' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 6 Researches
8
USERS' SCORE
Very Good
Based on 8 Reviews
8.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Calcitriol reduces age-related hypertension
Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function.
Directly addresses hypertension treatment
We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Read More
8
Vitamin D linked to hypertension management
Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis.
Highly relevant to hypertension studies
We aimed to understand the link between vitamin D levels and blood pressure in elderly patients who are experiencing both hypertension and osteoporosis. Our investigation was conducted as a single-center observational study at Zhongshan Hospital, where we gathered data on blood pressure, bone density, and vitamin D levels from newly diagnosed patients.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
Read More
8
Vitamin D3 improves blood pressure
High dose cholecalciferol supplementation causing morning blood pressure reduction in patients with type 1 diabetes mellitus and cardiovascular autonomic neuropathy.
High relevance to hypertension study
We evaluated how high doses of vitamin D3, specifically cholecalciferol, affect blood pressure in patients diagnosed with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). Our study included 67 participants, divided into two groups: those with CAN and those without.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
Read More
Most Useful Reviews
8.8
Vital vitamin D3
Vitamin D3 is crucial for the body. It aids in bone development and mineral absorption, preventing conditions such as osteomalacia and osteoporosis. With receptors found throughout the body, it enhances immunity and may help mitigate risks related to hypertension. I take it with fats for optimum absorption, and it invigorates me.
Read More
8.3
Supports COVID recovery
My family and I took vitamin D during our COVID illness, and we all recovered well, even my dad with hypertension. This vitamin seemed to support our recovery and overall health.
Read More
9.5
Crucial for bone health
Vitamin D deficiency can disrupt calcium metabolism, increasing osteoporosis risk and impacting health conditions like hypertension. This vitamin is essential for my well-being, especially when combined with calcium and magnesium.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 6 Researches
8
9
Calcitriol reduces age-related hypertension
Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function.
Directly addresses hypertension treatment
We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Read More
8
Vitamin D3 reduces blood pressure
Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial.
Study evaluates combined supplementation.
We investigated the effects of vitamin D3, also known as cholecalciferol, on blood pressure among overweight elderly individuals. In a well-structured study, 221 participants took part in a year-long trial that was double-blind and randomized. They received vitamin D3 along with calcium at two different doses—600 IU/day or 3750 IU/day—to see how it impacted their systolic and diastolic blood pressure.
Our findings revealed that both the low and high doses of vitamin D3 alongside calcium resulted in significant reductions in blood pressure for participants who were overweight, particularly those with a body mass index (BMI) over 30 and those with hypertension. Notably, while the high dose showed a more pronounced effect, the results suggest that higher doses may not necessarily lead to better outcomes. In those with high blood pressure, we found decreases in systolic and diastolic readings that were consistent regardless of the dose.
Overall, it appears that vitamin D3 and calcium could be beneficial in managing blood pressure for certain groups, particularly older adults who are overweight. However, more is not always better, as we observed that the effectiveness was relatively independent of the dosage administered.
Our findings revealed that both the low and high doses of vitamin D3 alongside calcium resulted in significant reductions in blood pressure for participants who were overweight, particularly those with a body mass index (BMI) over 30 and those with hypertension. Notably, while the high dose showed a more pronounced effect, the results suggest that higher doses may not necessarily lead to better outcomes. In those with high blood pressure, we found decreases in systolic and diastolic readings that were consistent regardless of the dose.
Overall, it appears that vitamin D3 and calcium could be beneficial in managing blood pressure for certain groups, particularly older adults who are overweight. However, more is not always better, as we observed that the effectiveness was relatively independent of the dosage administered.
Read More
8
Potential benefits of vitamin D3
Vitamin D3 supplementation in COVID-19 patients with cardiovascular disease and gut dysbiosis.
Moderate relevance to hypertension
We embarked on a study to evaluate how vitamin D3 supplementation might influence hypertension, particularly among patients coping with COVID-19 and cardiovascular diseases. By involving 50 adult participants, we effectively organized them into two groups: one receiving daily doses of 10,000 IU of vitamin D3 and the other receiving a placebo.
Our findings revealed promising results for those taking vitamin D3. We observed an increase in the Ang-(1-7)/Ang II ratio, which suggests enhanced ACE2 activity, an important factor in heart and blood vessel function. Notably, patients treated with vitamin D3 experienced a significant decline in inflammatory markers, which often exacerbate hypertension.
Moreover, we noted a trend towards reductions in blood pressure levels among hypertensive patients in the vitamin D3 group. This suggests that vitamin D3 could play a role in better managing blood pressure, alongside potentially influencing overall recovery from COVID-19.
Overall, our research indicates that vitamin D3 supplementation may hold therapeutic promise for individuals with hypertension, especially during challenging times such as the COVID-19 pandemic.
Our findings revealed promising results for those taking vitamin D3. We observed an increase in the Ang-(1-7)/Ang II ratio, which suggests enhanced ACE2 activity, an important factor in heart and blood vessel function. Notably, patients treated with vitamin D3 experienced a significant decline in inflammatory markers, which often exacerbate hypertension.
Moreover, we noted a trend towards reductions in blood pressure levels among hypertensive patients in the vitamin D3 group. This suggests that vitamin D3 could play a role in better managing blood pressure, alongside potentially influencing overall recovery from COVID-19.
Overall, our research indicates that vitamin D3 supplementation may hold therapeutic promise for individuals with hypertension, especially during challenging times such as the COVID-19 pandemic.
Read More
8
Vitamin D linked to hypertension management
Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis.
Highly relevant to hypertension studies
We aimed to understand the link between vitamin D levels and blood pressure in elderly patients who are experiencing both hypertension and osteoporosis. Our investigation was conducted as a single-center observational study at Zhongshan Hospital, where we gathered data on blood pressure, bone density, and vitamin D levels from newly diagnosed patients.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
Read More
8
Vitamin D3 improves blood pressure
High dose cholecalciferol supplementation causing morning blood pressure reduction in patients with type 1 diabetes mellitus and cardiovascular autonomic neuropathy.
High relevance to hypertension study
We evaluated how high doses of vitamin D3, specifically cholecalciferol, affect blood pressure in patients diagnosed with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). Our study included 67 participants, divided into two groups: those with CAN and those without.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 8 Reviews
8.9
9.5
Crucial for bone health
Vitamin D deficiency can disrupt calcium metabolism, increasing osteoporosis risk and impacting health conditions like hypertension. This vitamin is essential for my well-being, especially when combined with calcium and magnesium.
9
Health benefits confirmed
About 85% of individuals have low vitamin D levels, which can impair the absorption of minerals. It's essential for immunity, heart health, and hormonal balance. Vitamin D deficiency can increase the risk of various diseases, including hypertension. I use this supplement daily, and it helps during colds while ensuring good absorption with fats.
Read More
9
Essential for immunity
About 85% of people lack sufficient vitamin D, which is crucial for immunity and reducing risks of diseases like hypertension. I monitor my levels and take this supplement, finding it beneficial during colds. I ensure I take it with fats for better absorption, and it works effectively for me.
Read More
8.8
Vital vitamin D3
Vitamin D3 is crucial for the body. It aids in bone development and mineral absorption, preventing conditions such as osteomalacia and osteoporosis. With receptors found throughout the body, it enhances immunity and may help mitigate risks related to hypertension. I take it with fats for optimum absorption, and it invigorates me.
Read More
8.8
Improves overall health
This vitamin strengthens the immune system, aids in calcium absorption, and prevents osteoporosis, while also providing protection against autoimmune diseases and hypertension. I've noticed improvements in my mood and memory as well.
