoid receptors could be a viable new approach for managing migraines and related medication overuse headaches.
Notably, when we administered these peripherally restricted cannabinoids before migraine-triggering agents, we noted a significant reduction in pain sensitivity and biochemical responses typically associated with migraines. Interestingly, these cannabinoids did not seem to cause any negative side effects linked to tolerance development.
This study supports the idea that targeting peripheral cannabinoid receptors could be a viable new approach for managing migraines and related medication overuse headaches.
Read More
9
We explored the impact of ginkgolide B, an extract from Ginkgo biloba, on migraine with aura. In a six-month study with fifty women, we observed beneficial results after participants took a combination of ginkgolide B, coenzyme Q10, and vitamin B2.
Notably, migraine aura frequency dropped from an average of 3.7 to 1.2 episodes by the end of the treatment. Moreover, the duration of migraines significantly decreased as well. Overall, ginkgolide B showed promise in reducing the occurrence and duration of migraines with aura.
Notably, migraine aura frequency dropped from an average of 3.7 to 1.2 episodes by the end of the treatment. Moreover, the duration of migraines significantly decreased as well. Overall, ginkgolide B showed promise in reducing the occurrence and duration of migraines with aura.
Read More
9
We explored the effects of naproxen sodium (NxS) as a short-term treatment for women with pure menstrual migraine. Involving 25 participants, we administered NxS daily around their menstrual cycle for three cycles.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Our findings revealed a significant drop in migraine attack frequency, duration, and intensity. The average number of attacks decreased markedly, from 1.7 to 1.1. Additionally, the duration of each migraine lessened from nearly 26 hours to about 13 hours, demonstrating promising results for using NxS in managing menstrual migraines.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 30 Reviews
9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing solution
142 people found this helpful
Vitamin B2 has changed my life, not an exaggeration. I’ve had chronic migraines for years and tried numerous medications without success. Initially sceptical, I tried B2 to reduce migraine frequency and severity. My daily migraines decreased to about one a week, with a record of 18 days without a migraine! I take 200 mg each morning and night, and I believe it's worth trying for anyone with frequent migraines.
Read More
9
Reduced migraine frequency
66 people found this helpful
Excellent quality and results. I struggled for over fifty years with migraine, anxiety, stress, and allergy headaches. I began researching supplements as I wanted to avoid Topamax due to side effects. I discovered that Vitamin B2, Butterbur, and Feverfew effectively prevent migraines without adverse effects, unlike Topamax. My hair's texture improved without Minoxidil, and I also take Turmeric Curcumin, Magnesium, Potassium, and Devil's Claw to alleviate chronic pain.
Read More
9
Increased quality of life
45 people found this helpful
I had severe migraine headaches and read about taking 400mg of B-2 daily to decrease the frequency of migraines. After three months, I’m pleased to report it works! I reduced my rescue medication use from twice a week to twice a month. The difference is incredible, leading to fewer headaches and an improved quality of life.
Read More
10
Prevented migraines
30 people found this helpful
I take four pills a day (two in the morning and two at night), and it seems to prevent migraines effectively. I haven't had one since I started taking them, having previously experienced them every month and a half.
Read More
9
Miraculous prevention method
24 people found this helpful
After nearly 20 years of managing migraines, I began experiencing them more frequently, sometimes several times a week. Reluctant to restart my prescription medications, I decided to try Vitamin B2 and magnesium oil instead. Starting with 200 mg per day, I saw immediate improvement and even went weeks without a migraine. This combination has been miraculous for me, and I highly recommend it to fellow migraine sufferers.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Szabo E, Bolo NR, Borsook D, Burstein R, Ashina S. Peripherally acting anti-CGRP monoclonal antibodies attenuate cortical resting-state connectivity in migraine patients. Cephalalgia. 2025;45:3331024241313377. 10.1177/03331024241313377
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Son H, Zhang Y, Shannonhouse J, Gomez R, Kim YS. PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice. J Headache Pain. 2024;25:87. 10.1186/s10194-024-01786-3
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. 10.1080/1028415X.2021.1904542
- Yamamoto T, Mulpuri Y, Izraylev M, Li Q, Simonian M, et al. Selective targeting of peripheral cannabinoid receptors prevents behavioral symptoms and sensitization of trigeminal neurons in mouse models of migraine and medication overuse headache. Pain. 2021;162:2246. 10.1097/j.pain.0000000000002214
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. 10.1016/j.pediatrneurol.2020.09.009
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Cesarone MR, Dugall M, Hu S, Belcaro G, Hosoi M, et al. Episodic primary migraine headache: supplementary prophylaxis with Pycnogenol® prevents attacks and controls oxidative stress. Panminerva Med. 2020;62:102. 10.23736/S0031-0808.19.03745-5
- Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85:79. 10.1024/0300-9831/a000225
- Rahimdel A, Zeinali A, Yazdian-Anari P, Hajizadeh R, Arefnia E. Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial. Electron Physician. 2015;7:1344. 10.14661/1344
- Tepper SJ. Nutraceutical and Other Modalities for the Treatment of Headache. Continuum (Minneap Minn). 2015;21:1018. 10.1212/CON.0000000000000211
- Yorns WR, Hardison HH. Mitochondrial dysfunction in migraine. Semin Pediatr Neurol. 2013;20:188. 10.1016/j.spen.2013.09.002
- Allais G, D'Andrea G, Maggio M, Benedetto C. The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial. Neurol Sci. 2013;34 Suppl 1:S161. 10.1007/s10072-013-1413-x
- D'Andrea G, Bussone G, Allais G, Aguggia M, D'Onofrio F, et al. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurol Sci. 2009;30 Suppl 1:S121. 10.1007/s10072-009-0074-2
- Allais G, Bussone G, De Lorenzo C, Castagnoli Gabellari I, Zonca M, et al. Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations. Neurol Sci. 2007;28 Suppl 2:S225.
