Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9.5
Vitamin D may alleviate chronic hives
We explored the intriguing connection between vitamin D and chronic hives, also known as chronic urticaria. This condition involves recurring itchy welts that can be quite frustrating, especially when the triggers are often elusive. In this case, we observed a 14-year-old boy suffering from persistent hives that weren’t responding to conventional treatments. Thankfully, during his medical evaluation, we discovered he had a vitamin D deficiency.
The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.
Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.
The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.
Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.
Read More
9.5
We explored the potential benefits of vitamin D3 supplementation specifically for individuals experiencing chronic hives. This study focused on the direct impact of vitamin D3, allowing us to isolate its effects from other treatments.
Over the course of the study, we observed significant improvements in symptoms among participants who received vitamin D3. Many reported a noticeable reduction in hives, suggesting that vitamin D3 may help alleviate this bothersome condition.
The findings point towards vitamin D3 as an effective treatment option for managing chronic urticaria. This could offer new hope for those who have struggled with persistent hives, emphasizing the importance of considering vitamin D levels in treatment strategies.
Over the course of the study, we observed significant improvements in symptoms among participants who received vitamin D3. Many reported a noticeable reduction in hives, suggesting that vitamin D3 may help alleviate this bothersome condition.
The findings point towards vitamin D3 as an effective treatment option for managing chronic urticaria. This could offer new hope for those who have struggled with persistent hives, emphasizing the importance of considering vitamin D levels in treatment strategies.
Read More
8
We conducted a comprehensive review to understand how vitamin D affects hives (urticaria) and its role in improving symptoms. Our analysis included a number of studies that compared vitamin D levels in people with hives to those without, as well as some clinical trials focusing on vitamin D supplementation.
Through our evaluation, we discovered that individuals with hives, especially those suffering from chronic conditions, tend to have lower serum levels of 25-hydroxyvitamin D. Specifically, the difference was about 9.35 ng/mL lower in the urticaria group compared to the control group.
Moreover, we found encouraging evidence from vitamin D supplementation trials. In six trials, those who received vitamin D treatment showed a notable reduction in their hives symptoms, with a mean reduction in clinical scores of approximately 3.63 in randomized control studies and 1.54 in repeated measure trials.
Overall, it seems that vitamin D deficiency may be a risk factor for hives, and supplementation could potentially lead to significant improvements in symptoms for affected individuals.
Through our evaluation, we discovered that individuals with hives, especially those suffering from chronic conditions, tend to have lower serum levels of 25-hydroxyvitamin D. Specifically, the difference was about 9.35 ng/mL lower in the urticaria group compared to the control group.
Moreover, we found encouraging evidence from vitamin D supplementation trials. In six trials, those who received vitamin D treatment showed a notable reduction in their hives symptoms, with a mean reduction in clinical scores of approximately 3.63 in randomized control studies and 1.54 in repeated measure trials.
Overall, it seems that vitamin D deficiency may be a risk factor for hives, and supplementation could potentially lead to significant improvements in symptoms for affected individuals.
Read More
Most Useful Reviews
9
Atopy elimination
After switching from niacinamide to this vitamin D3 for my child’s atopic dermatitis, the hives and skin irritation disappeared within weeks. The eczema on joints has completely resolved! I am astounded at this transformation after years of suffering.
Read More
9
Hives and pressure
I discovered that I had a significant vitamin D deficiency. After taking this vitamin D for over six months, I am no longer troubled by hives or fluctuations in blood pressure. I prefer this brand over others.
Read More
9
Chronic hives cure
Since starting this vitamin, I have been cured of chronic hives that plagued me last winter. I am now a firm believer in the benefits of vitamin D.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
- All Researches
9.5
Vitamin D may alleviate chronic hives
We explored the intriguing connection between vitamin D and chronic hives, also known as chronic urticaria. This condition involves recurring itchy welts that can be quite frustrating, especially when the triggers are often elusive. In this case, we observed a 14-year-old boy suffering from persistent hives that weren’t responding to conventional treatments. Thankfully, during his medical evaluation, we discovered he had a vitamin D deficiency.
The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.
Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.
The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.
Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.
Read More
9.5
We explored the potential benefits of vitamin D3 supplementation specifically for individuals experiencing chronic hives. This study focused on the direct impact of vitamin D3, allowing us to isolate its effects from other treatments.
Over the course of the study, we observed significant improvements in symptoms among participants who received vitamin D3. Many reported a noticeable reduction in hives, suggesting that vitamin D3 may help alleviate this bothersome condition.
The findings point towards vitamin D3 as an effective treatment option for managing chronic urticaria. This could offer new hope for those who have struggled with persistent hives, emphasizing the importance of considering vitamin D levels in treatment strategies.
Over the course of the study, we observed significant improvements in symptoms among participants who received vitamin D3. Many reported a noticeable reduction in hives, suggesting that vitamin D3 may help alleviate this bothersome condition.
The findings point towards vitamin D3 as an effective treatment option for managing chronic urticaria. This could offer new hope for those who have struggled with persistent hives, emphasizing the importance of considering vitamin D levels in treatment strategies.
Read More
9
We conducted a detailed study to understand how vitamin D might improve the lives of those suffering from chronic spontaneous urticaria, commonly known as hives. In our research, we randomly assigned 80 participants to two groups: one receiving a lower dose of vitamin D (4200 IU/week) and the other a higher dose (28,000 IU/week) over 12 weeks.
We measured various factors including participants' quality of life, the severity of their hives, and levels of vitamin D in their blood. Our findings revealed that both groups experienced a significant decrease in the severity of hives over the 12 weeks. Interestingly, those who received the higher dose of vitamin D saw even more notable improvements, particularly at the 6 and 12-week marks.
Additionally, quality of life ratings improved more substantially in the high-dose group compared to the lower-dose group. While the medication scores dropped for both groups, there wasn't a significant difference between them. Overall, we found that taking vitamin D, especially at higher doses, could be a safe and effective way to help manage the distress of hives and enhance overall well-being.
We measured various factors including participants' quality of life, the severity of their hives, and levels of vitamin D in their blood. Our findings revealed that both groups experienced a significant decrease in the severity of hives over the 12 weeks. Interestingly, those who received the higher dose of vitamin D saw even more notable improvements, particularly at the 6 and 12-week marks.
Additionally, quality of life ratings improved more substantially in the high-dose group compared to the lower-dose group. While the medication scores dropped for both groups, there wasn't a significant difference between them. Overall, we found that taking vitamin D, especially at higher doses, could be a safe and effective way to help manage the distress of hives and enhance overall well-being.
Read More
9
We explored the potential benefits of vitamin D3 supplementation for people suffering from chronic urticaria, commonly known as hives. In this study, we included 58 patients diagnosed with chronic spontaneous urticaria (CSU) and compared them with 45 control subjects.
The participants' vitamin D levels were measured, revealing that many CSU patients had lower levels than normal. For those with vitamin D levels below 30 µg/L, we administered a significant dose of 300,000 IU of vitamin D3 each month alongside their standard treatment.
After three months, we evaluated the impact of this supplementation through specific measures of urticaria severity and quality of life. Our findings indicate that vitamin D3 may play a beneficial role in improving both the frequency and intensity of hives symptoms, as well as enhancing the overall quality of life for these patients.
Overall, our results support the idea that replacing vitamin D can lead to meaningful improvements for those dealing with chronic urticaria.
The participants' vitamin D levels were measured, revealing that many CSU patients had lower levels than normal. For those with vitamin D levels below 30 µg/L, we administered a significant dose of 300,000 IU of vitamin D3 each month alongside their standard treatment.
After three months, we evaluated the impact of this supplementation through specific measures of urticaria severity and quality of life. Our findings indicate that vitamin D3 may play a beneficial role in improving both the frequency and intensity of hives symptoms, as well as enhancing the overall quality of life for these patients.
Overall, our results support the idea that replacing vitamin D can lead to meaningful improvements for those dealing with chronic urticaria.
Read More
9
We examined how Vitamin D3 might impact Chronic Urticaria (hives) symptoms in a study involving 192 participants. The subjects were categorized based on their initial Vitamin D levels and divided into three groups. One group received only Vitamin D3, another group was treated with antihistamines and corticosteroids, and the third group received a combination of both VitD3 and the other medications.
Over a period of six weeks, we measured the changes in urticarial symptoms using a visual analogue scale and a 5-D itch score. Our findings revealed that a significant number of Chronic Urticaria patients had low Vitamin D levels at the outset. After treatment, participants who received both Vitamin D3 and the standard medications showed the most improvement in their symptoms.
However, the data indicates that Vitamin D3 alone may not be a standalone solution for hives. Instead, its best effect seems to emerge when used alongside traditional treatments. This research emphasizes the importance of checking Vitamin D levels in individuals with Chronic Urticaria before starting any treatment.
Over a period of six weeks, we measured the changes in urticarial symptoms using a visual analogue scale and a 5-D itch score. Our findings revealed that a significant number of Chronic Urticaria patients had low Vitamin D levels at the outset. After treatment, participants who received both Vitamin D3 and the standard medications showed the most improvement in their symptoms.
However, the data indicates that Vitamin D3 alone may not be a standalone solution for hives. Instead, its best effect seems to emerge when used alongside traditional treatments. This research emphasizes the importance of checking Vitamin D levels in individuals with Chronic Urticaria before starting any treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Atopy elimination
After switching from niacinamide to this vitamin D3 for my child’s atopic dermatitis, the hives and skin irritation disappeared within weeks. The eczema on joints has completely resolved! I am astounded at this transformation after years of suffering.
Read More
9
Hives and pressure
I discovered that I had a significant vitamin D deficiency. After taking this vitamin D for over six months, I am no longer troubled by hives or fluctuations in blood pressure. I prefer this brand over others.
Read More
9
Chronic hives cure
Since starting this vitamin, I have been cured of chronic hives that plagued me last winter. I am now a firm believer in the benefits of vitamin D.
Read More
7.5
Hives disappearance
7 people found this helpful
Very good! Since staying at home more due to Covid, I developed terrible hives from the waist down. Despite taking medicine from a dermatologist for six months, it was ineffective. However, after learning about the benefits of sunlight and vitamin D, my hives vanished the next day! It appears my issue was due to a vitamin D deficiency.
Read More
7.5
Hives relief
The dosage is very good for the endless grey days. It quickly raises vitamin D levels, enhancing mood and helping stave off hives.
Read More
Frequently Asked Questions
7.5
Hives disappearance
7 people found this helpful
Very good! Since staying at home more due to Covid, I developed terrible hives from the waist down. Despite taking medicine from a dermatologist for six months, it was ineffective. However, after learning about the benefits of sunlight and vitamin D, my hives vanished the next day! It appears my issue was due to a vitamin D deficiency.
9
Hives and pressure
I discovered that I had a significant vitamin D deficiency. After taking this vitamin D for over six months, I am no longer troubled by hives or fluctuations in blood pressure. I prefer this brand over others.
9
Atopy elimination
After switching from niacinamide to this vitamin D3 for my child’s atopic dermatitis, the hives and skin irritation disappeared within weeks. The eczema on joints has completely resolved! I am astounded at this transformation after years of suffering.
9
Chronic hives cure
Since starting this vitamin, I have been cured of chronic hives that plagued me last winter. I am now a firm believer in the benefits of vitamin D.
7
We aimed to explore the relationship between vitamin D levels and chronic spontaneous urticaria (CSU), a condition characterized by persistent hives. Our study involved 101 patients suffering from CSU and 115 healthy individuals, allowing us to compare the circumstances surrounding these two groups.
We discovered that patients with CSU tended to have significantly lower levels of vitamin D compared to healthy subjects. Interestingly, we observed a negative correlation between the levels of vitamin D and the severity of hives in these patients. This means that lower vitamin D levels were associated with more severe symptoms. Conversely, total IgE levels, which often indicate allergy severity, were positively linked to the activity score of hives.
Additionally, we found that age and gender also influenced vitamin D levels. In patients, as age increased, vitamin D levels tended to rise, while being male was associated with higher vitamin D levels as well. When we conducted additional analyses, only vitamin D was significantly tied to the severity of hives, underscoring its potential importance in managing this condition.
Overall, our findings suggest that maintaining adequate vitamin D levels might play a critical role in managing chronic hives, although further studies are needed to establish a direct therapeutic benefit.
We discovered that patients with CSU tended to have significantly lower levels of vitamin D compared to healthy subjects. Interestingly, we observed a negative correlation between the levels of vitamin D and the severity of hives in these patients. This means that lower vitamin D levels were associated with more severe symptoms. Conversely, total IgE levels, which often indicate allergy severity, were positively linked to the activity score of hives.
Additionally, we found that age and gender also influenced vitamin D levels. In patients, as age increased, vitamin D levels tended to rise, while being male was associated with higher vitamin D levels as well. When we conducted additional analyses, only vitamin D was significantly tied to the severity of hives, underscoring its potential importance in managing this condition.
Overall, our findings suggest that maintaining adequate vitamin D levels might play a critical role in managing chronic hives, although further studies are needed to establish a direct therapeutic benefit.
9
We conducted a detailed study to understand how vitamin D might improve the lives of those suffering from chronic spontaneous urticaria, commonly known as hives. In our research, we randomly assigned 80 participants to two groups: one receiving a lower dose of vitamin D (4200 IU/week) and the other a higher dose (28,000 IU/week) over 12 weeks.
We measured various factors including participants' quality of life, the severity of their hives, and levels of vitamin D in their blood. Our findings revealed that both groups experienced a significant decrease in the severity of hives over the 12 weeks. Interestingly, those who received the higher dose of vitamin D saw even more notable improvements, particularly at the 6 and 12-week marks.
Additionally, quality of life ratings improved more substantially in the high-dose group compared to the lower-dose group. While the medication scores dropped for both groups, there wasn't a significant difference between them. Overall, we found that taking vitamin D, especially at higher doses, could be a safe and effective way to help manage the distress of hives and enhance overall well-being.
We measured various factors including participants' quality of life, the severity of their hives, and levels of vitamin D in their blood. Our findings revealed that both groups experienced a significant decrease in the severity of hives over the 12 weeks. Interestingly, those who received the higher dose of vitamin D saw even more notable improvements, particularly at the 6 and 12-week marks.
Additionally, quality of life ratings improved more substantially in the high-dose group compared to the lower-dose group. While the medication scores dropped for both groups, there wasn't a significant difference between them. Overall, we found that taking vitamin D, especially at higher doses, could be a safe and effective way to help manage the distress of hives and enhance overall well-being.
9
We examined how Vitamin D3 might impact Chronic Urticaria (hives) symptoms in a study involving 192 participants. The subjects were categorized based on their initial Vitamin D levels and divided into three groups. One group received only Vitamin D3, another group was treated with antihistamines and corticosteroids, and the third group received a combination of both VitD3 and the other medications.
Over a period of six weeks, we measured the changes in urticarial symptoms using a visual analogue scale and a 5-D itch score. Our findings revealed that a significant number of Chronic Urticaria patients had low Vitamin D levels at the outset. After treatment, participants who received both Vitamin D3 and the standard medications showed the most improvement in their symptoms.
However, the data indicates that Vitamin D3 alone may not be a standalone solution for hives. Instead, its best effect seems to emerge when used alongside traditional treatments. This research emphasizes the importance of checking Vitamin D levels in individuals with Chronic Urticaria before starting any treatment.
Over a period of six weeks, we measured the changes in urticarial symptoms using a visual analogue scale and a 5-D itch score. Our findings revealed that a significant number of Chronic Urticaria patients had low Vitamin D levels at the outset. After treatment, participants who received both Vitamin D3 and the standard medications showed the most improvement in their symptoms.
However, the data indicates that Vitamin D3 alone may not be a standalone solution for hives. Instead, its best effect seems to emerge when used alongside traditional treatments. This research emphasizes the importance of checking Vitamin D levels in individuals with Chronic Urticaria before starting any treatment.
References
- Liu J, Wang F, Cao H, Wang Y, Liang F, et al. The Correlation between Serum Vitamin D and Total IgE Levels and Chronic Spontaneous Urticaria among Chinese Population: A Retrospective Study. Indian J Dermatol. 2024;69:106. 10.4103/ijd.ijd_634_22
- Egea E, Domínguez-Vargas A, Fang L, Moreno-Woo S, Serrano C, et al. Significant association between and gene polymorphisms and chronic spontaneous urticaria in a Colombian Caribbean population. Allergol Immunopathol (Madr). 2022;50:8. 10.15586/aei.v50iSP2.696
- Li Y, Cao Z, Guo J, Li Q, Su J. Effects of Serum Vitamin D Levels and Vitamin D Supplementation on Urticaria: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2021;18. 10.3390/ijerph18094911
- Nabavizadeh SH, Alyasin S, Esmaeilzadeh H, Mosavat F, Ebrahimi N. The effect of vitamin D add-on therapy on the improvement of quality of life and clinical symptoms of patients with chronic spontaneous urticaria. Asian Pac J Allergy Immunol. 2023;41:150. 10.12932/AP-021219-0705
- Mohamed AA, Hussein MS, Salah EM, Eldemery A, Darwish MM, et al. Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients. J Dermatolog Treat. 2022;33:427. 10.1080/09546634.2020.1762838
- Zhao JW, Ping JD, Wang YF, Liu XN, Li N, et al. Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1α pathway in chronic spontaneous urticaria. Clin Immunol. 2020;215:108444. 10.1016/j.clim.2020.108444
- Mony A, Chandrashekar L, Rajappa M, Munisamy M, Sahoo JP, et al. Effect of vitamin D supplementation on clinical outcome and biochemical profile in South Indian population with vitamin D-deficient chronic urticarial - A randomized double-blind placebo controlled trial. Clin Chim Acta. 2020;504:1. 10.1016/j.cca.2020.01.003
- Xiong X, Song L, Chen F, Ma X. Effects of combination of mizolastine and proteoglycan on chronic urticaria: a randomized controlled trial. Arch Dermatol Res. 2019;311:801. 10.1007/s00403-019-01967-0
- Yuan I, Katari P, Shaker M. Vitamin D treatment for chronic urticaria: a case report. J Med Case Rep. 2019;13:193. 10.1186/s13256-019-2121-9
- Tuchinda P, Kulthanan K, Chularojanamontri L, Arunkajohnsak S, Sriussadaporn S. Relationship between vitamin D and chronic spontaneous urticaria: a systematic review. Clin Transl Allergy. 2018;8:51. 10.1186/s13601-018-0234-7
- Ariaee N, Zarei S, Mohamadi M, Jabbari F. Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement. Clin Mol Allergy. 2017;15:22. 10.1186/s12948-017-0078-z
- Nasiri-Kalmarzi R, Abdi M, Hosseini J, Babaei E, Mokarizadeh A, et al. Evaluation of 1,25-dihydroxyvitamin D3 pathway in patients with chronic urticaria. QJM. 2018;111:161. 10.1093/qjmed/hcx223
- Sachinvala ND, Stergiou A, Haines DE. Remitting long-standing major depression in a multiple sclerosis patient with several concurrent conditions. Neuropsychiatr Dis Treat. 2018;14:2545. 10.2147/NDT.S169292
- Oguz Topal I, Kocaturk E, Gungor S, Durmuscan M, Sucu V, et al. Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria?. J Dermatolog Treat. 2016;27:163. 10.3109/09546634.2015.1079297
- Woo YR, Jung KE, Koo DW, Lee JS. Vitamin D as a Marker for Disease Severity in Chronic Urticaria and Its Possible Role in Pathogenesis. Ann Dermatol. 2015;27:423. 10.5021/ad.2015.27.4.423
- Rasool R, Masoodi KZ, Shera IA, Yosuf Q, Bhat IA, et al. Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study. World Allergy Organ J. 2015;8:15. 10.1186/s40413-015-0066-z
- Rorie A, Poole JA. Vitamin D supplementation: a potential booster for urticaria therapy. Expert Rev Clin Immunol. 2014;10:1269. 10.1586/1744666X.2014.951636
- Rorie A, Goldner WS, Lyden E, Poole JA. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Ann Allergy Asthma Immunol. 2014;112:376. 10.1016/j.anai.2014.01.010
- Sindher SB, Jariwala S, Gilbert J, Rosenstreich D. Resolution of chronic urticaria coincident with vitamin D supplementation. Ann Allergy Asthma Immunol. 2012;109:359. 10.1016/j.anai.2012.07.025
