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SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 may aid inflammation
Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.
Directly investigates vitamin D3 effects
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
Most Useful Reviews
0
Stomach irritation
My reflux and gastroesophagitis worsened after taking these capsules. I initially bought three bottles and taking one at a time led to stomach pain. After a few days, I tried another D3 capsule but regretted it as my stomach hurt even more.
Read More
9.5
Effective dosage
This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.
Read More
9.5
Good for immunity
I find it very effective for immune issues and depression, not just for bones. The pill is small with no reflux, and it’s reasonably priced from a trustworthy company. It’s also suitable for calcium deficiency.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
9
Vitamin D3 may aid inflammation
Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.
Directly investigates vitamin D3 effects
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
9.5
Effective dosage
This vitamin D is great for times when there’s a lack of sun. The dosage is good, there's no reflux, and the small cap size makes it easy to swallow.
9.5
Good for immunity
I find it very effective for immune issues and depression, not just for bones. The pill is small with no reflux, and it’s reasonably priced from a trustworthy company. It’s also suitable for calcium deficiency.
8.8
No stomach issues
I haven’t had any problems with my stomach, though I do experience heartburn and reflux. I'm taking one softgel daily to help improve my TSH hormone levels as recommended by my doctor. It’s a good quality product, tasteless, and the size and ingredients are fine. I'm uncertain about how well it absorbs.
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0
Stomach irritation
My reflux and gastroesophagitis worsened after taking these capsules. I initially bought three bottles and taking one at a time led to stomach pain. After a few days, I tried another D3 capsule but regretted it as my stomach hurt even more.
