Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
Most Useful Reviews
0
Stomach irritation
My reflux and gastroesophagitis worsened after taking these capsules. I initially bought three bottles and taking one at a time led to stomach pain. After a few days, I tried another D3 capsule but regretted it as my stomach hurt even more.
Read More
9
Effective dosage
This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.
Read More
9
Good for immunity
I find it very effective for immune issues and depression, not just for bones. The pill is small with no reflux, and it’s reasonably priced from a trustworthy company. It’s also suitable for calcium deficiency.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
0
Stomach irritation
My reflux and gastroesophagitis worsened after taking these capsules. I initially bought three bottles and taking one at a time led to stomach pain. After a few days, I tried another D3 capsule but regretted it as my stomach hurt even more.
Read More
9
Effective dosage
This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.
Read More
9
Good for immunity
I find it very effective for immune issues and depression, not just for bones. The pill is small with no reflux, and it’s reasonably priced from a trustworthy company. It’s also suitable for calcium deficiency.
Read More
7.5
No stomach issues
I haven’t had any problems with my stomach, though I do experience heartburn and reflux. I'm taking one softgel daily to help improve my TSH hormone levels as recommended by my doctor. It’s a good quality product, tasteless, and the size and ingredients are fine. I'm uncertain about how well it absorbs.
Read More
Frequently Asked Questions
9
Good for immunity
I find it very effective for immune issues and depression, not just for bones. The pill is small with no reflux, and it’s reasonably priced from a trustworthy company. It’s also suitable for calcium deficiency.
7.5
No stomach issues
I haven’t had any problems with my stomach, though I do experience heartburn and reflux. I'm taking one softgel daily to help improve my TSH hormone levels as recommended by my doctor. It’s a good quality product, tasteless, and the size and ingredients are fine. I'm uncertain about how well it absorbs.
0
Stomach irritation
My reflux and gastroesophagitis worsened after taking these capsules. I initially bought three bottles and taking one at a time led to stomach pain. After a few days, I tried another D3 capsule but regretted it as my stomach hurt even more.
9
Effective dosage
This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056
