Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7
USERS' SCORE
Good
Based on 13 Reviews
8.7
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored the connection between vitamin B levels and depression in older adults over four years. Our study followed nearly 3,850 participants and found that those with low blood levels of vitamin B were significantly more likely to report depressive symptoms. Specifically, individuals with low vitamin B had a 51% higher chance of developing depression compared to those with adequate levels.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
However, we did not find any significant link between folate levels and depression. These insights suggest that boosting vitamin B might be a simple, cost-effective way to help improve mental health in older adults.
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2
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
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9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
Most Useful Reviews
9.5
Strengthens memory
Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders.
Read More
9.5
Improves well-being
This excellent supplement is my second purchase. Vitamin B-12 plays crucial roles in the body, enhancing metabolism and vital functions, including improving cardiovascular health, protecting the central nervous system, reducing depression, and boosting energy. If this review was helpful, please click "like."
Read More
7.5
Helps relieve depression
Excellent! This vitamin is part of the B complex and I believe this active form of B12 (methyl) is the best. After taking it, I noticed a relief in pain and depression. The sublingual gum tastes delightful, but it melted a bit in the heat when I had only a few tablets left.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7
- All Researches
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
9
We explored the relationship between vitamin B12 levels and major depressive disorder (MDD) by examining serum vitamin B12, homocysteine (Hcy), and blood profiles in 59 patients diagnosed with MDD. The severity of depression was evaluated using the HAM-D scale, which allows for a clear understanding of how vitamin B12 might be linked to depressive symptoms.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
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8
We looked into how Vitamin B could change behaviors and brain chemistry in rats experiencing depression-like symptoms. Rats were split into groups to compare a control group, one exposed to chronic mild stress, and a group receiving Vitamin B injections.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Results showed that Vitamin B helped boost levels of key neurotransmitters associated with mood, reducing anxiety and depressive behaviors. It also positively impacted brain cell health by activating important signaling pathways.
Overall, Vitamin B appears promising in helping to combat depression-related issues in this rat model.
Read More
8
We explored how vitamin B12 influences stress resilience and depression using sophisticated methods in a mouse model. Our findings linked vitamin B12 supplementation to changes in a gene called Ttr, which plays a role in managing stress.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Interestingly, we noticed that vitamin B12 reduced genetic markers associated with stress in specific areas of the brain. This important discovery encourages further research into how dietary changes might help improve mood disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Strengthens memory
Forgetting information or people can indicate vitamin B12 deficiency. Adequate amounts support memory and are especially recommended for students. Research indicates that a deficiency raises the risk of developing Alzheimer's, highlighting its importance for brain health and focus. B12 may also benefit those prone to depression and mood disorders.
Read More
9.5
Improves well-being
This excellent supplement is my second purchase. Vitamin B-12 plays crucial roles in the body, enhancing metabolism and vital functions, including improving cardiovascular health, protecting the central nervous system, reducing depression, and boosting energy. If this review was helpful, please click "like."
Read More
7.5
Helps relieve depression
Excellent! This vitamin is part of the B complex and I believe this active form of B12 (methyl) is the best. After taking it, I noticed a relief in pain and depression. The sublingual gum tastes delightful, but it melted a bit in the heat when I had only a few tablets left.
Read More
8.8
Restores mental health
An effective remedy for restoring the nervous system, this ACTIVE form of vitamin B12 is key for brain function. B12 is hard to absorb from food, which can lead to deficiency. It's vital for addressing issues such as depression, stress, chronic fatigue, and insomnia. I take it alongside folic acid, as they are interrelated vitamins recommended to be taken together.
Read More
8.8
Enhances sleep quality
This vitamin significantly improves sleep quality and helps maintain an average of 8 hours, thereby reducing depression associated with lack of sleep. It is easy to chew and absorb, making it a great addition to breakfast. I recommend it to anyone seeking to improve mood and sleep.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Laird EJ, O'Halloran AM, Molloy AM, Healy M, Hernandez B, et al. Low vitamin B but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study. Br J Nutr. 2023;130:268. doi:10.1017/S0007114521004748
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
- Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720
- Wu Y, Zhang L, Li S, Zhang D. Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutr Rev. 2022;80:351. doi:10.1093/nutrit/nuab014
- Dhiman P, Pillai RR, Wilson AB, Premkumar N, Bharadwaj B, et al. Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. BMC Pregnancy Childbirth. 2021;21:146. doi:10.1186/s12884-021-03622-x
- Bou Khalil R, Atallah E, Dirani E, Kallab M, Kassab A, et al. Can atypical dysgeusia in depression be related to a deafferentation syndrome?. Med Hypotheses. 2020;144:110047. doi:10.1016/j.mehy.2020.110047
- Trautmann C, Bock A, Urbach A, Hübner CA, Engmann O. Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2. Neuropharmacology. 2020;171:108112. doi:10.1016/j.neuropharm.2020.108112
- Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents. Child Adolesc Ment Health. 2020;25:249. doi:10.1111/camh.12387
- Lv P, Xiang F, Zhang S, Lei D, Zhou C, et al. Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis. J Ethnopharmacol. 2025;342:119392. doi:10.1016/j.jep.2025.119392
- Alzahrani H. Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. Cureus. 2024;16:e73350. doi:10.7759/cureus.73350
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Hui J, Zhang N, Kang M, Gou Y, Liu C, et al. Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16132042
- Harikaran S, Basu S, Mukherjee MP, Kar R, Nair S, et al. Vitamin B12 and homocysteine in patients with major depressive disorder. J Family Med Prim Care. 2024;13:2049. doi:10.4103/jfmpc.jfmpc_1460_23
- Gao Y, Yang J, Sun H, Zhou H. Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial. BMC Oral Health. 2024;24:603. doi:10.1186/s12903-024-04318-2
- Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Arija V. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study. J Reprod Infant Psychol. 2024. doi:10.1080/02646838.2024.2324043
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
- Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
