Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2 (as Menaquinone-4) (MK-4)
100 mcg
**
Alfalfa Powder (Aerial Parts)
250 mg
**
Top Medical Research Studies
8
We explored the potential benefits of low-dose vitamin K2, specifically menaquinone-7 (MK-7), on bone health in healthy postmenopausal women. Over a three-year study with 244 participants, we found that MK-7 significantly improved bone mineral density and strength, suggesting it could mitigate age-related bone loss.
While the results are promising for postmenopausal women, more research is needed to determine if these findings apply to other groups, such as men and children.
While the results are promising for postmenopausal women, more research is needed to determine if these findings apply to other groups, such as men and children.
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3
We examined the impact of vitamin K2, specifically MK-7, on bone health in early menopausal women through a rigorous randomized double-blind placebo-controlled trial.
Over one year, 334 healthy Norwegian women were given either MK-7 supplements or a placebo. Despite reduced levels of certain bone markers, our results showed that vitamin K2 did not actually prevent bone loss in these participants.
This suggests that while vitamin K2 might have some biochemical benefits, it doesn’t significantly improve bone density during menopause.
Over one year, 334 healthy Norwegian women were given either MK-7 supplements or a placebo. Despite reduced levels of certain bone markers, our results showed that vitamin K2 did not actually prevent bone loss in these participants.
This suggests that while vitamin K2 might have some biochemical benefits, it doesn’t significantly improve bone density during menopause.
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9
We explored whether vitamin K could play a role in supporting bone health during menopause by studying ovariectomized mice. Through various scientific techniques, we observed that vitamin K treatment significantly improved bone structure and mineral metabolism.
It appeared to enhance bone formation and reduce bone resorption, suggesting it helps maintain stronger bones. However, while the findings are promising for potential treatments in osteopenic patients, the study was conducted on mice and may not directly translate to human health benefits.
It appeared to enhance bone formation and reduce bone resorption, suggesting it helps maintain stronger bones. However, while the findings are promising for potential treatments in osteopenic patients, the study was conducted on mice and may not directly translate to human health benefits.
Read More
Most Useful Reviews
9
Menopausal supplement
This is a perfect supplement for the effects of menopause; I have little in my diet.
Read More
9
Improved well-being
Essential for women during menopause. It definitely helped me feel and look better.
Read More
9
Highly effective supplement
A MUST for every woman experiencing menopause. This vitamin K offers excellent value for money!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
- All Researches
9
We explored whether vitamin K could play a role in supporting bone health during menopause by studying ovariectomized mice. Through various scientific techniques, we observed that vitamin K treatment significantly improved bone structure and mineral metabolism.
It appeared to enhance bone formation and reduce bone resorption, suggesting it helps maintain stronger bones. However, while the findings are promising for potential treatments in osteopenic patients, the study was conducted on mice and may not directly translate to human health benefits.
It appeared to enhance bone formation and reduce bone resorption, suggesting it helps maintain stronger bones. However, while the findings are promising for potential treatments in osteopenic patients, the study was conducted on mice and may not directly translate to human health benefits.
Read More
9
We examined how the combined use of vitamin D3 and vitamin K2 affects bone mineral density (BMD) in postmenopausal women suffering from osteoporosis. In a study involving ninety-two women, participants were divided into four groups receiving different treatments, with BMD measured over two years.
Results showed that those receiving vitamin D3 and vitamin K2 had significant improvements in their spine BMD compared to a control group taking calcium alone. This suggests that supplementing with both vitamins may be a more beneficial approach for improving bone health during menopause.
Results showed that those receiving vitamin D3 and vitamin K2 had significant improvements in their spine BMD compared to a control group taking calcium alone. This suggests that supplementing with both vitamins may be a more beneficial approach for improving bone health during menopause.
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8
We investigated the impact of menaquinone-7 (MK-7) supplementation on cardiovascular health in post-menopausal women. Over a year, 165 women took either MK-7 or a placebo.
The results revealed that MK-7 significantly reduced vascular stiffness and improved blood pressure, especially in women with high arterial stiffness. While MK-7 showed promise for enhancing vascular health, further studies are needed to fully understand its benefits for post-menopausal women.
The results revealed that MK-7 significantly reduced vascular stiffness and improved blood pressure, especially in women with high arterial stiffness. While MK-7 showed promise for enhancing vascular health, further studies are needed to fully understand its benefits for post-menopausal women.
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8
We examined the connection between serum vitamin K1 levels and bone mineral density in post-menopausal women. Through testing 23 osteoporotic and 15 healthy control women, we discovered that those with osteoporosis had significantly lower vitamin K1 levels.
Notably, higher vitamin K1 levels were associated with better bone density. Our findings suggest that vitamin K1 could play a critical role in both diagnosing and managing post-menopausal osteoporosis, making it a promising marker for further research.
Notably, higher vitamin K1 levels were associated with better bone density. Our findings suggest that vitamin K1 could play a critical role in both diagnosing and managing post-menopausal osteoporosis, making it a promising marker for further research.
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8
We explored how vitamin K impacts bone health and vascular health, particularly for post-menopausal women at risk of osteoporosis.
The study reveals that vitamin K can boost bone formation by supporting the growth of bone-forming cells and enhancing key proteins linked to bone strength. Interestingly, it also plays a role in reducing harmful processes in both bones and blood vessels.
While the benefits of vitamin K in promoting bone health are promising, further research is needed to better understand its long-term effects and optimal usage in treating menopause-related conditions.
The study reveals that vitamin K can boost bone formation by supporting the growth of bone-forming cells and enhancing key proteins linked to bone strength. Interestingly, it also plays a role in reducing harmful processes in both bones and blood vessels.
While the benefits of vitamin K in promoting bone health are promising, further research is needed to better understand its long-term effects and optimal usage in treating menopause-related conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Menopausal supplement
This is a perfect supplement for the effects of menopause; I have little in my diet.
Read More
9
Improved well-being
Essential for women during menopause. It definitely helped me feel and look better.
Read More
9
Highly effective supplement
A MUST for every woman experiencing menopause. This vitamin K offers excellent value for money!
Read More
7
Bone health improvement
4 people found this helpful
It is advised not to take D3 without vitamin K2. I have been taking vitamin K2 for a considerable time. Numerous studies indicate that vitamin K2 can entirely prevent bone loss and even enhance it in osteoporosis patients, whilst reducing fracture risk by up to 87%. There have been no observed side effects over the years of consistent use. Its regular intake is particularly vital for individuals during their growing years to form optimal peak bone mass, for women during menopause, and for those over 50 to assist with calcium absorption. Research also suggests it can prevent vascular calcification.
Read More
9
Bone loss prevention
This supplement prevents bone loss and osteoporosis during menopause.
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Frequently Asked Questions
9
Menopause relief
I take it with vitamin D. Since starting, my monthly symptoms have noticeably decreased! Menopause was difficult, but it's easier now.
7.5
Health improvement
I’ve been taking it regularly due to severe menopause symptoms and various physical changes, including anaemia. My health has progressively improved, so I've continued with it. It’s also better absorbed than Japanese iron supplements, and the price is reasonable. I highly recommend it.
7
Bone health improvement
4 people found this helpful
It is advised not to take D3 without vitamin K2. I have been taking vitamin K2 for a considerable time. Numerous studies indicate that vitamin K2 can entirely prevent bone loss and even enhance it in osteoporosis patients, whilst reducing fracture risk by up to 87%. There have been no observed side effects over the years of consistent use. Its regular intake is particularly vital for individuals during their growing years to form optimal peak bone mass, for women during menopause, and for those over 50 to assist with calcium absorption. Research also suggests it can prevent vascular calcification.
7.5
Calcium transport
I take it with vitamin D3 during menopause, and it helps transport calcium effectively.
9
Bone loss prevention
This supplement prevents bone loss and osteoporosis during menopause.
6
Menopausal relief
I adore this brand. Following the onset of menopause, I encountered issues with my musculoskeletal system. I now consistently take calcium and D3, alongside K2 for proper calcium distribution.
References
- de Vries F, Bittner R, Maresz K, Machuron F, Gåserød O, et al. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women. Nutrients. 2025;17. doi:10.3390/nu17050815
- Tanaka N, Arima K, Nishimura T, Tomita Y, Mizukami S, et al. Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women. J Physiol Anthropol. 2020;39:9. doi:10.1186/s40101-020-00221-1
- Rangel LBA, de Siqueira D, Soares ODR, Santana HS, Miguel EC, et al. Vitamin K Supplementation Modulates Bone Metabolism and Ultra-Structure of Ovariectomized Mice. Cell Physiol Biochem. 2018;51:356. doi:10.1159/000495234
- Jaghsi S, Hammoud T, Haddad S. Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women. Open Rheumatol J. 2018;12:1. doi:10.2174/1874312901812010001
- Vignini A, Nanetti L, Raffaelli F, Sabbatinelli J, Salvolini E, et al. Effect of 1-y oral supplementation with vitaminized olive oil on platelets from healthy postmenopausal women. Nutrition. 2017;42:92. doi:10.1016/j.nut.2017.06.013
- Villa JKD, Diaz MAN, Pizziolo VR, Martino HSD. Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences. Crit Rev Food Sci Nutr. 2017;57:3959. doi:10.1080/10408398.2016.1211616
- Guralp O, Erel CT. Effects of vitamin K in postmenopausal women: mini review. Maturitas. 2014;77:294. doi:10.1016/j.maturitas.2013.11.002
- Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013;24:2499. doi:10.1007/s00198-013-2325-6
- Borrelli F, Ernst E. Alternative and complementary therapies for the menopause. Maturitas. 2010;66:333. doi:10.1016/j.maturitas.2010.05.010
- Emaus N, Gjesdal CG, Almås B, Christensen M, Grimsgaard AS, et al. Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int. 2010;21:1731. doi:10.1007/s00198-009-1126-4
- Yasui T, Uemura H, Tomita J, Miyatani Y, Yamada M, et al. Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women. J Endocrinol Invest. 2006;29:913.
- Katsuyama H, Ideguchi S, Fukunaga M, Fukunaga T, Saijoh K, et al. Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women. J Nutr Sci Vitaminol (Tokyo). 2004;50:114.
- Booth SL, Broe KE, Gagnon DR, Tucker KL, Hannan MT, et al. Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr. 2003;77:512.
- Iwamoto J, Takeda T, Ichimura S. Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate. J Orthop Sci. 2001;6:487.
- Iwamoto J, Takeda T, Ichimura S. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. J Orthop Sci. 2000;5:546.
- Iwamoto I, Kosha S, Noguchi S, Murakami M, Fujino T, et al. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas. 1999;31:161.
