Overview

SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.9
USERS' SCORE
Good
Based on 19 Reviews
8
Supplement Facts
Serving Size:   1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%

Top Medical Research Studies

8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.

Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.

This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
8
Vitamin D maintains levels, no menopause impact
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.

As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.

However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.

Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
Read More

Most Useful Reviews

7.5
Improved symptoms
33 people found this helpful
I previously had low vitamin D levels at 11ng/ml, alongside muscle pain, tiredness, and recurrent colds. After using this product, I'm experiencing improvement in these symptoms. Vitamin D also aids in alleviating menopause and PMS symptoms. I purchased it on sale for 18 reais, which is much cheaper than other markets. I live in Minas Gerais, and my orders arrived within 10 days.
Read More
9
Better sleep quality
8 people found this helpful
Since experiencing early awakening a few months ago, I struggled with menopause. After reading positive reviews, I decided to try this product, and within days, I was sleeping through the night. I feel much brighter now.
Read More
10
Health restoration
7 people found this helpful
I had a severe vitamin D deficiency that caused onycholysis of nails. After taking Vitamin D-3 from NOW for two months, I completely restored my levels and eliminated the nail issue. Now, I take 2000 IU daily, as this vitamin is crucial, especially for pregnant women and during menopause.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.9
  • All Researches
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.

Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.

This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
8
Vitamin D and K for menopause health
We explored how the combination of vitamins D and K may influence menopausal health in women. Our review incorporated findings from 31 randomized clinical trials, which looked at how these vitamins work together to support bone density and cardiovascular health.

Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.

We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.

Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
Read More
8
Vitamin D maintains levels, no menopause impact
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.

As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.

However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.

Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
Read More
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.

Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.

This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.

Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
8
Vitamin D helps postmenopausal women
We conducted a study to assess the effectiveness of vitamin D treatment, particularly its role in menopausal women's bone health. This randomized, double-blind study included 25 postmenopausal women ages 50 to 64, who were divided into two groups: one group consumed home meal replacements (HMRs) containing eggshell powder and vitamin D, while the other group had HMRs without these additions.

Over the course of six months, we observed that the treatment group significantly increased their daily intake of calcium and vitamin D. Specifically, they consumed an additional 261 mg of calcium and 10.3 μg of vitamin D, which helped them meet the recommended dietary allowances for these nutrients in Korea.

The results were promising; after six months, the treatment group experienced less decline in femoral neck bone density compared to the control group. This suggests that incorporating fortified HMRs could be a viable dietary strategy to help support bone health during menopause. Overall, the study highlights the potential of eggshell powder and vitamin D as effective tools for addressing common deficiencies and supporting women’s health during this life stage.
Read More

User Reviews

USERS' SCORE
Good
Based on 19 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Improved symptoms
33 people found this helpful
I previously had low vitamin D levels at 11ng/ml, alongside muscle pain, tiredness, and recurrent colds. After using this product, I'm experiencing improvement in these symptoms. Vitamin D also aids in alleviating menopause and PMS symptoms. I purchased it on sale for 18 reais, which is much cheaper than other markets. I live in Minas Gerais, and my orders arrived within 10 days.
Read More
9
Better sleep quality
8 people found this helpful
Since experiencing early awakening a few months ago, I struggled with menopause. After reading positive reviews, I decided to try this product, and within days, I was sleeping through the night. I feel much brighter now.
Read More
10
Health restoration
7 people found this helpful
I had a severe vitamin D deficiency that caused onycholysis of nails. After taking Vitamin D-3 from NOW for two months, I completely restored my levels and eliminated the nail issue. Now, I take 2000 IU daily, as this vitamin is crucial, especially for pregnant women and during menopause.
Read More
7.5
Addressing deficiency
2 people found this helpful
I rarely get sun exposure and suffered from a persistent runny nose. After testing, I found I had a significant vitamin D3 deficiency. Taking this supplement is essential as many women and children are deficient. This could lead to serious health issues including problems during menopause.
Read More
9
Mood enhancement
1 people found this helpful
Last year, my vitamin D levels were critically low, leaving me tired, in pain, and depressed, similar to menopausal symptoms. After taking this product for eight weeks, my levels normalised, and I feel cheerful again.
Read More

Frequently Asked Questions

9
Better sleep quality
8 people found this helpful
Since experiencing early awakening a few months ago, I struggled with menopause. After reading positive reviews, I decided to try this product, and within days, I was sleeping through the night. I feel much brighter now.
10
Health restoration
7 people found this helpful
I had a severe vitamin D deficiency that caused onycholysis of nails. After taking Vitamin D-3 from NOW for two months, I completely restored my levels and eliminated the nail issue. Now, I take 2000 IU daily, as this vitamin is crucial, especially for pregnant women and during menopause.
6
Reduced tides
3 people found this helpful
I self-prescribed a significant dose of vitamin D due to limited sun exposure and diagnosed osteopenia at 45. I've noticed a decrease in hot flashes within two weeks. I plan to get my levels tested soon.
7.5
Complementary support
1 people found this helpful
This vitamin D is excellent for replenishing deficiencies, but don’t forget magnesium and vitamin K during menopause. If you have unexplained fatigue or mood issues, consider getting tested for vitamin D and iron deficiencies. This supplement is effective, but magnesium is crucial for absorption.
7.5
Bone health support
3 people found this helpful
This D3 is ideal for adults with healthy kidneys. If your kidneys are not optimal, it’s vital to take it with vitamin K2. It helps calcium absorption, directing it to bones, thus preventing damage to arteries. This combination can reduce fractures and enhance post-menopause survival rates.
7.5
Menopause relief
3 people found this helpful
Vitamin D-3, 5000 IU, is fantastic! It has significantly helped with menopause symptoms, and I will continue using this product.
7.5
Calcium absorption
Fat-soluble vitamin D3 is essential at any age. It aids calcium absorption and supports skeleton growth, hormonal regulation, and detoxification. The requirement for vitamin D increases in women during menopause and older adults.
8
Vitamin D and K for menopause health
We explored how the combination of vitamins D and K may influence menopausal health in women. Our review incorporated findings from 31 randomized clinical trials, which looked at how these vitamins work together to support bone density and cardiovascular health.

Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.

We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.

Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.

Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.

This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
We examined the effects of vitamin D on the risk of falls among post-menopausal women, based on a comprehensive analysis of a four-year trial involving vitamin and calcium supplementation. Our assessment included over 2,300 participants, allowing us to gather substantial data on the relationship between serum 25-hydroxyvitamin D (or s25D) levels and fall incidents.

Interestingly, our findings indicated that having standardized s25D levels up to 60 ng/mL did not show a significant increase in the risk of falling. Participants with levels above 60 ng/mL experienced higher odds of having two or more falls. However, it is crucial to note that this higher risk group represented only about 2% of our collected data.

This analysis suggests that normal to elevated levels of vitamin D generally do not contribute to an extensive risk of falls in post-menopausal women, though the potential concerns of exceedingly high levels remain. Overall, while vitamin D is essential for bone health, maintaining it within recommended limits appears to be a prudent approach.
4
High-dose vitamin D effects unclear
Our study examined how high-dose vitamin D, specifically cholecalciferol, influences postmenopausal women. We designed a rigorous trial with a randomized, double-blind, controlled approach involving three distinct oral doses: 50,000 IU, 150,000 IU, and a hefty 500,000 IU. Participants included healthy postmenopausal women who were vitamin D deficient, and we also recruited a control group that had adequate vitamin D levels.

We carefully measured various important outcomes over three months, including total and free vitamin D levels, key bone turnover markers, and even assessed muscle strength and physical function. Initial findings showed that total and free vitamin D levels increased in response to the doses, with a proportional rise in related metabolites. However, we observed no significant effects on physical function or blood pressure regulation, which might explain why some women experience increased falls after high doses.

Interestingly, after administering the highest dosage of 500,000 IU, there was a temporary spike in bone turnover markers. However, the clinical significance of this short-term increase remains uncertain. Overall, while we documented changes in vitamin D levels after supplementation, the treatment didn’t lead to meaningful benefits regarding menopausal symptoms or outcomes specifically related to overall health.
8
Vitamin D maintains levels, no menopause impact
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.

As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.

However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.

Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.

References

  1. Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
  2. Binkley N, Sempos CT, Borchardt G, Larsen J, Stacey ML, et al. Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Osteoporos Int. 2025;36:255. 10.1007/s00198-024-07310-2
  3. Cocetta V, Zorzi M, Bejor S, Cesta MC, De Pizzol M, et al. Retrospective Analysis of the Effect of Postmenopausal Women Medications on SARS-CoV-2 Infection Progression. Life (Basel). 2024;14. 10.3390/life14091107
  4. Bowles SD, Jacques R, Hill TR, Eastell R, Walsh JS. Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients. 2024;16. 10.3390/nu16172888
  5. Korkmaz H, Pehlivanoğlu B. Is Vitamin D a Crucial Molecule for Musculoskeletal and Cardiovascular Systems in Postmenopausal Women?. Front Biosci (Landmark Ed). 2024;29:281. 10.31083/j.fbl2908281
  6. Rusu ME, Bigman G, Ryan AS, Popa DS. Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies. Nutrients. 2024;16. 10.3390/nu16142356
  7. Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, et al. Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency. Nutrients. 2024;16. 10.3390/nu16111754
  8. G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. 10.52225/narra.v4i1.452
  9. Joo NS, Shin SH, Kim KN, Lee SH, Jung S, et al. Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study. Nutrients. 2024;16. 10.3390/nu16081152
  10. Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04476-y
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