Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
7
We set out to understand how vitamin B12 levels relate to migraine frequency and pain severity. In our study, we included 127 migraine patients and 45 healthy controls from Okmeydanı Training and Research Hospital. Notably, we measured the frequency and duration of migraine attacks and assessed pain severity using a visual analogue scale (VAS).
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Our findings revealed that migraine patients had significantly lower vitamin B12 levels compared to the healthy controls. Specifically, the average vitamin B12 level in migraine sufferers was 227.30 ng/L, while the controls had an average of 278.44 ng/L.
Furthermore, we observed that chronic migraine patients had even lower vitamin B12 levels than those experiencing less frequent migraines. While our study suggests a correlation between low vitamin B12 and increased migraine severity, we did not explicitly evaluate the treatment effects of vitamin B12 supplements on migraines.
Thus, while low vitamin B12 may be associated with more severe migraines, it remains unclear if supplementation would provide a significant therapeutic benefit. Regular monitoring of vitamin B12 levels in patients with migraines could still be a valuable practice.
Read More
7
We set out to investigate the connection between vitamin B12 levels and migraines by comparing serum vitamin B12 and methylmalonic acid (MMA) levels in migraine patients and healthy individuals. Our study involved 70 migraine sufferers and 70 controls, aiming to understand whether vitamin B12 deficiencies might be linked to migraine frequency and intensity.
The results indicated that migraine patients had significantly lower vitamin B12 levels compared to the healthy group, alongside higher MMA levels. Importantly, those with the lowest vitamin B12 levels had an 80% higher chance of experiencing migraines. Conversely, participants with elevated MMA levels faced more than a fivefold increase in migraine risk.
While the findings provide insightful associations between vitamin B12 status and migraines, it's crucial to note that the study doesn't include direct treatment interventions. This means while we observed intriguing links, we cannot confirm that vitamin B12 supplementation would definitively alleviate migraine symptoms based solely on this study.
The results indicated that migraine patients had significantly lower vitamin B12 levels compared to the healthy group, alongside higher MMA levels. Importantly, those with the lowest vitamin B12 levels had an 80% higher chance of experiencing migraines. Conversely, participants with elevated MMA levels faced more than a fivefold increase in migraine risk.
While the findings provide insightful associations between vitamin B12 status and migraines, it's crucial to note that the study doesn't include direct treatment interventions. This means while we observed intriguing links, we cannot confirm that vitamin B12 supplementation would definitively alleviate migraine symptoms based solely on this study.
Read More
Most Useful Reviews
9.5
Well absorbed
This product absorbed well in my body and is excellent for migraines.
Read More
9.5
Saved from migraines
Above all, I praise B12; these delicious sweets are fantastic. The active form of methyl has truly saved me from migraines! I will continue to buy it.
Read More
8.8
Effective energy boost
Ingredients and taste are spot on; I adore the cherry flavour. The potency provides me with an extra energy boost and helps to enhance my metabolism. It also regulates my nervous system and manages my migraine effectively. The packaging was secure and arrived promptly, and the size represents great value for money. Well done!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.7
- All Researches
9
We conducted a comprehensive study to explore the effectiveness of vitamin B supplementation, including B12, in reducing migraine occurrences, particularly in women diagnosed with migraines accompanied by aura. Over a period of six months, we administered daily vitamin B supplements to a group of 206 participants, comparing their results to those taking a placebo.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
Our findings were quite promising. Vitamin supplementation notably lowered homocysteine levels, which is linked to migraine severity. We observed significant reductions in headache severity and the degree of migraine-related disability among those taking the vitamins compared to those on the placebo.
Furthermore, when we examined the genetic backgrounds of participants, we found that specific variants in the MTHFR and MTRR genes influenced the response to vitamin B supplementation. Carriers of certain gene variants experienced even greater improvements. Importantly, the positive effects from vitamin treatments seemed independent of the MTHFR variant, suggesting a broader impact of B vitamins on migraines.
Overall, our research indicates that vitamin B supplementation, including B12, holds potential as an effective intervention for reducing migraine symptoms, enhancing the quality of life for those affected.
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9
We conducted a thorough investigation into the effects of vitamin B12 supplementation on individuals suffering from migraines, specifically those with aura. Our study focused on how daily doses of a vitamin combination, including B12, influenced migraine symptoms and disability levels over six months. We employed a randomized, double-blind, placebo-controlled trial to ensure the reliability of our findings.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Our results were promising. Participants who received vitamin supplementation showed a significant drop in homocysteine levels by 39%, which was markedly more than those in the placebo group. This reduction was linked to a substantial decrease in migraine disability; moving from 60% prevalence at the start to just 30% after six months of treatment.
Furthermore, we noted that headache frequency and pain severity also improved with vitamin supplementation. Notably, those carrying the C allele of the MTHFR (C677T) genotype responded even better to this treatment compared to the TT genotype individuals. This suggests that genotype can play a role in how effective vitamin B12 and its related vitamins can be for migraine sufferers.
While these findings highlight the potential benefits of vitamin B12, more extensive research is necessary to determine if this combination therapy is a safe and effective long-term option for preventing migraines. Our work shines a light on a possible new pathway to relief for many individuals who struggle with this debilitating condition.
Read More
8
Vitamin B12 shows promise for migraines
We conducted a study to explore the effects of vitamin B12, when combined with magnesium and high-intensity interval training (HIIT), on alleviating migraine symptoms. Our research involved 60 participants who were divided into four groups: one group practiced HIIT, another consumed vitamin B12 and magnesium supplements, a third group did both HIIT and supplements, and a control group received no intervention.
Over two months, we measured changes in migraine frequency, intensity, and duration, along with serum levels of a specific marker known as calcitonin gene-related peptide (CGRP). We noted that the combination of vitamin B12 and magnesium, coupled with regular exercise, appeared to positively influence inflammation pathways related to migraines, suggesting a potential way to reduce migraine pain.
However, it is important to recognize that the study had limitations in isolating the specific effects of vitamin B12 from the other treatment components. Nonetheless, our findings indicate that incorporating vitamin B12 and magnesium with physical activity could be a promising approach to help those suffering from migraines.
Over two months, we measured changes in migraine frequency, intensity, and duration, along with serum levels of a specific marker known as calcitonin gene-related peptide (CGRP). We noted that the combination of vitamin B12 and magnesium, coupled with regular exercise, appeared to positively influence inflammation pathways related to migraines, suggesting a potential way to reduce migraine pain.
However, it is important to recognize that the study had limitations in isolating the specific effects of vitamin B12 from the other treatment components. Nonetheless, our findings indicate that incorporating vitamin B12 and magnesium with physical activity could be a promising approach to help those suffering from migraines.
Read More
7
We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.
This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.
Read More
7
We explored the potential impact of vitamin B12 on migraine pathogenesis by analyzing data from several sources including the UK Biobank and others. Our study involved participants suffering from migraines without aura (MwoA) and migraines with aura (MwA), and we looked at 51 different risk factors that could influence these conditions.
Our findings suggested that higher vitamin B12 intake was associated with lower odds of developing migraines without aura. Specifically, the odds ratio for vitamin B12 was 0.49, indicating a potentially significant protective effect. This suggests that increasing vitamin B12 intake might be a beneficial strategy for reducing the risk of MwoA, adding to a growing body of evidence about the nutrient's importance.
However, we also recognized the need for further exploration of how vitamin B12 should be administered and its isolated effects on different types of migraines. It's important to note that while these results are promising, they are just part of a larger picture of migraine management, which includes various lifestyle factors we also examined, such as stress and physical activity.
Overall, identifying vitamin B12 as a protective factor opens doors for potential interventions in migraine prophylaxis focused on dietary modifications and increased awareness of nutrient consumption.
Our findings suggested that higher vitamin B12 intake was associated with lower odds of developing migraines without aura. Specifically, the odds ratio for vitamin B12 was 0.49, indicating a potentially significant protective effect. This suggests that increasing vitamin B12 intake might be a beneficial strategy for reducing the risk of MwoA, adding to a growing body of evidence about the nutrient's importance.
However, we also recognized the need for further exploration of how vitamin B12 should be administered and its isolated effects on different types of migraines. It's important to note that while these results are promising, they are just part of a larger picture of migraine management, which includes various lifestyle factors we also examined, such as stress and physical activity.
Overall, identifying vitamin B12 as a protective factor opens doors for potential interventions in migraine prophylaxis focused on dietary modifications and increased awareness of nutrient consumption.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Well absorbed
This product absorbed well in my body and is excellent for migraines.
Read More
9.5
Saved from migraines
Above all, I praise B12; these delicious sweets are fantastic. The active form of methyl has truly saved me from migraines! I will continue to buy it.
Read More
8.8
Effective energy boost
Ingredients and taste are spot on; I adore the cherry flavour. The potency provides me with an extra energy boost and helps to enhance my metabolism. It also regulates my nervous system and manages my migraine effectively. The packaging was secure and arrived promptly, and the size represents great value for money. Well done!
Read More
8
Stops some migraines
This is the best B-12 I have found. I love using this brand as it seems to work best for me. The Methyl form is particularly effective if you have low B-12 levels and it helps stop some of my migraines.
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8.8
Fewer migraine attacks
I will repurchase this series; the taste is good, and I've experienced fewer migraine attacks after consuming it.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Abdelsadek SE, Tahoun SA, Mansour FM, Abdulsalam MF, Ahmed AM. The correlation between vitamin B12 serum levels and migraine: a case-control study. Neurol Res. 2025;47:195. doi:10.1080/01616412.2025.2462735
- Zheng H, Shi YZ, Liang JT, Lu LL, Chen M. Modifiable factors for migraine prophylaxis: A mendelian randomization analysis. Front Pharmacol. 2023;14:1010996. doi:10.3389/fphar.2023.1010996
- Üstün Özek S. A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine. Arq Neuropsiquiatr. 2022;80:586. doi:10.1590/0004-282X-ANP-2021-0192
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Aydin H, Bucak IH, Geyik M. Vitamin B12 and folic acid levels in pediatric migraine patients. Acta Neurol Belg. 2021;121:1741. doi:10.1007/s13760-020-01491-3
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. doi:10.1186/s10194-016-0652-7
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. doi:10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. doi:10.1097/FPC.0b013e32832af5a3
- van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM. Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia. 2002;22:513.
