Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
We conducted a double-blind, randomized, placebo-controlled trial to investigate the impact of vitamin D2 supplementation on high-sensitivity C-reactive protein (hsCRP) levels and other metabolic measures among menopausal Thai women.
Eighty postmenopausal women participated in the study, where they were split into two groups: one receiving vitamin D2 at a dose of 40,000 IU per week and the other receiving a placebo for a duration of 12 weeks. The primary focus was on hsCRP levels, a marker linked to inflammation, while secondary outcomes included various cardio-metabolic profiles and the risk of developing cardiovascular disease.
Our findings showed that although the vitamin D2 group experienced a notable reduction in hsCRP levels compared to the placebo group, the difference wasn't statistically significant by the end of the study. Other measured cardiovascular and metabolic outcomes also didn't show significant differences between the two groups.
Thus, while vitamin D2 appears to reduce inflammation markers in menopausal women, the overall benefits in hsCRP levels didn't reach statistical significance when compared to the placebo. This indicates a need for further research before making definitive conclusions about the benefits of vitamin D2 in this context.
Eighty postmenopausal women participated in the study, where they were split into two groups: one receiving vitamin D2 at a dose of 40,000 IU per week and the other receiving a placebo for a duration of 12 weeks. The primary focus was on hsCRP levels, a marker linked to inflammation, while secondary outcomes included various cardio-metabolic profiles and the risk of developing cardiovascular disease.
Our findings showed that although the vitamin D2 group experienced a notable reduction in hsCRP levels compared to the placebo group, the difference wasn't statistically significant by the end of the study. Other measured cardiovascular and metabolic outcomes also didn't show significant differences between the two groups.
Thus, while vitamin D2 appears to reduce inflammation markers in menopausal women, the overall benefits in hsCRP levels didn't reach statistical significance when compared to the placebo. This indicates a need for further research before making definitive conclusions about the benefits of vitamin D2 in this context.
Read More
7
We conducted a double-blinded, randomized placebo-controlled trial to assess the effects of oral vitamin D2 supplements on vaginal health in postmenopausal women experiencing vulvovaginal atrophy (VVA). Over 12 weeks, participants took either 40,000 IU of vitamin D2 or a placebo, while we measured outcomes like the vaginal maturation index (VMI), vaginal pH, and a visual analog scale (VAS) for VVA symptoms.
While we observed some improvements in those taking vitamin D2, particularly in VMI, vaginal pH, and VAS in comparison to their own baseline results, our intention-to-treat analysis showed no significant differences when compared to the placebo group. This means that despite the vitamin D2 group showing enhancements at certain points, these benefits weren’t impressive enough to distinguish them from the placebo.
Overall, our study suggests that vitamin D2 supplementation may lead to some positive changes in vaginal health for postmenopausal women with VVA, but the lack of significant differences from placebo highlights the need for further research to truly confirm its effectiveness.
While we observed some improvements in those taking vitamin D2, particularly in VMI, vaginal pH, and VAS in comparison to their own baseline results, our intention-to-treat analysis showed no significant differences when compared to the placebo group. This means that despite the vitamin D2 group showing enhancements at certain points, these benefits weren’t impressive enough to distinguish them from the placebo.
Overall, our study suggests that vitamin D2 supplementation may lead to some positive changes in vaginal health for postmenopausal women with VVA, but the lack of significant differences from placebo highlights the need for further research to truly confirm its effectiveness.
Read More
Most Useful Reviews
9
Effective for menopause
It truly worked for my mother's menopause. She had uterine fibroid surgery and found it challenging to use female hormones, so I sought alternative options for her menopause management and it proved beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.5
- All Researches
9
High-dose vitamin D2 improves levels
We conducted a rigorous study to investigate the effectiveness of ergocalciferol, a form of vitamin D2, in combating vitamin D inadequacy among institutionalized postmenopausal women. This randomized double-blinded placebo-controlled trial involved 94 participants who were administered either 40,000 IU (standard dose) or 100,000 IU (high dose) weekly for 12 weeks, aiming to see which dosage would best improve vitamin D levels.
Remarkably, our findings revealed that those receiving the higher dose of ergocalciferol achieved significantly better results in terms of boosting their serum 25(OH)D levels compared to those on the lower dose. Specifically, 90.9% of the high dose group reached optimal vitamin D levels, while just 65.9% of the standard group achieved the same. Even more telling was that in the subgroup with severe vitamin D deficiency, all participants on the high dose succeeded in reaching optimal levels.
However, when we looked at measures of physical strength, mobility, and quality of life, there were no notable differences between the two groups. This indicates that while high-dose vitamin D2 effectively improves vitamin D levels, its impact on overall health and well-being requires further exploration.
Our study highlights the importance of vitamin D2 supplementation, particularly for those who are most vulnerable, like institutionalized postmenopausal women. It shows that higher doses can lead to better vitamin D status, but we must remain cautious about assuming that improving vitamin D levels will automatically enhance other aspects of health.
Remarkably, our findings revealed that those receiving the higher dose of ergocalciferol achieved significantly better results in terms of boosting their serum 25(OH)D levels compared to those on the lower dose. Specifically, 90.9% of the high dose group reached optimal vitamin D levels, while just 65.9% of the standard group achieved the same. Even more telling was that in the subgroup with severe vitamin D deficiency, all participants on the high dose succeeded in reaching optimal levels.
However, when we looked at measures of physical strength, mobility, and quality of life, there were no notable differences between the two groups. This indicates that while high-dose vitamin D2 effectively improves vitamin D levels, its impact on overall health and well-being requires further exploration.
Our study highlights the importance of vitamin D2 supplementation, particularly for those who are most vulnerable, like institutionalized postmenopausal women. It shows that higher doses can lead to better vitamin D status, but we must remain cautious about assuming that improving vitamin D levels will automatically enhance other aspects of health.
Read More
8
Vitamin D critical for fracture prevention
We explored the relationship between serum 25-hydroxyvitamin D levels and the occurrence of new vertebral fractures in postmenopausal women who have undergone percutaneous vertebral augmentation. This retrospective case-control study gathered clinical data from women aged 50 and older, focusing on those who had experienced either new osteoporotic vertebral refractures or cascade fractures after their surgery.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Our findings revealed that low serum levels of vitamin D significantly heighten the risk of new vertebral fractures. By employing sophisticated analysis models, we were able to determine that vitamin D deficiency acts as an independent risk factor for these fractures. Therefore, it's apparent that ensuring adequate vitamin D levels, possibly through supplementation, could aid in preventing further complications post-surgery.
This study highlights the importance of monitoring vitamin D status in postmenopausal women, especially after procedures aimed at managing spinal fractures. With appropriate vitamin D supplementation, we can potentially improve outcomes and lower the risk of future osteoporotic fractures in this vulnerable population.
Read More
8
We explored how the combination of vitamins D and K may influence menopausal health in women. Our review incorporated findings from 31 randomized clinical trials, which looked at how these vitamins work together to support bone density and cardiovascular health.
Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.
We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.
Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
Throughout the literature search, we consistently noted positive outcomes associated with the co-supplementation of these vitamins. The data indicated that combining these essential nutrients could be beneficial for postmenopausal women, especially in reducing risks associated with osteoporosis and heart disease.
We also found that a diet rich in vegetables and fermented dairy products could enhance these benefits. However, given dietary challenges, we recommend vitamin D and K supplements as a practical approach to fostering healthier aging.
Our comprehensive review emphasizes the importance of addressing nutritional needs during menopause to improve overall quality of life and well-being.
Read More
8
We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.
Read More
8
Vitamin D supports bone health
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for menopause
It truly worked for my mother's menopause. She had uterine fibroid surgery and found it challenging to use female hormones, so I sought alternative options for her menopause management and it proved beneficial.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
- Binkley N, Sempos CT, Borchardt G, Larsen J, Stacey ML, et al. Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Osteoporos Int. 2025;36:255. doi:10.1007/s00198-024-07310-2
- Cocetta V, Zorzi M, Bejor S, Cesta MC, De Pizzol M, et al. Retrospective Analysis of the Effect of Postmenopausal Women Medications on SARS-CoV-2 Infection Progression. Life (Basel). 2024;14. doi:10.3390/life14091107
- Bowles SD, Jacques R, Hill TR, Eastell R, Walsh JS. Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function. Nutrients. 2024;16. doi:10.3390/nu16172888
- Korkmaz H, Pehlivanoğlu B. Is Vitamin D a Crucial Molecule for Musculoskeletal and Cardiovascular Systems in Postmenopausal Women?. Front Biosci (Landmark Ed). 2024;29:281. doi:10.31083/j.fbl2908281
- Rusu ME, Bigman G, Ryan AS, Popa DS. Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies. Nutrients. 2024;16. doi:10.3390/nu16142356
- Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, et al. Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency. Nutrients. 2024;16. doi:10.3390/nu16111754
- G Siregar MF, Jabbar F, Effendi IH, Alhair T, Prabudi MO, et al. Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women. Narra J. 2024;4:e452. doi:10.52225/narra.v4i1.452
- Joo NS, Shin SH, Kim KN, Lee SH, Jung S, et al. Home Meal Replacement Fortified with Eggshell Powder and Vitamin D Prevents Bone Loss in Postmenopausal Women: A Randomized, Double-Blind, Controlled Study. Nutrients. 2024;16. doi:10.3390/nu16081152
- Indhavivadhana S, Boonyachan W, Rattanachaiyanont M, Wongwananuruk T, Techatraisak K, et al. Effectiveness of vitamin D2 supplementation on high-sensitivity C-reactive protein and other metabolic indices in menopausal Thai women: a randomized-controlled trial. Gynecol Endocrinol. 2022;38:83. doi:10.1080/09513590.2021.1988560
- Kamronrithisorn T, Manonai J, Vallibhakara SA, Sophonsritsuk A, Vallibhakara O. Effect of Vitamin D Supplement on Vulvovaginal Atrophy of the Menopause. Nutrients. 2020;12. doi:10.3390/nu12092876
- Mueangpaisarn P, Chaiamnuay S. A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100,000 IU per week for vitamin D inadequacy in institutionalized postmenopausal women. Aging Clin Exp Res. 2020;32:41. doi:10.1007/s40520-019-01151-4
- Won DJ, Seong KS, Jang CH, Lee JS, Ko JA, et al. Effects of vitamin D-fortified shiitake mushroom on bioavailability and bone structure. Biosci Biotechnol Biochem. 2019;83:942. doi:10.1080/09168451.2019.1576497
- Watcharanon W, Kaewrudee S, Soontrapa S, Somboonporn W, Srisaenpang P, et al. Effects of sunlight exposure and vitamin D supplementation on vitamin D levels in postmenopausal women in rural Thailand: A randomized controlled trial. Complement Ther Med. 2018;40:243. doi:10.1016/j.ctim.2018.06.004
- Suebthawinkul C, Panyakhamlerd K, Yotnuengnit P, Suwan A, Chaiyasit N, et al. The effect of vitamin D2 supplementation on muscle strength in early postmenopausal women: a randomized, double-blind, placebo-controlled trial. Climacteric. 2018;21:491. doi:10.1080/13697137.2018.1480600
- Cooper L, Clifton-Bligh PB, Nery ML, Figtree G, Twigg S, et al. Vitamin D supplementation and bone mineral density in early postmenopausal women. Am J Clin Nutr. 2003;77:1324.
