Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women.
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
8
Vitamin D critical for fracture prevention
Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study.
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
8
Vitamin D maintains levels, no menopause impact
Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency.
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
Read More
Most Useful Reviews
7.5
Improved symptoms
33 people found this helpful
I previously had low vitamin D levels at 11ng/ml, alongside muscle pain, tiredness, and recurrent colds. After using this product, I'm experiencing improvement in these symptoms. Vitamin D also aids in alleviating menopause and PMS symptoms. I purchased it on sale for 18 reais, which is much cheaper than other markets. I live in Minas Gerais, and my orders arrived within 10 days.
Read More
9
Better sleep quality
8 people found this helpful
Since experiencing early awakening a few months ago, I struggled with menopause. After reading positive reviews, I decided to try this product, and within days, I was sleeping through the night. I feel much brighter now.
Read More
10
Health restoration
7 people found this helpful
I had a severe vitamin D deficiency that caused onycholysis of nails. After taking Vitamin D-3 from NOW for two months, I completely restored my levels and eliminated the nail issue. Now, I take 2000 IU daily, as this vitamin is crucial, especially for pregnant women and during menopause.
Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study.
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
8
Vitamin D and K for menopause health
Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies.
We explored how the combination of vitamins D and K may influence menopausal health in women. Our review incorporated findings from 31 randomized clinical trials, which looked at how these vitamins work together to support bone density and cardiovascular health.
Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.
We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.
Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
Read More
8
Vitamin D maintains levels, no menopause impact
Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency.
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
Read More
8
Vitamin D supports bone health
Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women.
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
8
Vitamin D helps postmenopausal women
Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study.
We conducted a study to assess the effectiveness of vitamin D treatment, particularly its role in menopausal women's bone health. This randomized, double-blind study included 25 postmenopausal women ages 50 to 64, who were divided into two groups: one group consumed home meal replacements (HMRs) containing eggshell powder and vitamin D, while the other group had HMRs without these additions.
Over the course of six months, we observed that the treatment group significantly increased their daily intake of calcium and vitamin D. Specifically, they consumed an additional 261 mg of calcium and 10.3 μg of vitamin D, which helped them meet the recommended dietary allowances for these nutrients in Korea.
The results were promising; after six months, the treatment group experienced less decline in femoral neck bone density compared to the control group. This suggests that incorporating fortified HMRs could be a viable dietary strategy to help support bone health during menopause. Overall, the study highlights the potential of eggshell powder and vitamin D as effective tools for addressing common deficiencies and supporting women’s health during this life stage.
I previously had low vitamin D levels at 11ng/ml, alongside muscle pain, tiredness, and recurrent colds. After using this product, I'm experiencing improvement in these symptoms. Vitamin D also aids in alleviating menopause and PMS symptoms. I purchased it on sale for 18 reais, which is much cheaper than other markets. I live in Minas Gerais, and my orders arrived within 10 days.
Read More
9
Better sleep quality
8 people found this helpful
Since experiencing early awakening a few months ago, I struggled with menopause. After reading positive reviews, I decided to try this product, and within days, I was sleeping through the night. I feel much brighter now.
Read More
10
Health restoration
7 people found this helpful
I had a severe vitamin D deficiency that caused onycholysis of nails. After taking Vitamin D-3 from NOW for two months, I completely restored my levels and eliminated the nail issue. Now, I take 2000 IU daily, as this vitamin is crucial, especially for pregnant women and during menopause.
Read More
7.5
Addressing deficiency
2 people found this helpful
I rarely get sun exposure and suffered from a persistent runny nose. After testing, I found I had a significant vitamin D3 deficiency. Taking this supplement is essential as many women and children are deficient. This could lead to serious health issues including problems during menopause.
Read More
9
Mood enhancement
1 people found this helpful
Last year, my vitamin D levels were critically low, leaving me tired, in pain, and depressed, similar to menopausal symptoms. After taking this product for eight weeks, my levels normalised, and I feel cheerful again.
Menopause is a natural biological process that marks the end of a woman's reproductive years, characterized by the cessation of menstruation and a decline in hormonal levels, particularly estrogen and progesterone. Typically occurring between the ages of 45 and 55, menopause can bring a variety of physical and emotional changes. Common symptoms may include hot flashes, night sweats, mood swings, and changes in sleep patterns. It is important to note that menopause is a gradual process and often begins with perimenopause, where women may experience irregular periods and increased symptoms for several years before periods stop completely.
While menopause is a natural phase of life, it can have significant impacts on a woman's health and well-being. This transition can increase the risk of certain health issues, such as osteoporosis and cardiovascular disease, due in part to lowered hormone levels. Therefore, it is advisable for women to consult with healthcare providers to discuss potential management strategies and lifestyle adjustments during this time. These may include hormone replacement therapy, dietary changes, regular physical activity, and alternative therapies, all aimed at alleviating symptoms and promoting overall health during and after menopause.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Vitamin D is an essential nutrient that plays various roles in maintaining health, particularly in bone health and immune function. While research on the direct effects of vitamin D on menopause symptoms is still ongoing, some studies suggest that it may help alleviate certain symptoms associated with menopause, such as mood swings, fatigue, and osteoporosis. Women transitioning through menopause may experience decreased bone density, making vitamin D crucial as it aids calcium absorption and supports overall bone health.
Furthermore, vitamin D may also have a positive impact on hormonal balance and may provide some relief from hot flashes, though evidence varies. It’s important to note that while vitamin D can be a part of a holistic approach to managing menopause, it should complement other lifestyle modifications and treatments. As always, consult with a healthcare provider to tailor a strategy that addresses your specific needs during menopause, including the appropriate dosage of vitamin D, if necessary.
Based on user reviews, the time it takes to see results from taking vitamin D for menopause can vary significantly. Some users have reported noticeable improvements in their symptoms within just a few days. One user noted that after starting the supplement, they were able to sleep through the night and felt much brighter within days (Read Review). Others have experienced more gradual changes, with reports of significant benefits after about two months of consistent use (Read Review).
Additionally, users highlight specific benefits related to menopause, such as reduced hot flashes and increased energy levels. For instance, one reviewer indicated that they noticed a decrease in hot flashes within just two weeks of starting the supplement (Read Review). Overall, while some users see results quickly, others find that it may take several weeks to feel the full effects, suggesting that patience and consistent use are key.
The use of Vitamin D as a supplement during menopause is increasingly supported by scientific research, particularly its importance for bone health and overall wellness in postmenopausal women. For instance, studies have shown that adequate Vitamin D levels are crucial for maintaining bone density and preventing osteoporosis, a concern that escalates after menopause due to hormonal changes [6]. Additionally, another research indicates that Vitamin D deficiency is associated with a heightened risk of vertebral fractures and may affect muscle function, which is vital in reducing fall risks among older women [1][2].
However, while Vitamin D appears beneficial, particularly for bone health, its impact on menopausal symptoms directly is still under investigation. Some research notes that while supplementation effectively raises Vitamin D levels, it may not lead to significant improvements in menopausal symptoms or overall health outcomes [4][7]. Thus, while there is a growing body of evidence supporting Vitamin D's role in enhancing the health of postmenopausal women, personalized approaches considering dosage and the individual's health status are necessary for optimal results. Overall, Vitamin D supplementation could be a crucial component of managing menopause-related health concerns.
Based on user reviews, many individuals have reported significant improvements in their symptoms after incorporating vitamin D into their routine, particularly during menopause. Notable benefits include enhanced mood and energy levels, with one user experiencing a remarkable shift in their emotional state and sleep quality merely days after starting the supplement (Read Review). Others have highlighted reductions in hot flashes and overall menopause symptoms; for example, a reviewer noted a decrease in hot flashes within just two weeks of increased vitamin D intake (Read Review), indicating that timely benefits are possible for many users.
Additionally, reviews indicate improvements in physical ailments often linked to low vitamin D levels, such as muscle pain, fatigue, and even nail health. One user shared that after two months of vitamin D supplementation, their previously severe deficiency had been corrected, leading to a return to normal energy levels and no more symptoms related to onycholysis of nails (Read Review). While experiences can vary, it’s clear that many users find vitamin D essential for managing both menopausal symptoms and overall vitality.
Based on user reviews, many individuals have found positive outcomes when combining vitamin D with other supplements to manage menopause symptoms. Notably, a reviewer pointed out the importance of magnesium and vitamin K during this phase, as these nutrients play a crucial role in absorption and overall effectiveness of vitamin D, particularly for addressing fatigue and mood issues common in menopause (Read Review). Additionally, another account emphasized the need for vitamin K2 alongside vitamin D3 to enhance calcium absorption, which can prevent complications like fractures and improve health outcomes in post-menopausal women (Read Review).
Users have also reported that taking vitamin D has significantly alleviated various menopausal symptoms when used in conjunction with other supplements. For example, one user mentioned that their improved energy levels and mood coincided with vitamin D supplementation, but suggested considering magnesium as well to enhance overall wellness during menopause (Read Review). Overall, while vitamin D is praised for its benefits during menopause, users recommend a combined approach with other essential vitamins for optimal results.
Users report a variety of doses for Vitamin D while treating menopause symptoms, indicating that there's no one-size-fits-all recommendation. A common range mentioned is around 2000 IU to 5000 IU daily. For instance, one user noted taking 2000 IU daily specifically for menopause support Read Review. Others found success with 5000 IU, stating it significantly helped alleviate menopause symptoms Read Review. Another user, who self-prescribed a higher dose due to limited sun exposure, noticed a decrease in hot flashes within just two weeks Read Review.
In addition to basic dosing, some users highlighted the importance of taking Vitamin D with Vitamin K2 to aid absorption and enhance its effectiveness, especially for preventing osteoporosis during menopause Read Review. The need for vitamin D tends to increase during menopause and for older adults, making it crucial to monitor levels and adjust dosages accordingly Read Review. Regular testing is recommended to ensure proper dosing is achieved, as deficiencies can lead to a range of health issues Read Review.
9
Better sleep quality
8 people found this helpful
Since experiencing early awakening a few months ago, I struggled with menopause. After reading positive reviews, I decided to try this product, and within days, I was sleeping through the night. I feel much brighter now.
10
Health restoration
7 people found this helpful
I had a severe vitamin D deficiency that caused onycholysis of nails. After taking Vitamin D-3 from NOW for two months, I completely restored my levels and eliminated the nail issue. Now, I take 2000 IU daily, as this vitamin is crucial, especially for pregnant women and during menopause.
6
Reduced tides
3 people found this helpful
I self-prescribed a significant dose of vitamin D due to limited sun exposure and diagnosed osteopenia at 45. I've noticed a decrease in hot flashes within two weeks. I plan to get my levels tested soon.
7.5
Complementary support
1 people found this helpful
This vitamin D is excellent for replenishing deficiencies, but don’t forget magnesium and vitamin K during menopause. If you have unexplained fatigue or mood issues, consider getting tested for vitamin D and iron deficiencies. This supplement is effective, but magnesium is crucial for absorption.
7.5
Bone health support
3 people found this helpful
This D3 is ideal for adults with healthy kidneys. If your kidneys are not optimal, it’s vital to take it with vitamin K2. It helps calcium absorption, directing it to bones, thus preventing damage to arteries. This combination can reduce fractures and enhance post-menopause survival rates.
7.5
Menopause relief
3 people found this helpful
Vitamin D-3, 5000 IU, is fantastic! It has significantly helped with menopause symptoms, and I will continue using this product.
7.5
Calcium absorption
Fat-soluble vitamin D3 is essential at any age. It aids calcium absorption and supports skeleton growth, hormonal regulation, and detoxification. The requirement for vitamin D increases in women during menopause and older adults.
8
Vitamin D and K for menopause health
Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies.
We explored how the combination of vitamins D and K may influence menopausal health in women. Our review incorporated findings from 31 randomized clinical trials, which looked at how these vitamins work together to support bone density and cardiovascular health.
Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.
We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.
Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
8
Vitamin D critical for fracture prevention
Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study.
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
4
Vitamin D's limited impact on falls
Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women.
We examined the effects of vitamin D on the risk of falls among post-menopausal women, based on a comprehensive analysis of a four-year trial involving vitamin and calcium supplementation. Our assessment included over 2,300 participants, allowing us to gather substantial data on the relationship between serum 25-hydroxyvitamin D (or s25D) levels and fall incidents.
Interestingly, our findings indicated that having standardized s25D levels up to 60 ng/mL did not show a significant increase in the risk of falling. Participants with levels above 60 ng/mL experienced higher odds of having two or more falls. However, it is crucial to note that this higher risk group represented only about 2% of our collected data.
This analysis suggests that normal to elevated levels of vitamin D generally do not contribute to an extensive risk of falls in post-menopausal women, though the potential concerns of exceedingly high levels remain. Overall, while vitamin D is essential for bone health, maintaining it within recommended limits appears to be a prudent approach.
4
High-dose vitamin D effects unclear
Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function.
Our study examined how high-dose vitamin D, specifically cholecalciferol, influences postmenopausal women. We designed a rigorous trial with a randomized, double-blind, controlled approach involving three distinct oral doses: 50,000 IU, 150,000 IU, and a hefty 500,000 IU. Participants included healthy postmenopausal women who were vitamin D deficient, and we also recruited a control group that had adequate vitamin D levels.
We carefully measured various important outcomes over three months, including total and free vitamin D levels, key bone turnover markers, and even assessed muscle strength and physical function. Initial findings showed that total and free vitamin D levels increased in response to the doses, with a proportional rise in related metabolites. However, we observed no significant effects on physical function or blood pressure regulation, which might explain why some women experience increased falls after high doses.
Interestingly, after administering the highest dosage of 500,000 IU, there was a temporary spike in bone turnover markers. However, the clinical significance of this short-term increase remains uncertain. Overall, while we documented changes in vitamin D levels after supplementation, the treatment didn’t lead to meaningful benefits regarding menopausal symptoms or outcomes specifically related to overall health.
8
Vitamin D maintains levels, no menopause impact
Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency.
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
References
Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
Binkley N, Sempos CT, Borchardt G, Larsen J, Stacey ML, et al. Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Osteoporos Int. 2025;36:255. 10.1007/s00198-024-07310-2
Cocetta V, Zorzi M, Bejor S, Cesta MC, De Pizzol M, et al. Retrospective Analysis of the Effect of Postmenopausal Women Medications on SARS-CoV-2 Infection Progression. Life (Basel). 2024;14. 10.3390/life14091107
Bowles SD, Jacques R, Hill TR, Eastell R, Walsh JS. Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients. 2024;16. 10.3390/nu16172888
Korkmaz H, Pehlivanoğlu B. Is Vitamin D a Crucial Molecule for Musculoskeletal and Cardiovascular Systems in Postmenopausal Women?. Front Biosci (Landmark Ed). 2024;29:281. 10.31083/j.fbl2908281
Rusu ME, Bigman G, Ryan AS, Popa DS. Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies. Nutrients. 2024;16. 10.3390/nu16142356
Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, et al. Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency. Nutrients. 2024;16. 10.3390/nu16111754
G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. 10.52225/narra.v4i1.452
Joo NS, Shin SH, Kim KN, Lee SH, Jung S, et al. Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study. Nutrients. 2024;16. 10.3390/nu16081152
Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04476-y