Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.3
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
8
We investigated how vitamin D levels in the body are related to the risk of experiencing migraines. Using a method called Mendelian randomization, we carefully examined data from a large group of over 400,000 individuals to identify genetic factors linked to vitamin D levels. We found a total of 184 genetic instruments to analyze the potential relationship.
The findings were intriguing: as vitamin D levels increase, the risk of migraines appears to decrease. This association was confirmed through multiple datasets, showing that higher vitamin D is associated with a reduced likelihood of having migraines. The results were consistent not just for general migraine types but also for specific subtypes, such as migraines with and without aura.
Interestingly, while we checked for potential mediators like serum calcium, the contribution of calcium to this relationship was minimal. Our research suggests that low vitamin D levels could be a concern for migraine sufferers, and it highlighted the need for further well-designed studies. We recommend that future research explore the effects of vitamin D supplementation, especially for those who may be deficient in this important nutrient.
The findings were intriguing: as vitamin D levels increase, the risk of migraines appears to decrease. This association was confirmed through multiple datasets, showing that higher vitamin D is associated with a reduced likelihood of having migraines. The results were consistent not just for general migraine types but also for specific subtypes, such as migraines with and without aura.
Interestingly, while we checked for potential mediators like serum calcium, the contribution of calcium to this relationship was minimal. Our research suggests that low vitamin D levels could be a concern for migraine sufferers, and it highlighted the need for further well-designed studies. We recommend that future research explore the effects of vitamin D supplementation, especially for those who may be deficient in this important nutrient.
Read More
Most Useful Reviews
9
Reduces migraine frequency
4 people found this helpful
Possibly reduced the frequency of my migraines. I started taking this D3 supplement in late 2009 after a blood test showed low vitamin D levels. My migraines, which had been frequent for 17 years, became less frequent while taking this supplement. After running out, they returned to their previous frequency. I'm convinced this vitamin D helps, so I’ll continue taking it and monitoring my levels.
Read More
0
Caused headaches
3 people found this helpful
I suspected a vitamin D deficiency given my cold climate. After taking one capsule daily, my mood improved significantly, but I experienced severe headaches after a few days. I had never suffered migraines before this and had to stop taking the product.
Read More
9
No more migraines
1 people found this helpful
I began taking vitamin D3 during the pandemic after experiencing migraines and other symptoms. After starting the supplement, I noticed a significant improvement in my mood and realised I haven't had any migraines. I now enjoy better sleep and plan to continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.3
- All Researches
9.5
We conducted a thorough investigation into the effectiveness of simvastatin paired with vitamin D3 for preventing migraines in adults with episodic migraine. Our study was a well-structured randomized, double-blind, placebo-controlled trial involving 57 participants over a span of 24 weeks.
Participants were divided into two groups: one receiving simvastatin and vitamin D3, while the other received placebos. Throughout the trial, we observed that those taking the combination of simvastatin and vitamin D3 experienced a significant reduction in the number of migraine days when compared to those on placebos. Specifically, during the first 12 weeks, participants on the active regimen reported a decrease of 8.0 migraine days, whereas those on placebos noted an increase of 1.0 migraine days.
By the end of the 24-week period, an impressive 29% of participants taking the medication reported a 50% or more reduction in their migraine days. In contrast, only 3% of those taking the placebo experienced similar relief. Interestingly, we found that the occurrence of adverse events was similar in both groups, indicating that the combination therapy was generally well-tolerated.
Our findings showcase the potential benefits of using simvastatin alongside vitamin D3 as an effective strategy for managing migraines, while also addressing some underlying health risks associated with migraines, such as vascular issues.
Participants were divided into two groups: one receiving simvastatin and vitamin D3, while the other received placebos. Throughout the trial, we observed that those taking the combination of simvastatin and vitamin D3 experienced a significant reduction in the number of migraine days when compared to those on placebos. Specifically, during the first 12 weeks, participants on the active regimen reported a decrease of 8.0 migraine days, whereas those on placebos noted an increase of 1.0 migraine days.
By the end of the 24-week period, an impressive 29% of participants taking the medication reported a 50% or more reduction in their migraine days. In contrast, only 3% of those taking the placebo experienced similar relief. Interestingly, we found that the occurrence of adverse events was similar in both groups, indicating that the combination therapy was generally well-tolerated.
Our findings showcase the potential benefits of using simvastatin alongside vitamin D3 as an effective strategy for managing migraines, while also addressing some underlying health risks associated with migraines, such as vascular issues.
Read More
9
We aimed to understand how vitamin D impacts migraine headaches in children. Through a thorough review of existing literature, we explored the significant association between serum vitamin D levels and the frequency and duration of migraine episodes in the pediatric population.
Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.
It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.
It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Read More
9
We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Read More
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces migraine frequency
4 people found this helpful
Possibly reduced the frequency of my migraines. I started taking this D3 supplement in late 2009 after a blood test showed low vitamin D levels. My migraines, which had been frequent for 17 years, became less frequent while taking this supplement. After running out, they returned to their previous frequency. I'm convinced this vitamin D helps, so I’ll continue taking it and monitoring my levels.
Read More
0
Caused headaches
3 people found this helpful
I suspected a vitamin D deficiency given my cold climate. After taking one capsule daily, my mood improved significantly, but I experienced severe headaches after a few days. I had never suffered migraines before this and had to stop taking the product.
Read More
9
No more migraines
1 people found this helpful
I began taking vitamin D3 during the pandemic after experiencing migraines and other symptoms. After starting the supplement, I noticed a significant improvement in my mood and realised I haven't had any migraines. I now enjoy better sleep and plan to continue using it.
Read More
7.5
No migraines since
1 people found this helpful
I bought this supplement as a measure against my terrible migraines, taking it with magnesium and vitamin B2. Since starting this regimen, I've not had any migraines. It may be due to improved environmental conditions, but I believe it plays a role.
Read More
7.5
Improves mood and migraines
I usually suffer from migraines every autumn, but after my doctor prescribed vitamin D, I felt the effects immediately. My mood improved, sleep returned to normal, and I felt generally healthier. This product is wonderful!
Read More
Frequently Asked Questions
7.5
Improves mood and migraines
I usually suffer from migraines every autumn, but after my doctor prescribed vitamin D, I felt the effects immediately. My mood improved, sleep returned to normal, and I felt generally healthier. This product is wonderful!
9
No more migraines
1 people found this helpful
I began taking vitamin D3 during the pandemic after experiencing migraines and other symptoms. After starting the supplement, I noticed a significant improvement in my mood and realised I haven't had any migraines. I now enjoy better sleep and plan to continue using it.
7.5
No migraines since
1 people found this helpful
I bought this supplement as a measure against my terrible migraines, taking it with magnesium and vitamin B2. Since starting this regimen, I've not had any migraines. It may be due to improved environmental conditions, but I believe it plays a role.
9
Reduces migraine frequency
4 people found this helpful
Possibly reduced the frequency of my migraines. I started taking this D3 supplement in late 2009 after a blood test showed low vitamin D levels. My migraines, which had been frequent for 17 years, became less frequent while taking this supplement. After running out, they returned to their previous frequency. I'm convinced this vitamin D helps, so I’ll continue taking it and monitoring my levels.
0
Caused headaches
3 people found this helpful
I suspected a vitamin D deficiency given my cold climate. After taking one capsule daily, my mood improved significantly, but I experienced severe headaches after a few days. I had never suffered migraines before this and had to stop taking the product.
7.5
Beneficial for migraines
Regular intake of this vitamin normalises my sleep and improves my migraines. I find that combining it with magnesium helps relieve migraine pain. My chronic pain issues have also improved significantly since taking these.
0
Triggered migraines
The ingredients in this product triggered migraines and caused irritation for me.
7
We examined how vitamin D affects migraines, drawing from a systematic review and meta-analysis of various dietary supplements. The study brought together evidence from twenty-two trials, focusing on significant outcomes like the frequency and severity of migraine attacks.
Specifically, vitamin D supplementation showed notable benefits. Participants who took vitamin D had a reduction in migraine frequency and the number of monthly migraine days compared to those who received a placebo. This indicates that vitamin D might play a role in alleviating migraines effectively.
Overall, the results suggest that while vitamin D treatment can be beneficial for migraine sufferers, there's still a call for further high-quality clinical trials to solidify our understanding and confirm these findings.
Specifically, vitamin D supplementation showed notable benefits. Participants who took vitamin D had a reduction in migraine frequency and the number of monthly migraine days compared to those who received a placebo. This indicates that vitamin D might play a role in alleviating migraines effectively.
Overall, the results suggest that while vitamin D treatment can be beneficial for migraine sufferers, there's still a call for further high-quality clinical trials to solidify our understanding and confirm these findings.
7
We examined how vitamin D can influence migraine headaches, a complex and often debilitating condition affecting millions. Recent findings have highlighted that vitamin D might play a role in reducing migraine occurrences. Specifically, it was noted that for every 5 ng/ml increase in serum vitamin D levels, there was a reported 22% reduction in migraine incidents.
While we didn’t dive into the specific study designs, this information suggests that adequate vitamin D levels are worth considering in the broader conversation about migraine management. Supplementation with vitamin D, along with other nutrients such as magnesium and Coenzyme Q10, could be a promising option for those seeking preventive measures against migraine attacks.
Overall, this insight offers a light of hope for migraine sufferers, presenting vitamin D not just as a vitamin but as a potential ally in overcoming headaches. It’s a reminder of the essential role that proper nutrition and supplementation can play in managing health challenges.
While we didn’t dive into the specific study designs, this information suggests that adequate vitamin D levels are worth considering in the broader conversation about migraine management. Supplementation with vitamin D, along with other nutrients such as magnesium and Coenzyme Q10, could be a promising option for those seeking preventive measures against migraine attacks.
Overall, this insight offers a light of hope for migraine sufferers, presenting vitamin D not just as a vitamin but as a potential ally in overcoming headaches. It’s a reminder of the essential role that proper nutrition and supplementation can play in managing health challenges.
9
We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
8
Vitamin D3 may aid migraine treatment
We conducted a placebo-controlled trial to examine how daily supplementation of 2000 IU of vitamin D3 affects immune markers related to migraine. Over 12 weeks, we enrolled eighty episodic migraineurs, dividing them into two groups: one received vitamin D3, while the other received a placebo.
At the end of the trial, we found that vitamin D3 had a notable influence on certain immune indicators. Specifically, the serum levels of transforming growth factor-beta (TGF-β) were significantly higher in the vitamin D group compared to the placebo group. This suggests that vitamin D3 might enhance the balance of cytokines associated with immune response in those suffering from migraines.
On the flip side, vitamin D supplementation also appeared to prevent an increase in interleukin-17 (IL-17) levels, another immune marker linked to inflammation. Interestingly, we noted a positive correlation between changes in vitamin D levels and TGF-β, suggesting a beneficial connection. However, no such correlation was observed for IL-17.
These findings highlight the potential role of vitamin D3 in modulating immune responses in migraine patients, but further research is necessary to confirm these effects.
At the end of the trial, we found that vitamin D3 had a notable influence on certain immune indicators. Specifically, the serum levels of transforming growth factor-beta (TGF-β) were significantly higher in the vitamin D group compared to the placebo group. This suggests that vitamin D3 might enhance the balance of cytokines associated with immune response in those suffering from migraines.
On the flip side, vitamin D supplementation also appeared to prevent an increase in interleukin-17 (IL-17) levels, another immune marker linked to inflammation. Interestingly, we noted a positive correlation between changes in vitamin D levels and TGF-β, suggesting a beneficial connection. However, no such correlation was observed for IL-17.
These findings highlight the potential role of vitamin D3 in modulating immune responses in migraine patients, but further research is necessary to confirm these effects.
7
Our exploration into the connection between vitamin D levels and migraine prevalence drew on data from the National Health and Nutrition Examination Survey involving over 9,100 participants. The study specifically examined the concentration of vitamin D in the blood and how it relates to self-reported migraine experiences.
We observed that 20.53% of participants reported suffering from migraines, with a clear trend showing that those with lower levels of serum vitamin D tended to experience migraines more frequently. Interestingly, individuals in the highest vitamin D quartile reported a 16% lower incidence of migraines compared to those in the lowest quartile. This finding suggests that sufficient levels of vitamin D might play a role in reducing migraine frequency.
Overall, our analysis indicates a significant negative correlation between serum vitamin D levels and migraine prevalence among American adults. While the precise mechanisms behind this relationship warrant further investigation, our study provides valuable insights into how maintaining adequate vitamin D levels could potentially alleviate migraine symptoms for some individuals.
We observed that 20.53% of participants reported suffering from migraines, with a clear trend showing that those with lower levels of serum vitamin D tended to experience migraines more frequently. Interestingly, individuals in the highest vitamin D quartile reported a 16% lower incidence of migraines compared to those in the lowest quartile. This finding suggests that sufficient levels of vitamin D might play a role in reducing migraine frequency.
Overall, our analysis indicates a significant negative correlation between serum vitamin D levels and migraine prevalence among American adults. While the precise mechanisms behind this relationship warrant further investigation, our study provides valuable insights into how maintaining adequate vitamin D levels could potentially alleviate migraine symptoms for some individuals.
References
- Akif Özdemir FM, Çelik H. Assessment of Micronutrient Levels in Pediatric Migraine Patients. J Child Neurol. 2025. 10.1177/08830738241304868
- Hao S, Qian R, Chen Y, Liu J, Xu X, et al. Association between serum vitamin D and severe headache or migraine: A population-based analysis. PLoS One. 2025;20:e0313082. 10.1371/journal.pone.0313082
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
- Tirani SA, Khorvash F, Saneei P, Moradmand Z, Askari G. Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial. BMC Med. 2024;22:457. 10.1186/s12916-024-03684-6
- Papasavva M, Vikelis M, Siokas V, Katsarou MS, Dermitzakis EV, et al. Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study. Neurol Int. 2023;15:1117. 10.3390/neurolint15030069
- Ioannidou E, Tsakiris C, Goulis DG, Christoforidis A, Zafeiriou D. The association of serum vitamin D concentrations in paediatric migraine. Eur J Paediatr Neurol. 2023;47:60. 10.1016/j.ejpn.2023.09.007
- Das S, Roy A, Behera SK, Selvarajan S, Kamalanathan S, et al. Effects of Vitamin D on Migraine: A Meta-Analysis. Neurol India. 2023;71:655. 10.4103/0028-3886.383862
- Alipouri M, Amiri E, Hoseini R, Hezarkhani LA. Effects of eight weeks of aerobic exercise and vitamin D supplementation on psychiatric comorbidities in men with migraine and vitamin D insufficiency: A randomized controlled clinical trial. J Affect Disord. 2023;334:12. 10.1016/j.jad.2023.04.108
- Niu PP, Wang X, Xu YM. Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study. Front Nutr. 2022;9:907789. 10.3389/fnut.2022.907789
- Kotb Elmala M, Suliman HA, Al-Shokary AH, Ibrahim AO, Kamal NM, et al. The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis. J Child Neurol. 2022;37:833. 10.1177/08830738221092882
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Canpolat M, Topcu A, Kardas F, Ipekten F, Per H, et al. An assessment of the relation between vitamin D levels and electroencephalogram (EEG) changes in migraine patients. Bratisl Lek Listy. 2022;123:92. 10.4149/BLL_2022_014
- Bahrampour N, Mirzababaei A, Yarizadeh H, Barekzai AM, Khorsha F, et al. The relationship between dietary nutrients patterns and intensity and duration of migraine headaches. Br J Nutr. 2022. 10.1017/S0007114522000046
- Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. 10.1016/j.ajem.2021.07.062
- Sun S, Liu C, Jia Y, Wu J, Li H, et al. Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D. Front Neurol. 2021;12:777721. 10.3389/fneur.2021.777721
- Ghorbani Z, Rafiee P, Haghighi S, Razeghi Jahromi S, Djalali M, et al. The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial. J Pharm Health Care Sci. 2021;7:9. 10.1186/s40780-021-00192-0
- Bhuya MSI, Saiduzzaman M, Linckon K, Moniruzzaman AHM, Hossain MS, et al. Association of Serum Vitamin D Level in Patients with Migraine. Mymensingh Med J. 2025;34:312.
- Zhang YF, Xu ZQ, Zhou HJ, Liu YZ, Jiang XJ. The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies. Clin Neuropharmacol. 2021;44:5. 10.1097/WNF.0000000000000419
- Ghorbani Z, Rafiee P, Fotouhi A, Haghighi S, Rasekh Magham R, et al. The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial. J Headache Pain. 2020;21:22. 10.1186/s10194-020-01090-w
- Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial. Neurol Sci. 2020;41:1183. 10.1007/s10072-019-04220-8
- Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci. 2019;40:2459. 10.1007/s10072-019-04021-z
- Fallah R, Sarraf Yazd S, Sohrevardi SM. Efficacy of Topiramate Alone and Topiramate Plus Vitamin D3 in the Prophylaxis of Pediatric Migraine: A Randomized Clinical Trial. Iran J Child Neurol. 2020;14:77.
- Liampas I, Siokas V, Brotis A, Dardiotis E. Vitamin D serum levels in patients with migraine: A meta-analysis. Rev Neurol (Paris). 2020;176:560. 10.1016/j.neurol.2019.12.008
- Nowaczewska M, Wiciński M, Osiński S, Kaźmierczak H. The Role of Vitamin D in Primary Headache-from Potential Mechanism to Treatment. Nutrients. 2020;12. 10.3390/nu12010243
- Gallelli L, Michniewicz A, Cione E, Squillace A, Colosimo M, et al. 25-Hydroxy Vitamin D Detection Using Different Analytic Methods in Patients with Migraine. J Clin Med. 2019;8. 10.3390/jcm8060895
- Gazerani P, Fuglsang R, Pedersen JG, Sørensen J, Kjeldsen JL, et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D supplementation in adult patients with migraine. Curr Med Res Opin. 2019;35:715. 10.1080/03007995.2018.1519503
- Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, et al. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015;78:970. 10.1002/ana.24534
- Laursen JC, Cairns BE, Kumar U, Somvanshi RK, Dong XD, et al. Nitric oxide release from trigeminal satellite glial cells is attenuated by glial modulators and glutamate. Int J Physiol Pathophysiol Pharmacol. 2013;5:228.
- Thys-Jacobs S. Vitamin D and calcium in menstrual migraine. Headache. 1994;34:544.
