5/6/2025
Last update
5/6/2025
Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
Read More
9
Vitamin D aids hypothyroid complications
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Read More
9
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
Most Useful Reviews
7.5
Improved mood
4 people found this helpful
The mood has improved, and my TTG has decreased. I have hypothyroidism, and after taking vitamin D, my levels rose, leading to better well-being. A doctor prescribed 50,000 IU (one tablet every other day) for three weeks, with a follow-up on vitamin D levels due to individual digestibility variations.
Read More
9
Improved well-being
Along with K-2 (MK-7) from the same company, my relative's condition with hypothyroidism improved dramatically. All my family members take it regularly, enhancing our mood and well-being. Vitamin D is crucial for those in low-sunlight areas, and K2 aids in absorption, preventing calcium loss.
Read More
7.5
Strong recommendation
I have used this vitamin D for a long time, following my endocrinologist's recommendation. With hypothyroidism, I take 2,000 IU in summer and 5,000 IU in autumn and spring. I've been unwell for over ten years, but I strongly recommend this vitamin for thyroid issues, as I've had no problems with long-term use.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
- All Researches
9
Vitamin D aids hypothyroid complications
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Read More
9
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
Read More
9
We aimed to investigate the effects of Vitamin D supplements on women recently diagnosed with Hashimoto's Thyroiditis (HT), a condition that can lead to hypothyroidism. This study was carefully structured as a randomized clinical trial that included a control group for comparison, allowing us to draw clearer conclusions about the effectiveness of Vitamin D.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Read More
9
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
We investigated the potential benefits of vitamin D3 in treating hypothyroidism caused by high iodide intake in a study involving pregnant rats. The study involved adjusting iodide intake and supplementing with 1,25-dihydroxy-vitamin D (the active form of vitamin D) to see if these interventions could positively impact thyroid function and related complications.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved mood
4 people found this helpful
The mood has improved, and my TTG has decreased. I have hypothyroidism, and after taking vitamin D, my levels rose, leading to better well-being. A doctor prescribed 50,000 IU (one tablet every other day) for three weeks, with a follow-up on vitamin D levels due to individual digestibility variations.
Read More
9
Improved well-being
Along with K-2 (MK-7) from the same company, my relative's condition with hypothyroidism improved dramatically. All my family members take it regularly, enhancing our mood and well-being. Vitamin D is crucial for those in low-sunlight areas, and K2 aids in absorption, preventing calcium loss.
Read More
7.5
Strong recommendation
I have used this vitamin D for a long time, following my endocrinologist's recommendation. With hypothyroidism, I take 2,000 IU in summer and 5,000 IU in autumn and spring. I've been unwell for over ten years, but I strongly recommend this vitamin for thyroid issues, as I've had no problems with long-term use.
Read More
7.5
Feeling better
After experiencing severe weakness and fatigue due to my hypothyroidism, I discovered my vitamin D3 level was just 18. The endocrinologist recommended this particular brand, although I opted for 5,000 IU instead of 10,000 IU. The small capsules are easy to swallow, and I already feel the benefits after starting them.
Read More
7.5
Raised vitamin D
1 people found this helpful
I have taken vitamin D for three years, under medical supervision, at a dosage of 5,000 IU daily. With my hypothyroidism and osteopenia, my vitamin D levels have improved to the lower normal range. I highly recommend this vitamin.
Read More
Frequently Asked Questions
7.5
Feeling better
After experiencing severe weakness and fatigue due to my hypothyroidism, I discovered my vitamin D3 level was just 18. The endocrinologist recommended this particular brand, although I opted for 5,000 IU instead of 10,000 IU. The small capsules are easy to swallow, and I already feel the benefits after starting them.
7.5
Improved mood
4 people found this helpful
The mood has improved, and my TTG has decreased. I have hypothyroidism, and after taking vitamin D, my levels rose, leading to better well-being. A doctor prescribed 50,000 IU (one tablet every other day) for three weeks, with a follow-up on vitamin D levels due to individual digestibility variations.
7.5
Raised vitamin D
1 people found this helpful
I have taken vitamin D for three years, under medical supervision, at a dosage of 5,000 IU daily. With my hypothyroidism and osteopenia, my vitamin D levels have improved to the lower normal range. I highly recommend this vitamin.
9
Improved well-being
Along with K-2 (MK-7) from the same company, my relative's condition with hypothyroidism improved dramatically. All my family members take it regularly, enhancing our mood and well-being. Vitamin D is crucial for those in low-sunlight areas, and K2 aids in absorption, preventing calcium loss.
7.5
Improved condition
I followed my endocrinologist's advice and took this vitamin D for two months for my hypothyroidism, alongside selenium and vitamin E. There were no side effects, and my overall condition improved while antibodies decreased. I recommend this treatment for anyone with absorption issues regarding fat-soluble vitamins.
6
Supplementary use advised
I use it alongside other supplements, particularly for hypothyroidism. My doctor recommended taking at least 10,000 IU with magnesium and K2. The capsules are small, which is a plus.
7.5
Recommended vitamin D3
I take vitamin D3 regularly alongside vitamin K2 MK7. During winter, I consumed 10,000 IU as advised by my endocrinologist for my hypothyroidism. I recommend it to everyone.
9
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
9
We aimed to investigate the effects of Vitamin D supplements on women recently diagnosed with Hashimoto's Thyroiditis (HT), a condition that can lead to hypothyroidism. This study was carefully structured as a randomized clinical trial that included a control group for comparison, allowing us to draw clearer conclusions about the effectiveness of Vitamin D.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
4
We explored the relationship between vitamin D supplementation and hypothyroidism through the D-Health Trial, a well-structured study involving over 21,000 Australian participants aged 60 and older. This trial randomly assigned participants to receive either a monthly dose of 60,000 international units of vitamin D or a placebo, allowing us to effectively assess any potential benefits of vitamin D on thyroid function.
Our analysis revealed that, during an average follow-up of 4.1 years, 293 participants developed hypothyroidism. Interestingly, the rates were similar between the groups, with 1.5% of those taking vitamin D and 1.7% of those on placebo developing the condition. Overall, vitamin D supplementation did not significantly lower the risk of hypothyroidism, as shown by the hazard ratio of 0.89.
However, we did notice a slight difference when analyzing the data by gender. While there was some evidence suggesting a potential benefit for females (with a hazard ratio of 0.78), no such effect was observed in males. Given the findings, it seems that vitamin D supplementation does not provide a clear protective effect against hypothyroidism overall, although the intriguing trend observed in females deserves further research to better understand its implications.
Our analysis revealed that, during an average follow-up of 4.1 years, 293 participants developed hypothyroidism. Interestingly, the rates were similar between the groups, with 1.5% of those taking vitamin D and 1.7% of those on placebo developing the condition. Overall, vitamin D supplementation did not significantly lower the risk of hypothyroidism, as shown by the hazard ratio of 0.89.
However, we did notice a slight difference when analyzing the data by gender. While there was some evidence suggesting a potential benefit for females (with a hazard ratio of 0.78), no such effect was observed in males. Given the findings, it seems that vitamin D supplementation does not provide a clear protective effect against hypothyroidism overall, although the intriguing trend observed in females deserves further research to better understand its implications.
4
We set out to understand the role of vitamin D in managing hypothyroidism, particularly focusing on how it interacts with metformin treatment. In a detailed study, we looked at three groups of women with subclinical hypothyroidism, comparing those with vitamin D deficiency to those with adequate levels. All participants had type 2 diabetes or prediabetes and received metformin.
Throughout the six-month study, we monitored various hormones and health indicators. While metformin was effective in reducing glucose levels and insulin resistance across all groups, we noticed that its impact was less pronounced in women with low vitamin D levels. Interestingly, only those with sufficient vitamin D experienced significant reductions in TSH, the thyroid-stimulating hormone, suggesting that low vitamin D may dampen the effectiveness of metformin on thyroid function.
However, it’s crucial to note that metformin didn't increase vitamin D levels or significantly alter thyroid hormone concentrations or other thyroid-related markers. Our results indicate that vitamin D status may influence how effectively metformin can support thyroid function in women with hypothyroidism, highlighting the importance of maintaining adequate vitamin D levels for optimal health outcomes.
Throughout the six-month study, we monitored various hormones and health indicators. While metformin was effective in reducing glucose levels and insulin resistance across all groups, we noticed that its impact was less pronounced in women with low vitamin D levels. Interestingly, only those with sufficient vitamin D experienced significant reductions in TSH, the thyroid-stimulating hormone, suggesting that low vitamin D may dampen the effectiveness of metformin on thyroid function.
However, it’s crucial to note that metformin didn't increase vitamin D levels or significantly alter thyroid hormone concentrations or other thyroid-related markers. Our results indicate that vitamin D status may influence how effectively metformin can support thyroid function in women with hypothyroidism, highlighting the importance of maintaining adequate vitamin D levels for optimal health outcomes.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
- Rastegar-Moghaddam SH, Akbarian M, Rajabian A, Alipour F, Hojjati Shargh A, et al. Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat. Naunyn Schmiedebergs Arch Pharmacol. 2024. 10.1007/s00210-024-03593-8
- Krysiak R, Kowalcze K, Szkróbka W, Okopień B. The Association between Vitamin D Status and the Impact of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Subclinical Hypothyroidism. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16081093
- Maneewan S, Manosroi W, Jesadaporn P, Phimphilai M, Tipduangta P. Effect of Vitamin D Supplementation on Muscle Function in Patients With I131-Induced Hypothyroidism: A Pilot Randomized Trial. J Endocr Soc. 2024;8:bvae072. 10.1210/jendso/bvae072
- Donayeva A, Kulzhanova D, Amanzholkyzy A, Abdelazim IA, Abilov T, et al. Relationship between vitamin D and adolescents' hypothyroidism - a cross-sectional study. Prz Menopauzalny. 2023;22:186. 10.5114/pm.2023.133280
- Abdulateef M, Hilal N, Abdul-Aziz M. EVALUATION OF VITAMIN D SERUM LEVELS AND THYROID FUNCTION TEST IN HYPOTHYROIDISM IRAQI PATIENTS. Georgian Med News. 2023.
- Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. 10.1097/MD.0000000000036759
- Kuroda K, Horikawa T, Moriyama A, Ojiro Y, Takamizawa S, et al. Therapeutic efficacy of the optimization of thyroid function, thrombophilia, immunity and uterine milieu (OPTIMUM) treatment strategy on pregnancy outcomes after single euploid blastocyst transfer in advanced age women with recurrent reproductive failure. Reprod Med Biol. 2023;22:e12554. 10.1002/rmb2.12554
- Jiang X, Huang Y, Li Y, Xia Y, Liu L, et al. Therapeutic effect of vitamin D in Hashimoto's thyroiditis: a prospective, randomized and controlled clinical trial in China. Am J Transl Res. 2023;15:6234.
- Waterhouse M, Pham H, Rahman ST, Baxter C, Duarte Romero B, et al. The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial. Thyroid. 2023;33:1302. 10.1089/thy.2023.0317
- Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR. A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis. J Assoc Physicians India. 2023;71:1.
- Liu Q, Zhang Y, Zhao H, Yao X. Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats. Front Physiol. 2021;12:669652. 10.3389/fphys.2021.669652
- ElRawi HA, Ghanem NS, ElSayed NM, Ali HM, Rashed LA, et al. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. J Thyroid Res. 2019;2019:3583250. 10.1155/2019/3583250
- Ucan B, Sahin M, Sayki Arslan M, Colak Bozkurt N, Kizilgul M, et al. Vitamin D Treatment in Patients with Hashimoto's Thyroiditis may Decrease the Development of Hypothyroidism. Int J Vitam Nutr Res. 2016;86:9. 10.1024/0300-9831/a000269
- Anaraki PV, Aminorroaya A, Amini M, Feizi A, Iraj B, et al. Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. J Res Med Sci. 2017;22:5. 10.4103/1735-1995.199090
- Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest. 2014;37:473. 10.1007/s40618-014-0064-y
- Kemmochi S, Fujimoto H, Woo GH, Hirose M, Nishikawa A, et al. Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model. J Vet Med Sci. 2011;73:655.
