' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.8
USERS' SCORE
Very Good
Based on 34 Reviews
8.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2 (as Menaquinone-4) (MK-4)
100 mcg
**
Alfalfa Powder (Aerial Parts)
250 mg
**
Top Medical Research Studies
9
Vitamin K2 improves bone health
Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
Directly addresses osteoporosis treatment
Our exploration focused on how vitamin K2 supplementation may aid postmenopausal women dealing with osteoporosis, particularly regarding bone mineral density (BMD) and the incidence of fractures over the long term. We meticulously reviewed nine randomized controlled trials with nearly 6,900 participants to gather insightful data on this topic.
The results were promising, revealing that vitamin K2 significantly enhanced lumbar and forearm BMD. Specifically, we observed notable increases in bone density measurements, alongside a reduction in undercarboxylated osteocalcin—a marker associated with bone health, and a significant rise in total osteocalcin.
Although there was an increase in the rate of adverse reactions in the vitamin K2 group, we found no serious side effects stemming from the supplementation. Overall, our study supports the conclusion that vitamin K2 is not only effective but also safe for treating osteoporosis in postmenopausal women. This could provide a welcome option for those looking to improve their bone health.
The results were promising, revealing that vitamin K2 significantly enhanced lumbar and forearm BMD. Specifically, we observed notable increases in bone density measurements, alongside a reduction in undercarboxylated osteocalcin—a marker associated with bone health, and a significant rise in total osteocalcin.
Although there was an increase in the rate of adverse reactions in the vitamin K2 group, we found no serious side effects stemming from the supplementation. Overall, our study supports the conclusion that vitamin K2 is not only effective but also safe for treating osteoporosis in postmenopausal women. This could provide a welcome option for those looking to improve their bone health.
Read More
8
Vitamin K2's effect on osteoporosis
Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism.
Highly relevant osteoporosis research
We investigated how vitamin K2, particularly menaquinone-7 (MK-7), influences osteoporosis in postmenopausal women. Our study utilized a new approach with high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure levels of various vitamins, including vitamin K1, MK-4, MK-7, and vitamin D in serum samples from a group of 200 women. This included both premenopausal individuals and those diagnosed with postmenopausal osteoporosis.
The results revealed that MK-7 levels in women with osteoporosis were significantly lower than in their premenopausal counterparts. Interestingly, we found that MK-7 appeared to decrease before vitamin D levels in these patients. We believe these findings suggest that MK-7 could potentially be a marker for assessing bone health and osteoporosis risk in postmenopausal women, highlighting its important role in bone metabolism.
Overall, our study confirmed that while vitamin K2 is critical, particularly MK-7, it may serve as a useful biomarker for diagnosing and monitoring osteoporosis in postmenopausal individuals. However, it's essential to consider these findings in the broader context of osteoporosis treatment and prevention strategies.
The results revealed that MK-7 levels in women with osteoporosis were significantly lower than in their premenopausal counterparts. Interestingly, we found that MK-7 appeared to decrease before vitamin D levels in these patients. We believe these findings suggest that MK-7 could potentially be a marker for assessing bone health and osteoporosis risk in postmenopausal women, highlighting its important role in bone metabolism.
Overall, our study confirmed that while vitamin K2 is critical, particularly MK-7, it may serve as a useful biomarker for diagnosing and monitoring osteoporosis in postmenopausal individuals. However, it's essential to consider these findings in the broader context of osteoporosis treatment and prevention strategies.
Read More
8
Vitamin K2-7 benefits osteoporosis treatment
Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities.
Significant benefits for osteoporosis indicated
We focused on the potential of vitamin K2-7, particularly its impact on osteoporosis. This research highlights how vitamin K2-7 is effectively absorbed by the body and plays a crucial role in bone health.
We observed that vitamin K2-7 helps convert undercarboxylated proteins like osteocalcin into their carboxylated forms, which are essential for proper calcium deposition in bones. This means that K2-7 not only contributes to strengthening bones but also helps prevent fractures, which is a significant concern for individuals with osteoporosis.
Furthermore, we found that K2-7 promotes the production of osteoprotegerin, a protein that inhibits the breakdown of bones, thus supporting bone density and overall skeletal health. Clinical studies confirm these benefits, showing that supplementation with K2-7 can lead to remarkable improvements in bone health and reduce the risk of fractures.
Overall, this exploration of vitamin K2-7 lends strong support to its essential role in managing osteoporosis and highlights the need for its wider inclusion in dietary supplements to improve bone health.
We observed that vitamin K2-7 helps convert undercarboxylated proteins like osteocalcin into their carboxylated forms, which are essential for proper calcium deposition in bones. This means that K2-7 not only contributes to strengthening bones but also helps prevent fractures, which is a significant concern for individuals with osteoporosis.
Furthermore, we found that K2-7 promotes the production of osteoprotegerin, a protein that inhibits the breakdown of bones, thus supporting bone density and overall skeletal health. Clinical studies confirm these benefits, showing that supplementation with K2-7 can lead to remarkable improvements in bone health and reduce the risk of fractures.
Overall, this exploration of vitamin K2-7 lends strong support to its essential role in managing osteoporosis and highlights the need for its wider inclusion in dietary supplements to improve bone health.
Read More
Most Useful Reviews
7.5
Positive calcium trend
After my thyroid was removed and I began hormone therapy, I was told to take vitamin D. My tests showed calcium leaching from bones, indicating osteoporosis. The doctor recommended K2, which improved my calcium levels after a month. Now, K2 is essential for me.
Read More
9.5
Reduces fracture risk
Now Foods is my favourite brand. I take K2 to ensure calcium is properly distributed in my bones rather than soft tissues. I've learned it helps prevent osteoporosis and fractures while enhancing cellular health.
Read More
9.5
Helps osteoporosis
With the D3 supplement for calcium fixation in bones, this has excellent absorption and is a great aid for osteoporosis.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.8
9
Vitamin K2 enhances osteoporosis treatment
Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis.
Combination therapy shows superior benefits
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
Read More
9
UBIAD1 crucial for bone growth
Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice.
Vitamin K2's indirect role noted
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Read More
9
VK2 supports diabetic osteoporosis treatment
A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis.
Relevant but not fully conclusive
We explored how vitamin K2 (VK2) affects osteoporosis, particularly in the context of type 2 diabetes. In our research, we created a mouse model of type 2 diabetic osteoporosis by injecting a substance called streptozotocin and feeding them a high-fat, high-sugar diet. Additionally, we simulated this environment in the lab with bone marrow stem cells cultured in high glucose levels.
Our findings revealed that VK2 significantly helped in mitigating bone loss and reducing a type of cell death known as ferroptosis in these conditions. This was evidenced by lower levels of harmful molecules like mitochondrial reactive oxygen species and lipid peroxidation, alongside increased protection from oxidative stress indicated by higher glutathione levels. Notably, VK2 treatment also restored bone mass and boosted essential markers related to bone health in the distal femurs of our models.
Delving into the mechanisms, VK2 appeared to activate a pathway known as AMPK/SIRT1. Crucially, when we used a technique to knock down SIRT1, the beneficial effects of VK2 were diminished in the high-glucose cultured stem cells. Overall, VK2 proves to be a promising agent in combating type 2 diabetic osteoporosis by activating the AMPK/SIRT1 pathway to inhibit ferroptosis and ultimately support bone health.
Our findings revealed that VK2 significantly helped in mitigating bone loss and reducing a type of cell death known as ferroptosis in these conditions. This was evidenced by lower levels of harmful molecules like mitochondrial reactive oxygen species and lipid peroxidation, alongside increased protection from oxidative stress indicated by higher glutathione levels. Notably, VK2 treatment also restored bone mass and boosted essential markers related to bone health in the distal femurs of our models.
Delving into the mechanisms, VK2 appeared to activate a pathway known as AMPK/SIRT1. Crucially, when we used a technique to knock down SIRT1, the beneficial effects of VK2 were diminished in the high-glucose cultured stem cells. Overall, VK2 proves to be a promising agent in combating type 2 diabetic osteoporosis by activating the AMPK/SIRT1 pathway to inhibit ferroptosis and ultimately support bone health.
Read More
9
Vitamin K2 promotes bone health
Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells.
Relevant, but limited osteoporosis context
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.
Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.
Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.
Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.
Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.
Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Read More
9
Vitamin K2 improves bone health
Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
Directly addresses osteoporosis treatment
Our exploration focused on how vitamin K2 supplementation may aid postmenopausal women dealing with osteoporosis, particularly regarding bone mineral density (BMD) and the incidence of fractures over the long term. We meticulously reviewed nine randomized controlled trials with nearly 6,900 participants to gather insightful data on this topic.
The results were promising, revealing that vitamin K2 significantly enhanced lumbar and forearm BMD. Specifically, we observed notable increases in bone density measurements, alongside a reduction in undercarboxylated osteocalcin—a marker associated with bone health, and a significant rise in total osteocalcin.
Although there was an increase in the rate of adverse reactions in the vitamin K2 group, we found no serious side effects stemming from the supplementation. Overall, our study supports the conclusion that vitamin K2 is not only effective but also safe for treating osteoporosis in postmenopausal women. This could provide a welcome option for those looking to improve their bone health.
The results were promising, revealing that vitamin K2 significantly enhanced lumbar and forearm BMD. Specifically, we observed notable increases in bone density measurements, alongside a reduction in undercarboxylated osteocalcin—a marker associated with bone health, and a significant rise in total osteocalcin.
Although there was an increase in the rate of adverse reactions in the vitamin K2 group, we found no serious side effects stemming from the supplementation. Overall, our study supports the conclusion that vitamin K2 is not only effective but also safe for treating osteoporosis in postmenopausal women. This could provide a welcome option for those looking to improve their bone health.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 34 Reviews
8.8
9.5
Bone tissue health
Vitamin K2 is crucial as it directs calcium into bone tissue, helping to reduce osteoporosis risk. It also aids wound healing and can prevent cardiovascular diseases by averting arterial calcification. Furthermore, K2 supports brain function by contributing to nerve fibre health. I highly recommend it.
Read More
9.5
Fracture risk reduction
I've taken vitamin K2 for years and found it effectively eliminates bone loss, reducing fracture risks significantly. It's especially crucial for growing bodies, women in menopause, and those over 50 to aid in calcium absorption. Regular intake can also prevent vascular calcification. Highly recommended!
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9.5
Osteoporosis management
With grade 2 osteoporosis, I require calcium and higher doses of vitamin D3, necessarily combined with vitamin K2 to ensure calcium is utilised in the bones and not in vessels or kidneys. This product offers an excellent price and sufficient capsules, making it a worthwhile choice.
9.5
Osteoporosis prevention
I take this alongside vitamin D, magnesium, and zinc. The capsules are small and tasteless, making them easy to swallow. Following breast cancer surgery, I have high hopes that this will aid in preventing osteoporosis. I trust its efficacy for my health needs.
9.5
Improves bone strength
Vitamin K2 has been a vital part of my nutritional plan for reversing osteoporosis. At 74, I improved from osteoporosis to mild osteopenia within a year. I will definitely continue using this product.
