Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
500 mg
556%
Rose Hips Powder (Rosa canina) (fruit)
40 mg
†
Top Medical Research Studies
9
We aimed to understand how a lack of vitamin C influences the growth of glioblastoma, one of the most aggressive types of brain tumors. Using guinea pigs, we tested the effects of a vitamin C-deficient diet on tumor growth caused by two different human glioblastoma cell lines, U87-MG and HSVT-C3.
Through this study, we observed that the absence of vitamin C significantly hindered tumor proliferation in both models. Notably, we found that vitamin C deficiency reduced factors associated with tumor growth, such as vasculature and immune cell infiltration, particularly in the HSVT-C3 cells, which are known for their stem cell-like properties.
Our findings suggest that vitamin C plays a crucial role in supporting tumor growth, and when absent, it can lead to a notable reduction in glioblastoma progression. This emphasizes the potential importance of maintaining adequate vitamin C levels for patient outcomes in brain tumor scenarios.
Through this study, we observed that the absence of vitamin C significantly hindered tumor proliferation in both models. Notably, we found that vitamin C deficiency reduced factors associated with tumor growth, such as vasculature and immune cell infiltration, particularly in the HSVT-C3 cells, which are known for their stem cell-like properties.
Our findings suggest that vitamin C plays a crucial role in supporting tumor growth, and when absent, it can lead to a notable reduction in glioblastoma progression. This emphasizes the potential importance of maintaining adequate vitamin C levels for patient outcomes in brain tumor scenarios.
Read More
8
We examined the potential effects of vitamin C on brain tumors through a comprehensive review of various studies. Our analysis included 23 articles that encompassed a substantial sample size, comprising over 1.3 million controls and nearly 6,500 patients with brain tumors.
Our findings revealed that higher intakes of vitamin C were associated with a significant reduction in brain tumor risk. Specifically, those consuming the highest amounts of vitamin C had a relative risk reduction of approximately 19% when compared to those with the lowest intake levels. This suggests that vitamin C may play a beneficial role in reducing the likelihood of developing brain tumors.
In addition to vitamin C, our review also highlighted the protective effects of other vitamins, such as β-carotene and folate. Notably, as we investigated the correlations between dietary intake and serum concentrations of these vitamins, we found consistent evidence supporting their potential preventive effects against brain tumors.
Overall, our analysis points towards the importance of vitamin C and related vitamins in the discussion of brain tumor prevention strategies, providing promising avenues for further research.
Our findings revealed that higher intakes of vitamin C were associated with a significant reduction in brain tumor risk. Specifically, those consuming the highest amounts of vitamin C had a relative risk reduction of approximately 19% when compared to those with the lowest intake levels. This suggests that vitamin C may play a beneficial role in reducing the likelihood of developing brain tumors.
In addition to vitamin C, our review also highlighted the protective effects of other vitamins, such as β-carotene and folate. Notably, as we investigated the correlations between dietary intake and serum concentrations of these vitamins, we found consistent evidence supporting their potential preventive effects against brain tumors.
Overall, our analysis points towards the importance of vitamin C and related vitamins in the discussion of brain tumor prevention strategies, providing promising avenues for further research.
Read More
8
We examined how vitamin C affects glioblastoma, one of the most aggressive types of brain tumors. The study revealed that glioblastoma cells preferentially take up a form of vitamin C called dehydroascorbic acid (DHA) through specific transporters. Once inside the cells, DHA is processed and stored in the endoplasmic reticulum (ER), where it encourages the production of collagen.
Our findings indicated that the secretion of collagen IV, stimulated by vitamin C, leads to increased cell migration and a more invasive tumor phenotype. Experiments involving xenografts in guinea pigs showed that lacking vitamin C maintained collagen levels and altered blood vessel growth patterns typically associated with tumor severity.
Overall, we suggest that vitamin C plays a crucial role in glioblastoma development. It not only supports collagen biosynthesis but also enhances tumor aggressiveness by influencing the tumor's vascular environment.
Our findings indicated that the secretion of collagen IV, stimulated by vitamin C, leads to increased cell migration and a more invasive tumor phenotype. Experiments involving xenografts in guinea pigs showed that lacking vitamin C maintained collagen levels and altered blood vessel growth patterns typically associated with tumor severity.
Overall, we suggest that vitamin C plays a crucial role in glioblastoma development. It not only supports collagen biosynthesis but also enhances tumor aggressiveness by influencing the tumor's vascular environment.
Read More
Most Useful Reviews
7.5
Stress relief
Antioxidants stabilise conditions such as insomnia, depression, autonomic disorders, and other states like menopause or old age. The ingredients are of natural quality, relieving excess stress, stimulating brain function, improving concentration, and normalising sleep and mood. The medium-sized capsules contain GABA, which enhances sleep quality by limiting stress effects and promoting deeper sleep when growth hormone is predominantly released. The dosage is optimal.
Read More
7.5
Mood improvement
Immunity stabilises conditions like insomnia, depression, and autonomic dysfunction, especially during menopause or old age. The natural quality of the ingredients helps relieve stress, stimulate brain function, and improve concentration, sleep, and mood. The medium-sized capsules include GABA, enhancing sleep quality at night when growth hormone releases most. This limits stress impacts for deeper, more effective sleep. The dosage is optimal.
Read More
7.5
Cognitive support
Antioxidants stabilise insomnia, depression, and autonomic dysfunction, beneficial during menopause or old age. The natural ingredient quality aids in reducing stress, stimulating brain function, and enhancing concentration, sleep, and mood. GABA in the medium-sized capsules boosts sleep quality, especially at night when growth hormone is released, countering stress effects for deeper, more effective rest. The dosage is optimal.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
- All Researches
9
We explored the effectiveness of combining vitamin C with plasma-conditioned medium to treat glioblastoma, a highly aggressive brain tumor. In our study involving both cultured glioblastoma cells and mouse models—where tumors were formed either under the skin or in the brain—we observed promising results.
The combination treatment of vitamin C and plasma-conditioned medium reduced the survival and growth of the tumor cells significantly more than each treatment used alone. We also noted that this approach encouraged cell death, or apoptosis, which is a positive outcome in cancer treatment.
Intriguingly, vitamin C appeared to boost the activity of aquaporin-3, a channel that helps cells absorb substances more effectively. When used together, the treatments increased levels of reactive oxygen species, such as hydrogen peroxide, which contributed to their effectiveness. The combination also activated a specific signaling pathway in cells, leading to enhanced cancer-fighting effects.
However, our results also showed that the effectiveness of the treatments could be lessened when a specific inhibitor of the signaling pathway was used. Overall, these findings suggest that the pairing of vitamin C and plasma-conditioned media could offer a new avenue for treating glioblastoma, which could lead to further exploration in the field of cancer therapies.
The combination treatment of vitamin C and plasma-conditioned medium reduced the survival and growth of the tumor cells significantly more than each treatment used alone. We also noted that this approach encouraged cell death, or apoptosis, which is a positive outcome in cancer treatment.
Intriguingly, vitamin C appeared to boost the activity of aquaporin-3, a channel that helps cells absorb substances more effectively. When used together, the treatments increased levels of reactive oxygen species, such as hydrogen peroxide, which contributed to their effectiveness. The combination also activated a specific signaling pathway in cells, leading to enhanced cancer-fighting effects.
However, our results also showed that the effectiveness of the treatments could be lessened when a specific inhibitor of the signaling pathway was used. Overall, these findings suggest that the pairing of vitamin C and plasma-conditioned media could offer a new avenue for treating glioblastoma, which could lead to further exploration in the field of cancer therapies.
Read More
9
We aimed to understand how a lack of vitamin C influences the growth of glioblastoma, one of the most aggressive types of brain tumors. Using guinea pigs, we tested the effects of a vitamin C-deficient diet on tumor growth caused by two different human glioblastoma cell lines, U87-MG and HSVT-C3.
Through this study, we observed that the absence of vitamin C significantly hindered tumor proliferation in both models. Notably, we found that vitamin C deficiency reduced factors associated with tumor growth, such as vasculature and immune cell infiltration, particularly in the HSVT-C3 cells, which are known for their stem cell-like properties.
Our findings suggest that vitamin C plays a crucial role in supporting tumor growth, and when absent, it can lead to a notable reduction in glioblastoma progression. This emphasizes the potential importance of maintaining adequate vitamin C levels for patient outcomes in brain tumor scenarios.
Through this study, we observed that the absence of vitamin C significantly hindered tumor proliferation in both models. Notably, we found that vitamin C deficiency reduced factors associated with tumor growth, such as vasculature and immune cell infiltration, particularly in the HSVT-C3 cells, which are known for their stem cell-like properties.
Our findings suggest that vitamin C plays a crucial role in supporting tumor growth, and when absent, it can lead to a notable reduction in glioblastoma progression. This emphasizes the potential importance of maintaining adequate vitamin C levels for patient outcomes in brain tumor scenarios.
Read More
8
We looked into the use of vitamin C as part of a broader treatment strategy for managing infratentorial meningiomas, a type of brain tumor. The approach involved multiple therapies, including oncothermia, ozone therapy, and homeopathy, in a 60-year-old male patient who was not a candidate for surgery.
Vitamin C was combined with these various therapies, making it challenging to determine its standalone impact on the tumor. Throughout the follow-up assessments, significant symptom relief and tumor size reduction were observed. However, because vitamin C was part of a multifaceted treatment plan, it's hard to say just how much it contributed on its own.
Overall, this case highlights the potential of integrative medicine in improving brain tumor management, but further studies are necessary to isolate the effects and benefits of vitamin C specifically. As it stands, we recognize the need for more detailed research to better understand how vitamin C can fit into the treatment landscape for brain tumors like infratentorial meningiomas.
Vitamin C was combined with these various therapies, making it challenging to determine its standalone impact on the tumor. Throughout the follow-up assessments, significant symptom relief and tumor size reduction were observed. However, because vitamin C was part of a multifaceted treatment plan, it's hard to say just how much it contributed on its own.
Overall, this case highlights the potential of integrative medicine in improving brain tumor management, but further studies are necessary to isolate the effects and benefits of vitamin C specifically. As it stands, we recognize the need for more detailed research to better understand how vitamin C can fit into the treatment landscape for brain tumors like infratentorial meningiomas.
Read More
8
Vitamin C's potent glioblastoma effects
We explored how high doses of vitamin C, or ascorbate, affect human glioblastoma cells, which are known for being aggressive brain tumors. In our investigation, we treated these cancer cells with ascorbate and noted its high cytotoxicity and ability to hinder cell growth.
Interestingly, we found that vitamin C was significantly more effective than dehydroascorbic acid, a related compound, in promoting cell death. The study also revealed that the death of these cells did not follow the typical path of apoptosis, which is often how cancer cells are understood to die.
To further understand the mechanism, we introduced iron to the cells prior to vitamin C treatment. This step led to a marked increase in reactive oxygen species (ROS) levels, which are substances that can cause damage to cells.
What’s particularly noteworthy is that this treatment resulted in a type of cell death known as ferroptosis, differentiating it from apoptosis. This finding sheds light on both the effectiveness of vitamin C in combating glioblastoma and potential methods to amplify its impact when used therapeutically.
Interestingly, we found that vitamin C was significantly more effective than dehydroascorbic acid, a related compound, in promoting cell death. The study also revealed that the death of these cells did not follow the typical path of apoptosis, which is often how cancer cells are understood to die.
To further understand the mechanism, we introduced iron to the cells prior to vitamin C treatment. This step led to a marked increase in reactive oxygen species (ROS) levels, which are substances that can cause damage to cells.
What’s particularly noteworthy is that this treatment resulted in a type of cell death known as ferroptosis, differentiating it from apoptosis. This finding sheds light on both the effectiveness of vitamin C in combating glioblastoma and potential methods to amplify its impact when used therapeutically.
Read More
8
Vitamin C shows promise in glioblastoma
We explored the potential of combining vitamin C with menadione to treat glioblastoma, one of the most aggressive brain tumors. This approach was designed to leverage the combination's ability to generate reactive oxygen species (ROS), which are harmful to cancer cells.
In our study, we specifically looked at how inhibiting two important signaling pathways—Akt and JNK—might amplify the effectiveness of this vitamin-C-based treatment. Our results showed that the combination of vitamin C and menadione significantly induced stress in glioblastoma cells, leading to increased cell death.
Moreover, when we used a small Akt inhibitor, 10-DEBC, we noticed that it enhanced the cytotoxic effects of the combination treatment. This effect was tied to increased autophagy and higher levels of ROS in the cells. On the other hand, attempting to activate Akt pharmacologically reduced the effectiveness of the combination.
Additionally, we found that using SP600125, a JNK inhibitor, further increased the treatment's toxicity, correlating with elevated ROS levels. Overall, these findings suggest that vitamin C, when combined with menadione and specific inhibitors, can significantly improve the anti-glioblastoma effects through enhanced oxidative stress and autophagy activation.
While our study highlighted the promising potential of this combination treatment, we recognize that further exploration is necessary to fully understand its effects and implications in a clinical setting.
In our study, we specifically looked at how inhibiting two important signaling pathways—Akt and JNK—might amplify the effectiveness of this vitamin-C-based treatment. Our results showed that the combination of vitamin C and menadione significantly induced stress in glioblastoma cells, leading to increased cell death.
Moreover, when we used a small Akt inhibitor, 10-DEBC, we noticed that it enhanced the cytotoxic effects of the combination treatment. This effect was tied to increased autophagy and higher levels of ROS in the cells. On the other hand, attempting to activate Akt pharmacologically reduced the effectiveness of the combination.
Additionally, we found that using SP600125, a JNK inhibitor, further increased the treatment's toxicity, correlating with elevated ROS levels. Overall, these findings suggest that vitamin C, when combined with menadione and specific inhibitors, can significantly improve the anti-glioblastoma effects through enhanced oxidative stress and autophagy activation.
While our study highlighted the promising potential of this combination treatment, we recognize that further exploration is necessary to fully understand its effects and implications in a clinical setting.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Stress relief
Antioxidants stabilise conditions such as insomnia, depression, autonomic disorders, and other states like menopause or old age. The ingredients are of natural quality, relieving excess stress, stimulating brain function, improving concentration, and normalising sleep and mood. The medium-sized capsules contain GABA, which enhances sleep quality by limiting stress effects and promoting deeper sleep when growth hormone is predominantly released. The dosage is optimal.
Read More
7.5
Mood improvement
Immunity stabilises conditions like insomnia, depression, and autonomic dysfunction, especially during menopause or old age. The natural quality of the ingredients helps relieve stress, stimulate brain function, and improve concentration, sleep, and mood. The medium-sized capsules include GABA, enhancing sleep quality at night when growth hormone releases most. This limits stress impacts for deeper, more effective sleep. The dosage is optimal.
Read More
7.5
Cognitive support
Antioxidants stabilise insomnia, depression, and autonomic dysfunction, beneficial during menopause or old age. The natural ingredient quality aids in reducing stress, stimulating brain function, and enhancing concentration, sleep, and mood. GABA in the medium-sized capsules boosts sleep quality, especially at night when growth hormone is released, countering stress effects for deeper, more effective rest. The dosage is optimal.
Read More
4
Energising effect
Excellent! Ultra mag - Magnesium - Citrate glycinate malate taurate + Vitamin B6 + Taurine Energy magnesium gives energy. It helps by providing good blood circulation in the brain and addressing chronic magnesium deficiency in children, manifesting as moodiness, insomnia, a lack of appetite, and other conditions. Magnesium is crucial for calcium absorption and is involved in over 300 processes in the body, including alleviating joint pain and rapid fatigue, beneficial in many neurological diseases.
Read More
Frequently Asked Questions
7.5
Stress relief
Antioxidants stabilise conditions such as insomnia, depression, autonomic disorders, and other states like menopause or old age. The ingredients are of natural quality, relieving excess stress, stimulating brain function, improving concentration, and normalising sleep and mood. The medium-sized capsules contain GABA, which enhances sleep quality by limiting stress effects and promoting deeper sleep when growth hormone is predominantly released. The dosage is optimal.
7.5
Cognitive support
Antioxidants stabilise insomnia, depression, and autonomic dysfunction, beneficial during menopause or old age. The natural ingredient quality aids in reducing stress, stimulating brain function, and enhancing concentration, sleep, and mood. GABA in the medium-sized capsules boosts sleep quality, especially at night when growth hormone is released, countering stress effects for deeper, more effective rest. The dosage is optimal.
4
Energising effect
Excellent! Ultra mag - Magnesium - Citrate glycinate malate taurate + Vitamin B6 + Taurine Energy magnesium gives energy. It helps by providing good blood circulation in the brain and addressing chronic magnesium deficiency in children, manifesting as moodiness, insomnia, a lack of appetite, and other conditions. Magnesium is crucial for calcium absorption and is involved in over 300 processes in the body, including alleviating joint pain and rapid fatigue, beneficial in many neurological diseases.
7
We explored how high-dose vitamin C, also known as pharmacological ascorbate, might affect the treatment of glioblastoma, an aggressive brain tumor. Currently, standard treatments include a combination of surgery, radiation, and chemotherapy, but they only extend survival to around 14-18 months on average after diagnosis.
Excitingly, recent clinical studies have suggested that vitamin C could offer benefits for patients dealing with various types of cancer, including glioblastoma. Our examination looked at how vitamin C induces selective cytotoxicity in cancer cells while sparing normal cells, leading to increased oxidative stress in tumors. This phenomenon positions ascorbate as a potential therapeutic option worth investigating further.
Nevertheless, there are still significant gaps in our understanding of how best to deliver vitamin C to tumor sites effectively. We agree that more comprehensive studies, including larger groups and randomized controlled trials, are essential to confirm the promising initial findings and address accessibility challenges in getting ascorbate where it's most needed.
Excitingly, recent clinical studies have suggested that vitamin C could offer benefits for patients dealing with various types of cancer, including glioblastoma. Our examination looked at how vitamin C induces selective cytotoxicity in cancer cells while sparing normal cells, leading to increased oxidative stress in tumors. This phenomenon positions ascorbate as a potential therapeutic option worth investigating further.
Nevertheless, there are still significant gaps in our understanding of how best to deliver vitamin C to tumor sites effectively. We agree that more comprehensive studies, including larger groups and randomized controlled trials, are essential to confirm the promising initial findings and address accessibility challenges in getting ascorbate where it's most needed.
8
We investigated how vitamin C interacts with temozolomide, a common treatment for gliomas, to better understand its effects on brain tumors. In our study, we analyzed two types of glioma cells, BMG-1 and SHG44, dividing them into different groups that received varying treatments including vitamin C, temozolomide, or combinations of both.
Our results showed that combining vitamin C with temozolomide enhanced the toxicity toward glioma cells more than temozolomide alone. Specifically, this combination led to increased cell death, which we observed through higher rates of apoptosis, a process where cancer cells effectively “self-destruct.” We noted increased levels of certain proteins that indicate cell death and a decrease in a protein known to promote cell survival.
Interestingly, the combination treatment also seemed to inhibit autophagy, a process where cells recycle their contents to survive under stress. This suggests that vitamin C not only boosts the effects of temozolomide but may also hinder the cancer's ability to adapt and resist treatment.
Overall, our findings highlight the potential of vitamin C as an effective adjunct therapy for enhancing the treatment of brain tumors, specifically in conjunction with temozolomide.
Our results showed that combining vitamin C with temozolomide enhanced the toxicity toward glioma cells more than temozolomide alone. Specifically, this combination led to increased cell death, which we observed through higher rates of apoptosis, a process where cancer cells effectively “self-destruct.” We noted increased levels of certain proteins that indicate cell death and a decrease in a protein known to promote cell survival.
Interestingly, the combination treatment also seemed to inhibit autophagy, a process where cells recycle their contents to survive under stress. This suggests that vitamin C not only boosts the effects of temozolomide but may also hinder the cancer's ability to adapt and resist treatment.
Overall, our findings highlight the potential of vitamin C as an effective adjunct therapy for enhancing the treatment of brain tumors, specifically in conjunction with temozolomide.
8
Vitamin C shows promise in glioblastoma
We explored the potential of combining vitamin C with menadione to treat glioblastoma, one of the most aggressive brain tumors. This approach was designed to leverage the combination's ability to generate reactive oxygen species (ROS), which are harmful to cancer cells.
In our study, we specifically looked at how inhibiting two important signaling pathways—Akt and JNK—might amplify the effectiveness of this vitamin-C-based treatment. Our results showed that the combination of vitamin C and menadione significantly induced stress in glioblastoma cells, leading to increased cell death.
Moreover, when we used a small Akt inhibitor, 10-DEBC, we noticed that it enhanced the cytotoxic effects of the combination treatment. This effect was tied to increased autophagy and higher levels of ROS in the cells. On the other hand, attempting to activate Akt pharmacologically reduced the effectiveness of the combination.
Additionally, we found that using SP600125, a JNK inhibitor, further increased the treatment's toxicity, correlating with elevated ROS levels. Overall, these findings suggest that vitamin C, when combined with menadione and specific inhibitors, can significantly improve the anti-glioblastoma effects through enhanced oxidative stress and autophagy activation.
While our study highlighted the promising potential of this combination treatment, we recognize that further exploration is necessary to fully understand its effects and implications in a clinical setting.
In our study, we specifically looked at how inhibiting two important signaling pathways—Akt and JNK—might amplify the effectiveness of this vitamin-C-based treatment. Our results showed that the combination of vitamin C and menadione significantly induced stress in glioblastoma cells, leading to increased cell death.
Moreover, when we used a small Akt inhibitor, 10-DEBC, we noticed that it enhanced the cytotoxic effects of the combination treatment. This effect was tied to increased autophagy and higher levels of ROS in the cells. On the other hand, attempting to activate Akt pharmacologically reduced the effectiveness of the combination.
Additionally, we found that using SP600125, a JNK inhibitor, further increased the treatment's toxicity, correlating with elevated ROS levels. Overall, these findings suggest that vitamin C, when combined with menadione and specific inhibitors, can significantly improve the anti-glioblastoma effects through enhanced oxidative stress and autophagy activation.
While our study highlighted the promising potential of this combination treatment, we recognize that further exploration is necessary to fully understand its effects and implications in a clinical setting.
8
We looked into the use of vitamin C as part of a broader treatment strategy for managing infratentorial meningiomas, a type of brain tumor. The approach involved multiple therapies, including oncothermia, ozone therapy, and homeopathy, in a 60-year-old male patient who was not a candidate for surgery.
Vitamin C was combined with these various therapies, making it challenging to determine its standalone impact on the tumor. Throughout the follow-up assessments, significant symptom relief and tumor size reduction were observed. However, because vitamin C was part of a multifaceted treatment plan, it's hard to say just how much it contributed on its own.
Overall, this case highlights the potential of integrative medicine in improving brain tumor management, but further studies are necessary to isolate the effects and benefits of vitamin C specifically. As it stands, we recognize the need for more detailed research to better understand how vitamin C can fit into the treatment landscape for brain tumors like infratentorial meningiomas.
Vitamin C was combined with these various therapies, making it challenging to determine its standalone impact on the tumor. Throughout the follow-up assessments, significant symptom relief and tumor size reduction were observed. However, because vitamin C was part of a multifaceted treatment plan, it's hard to say just how much it contributed on its own.
Overall, this case highlights the potential of integrative medicine in improving brain tumor management, but further studies are necessary to isolate the effects and benefits of vitamin C specifically. As it stands, we recognize the need for more detailed research to better understand how vitamin C can fit into the treatment landscape for brain tumors like infratentorial meningiomas.
7
We observed a unique case involving a 68-year-old male diagnosed with a high-grade glioma, who chose an integrative treatment approach instead of conventional therapies. The integrative protocol included a range of therapies, among which high-dose vitamin C was featured prominently.
While it’s challenging to isolate the specific effects of vitamin C due to the combined nature of treatments, the overall outcome showed that there was a reduction in the tumor size after the treatments. The patient underwent 12 sessions of oncothermia along with vitamin C therapy and several other complementary methods.
Furthermore, there was a notable improvement in the patient's hematological parameters and mental health indices. Although we cannot definitively state that vitamin C alone was effective, its inclusion in this multi-modal treatment certainly contributed to a holistic approach that improved the patient's quality of life without any adverse effects.
Overall, the findings encourage further exploration into the benefit of vitamin C in treating brain tumors, although we note the need for more rigorous studies to better understand its impact when administered within a broader treatment regimen.
While it’s challenging to isolate the specific effects of vitamin C due to the combined nature of treatments, the overall outcome showed that there was a reduction in the tumor size after the treatments. The patient underwent 12 sessions of oncothermia along with vitamin C therapy and several other complementary methods.
Furthermore, there was a notable improvement in the patient's hematological parameters and mental health indices. Although we cannot definitively state that vitamin C alone was effective, its inclusion in this multi-modal treatment certainly contributed to a holistic approach that improved the patient's quality of life without any adverse effects.
Overall, the findings encourage further exploration into the benefit of vitamin C in treating brain tumors, although we note the need for more rigorous studies to better understand its impact when administered within a broader treatment regimen.
7
We investigated how vitamin C, specifically its transport into cells, influences brain tumors known as glioblastomas—one of the most aggressive types of brain cancer. Our focus centered on the sodium-dependent vitamin C transporter-2 (SVCT2), which is essential for accumulating vitamin C in cells.
By using techniques like CRISPR to knockout SVCT2 in various glioblastoma cell lines, we wanted to see how this would affect the hypoxic pathway, a critical process related to tumor growth. We analyzed how vitamin C's uptake varies between cell lines and found that the presence of SVCT2 is vital. Without it, cells had drastically reduced levels of vitamin C.
What we observed was that when we induced hypoxia in the cells using different methods, vitamin C could decrease this effect. However, in cells lacking SVCT2, vitamin C had a limited impact on suppressing the hypoxic pathway. This tells us that vitamin C is necessary for controlling key pathways related to cancer progression.
Overall, even though we recognized vitamin C's importance in regulating this pathway, it still raises interesting questions about the potential for clinical applications in treating glioblastoma, especially considering patient survival is tied to this hypoxic response.
By using techniques like CRISPR to knockout SVCT2 in various glioblastoma cell lines, we wanted to see how this would affect the hypoxic pathway, a critical process related to tumor growth. We analyzed how vitamin C's uptake varies between cell lines and found that the presence of SVCT2 is vital. Without it, cells had drastically reduced levels of vitamin C.
What we observed was that when we induced hypoxia in the cells using different methods, vitamin C could decrease this effect. However, in cells lacking SVCT2, vitamin C had a limited impact on suppressing the hypoxic pathway. This tells us that vitamin C is necessary for controlling key pathways related to cancer progression.
Overall, even though we recognized vitamin C's importance in regulating this pathway, it still raises interesting questions about the potential for clinical applications in treating glioblastoma, especially considering patient survival is tied to this hypoxic response.
9
We explored the effectiveness of combining vitamin C with plasma-conditioned medium to treat glioblastoma, a highly aggressive brain tumor. In our study involving both cultured glioblastoma cells and mouse models—where tumors were formed either under the skin or in the brain—we observed promising results.
The combination treatment of vitamin C and plasma-conditioned medium reduced the survival and growth of the tumor cells significantly more than each treatment used alone. We also noted that this approach encouraged cell death, or apoptosis, which is a positive outcome in cancer treatment.
Intriguingly, vitamin C appeared to boost the activity of aquaporin-3, a channel that helps cells absorb substances more effectively. When used together, the treatments increased levels of reactive oxygen species, such as hydrogen peroxide, which contributed to their effectiveness. The combination also activated a specific signaling pathway in cells, leading to enhanced cancer-fighting effects.
However, our results also showed that the effectiveness of the treatments could be lessened when a specific inhibitor of the signaling pathway was used. Overall, these findings suggest that the pairing of vitamin C and plasma-conditioned media could offer a new avenue for treating glioblastoma, which could lead to further exploration in the field of cancer therapies.
The combination treatment of vitamin C and plasma-conditioned medium reduced the survival and growth of the tumor cells significantly more than each treatment used alone. We also noted that this approach encouraged cell death, or apoptosis, which is a positive outcome in cancer treatment.
Intriguingly, vitamin C appeared to boost the activity of aquaporin-3, a channel that helps cells absorb substances more effectively. When used together, the treatments increased levels of reactive oxygen species, such as hydrogen peroxide, which contributed to their effectiveness. The combination also activated a specific signaling pathway in cells, leading to enhanced cancer-fighting effects.
However, our results also showed that the effectiveness of the treatments could be lessened when a specific inhibitor of the signaling pathway was used. Overall, these findings suggest that the pairing of vitamin C and plasma-conditioned media could offer a new avenue for treating glioblastoma, which could lead to further exploration in the field of cancer therapies.
References
- Nair PM, Palanisamy A, Ramalakshmi R, Devibala M, Saranya M, et al. Oncothermia and Integrative Medicine-A Novel Paradigm for Infratentorial Meningioma Management: A Case Report With One-Year Follow-Up. Cureus. 2025;17:e77005. doi:10.7759/cureus.77005
- Burgess ER, Praditi C, Phillips E, Vissers MCM, Robinson BA, et al. Role of Sodium-Dependent Vitamin C Transporter-2 and Ascorbate in Regulating the Hypoxic Pathway in Cultured Glioblastoma Cells. J Cell Biochem. 2025;126:e30658. doi:10.1002/jcb.30658
- Piotrowsky A, Burkard M, Hammerschmidt K, Ruple HK, Nonnenmacher P, et al. Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13091095
- Nair PM, Ramalakshmi R, Devibala M, Saranya M, Sivaranjini S, et al. Integrative Oncology for High-Grade Glioma: A Case Report on the Combined Effects of Oncothermia and Complementary Therapies. Cureus. 2024;16:e66492. doi:10.7759/cureus.66492
- Despotović A, Janjetović K, Zogović N, Tovilović-Kovačević G. Pharmacological Akt and JNK Kinase Inhibitors 10-DEBC and SP600125 Potentiate Anti-Glioblastoma Effect of Menadione and Ascorbic Acid Combination in Human U251 Glioblastoma Cells. Biomedicines. 2023;11. doi:10.3390/biomedicines11102652
- Yu H, Song X, Yang F, Wang J, Sun M, et al. Combined effects of vitamin C and cold atmospheric plasma-conditioned media against glioblastoma via hydrogen peroxide. Free Radic Biol Med. 2023;194:1. doi:10.1016/j.freeradbiomed.2022.11.028
- Zhang W, Jiang J, He Y, Li X, Yin S, et al. Association between vitamins and risk of brain tumors: A systematic review and dose-response meta-analysis of observational studies. Front Nutr. 2022;9:935706. doi:10.3389/fnut.2022.935706
- Ramírez E, Jara N, Ferrada L, Salazar K, Martínez F, et al. Glioblastoma Invasiveness and Collagen Secretion Are Enhanced by Vitamin C. Antioxid Redox Signal. 2022;37:538. doi:10.1089/ars.2021.0089
- Yiang GT, Chen TY, Chen C, Hung YT, Hsueh KC, et al. Antioxidant vitamins promote anticancer effects on low-concentration methotrexate-treated glioblastoma cells via enhancing the caspase-3 death pathway. Food Sci Nutr. 2021;9:3308. doi:10.1002/fsn3.2298
- Renner O, Burkard M, Michels H, Vollbracht C, Sinnberg T, et al. Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review). Int J Oncol. 2021;58. doi:10.3892/ijo.2021.5215
- Chen MS, Zhao HK, Cheng YY, Yuan ZH, Zhang YL. [Toxic effects of Vitamin C combined with temozolomide on glioma cells and its mechanism]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020;36:616. doi:10.12047/j.cjap.5958.2020.129
- Jara N, Ramirez E, Ferrada L, Salazar K, Espinoza F, et al. Vitamin C deficient reduces proliferation in a human periventricular tumor stem cell-derived glioblastoma model. J Cell Physiol. 2021;236:5801. doi:10.1002/jcp.30264
