5/12/2025
Last update
5/12/2025
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
7
We explored the connection between vitamin B12 levels and heart rate variability (HRV) in patients who have experienced ischemic stroke. The study involved a look back at the medical records of 87 patients from January 2015 to December 2022. Each patient had their serum vitamin B12 levels measured and underwent 24-hour heart rhythm monitoring.
Our findings revealed a significant relationship between vitamin B12 status and HRV, particularly in the frequency domain, which is a crucial area for understanding autonomic function. The statistical analysis indicated that vitamin B12 levels are a substantial predictor of HRV parameters, suggesting that lower levels of this vitamin may coincide with poorer heart rate regulation in stroke patients.
This research highlights the potential impact of vitamin B12 on maintaining heart health in those who have suffered strokes. By demonstrating that vitamin B12 status could be linked to autonomic dysfunction, we provide valuable insights into how maintaining proper vitamin levels might aid recovery and improve overall cardiovascular health in these patients.
Our findings revealed a significant relationship between vitamin B12 status and HRV, particularly in the frequency domain, which is a crucial area for understanding autonomic function. The statistical analysis indicated that vitamin B12 levels are a substantial predictor of HRV parameters, suggesting that lower levels of this vitamin may coincide with poorer heart rate regulation in stroke patients.
This research highlights the potential impact of vitamin B12 on maintaining heart health in those who have suffered strokes. By demonstrating that vitamin B12 status could be linked to autonomic dysfunction, we provide valuable insights into how maintaining proper vitamin levels might aid recovery and improve overall cardiovascular health in these patients.
4
We examined whether high levels of vitamin B-12 affect the risk of stroke, with a particular focus on gender differences. Utilizing data from the Korean Genome Epidemiology Study, we assessed stroke occurrence in relation to vitamin B-12 plasma levels using various statistical methods.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
Most Useful Reviews
9
Life quality improvement
Excellent! I frequently order from this site for my father-in-law, who has diabetes, hypertension, and previously had a stroke. The noticeable effect of these supplements combined has significantly improved his quality of life, alleviating many issues related to his blood vessels and nervous system.
7.5
Nervous system support
5 people found this helpful
Excellent! This review highlights the importance of vitamin B12, particularly for those experiencing fatigue, concentration issues, or deficiencies. It has become clear that many suffer from this deficiency, especially vegetarians and those over 50. Vitamin B12 is crucial for producing genetic material, supporting the nervous system, and lowering the risk of heart disease and stroke. Deficiency may lead to various health issues, including severe neurological problems and anemia.
6
Memory improvement
1 people found this helpful
I choose to take vitamin B12 due to its numerous advantages. It alleviates fatigue, enhances memory and sleep, aids in red blood cell production, and is involved in DNA synthesis. It also supports protein synthesis and the creation of neurotransmitters to combat depression, while effectively reducing homocysteine levels that are linked to an increased risk of dementia, heart disease, and stroke.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
B12 deficiency mimics stroke symptoms
We examined a fascinating case involving a 53-year-old woman who showed atypical signs of vitamin B12 deficiency, resulting in gait instability that mimicked stroke symptoms. Neuroimaging confirmed spinal cord damage typical of subacute combined degeneration, while lab tests showed low B12 levels.
Despite the absence of classic symptoms, the patient responded remarkably well to immediate B12 treatment, restoring her gait stability and neurological functions. This emphasizes the importance of recognizing varied symptoms of B12 deficiency and the need for swift intervention.
Despite the absence of classic symptoms, the patient responded remarkably well to immediate B12 treatment, restoring her gait stability and neurological functions. This emphasizes the importance of recognizing varied symptoms of B12 deficiency and the need for swift intervention.
8
We explored the relationship between vitamin B12, folate, and plasma total homocysteine levels in predicting the risk of acute ischemic stroke. This study involved 259 stroke patients and an equal number of healthy control participants.
Through careful analysis, we found that vitamin B12 acted as an independent risk factor for ischemic stroke. Additionally, the model combining vitamin B12, folate, and homocysteine levels demonstrated the best diagnostic value, particularly for small vessel disease cases.
Overall, our research indicates a significant connection between vitamin B12 levels and stroke risk.
Through careful analysis, we found that vitamin B12 acted as an independent risk factor for ischemic stroke. Additionally, the model combining vitamin B12, folate, and homocysteine levels demonstrated the best diagnostic value, particularly for small vessel disease cases.
Overall, our research indicates a significant connection between vitamin B12 levels and stroke risk.
8
We explored the role of vitamin B12 in managing neuroinflammation after an ischemic stroke. Through preclinical studies, we observed that vitamin B12 effectively influenced microglial cells, which are key to the brain's immune response. This treatment promoted important cellular processes, leading to reduced brain damage and better neurological outcomes. However, when microglia were depleted before stroke, the positive effects of vitamin B12 disappeared. Overall, while vitamin B12 shows promise in enhancing recovery post-stroke, its impact hinges on these immune cells.
8
We examined how different dosages of B-vitamins, specifically folic acid, vitamin B12, and vitamin B6, affect stroke prevention. Our review included 14 studies with over 76,000 participants and assessed the risk of stroke after supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
8
We delved into the relationship between serum vitamin B levels and the risk of ischemic stroke by examining hospitalized patients at a major medical center. Our study involved over 2,200 patients and analyzed data using logistic regression, adjusting for various factors.
The results indicated that low vitamin B levels could signal an increased risk for ischemic stroke. Specifically, patients with lower serum vitamin B showed a higher prevalence of stroke, while higher levels appeared to lower that risk. These findings suggest that monitoring and supplementation of vitamin B could potentially benefit stroke outcomes.
The results indicated that low vitamin B levels could signal an increased risk for ischemic stroke. Specifically, patients with lower serum vitamin B showed a higher prevalence of stroke, while higher levels appeared to lower that risk. These findings suggest that monitoring and supplementation of vitamin B could potentially benefit stroke outcomes.
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life quality improvement
Excellent! I frequently order from this site for my father-in-law, who has diabetes, hypertension, and previously had a stroke. The noticeable effect of these supplements combined has significantly improved his quality of life, alleviating many issues related to his blood vessels and nervous system.
7.5
Nervous system support
5 people found this helpful
Excellent! This review highlights the importance of vitamin B12, particularly for those experiencing fatigue, concentration issues, or deficiencies. It has become clear that many suffer from this deficiency, especially vegetarians and those over 50. Vitamin B12 is crucial for producing genetic material, supporting the nervous system, and lowering the risk of heart disease and stroke. Deficiency may lead to various health issues, including severe neurological problems and anemia.
6
Memory improvement
1 people found this helpful
I choose to take vitamin B12 due to its numerous advantages. It alleviates fatigue, enhances memory and sleep, aids in red blood cell production, and is involved in DNA synthesis. It also supports protein synthesis and the creation of neurotransmitters to combat depression, while effectively reducing homocysteine levels that are linked to an increased risk of dementia, heart disease, and stroke.
7.5
Effective supplement
The quality is excellent; vitamin B12 is crucial for metabolism, red blood cell formation, neuron development, and DNA synthesis. It promptly aids in pain elimination and in preventing pernicious anaemia, heart attacks, and stroke. The effects are apparent shortly after starting the supplement, making it an ideal choice for daily maintenance of health.
6
Pain elimination
Vitamin B12 is essential as it helps alleviate pain and prevents pernicious anaemia, heart attacks, and stroke. It aids in treating nervous disorders, anaemia, depression, hypertension, and sclerosis. A two-week course is recommended for optimal effects, especially when taken alongside other B vitamins and foods rich in vitamin A, iron, calcium, potassium, and sodium.
Frequently Asked Questions
6
Pain elimination
Vitamin B12 is essential as it helps alleviate pain and prevents pernicious anaemia, heart attacks, and stroke. It aids in treating nervous disorders, anaemia, depression, hypertension, and sclerosis. A two-week course is recommended for optimal effects, especially when taken alongside other B vitamins and foods rich in vitamin A, iron, calcium, potassium, and sodium.
7.5
Effective supplement
The quality is excellent; vitamin B12 is crucial for metabolism, red blood cell formation, neuron development, and DNA synthesis. It promptly aids in pain elimination and in preventing pernicious anaemia, heart attacks, and stroke. The effects are apparent shortly after starting the supplement, making it an ideal choice for daily maintenance of health.
6
Fatigue reduction
Vitamin B12 reduces fatigue, optimises memory, enhances sleep, and promotes red blood cell production. It’s involved in DNA synthesis, aids protein production, and generates neurotransmitters that prevent depression. Additionally, it helps improve nerve function and communication skills while lowering homocysteine levels, which are associated with an increased risk of dementia, heart disease, and stroke.
6
Memory improvement
1 people found this helpful
I choose to take vitamin B12 due to its numerous advantages. It alleviates fatigue, enhances memory and sleep, aids in red blood cell production, and is involved in DNA synthesis. It also supports protein synthesis and the creation of neurotransmitters to combat depression, while effectively reducing homocysteine levels that are linked to an increased risk of dementia, heart disease, and stroke.
9
Life quality improvement
Excellent! I frequently order from this site for my father-in-law, who has diabetes, hypertension, and previously had a stroke. The noticeable effect of these supplements combined has significantly improved his quality of life, alleviating many issues related to his blood vessels and nervous system.
6
Cardiovascular health
The drug is effective and dissolves quickly. Sublingual absorption is optimal, and combining vitamin B12 with calcium enhances its efficacy. Vitamin B12 lowers homocysteine levels linked to heart attacks and strokes. It also aids in synthesising choline, combats unbalanced nutrition, and helps in amino acid production, significantly impacting mental activity and positive emotions.
7.5
Reduces stroke risk
Vitamin B12 serves various functions, including reducing fatigue, optimising memory, and enhancing sleep. It promotes the production of red blood cells, aids in DNA synthesis, and fosters protein production. Additionally, it bolsters the generation of brain chemicals (neurotransmitters) to alleviate depression and improves nerve function and communication. Importantly, Vitamin B12 reduces elevated homocysteine levels, an amino acid linked to a heightened risk of dementia, heart disease, and stroke. Thus, vitamin B12 plays a crucial role in lowering stroke risk.
7
Vitamin B12 deficiency and stroke
We focused on understanding how vitamin B12 levels relate to stroke severity and outcomes. In a study involving 75 patients with ischemic stroke and 75 matched controls, we found stroke patients had notably lower vitamin B12 levels and higher homocysteine levels than the control group.
Specifically, those with the lowest B12 levels faced more severe strokes and worse functional outcomes after discharge. Although this study shows a clear connection, further research is needed to determine if B12 supplementation can genuinely reduce stroke risk or improve recovery.
Specifically, those with the lowest B12 levels faced more severe strokes and worse functional outcomes after discharge. Although this study shows a clear connection, further research is needed to determine if B12 supplementation can genuinely reduce stroke risk or improve recovery.
4
We examined data from over 8,000 adults in the National Health and Examination Survey to understand how vitamin B levels and homocysteine relate to stroke risk.
Our findings revealed complex relationships: higher levels of homocysteine were positively associated with stroke prevalence, while vitamin B6 and folate showed L-shaped trends.
Interestingly, vitamin B12 had a U-shaped relationship with stroke, suggesting both low and high levels might be concerning. These results indicate a need for balanced vitamin levels in stroke prevention.
Our findings revealed complex relationships: higher levels of homocysteine were positively associated with stroke prevalence, while vitamin B6 and folate showed L-shaped trends.
Interestingly, vitamin B12 had a U-shaped relationship with stroke, suggesting both low and high levels might be concerning. These results indicate a need for balanced vitamin levels in stroke prevention.
7
B12’s inconclusive effects on mental health
We explored the effects of vitamin B12 supplementation on mental health outcomes, particularly focusing on its role in preventing post-stroke depression.
Our review involved a systematic approach, analyzing five randomized controlled trials that assessed B12's impact alongside other vitamins like folic acid and B6.
While the results were mostly inconclusive, evidence suggested benefits for specific high-risk groups, particularly in preventing post-stroke depression. There’s a real need for further research to confirm these findings and tailor B12 treatment effectively.
Our review involved a systematic approach, analyzing five randomized controlled trials that assessed B12's impact alongside other vitamins like folic acid and B6.
While the results were mostly inconclusive, evidence suggested benefits for specific high-risk groups, particularly in preventing post-stroke depression. There’s a real need for further research to confirm these findings and tailor B12 treatment effectively.
4
We investigated the link between certain biomarkers and early neurological deterioration (END) in ischemic stroke patients. Our study involved 100 patients from a tertiary care hospital, assessing their neurological health and various biochemical indicators.
While 12% experienced END, we discovered low vitamin B12 levels in those affected compared to those without END. Although we identified some risk factors like substance use, the results indicate that boosting vitamin B12 alone may not significantly alter outcomes. Monitoring these biomarkers can help personalize treatment approaches.
While 12% experienced END, we discovered low vitamin B12 levels in those affected compared to those without END. Although we identified some risk factors like substance use, the results indicate that boosting vitamin B12 alone may not significantly alter outcomes. Monitoring these biomarkers can help personalize treatment approaches.
8
We explored the relationship between vitamin B12, folate, and plasma total homocysteine levels in predicting the risk of acute ischemic stroke. This study involved 259 stroke patients and an equal number of healthy control participants.
Through careful analysis, we found that vitamin B12 acted as an independent risk factor for ischemic stroke. Additionally, the model combining vitamin B12, folate, and homocysteine levels demonstrated the best diagnostic value, particularly for small vessel disease cases.
Overall, our research indicates a significant connection between vitamin B12 levels and stroke risk.
Through careful analysis, we found that vitamin B12 acted as an independent risk factor for ischemic stroke. Additionally, the model combining vitamin B12, folate, and homocysteine levels demonstrated the best diagnostic value, particularly for small vessel disease cases.
Overall, our research indicates a significant connection between vitamin B12 levels and stroke risk.
8
We examined how different dosages of B-vitamins, specifically folic acid, vitamin B12, and vitamin B6, affect stroke prevention. Our review included 14 studies with over 76,000 participants and assessed the risk of stroke after supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
We discovered that in areas lacking sufficient folic acid fortification, this B-vitamin combination significantly lowered stroke risk. Optimal doses were identified at 0.8 mg/d for folic acid and 0.4 mg/d for vitamin B12. However, in regions with adequate fortification, no benefit was observed from supplementation.
4
We examined whether high levels of vitamin B-12 affect the risk of stroke, with a particular focus on gender differences. Utilizing data from the Korean Genome Epidemiology Study, we assessed stroke occurrence in relation to vitamin B-12 plasma levels using various statistical methods.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
Our findings indicated that while excessive vitamin B-12 did not significantly increase overall stroke risk, it was linked to a higher risk in males. This suggests that the effects of vitamin B-12 might vary based on sex, making it a noteworthy consideration in stroke research.
References
- Saeed Z, Zehra SA, Muhammad A, Ashraf I. Atypical Motor-Predominant Presentation of Subacute Combined Degeneration of Spinal Cord Due to Vitamin B12 Deficiency: A Case Report of Stroke Mimicry in the Absence of Classic Symptoms. Cureus. 2024;16:e74697. 10.7759/cureus.74697
- Atam V, Srivastava S, Sharma A, Atam I, Tewari J, et al. Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study. Cureus. 2024;16:e70473. 10.7759/cureus.70473
- Harale M, Oommen A, Faruqi A, Mundada M, Reddy RH, et al. Study of Biochemical Predictors of Early Neurological Deterioration in Ischemic Stroke in a Tertiary Care Hospital. Cureus. 2024;16:e68183. 10.7759/cureus.68183
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. 10.1016/j.tjnut.2024.08.002
- Zhou L, Wang J, Wu H, Yu P, He Z, et al. Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study. Nutr J. 2024;23:76. 10.1186/s12937-024-00977-7
- Moti Wala S, AlEdani EM, Samuel EA, Ahmad K, Manongi NJ, et al. Exploring the Nexus: A Systematic Review on the Interplay of the Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Genotype, Hyperhomocysteinemia, and Spontaneous Cervical/Vertebral Artery Dissection in Young Adults. Cureus. 2024;16:e60878. 10.7759/cureus.60878
- Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. 10.1016/j.isci.2024.109480
- Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. 10.1016/j.ajcnut.2023.12.021
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. 10.12968/bjcn.2024.29.3.137
- Rafay A, Abdul Fatir C, Hiba HT, Jamil M, Talha Awan M. Hyperhomocysteinemia Presenting as Stroke in a Young Individual: A Case Report. Cureus. 2024;16:e52381. 10.7759/cureus.52381
- Zhou L, Wang J, Li M, Tan Y, Wu Y, et al. Low vitamin B levels may predict the risk of ischemic stroke: A cross-sectional study. J Clin Neurosci. 2023;117:125. 10.1016/j.jocn.2023.09.024
- Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141. 10.3389/fneur.2023.1184141
- Hu X, Jiang Y. The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol. 2024;4:1465380. 10.3389/fneph.2024.1465380
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. 10.2147/NDT.S480417
- Park EJ. Association between vitamin B12 status and heart rate variability in patients with ischemic stroke. Medicine (Baltimore). 2023;102:e33428. 10.1097/MD.0000000000033428
- Rasyid A, Mesiano T, Kurniawan M, Hidayat R, Eddy Yunus R, et al. Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient. Case Rep Dermatol Med. 2023;2023:6580971. 10.1155/2023/6580971
