Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
7
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Read More
4
Vitamin B12 linked to hypothyroidism
We explored the relationship between vitamin B12 levels and hypothyroidism by reviewing a range of research studies on this topic. Our analysis included 64 studies, involving nearly 29,000 participants, to understand how vitamin B12 levels differ in those with thyroid disorders compared to healthy individuals.
Our findings indicate that patients with hypothyroidism tend to have lower levels of vitamin B12 compared to those without thyroid issues. Specifically, the data showed a significant mean difference, suggesting that as thyroid dysfunction increases, so may the risk of vitamin B12 deficiency.
However, we did not find any significant differences in vitamin B12 levels when looking at hyperthyroidism or other related thyroid conditions. The prevalence of vitamin B12 deficiency varied among thyroid patients, with 27% of those with hypothyroidism being deficient, compared to lower rates in hyperthyroidism and autoimmune thyroid disease.
While these findings are interesting, it's important to note that the study did not directly assess the effects of vitamin B12 treatment on hypothyroidism. Therefore, we cannot conclude that treating with vitamin B12 leads to significant improvement in hypothyroid conditions.
Our findings indicate that patients with hypothyroidism tend to have lower levels of vitamin B12 compared to those without thyroid issues. Specifically, the data showed a significant mean difference, suggesting that as thyroid dysfunction increases, so may the risk of vitamin B12 deficiency.
However, we did not find any significant differences in vitamin B12 levels when looking at hyperthyroidism or other related thyroid conditions. The prevalence of vitamin B12 deficiency varied among thyroid patients, with 27% of those with hypothyroidism being deficient, compared to lower rates in hyperthyroidism and autoimmune thyroid disease.
While these findings are interesting, it's important to note that the study did not directly assess the effects of vitamin B12 treatment on hypothyroidism. Therefore, we cannot conclude that treating with vitamin B12 leads to significant improvement in hypothyroid conditions.
Read More
4
Our research centered on exploring how vitamin B12 levels relate to hypothyroidism, a condition where the thyroid doesn’t produce enough hormones. We analyzed data from a case-control study that included 885 participants, comparing 170 patients with hypothyroidism to 715 healthy individuals.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Read More
Most Useful Reviews
9
Essential for energy
4 people found this helpful
Excellent! Vitamin B12 is indispensable for the body. It boosts haemoglobin, benefits heart muscle, aids in DNA synthesis, and supports energy production. As many of us suffer from anaemia, B12 is vital. I take at least 1000 mcg in methylated sublingual form, which is absorbed immediately. Living with hypothyroidism, it is essential for me, and I consume it regularly with meals, avoiding other vitamins.
Read More
10
Reduced homocysteine
Source of Life! I'm thrilled with this vitamin, as it aids my entire family with hypothyroidism and gastrointestinal malabsorption. Previous forms were not absorbed, but this Methyl B12 is effective. It's like candy! My test results are promising. Alongside B6, Methylfolate, Omega-3, and D3, my homocysteine levels have halved, reducing risks of serious illnesses. This vitamin is truly a source of life.
Read More
9
Vital for energy
Vitamin B12 is essential for the body. It raises haemoglobin, supports heart muscle, and is required for DNA synthesis and energy production. Given the prevalence of anaemia, B12 is critical. I regularly take 1000 mcg in methylated sublingual form while avoiding other vitamins during meals, especially due to my hypothyroidism.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.8
- All Researches
7
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Read More
4
Our research centered on exploring how vitamin B12 levels relate to hypothyroidism, a condition where the thyroid doesn’t produce enough hormones. We analyzed data from a case-control study that included 885 participants, comparing 170 patients with hypothyroidism to 715 healthy individuals.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Read More
4
We conducted a focused study on vitamin B12 levels among patients with hypothyroidism to see how these levels relate to their overall health, particularly in terms of anemia. The analysis involved 100 individuals diagnosed with hypothyroidism, revealing that a significant 68% of them were found to be vitamin B12 deficient.
Among those deficient in vitamin B12, a large majority were women, making up 73.5% of the group. We observed that those with higher levels of anti-thyroid antibodies—specifically anti-TPO and anti-Tg—also tended to experience vitamin B12 deficiency. In fact, 78.6% of patients with raised anti-TPO antibodies were vitamin B12 deficient, indicating a potential relationship between autoimmune responses and vitamin deficiencies in this population.
Despite these insights into the correlation between vitamin B12 levels and thyroid-related antibodies, our findings suggest that vitamin B12 treatment alone does not specifically address hypothyroidism symptoms or provide a significant improvement in their management. Hence, while vitamin B12 deficiency is prevalent among hypothyroid patients, its treatment isn't shown to dramatically influence hypothyroid symptoms directly.
Among those deficient in vitamin B12, a large majority were women, making up 73.5% of the group. We observed that those with higher levels of anti-thyroid antibodies—specifically anti-TPO and anti-Tg—also tended to experience vitamin B12 deficiency. In fact, 78.6% of patients with raised anti-TPO antibodies were vitamin B12 deficient, indicating a potential relationship between autoimmune responses and vitamin deficiencies in this population.
Despite these insights into the correlation between vitamin B12 levels and thyroid-related antibodies, our findings suggest that vitamin B12 treatment alone does not specifically address hypothyroidism symptoms or provide a significant improvement in their management. Hence, while vitamin B12 deficiency is prevalent among hypothyroid patients, its treatment isn't shown to dramatically influence hypothyroid symptoms directly.
Read More
4
Vitamin B12 linked to hypothyroidism
We explored the relationship between vitamin B12 levels and hypothyroidism by reviewing a range of research studies on this topic. Our analysis included 64 studies, involving nearly 29,000 participants, to understand how vitamin B12 levels differ in those with thyroid disorders compared to healthy individuals.
Our findings indicate that patients with hypothyroidism tend to have lower levels of vitamin B12 compared to those without thyroid issues. Specifically, the data showed a significant mean difference, suggesting that as thyroid dysfunction increases, so may the risk of vitamin B12 deficiency.
However, we did not find any significant differences in vitamin B12 levels when looking at hyperthyroidism or other related thyroid conditions. The prevalence of vitamin B12 deficiency varied among thyroid patients, with 27% of those with hypothyroidism being deficient, compared to lower rates in hyperthyroidism and autoimmune thyroid disease.
While these findings are interesting, it's important to note that the study did not directly assess the effects of vitamin B12 treatment on hypothyroidism. Therefore, we cannot conclude that treating with vitamin B12 leads to significant improvement in hypothyroid conditions.
Our findings indicate that patients with hypothyroidism tend to have lower levels of vitamin B12 compared to those without thyroid issues. Specifically, the data showed a significant mean difference, suggesting that as thyroid dysfunction increases, so may the risk of vitamin B12 deficiency.
However, we did not find any significant differences in vitamin B12 levels when looking at hyperthyroidism or other related thyroid conditions. The prevalence of vitamin B12 deficiency varied among thyroid patients, with 27% of those with hypothyroidism being deficient, compared to lower rates in hyperthyroidism and autoimmune thyroid disease.
While these findings are interesting, it's important to note that the study did not directly assess the effects of vitamin B12 treatment on hypothyroidism. Therefore, we cannot conclude that treating with vitamin B12 leads to significant improvement in hypothyroid conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for energy
4 people found this helpful
Excellent! Vitamin B12 is indispensable for the body. It boosts haemoglobin, benefits heart muscle, aids in DNA synthesis, and supports energy production. As many of us suffer from anaemia, B12 is vital. I take at least 1000 mcg in methylated sublingual form, which is absorbed immediately. Living with hypothyroidism, it is essential for me, and I consume it regularly with meals, avoiding other vitamins.
Read More
10
Reduced homocysteine
Source of Life! I'm thrilled with this vitamin, as it aids my entire family with hypothyroidism and gastrointestinal malabsorption. Previous forms were not absorbed, but this Methyl B12 is effective. It's like candy! My test results are promising. Alongside B6, Methylfolate, Omega-3, and D3, my homocysteine levels have halved, reducing risks of serious illnesses. This vitamin is truly a source of life.
Read More
9
Vital for energy
Vitamin B12 is essential for the body. It raises haemoglobin, supports heart muscle, and is required for DNA synthesis and energy production. Given the prevalence of anaemia, B12 is critical. I regularly take 1000 mcg in methylated sublingual form while avoiding other vitamins during meals, especially due to my hypothyroidism.
Read More
8
Joint pain relief
Excellent formula! It is essential for me. I absorb it well. With hypothyroidism, replenishing B12 is crucial. I take it once daily in the morning after meals, and I've experienced increased strength, reduced joint inflammation, and less pain. Be healthy! I trust iHerb. Thanks!
Read More
7.5
Improved mood
1 people found this helpful
Having hypothyroidism with no thyroid gland, I've felt vigorous and my mood has improved in the first month of taking this supplement. I recommend it.
Read More
Frequently Asked Questions
7.5
Improved mood
1 people found this helpful
Having hypothyroidism with no thyroid gland, I've felt vigorous and my mood has improved in the first month of taking this supplement. I recommend it.
8
Joint pain relief
Excellent formula! It is essential for me. I absorb it well. With hypothyroidism, replenishing B12 is crucial. I take it once daily in the morning after meals, and I've experienced increased strength, reduced joint inflammation, and less pain. Be healthy! I trust iHerb. Thanks!
10
Reduced homocysteine
Source of Life! I'm thrilled with this vitamin, as it aids my entire family with hypothyroidism and gastrointestinal malabsorption. Previous forms were not absorbed, but this Methyl B12 is effective. It's like candy! My test results are promising. Alongside B6, Methylfolate, Omega-3, and D3, my homocysteine levels have halved, reducing risks of serious illnesses. This vitamin is truly a source of life.
9
Essential for energy
4 people found this helpful
Excellent! Vitamin B12 is indispensable for the body. It boosts haemoglobin, benefits heart muscle, aids in DNA synthesis, and supports energy production. As many of us suffer from anaemia, B12 is vital. I take at least 1000 mcg in methylated sublingual form, which is absorbed immediately. Living with hypothyroidism, it is essential for me, and I consume it regularly with meals, avoiding other vitamins.
4
We conducted a focused study on vitamin B12 levels among patients with hypothyroidism to see how these levels relate to their overall health, particularly in terms of anemia. The analysis involved 100 individuals diagnosed with hypothyroidism, revealing that a significant 68% of them were found to be vitamin B12 deficient.
Among those deficient in vitamin B12, a large majority were women, making up 73.5% of the group. We observed that those with higher levels of anti-thyroid antibodies—specifically anti-TPO and anti-Tg—also tended to experience vitamin B12 deficiency. In fact, 78.6% of patients with raised anti-TPO antibodies were vitamin B12 deficient, indicating a potential relationship between autoimmune responses and vitamin deficiencies in this population.
Despite these insights into the correlation between vitamin B12 levels and thyroid-related antibodies, our findings suggest that vitamin B12 treatment alone does not specifically address hypothyroidism symptoms or provide a significant improvement in their management. Hence, while vitamin B12 deficiency is prevalent among hypothyroid patients, its treatment isn't shown to dramatically influence hypothyroid symptoms directly.
Among those deficient in vitamin B12, a large majority were women, making up 73.5% of the group. We observed that those with higher levels of anti-thyroid antibodies—specifically anti-TPO and anti-Tg—also tended to experience vitamin B12 deficiency. In fact, 78.6% of patients with raised anti-TPO antibodies were vitamin B12 deficient, indicating a potential relationship between autoimmune responses and vitamin deficiencies in this population.
Despite these insights into the correlation between vitamin B12 levels and thyroid-related antibodies, our findings suggest that vitamin B12 treatment alone does not specifically address hypothyroidism symptoms or provide a significant improvement in their management. Hence, while vitamin B12 deficiency is prevalent among hypothyroid patients, its treatment isn't shown to dramatically influence hypothyroid symptoms directly.
7
We explored the connection between vitamin B12 deficiency and hypothyroidism through a focused study involving 100 hypothyroid patients. This research took place over a year and aimed to determine how common vitamin B12 deficiency is among these individuals and how it correlates with thyroid antibodies.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
Our findings revealed that a significant 68% of the hypothyroid patients were vitamin B12 deficient. Interestingly, a large majority of these deficient patients were female, specifically 73.5%. Additionally, we noted that a high percentage of patients with elevated Anti TPO and Anti Thyroglobulin antibodies also had low vitamin B12 levels.
Although vitamin B12 deficiency was present in a notable portion of the hypothyroid population, we're careful to point out that the study does not state that vitamin B12 supplementation alone can fully alleviate hypothyroid symptoms. However, it suggests that addressing this deficiency could be a valuable addition to current hypothyroid treatments. By recognizing and treating vitamin B12 deficiency, we may improve the overall management of hypothyroid conditions for some patients.
4
Our research centered on exploring how vitamin B12 levels relate to hypothyroidism, a condition where the thyroid doesn’t produce enough hormones. We analyzed data from a case-control study that included 885 participants, comparing 170 patients with hypothyroidism to 715 healthy individuals.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
Through blood tests, we measured various hormone and vitamin levels, including TSH, T3, T4, vitamin D, and vitamin B12. We observed that hypothyroid patients had significantly higher TSH levels and lower T4 levels than the control group. Notably, vitamin B12 levels were also lower in those with hypothyroidism.
Despite these findings suggesting an association between low vitamin B12 and thyroid dysfunction, the study did not specifically test the effects of vitamin B12 treatment on hypothyroidism itself. Therefore, while we can conclude there is a connection, we cannot say for certain that vitamin B12 treatment would improve hypothyroidism. This opens up avenues for future research to further investigate the potential benefits of addressing vitamin B12 deficiencies in managing thyroid conditions.
4
Vitamin B12 linked to hypothyroidism
We explored the relationship between vitamin B12 levels and hypothyroidism by reviewing a range of research studies on this topic. Our analysis included 64 studies, involving nearly 29,000 participants, to understand how vitamin B12 levels differ in those with thyroid disorders compared to healthy individuals.
Our findings indicate that patients with hypothyroidism tend to have lower levels of vitamin B12 compared to those without thyroid issues. Specifically, the data showed a significant mean difference, suggesting that as thyroid dysfunction increases, so may the risk of vitamin B12 deficiency.
However, we did not find any significant differences in vitamin B12 levels when looking at hyperthyroidism or other related thyroid conditions. The prevalence of vitamin B12 deficiency varied among thyroid patients, with 27% of those with hypothyroidism being deficient, compared to lower rates in hyperthyroidism and autoimmune thyroid disease.
While these findings are interesting, it's important to note that the study did not directly assess the effects of vitamin B12 treatment on hypothyroidism. Therefore, we cannot conclude that treating with vitamin B12 leads to significant improvement in hypothyroid conditions.
Our findings indicate that patients with hypothyroidism tend to have lower levels of vitamin B12 compared to those without thyroid issues. Specifically, the data showed a significant mean difference, suggesting that as thyroid dysfunction increases, so may the risk of vitamin B12 deficiency.
However, we did not find any significant differences in vitamin B12 levels when looking at hyperthyroidism or other related thyroid conditions. The prevalence of vitamin B12 deficiency varied among thyroid patients, with 27% of those with hypothyroidism being deficient, compared to lower rates in hyperthyroidism and autoimmune thyroid disease.
While these findings are interesting, it's important to note that the study did not directly assess the effects of vitamin B12 treatment on hypothyroidism. Therefore, we cannot conclude that treating with vitamin B12 leads to significant improvement in hypothyroid conditions.
References
- Adam LN, Abbas AM. Thyroid function and its association with vitamin deficiencies: a case-control study in Duhok. Expert Rev Endocrinol Metab. 2025. 10.1080/17446651.2025.2469686
- Gupta R, Choudhary S, Chatterjee T. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. Cureus. 2023;15:e44197. 10.7759/cureus.44197
- Chatterjee T, Gupta R, Choudhary S. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. J Assoc Physicians India. 2023;71:1.
- Benites-Zapata VA, Ignacio-Cconchoy FL, Ulloque-Badaracco JR, Hernandez-Bustamante EA, Alarcón-Braga EA, et al. Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1070592. 10.3389/fendo.2023.1070592
