' 
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
6
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
4
Vitamin D2 shows limited impact
Effectiveness of vitamin D2 supplementation on high-sensitivity C-reactive protein and other metabolic indices in menopausal Thai women: a randomized-controlled trial.
Highly relevant to menopause treatment
We conducted a double-blind, randomized, placebo-controlled trial to investigate the impact of vitamin D2 supplementation on high-sensitivity C-reactive protein (hsCRP) levels and other metabolic measures among menopausal Thai women.
Eighty postmenopausal women participated in the study, where they were split into two groups: one receiving vitamin D2 at a dose of 40,000 IU per week and the other receiving a placebo for a duration of 12 weeks. The primary focus was on hsCRP levels, a marker linked to inflammation, while secondary outcomes included various cardio-metabolic profiles and the risk of developing cardiovascular disease.
Our findings showed that although the vitamin D2 group experienced a notable reduction in hsCRP levels compared to the placebo group, the difference wasn't statistically significant by the end of the study. Other measured cardiovascular and metabolic outcomes also didn't show significant differences between the two groups.
Thus, while vitamin D2 appears to reduce inflammation markers in menopausal women, the overall benefits in hsCRP levels didn't reach statistical significance when compared to the placebo. This indicates a need for further research before making definitive conclusions about the benefits of vitamin D2 in this context.
Eighty postmenopausal women participated in the study, where they were split into two groups: one receiving vitamin D2 at a dose of 40,000 IU per week and the other receiving a placebo for a duration of 12 weeks. The primary focus was on hsCRP levels, a marker linked to inflammation, while secondary outcomes included various cardio-metabolic profiles and the risk of developing cardiovascular disease.
Our findings showed that although the vitamin D2 group experienced a notable reduction in hsCRP levels compared to the placebo group, the difference wasn't statistically significant by the end of the study. Other measured cardiovascular and metabolic outcomes also didn't show significant differences between the two groups.
Thus, while vitamin D2 appears to reduce inflammation markers in menopausal women, the overall benefits in hsCRP levels didn't reach statistical significance when compared to the placebo. This indicates a need for further research before making definitive conclusions about the benefits of vitamin D2 in this context.
Read More
7
Vitamin D2's limited impact on menopause
Effect of Vitamin D Supplement on Vulvovaginal Atrophy of the Menopause.
Focus on menopause-related symptoms
We conducted a double-blinded, randomized placebo-controlled trial to assess the effects of oral vitamin D2 supplements on vaginal health in postmenopausal women experiencing vulvovaginal atrophy (VVA). Over 12 weeks, participants took either 40,000 IU of vitamin D2 or a placebo, while we measured outcomes like the vaginal maturation index (VMI), vaginal pH, and a visual analog scale (VAS) for VVA symptoms.
While we observed some improvements in those taking vitamin D2, particularly in VMI, vaginal pH, and VAS in comparison to their own baseline results, our intention-to-treat analysis showed no significant differences when compared to the placebo group. This means that despite the vitamin D2 group showing enhancements at certain points, these benefits weren’t impressive enough to distinguish them from the placebo.
Overall, our study suggests that vitamin D2 supplementation may lead to some positive changes in vaginal health for postmenopausal women with VVA, but the lack of significant differences from placebo highlights the need for further research to truly confirm its effectiveness.
While we observed some improvements in those taking vitamin D2, particularly in VMI, vaginal pH, and VAS in comparison to their own baseline results, our intention-to-treat analysis showed no significant differences when compared to the placebo group. This means that despite the vitamin D2 group showing enhancements at certain points, these benefits weren’t impressive enough to distinguish them from the placebo.
Overall, our study suggests that vitamin D2 supplementation may lead to some positive changes in vaginal health for postmenopausal women with VVA, but the lack of significant differences from placebo highlights the need for further research to truly confirm its effectiveness.
Read More
8
Vitamin D from mushrooms improves bone
Effects of vitamin D-fortified shiitake mushroom on bioavailability and bone structure.
Relates to menopause and bone health
We investigated the potential of vitamin D derived from UV-irradiated shiitake mushrooms to enhance bone health, particularly in the context of menopause. Our study involved both sham-operated and ovariectomized (OVX) rats that were given different diets—some with the mushroom powder and others without.
The results showed that vitamin D from these mushrooms significantly improved bone mineral density and the structure of the femur bone. This suggests that incorporating vitamin D through shiitake mushrooms could be beneficial for women post-menopause, who may be experiencing bone density loss.
We also observed that the absence of estrogen, a common effect of menopause, negatively impacted vitamin D bioavailability and bone structure. In essence, this study highlights the potential role of vitamin D-rich shiitake mushrooms in mitigating some of the bone health challenges faced by postmenopausal women while also reflecting on hormonal influences.
The results showed that vitamin D from these mushrooms significantly improved bone mineral density and the structure of the femur bone. This suggests that incorporating vitamin D through shiitake mushrooms could be beneficial for women post-menopause, who may be experiencing bone density loss.
We also observed that the absence of estrogen, a common effect of menopause, negatively impacted vitamin D bioavailability and bone structure. In essence, this study highlights the potential role of vitamin D-rich shiitake mushrooms in mitigating some of the bone health challenges faced by postmenopausal women while also reflecting on hormonal influences.
Read More
Most Useful Reviews
9.5
Effective for menopause
It truly worked for my mother's menopause. She had uterine fibroid surgery and found it challenging to use female hormones, so I sought alternative options for her menopause management and it proved beneficial.
Read More
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
6
9
High-dose vitamin D2 improves levels
A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100,000 IU per week for vitamin D inadequacy in institutionalized postmenopausal women.
Moderate relevance due to focus
We conducted a rigorous study to investigate the effectiveness of ergocalciferol, a form of vitamin D2, in combating vitamin D inadequacy among institutionalized postmenopausal women. This randomized double-blinded placebo-controlled trial involved 94 participants who were administered either 40,000 IU (standard dose) or 100,000 IU (high dose) weekly for 12 weeks, aiming to see which dosage would best improve vitamin D levels.
Remarkably, our findings revealed that those receiving the higher dose of ergocalciferol achieved significantly better results in terms of boosting their serum 25(OH)D levels compared to those on the lower dose. Specifically, 90.9% of the high dose group reached optimal vitamin D levels, while just 65.9% of the standard group achieved the same. Even more telling was that in the subgroup with severe vitamin D deficiency, all participants on the high dose succeeded in reaching optimal levels.
However, when we looked at measures of physical strength, mobility, and quality of life, there were no notable differences between the two groups. This indicates that while high-dose vitamin D2 effectively improves vitamin D levels, its impact on overall health and well-being requires further exploration.
Our study highlights the importance of vitamin D2 supplementation, particularly for those who are most vulnerable, like institutionalized postmenopausal women. It shows that higher doses can lead to better vitamin D status, but we must remain cautious about assuming that improving vitamin D levels will automatically enhance other aspects of health.
Remarkably, our findings revealed that those receiving the higher dose of ergocalciferol achieved significantly better results in terms of boosting their serum 25(OH)D levels compared to those on the lower dose. Specifically, 90.9% of the high dose group reached optimal vitamin D levels, while just 65.9% of the standard group achieved the same. Even more telling was that in the subgroup with severe vitamin D deficiency, all participants on the high dose succeeded in reaching optimal levels.
However, when we looked at measures of physical strength, mobility, and quality of life, there were no notable differences between the two groups. This indicates that while high-dose vitamin D2 effectively improves vitamin D levels, its impact on overall health and well-being requires further exploration.
Our study highlights the importance of vitamin D2 supplementation, particularly for those who are most vulnerable, like institutionalized postmenopausal women. It shows that higher doses can lead to better vitamin D status, but we must remain cautious about assuming that improving vitamin D levels will automatically enhance other aspects of health.
Read More
8
Vitamin D from mushrooms improves bone
Effects of vitamin D-fortified shiitake mushroom on bioavailability and bone structure.
Relates to menopause and bone health
We investigated the potential of vitamin D derived from UV-irradiated shiitake mushrooms to enhance bone health, particularly in the context of menopause. Our study involved both sham-operated and ovariectomized (OVX) rats that were given different diets—some with the mushroom powder and others without.
The results showed that vitamin D from these mushrooms significantly improved bone mineral density and the structure of the femur bone. This suggests that incorporating vitamin D through shiitake mushrooms could be beneficial for women post-menopause, who may be experiencing bone density loss.
We also observed that the absence of estrogen, a common effect of menopause, negatively impacted vitamin D bioavailability and bone structure. In essence, this study highlights the potential role of vitamin D-rich shiitake mushrooms in mitigating some of the bone health challenges faced by postmenopausal women while also reflecting on hormonal influences.
The results showed that vitamin D from these mushrooms significantly improved bone mineral density and the structure of the femur bone. This suggests that incorporating vitamin D through shiitake mushrooms could be beneficial for women post-menopause, who may be experiencing bone density loss.
We also observed that the absence of estrogen, a common effect of menopause, negatively impacted vitamin D bioavailability and bone structure. In essence, this study highlights the potential role of vitamin D-rich shiitake mushrooms in mitigating some of the bone health challenges faced by postmenopausal women while also reflecting on hormonal influences.
Read More
8
Vitamin D2 enhances vitamin D levels
Effects of sunlight exposure and vitamin D supplementation on vitamin D levels in postmenopausal women in rural Thailand: A randomized controlled trial.
Moderate relevance to menopause research
We conducted a study to evaluate how vitamin D2 supplementation, alongside sunlight exposure, influences vitamin D levels in postmenopausal women. Over 12 weeks, we worked with 52 women aged 50 to 70, splitting them into two groups. One group received sunlight exposure alone, while the other group combined sunlight with a weekly vitamin D2 dose of 20,000 IU.
We observed that, surprisingly, the group that only received sunlight exposure had decreased vitamin D levels at the end of the study, dropping from 32.3 to 29.7 ng/ml. In contrast, the group that received vitamin D2 supplementation, in addition to sunlight, experienced an increase in their vitamin D levels, rising from 29.9 to 32.4 ng/ml. Although both groups saw a decrease in parathyroid hormone (PTH) levels, the changes were not significant.
In essence, our findings suggest that simply getting sunlight isn’t enough to maintain adequate vitamin D levels in postmenopausal women in Thailand. Adding vitamin D2 supplementation significantly boosts vitamin D levels, showing that a combined approach is more effective than relying on sunlight alone.
We observed that, surprisingly, the group that only received sunlight exposure had decreased vitamin D levels at the end of the study, dropping from 32.3 to 29.7 ng/ml. In contrast, the group that received vitamin D2 supplementation, in addition to sunlight, experienced an increase in their vitamin D levels, rising from 29.9 to 32.4 ng/ml. Although both groups saw a decrease in parathyroid hormone (PTH) levels, the changes were not significant.
In essence, our findings suggest that simply getting sunlight isn’t enough to maintain adequate vitamin D levels in postmenopausal women in Thailand. Adding vitamin D2 supplementation significantly boosts vitamin D levels, showing that a combined approach is more effective than relying on sunlight alone.
Read More
7
Vitamin D2's limited impact on menopause
Effect of Vitamin D Supplement on Vulvovaginal Atrophy of the Menopause.
Focus on menopause-related symptoms
We conducted a double-blinded, randomized placebo-controlled trial to assess the effects of oral vitamin D2 supplements on vaginal health in postmenopausal women experiencing vulvovaginal atrophy (VVA). Over 12 weeks, participants took either 40,000 IU of vitamin D2 or a placebo, while we measured outcomes like the vaginal maturation index (VMI), vaginal pH, and a visual analog scale (VAS) for VVA symptoms.
While we observed some improvements in those taking vitamin D2, particularly in VMI, vaginal pH, and VAS in comparison to their own baseline results, our intention-to-treat analysis showed no significant differences when compared to the placebo group. This means that despite the vitamin D2 group showing enhancements at certain points, these benefits weren’t impressive enough to distinguish them from the placebo.
Overall, our study suggests that vitamin D2 supplementation may lead to some positive changes in vaginal health for postmenopausal women with VVA, but the lack of significant differences from placebo highlights the need for further research to truly confirm its effectiveness.
While we observed some improvements in those taking vitamin D2, particularly in VMI, vaginal pH, and VAS in comparison to their own baseline results, our intention-to-treat analysis showed no significant differences when compared to the placebo group. This means that despite the vitamin D2 group showing enhancements at certain points, these benefits weren’t impressive enough to distinguish them from the placebo.
Overall, our study suggests that vitamin D2 supplementation may lead to some positive changes in vaginal health for postmenopausal women with VVA, but the lack of significant differences from placebo highlights the need for further research to truly confirm its effectiveness.
Read More
4
Vitamin D2 shows limited impact
Effectiveness of vitamin D2 supplementation on high-sensitivity C-reactive protein and other metabolic indices in menopausal Thai women: a randomized-controlled trial.
Highly relevant to menopause treatment
We conducted a double-blind, randomized, placebo-controlled trial to investigate the impact of vitamin D2 supplementation on high-sensitivity C-reactive protein (hsCRP) levels and other metabolic measures among menopausal Thai women.
Eighty postmenopausal women participated in the study, where they were split into two groups: one receiving vitamin D2 at a dose of 40,000 IU per week and the other receiving a placebo for a duration of 12 weeks. The primary focus was on hsCRP levels, a marker linked to inflammation, while secondary outcomes included various cardio-metabolic profiles and the risk of developing cardiovascular disease.
Our findings showed that although the vitamin D2 group experienced a notable reduction in hsCRP levels compared to the placebo group, the difference wasn't statistically significant by the end of the study. Other measured cardiovascular and metabolic outcomes also didn't show significant differences between the two groups.
Thus, while vitamin D2 appears to reduce inflammation markers in menopausal women, the overall benefits in hsCRP levels didn't reach statistical significance when compared to the placebo. This indicates a need for further research before making definitive conclusions about the benefits of vitamin D2 in this context.
Eighty postmenopausal women participated in the study, where they were split into two groups: one receiving vitamin D2 at a dose of 40,000 IU per week and the other receiving a placebo for a duration of 12 weeks. The primary focus was on hsCRP levels, a marker linked to inflammation, while secondary outcomes included various cardio-metabolic profiles and the risk of developing cardiovascular disease.
Our findings showed that although the vitamin D2 group experienced a notable reduction in hsCRP levels compared to the placebo group, the difference wasn't statistically significant by the end of the study. Other measured cardiovascular and metabolic outcomes also didn't show significant differences between the two groups.
Thus, while vitamin D2 appears to reduce inflammation markers in menopausal women, the overall benefits in hsCRP levels didn't reach statistical significance when compared to the placebo. This indicates a need for further research before making definitive conclusions about the benefits of vitamin D2 in this context.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
Effective for menopause
It truly worked for my mother's menopause. She had uterine fibroid surgery and found it challenging to use female hormones, so I sought alternative options for her menopause management and it proved beneficial.
