Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Good
Based on 38 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2 (as Menaquinone-4) (MK-4)
100 mcg
**
Alfalfa Powder (Aerial Parts)
250 mg
**
Top Medical Research Studies
9
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Read More
9
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
Most Useful Reviews
9
Improves bone density
301 people found this helpful
I have found the combination of Strontium, D3, and K2 to be beneficial. Research supports that K2 aids in improving bone density, especially crucial after developing osteoporosis. This product has dramatically increased my bone density and significantly reduced my risk of hip fractures, making me feel hopeful about my bone health as I once thought I had osteoporosis but may now be normal.
Read More
9
Aids calcium metabolism
22 people found this helpful
This reasonably priced product helps counteract the calcium paradox seen in many older women with osteoporosis who experience increased calcium deposition in soft tissues. This vitamin has proven vital for calcium metabolism, promoting calcium retention in bones rather than in arteries. Officially used in Japan to treat osteoporosis since 1995, it's unnecessary to take calcium supplements and bisphosphonates which offer limited long-term efficacy. Vitamin K2, combined with a normal diet, is sufficient for maintaining bone health.
Read More
9
Prevents osteoporosis
4 people found this helpful
Since taking K-2 on my physician's recommendation, I have no osteoporosis, as confirmed by my latest Dexa scan at over 70. I ensure to take it 12 hours after my coral calcium, and my tests indicate that it works effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
- All Researches
9
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
9
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
9
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
Read More
9
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Read More
9
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.
Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.
Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.
Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.
Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.
Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Read More
User Reviews
USERS' SCORE
Good
Based on 38 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves bone density
301 people found this helpful
I have found the combination of Strontium, D3, and K2 to be beneficial. Research supports that K2 aids in improving bone density, especially crucial after developing osteoporosis. This product has dramatically increased my bone density and significantly reduced my risk of hip fractures, making me feel hopeful about my bone health as I once thought I had osteoporosis but may now be normal.
Read More
9
Aids calcium metabolism
22 people found this helpful
This reasonably priced product helps counteract the calcium paradox seen in many older women with osteoporosis who experience increased calcium deposition in soft tissues. This vitamin has proven vital for calcium metabolism, promoting calcium retention in bones rather than in arteries. Officially used in Japan to treat osteoporosis since 1995, it's unnecessary to take calcium supplements and bisphosphonates which offer limited long-term efficacy. Vitamin K2, combined with a normal diet, is sufficient for maintaining bone health.
Read More
9
Prevents osteoporosis
4 people found this helpful
Since taking K-2 on my physician's recommendation, I have no osteoporosis, as confirmed by my latest Dexa scan at over 70. I ensure to take it 12 hours after my coral calcium, and my tests indicate that it works effectively.
Read More
9
Effective for osteoporosis
2 people found this helpful
You can too, with NOW K-2. I believe it’s aiding in the fight against osteoporosis, which has now retreated back to osteopenia: a positive development. My doctor mentioned that K2 would be beneficial.
Read More
7.5
Positive calcium trend
2 people found this helpful
After my thyroid was removed and I began hormone therapy, I was told to take vitamin D. My tests showed calcium leaching from bones, indicating osteoporosis. The doctor recommended K2, which improved my calcium levels after a month. Now, K2 is essential for me.
Read More
Frequently Asked Questions
7.5
Positive calcium trend
2 people found this helpful
After my thyroid was removed and I began hormone therapy, I was told to take vitamin D. My tests showed calcium leaching from bones, indicating osteoporosis. The doctor recommended K2, which improved my calcium levels after a month. Now, K2 is essential for me.
9
Improves bone strength
2 people found this helpful
Vitamin K2 has been a vital part of my nutritional plan for reversing osteoporosis. At 74, I improved from osteoporosis to mild osteopenia within a year. I will definitely continue using this product.
7.5
Bone protection
3 people found this helpful
Balancing vitamin D with K is crucial; excessive vitamin D can lead to K deficiency. For every 10,000 IU of vitamin D, 100-200 mcg of K2 is necessary to enhance bone protection. Studies indicate that taking them together boosts bone density in women with osteoporosis significantly.
9
Osteoporosis management
4 people found this helpful
With grade 2 osteoporosis, I require calcium and higher doses of vitamin D3, necessarily combined with vitamin K2 to ensure calcium is utilised in the bones and not in vessels or kidneys. This product offers an excellent price and sufficient capsules, making it a worthwhile choice.
7.5
Preventing osteoporosis
16 people found this helpful
I take vitamin K-2 twice a year, alternating between MK4 and MK7, to prevent osteoporosis, always alongside vitamin D3. I trust NF products and recommend them for women over 40 to maintain bone and dental health, as well as for vascular wellness. It’s essential for good health.
7.5
Improving bone density
3 people found this helpful
Combining Strontium, D3, and K2 has proven effective in my experience. Research shows K2 positively affects tooth and bone density, particularly beneficial for my osteoporosis. Although not included in meta-analyses, findings across numerous studies suggest a significant positive impact on bone density. This product hasn't affected me adversely.
6
Recommended for health
K2 is highly recommended to support bone health for those with osteoporosis. I take it every other day as the dosage guidelines are unclear.
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
7
Vitamin K's link to osteoporosis explored
By developing an advanced method to analyze vitamin K1, MK-4, MK-7, and vitamin D levels in serum, we investigated their roles in osteoporosis among postmenopausal women.
Our study with 200 participants found that MK-7 levels declined earlier than vitamin D in those with osteoporosis. Crucially, we observed that MK-7 could serve as a valuable biomarker for diagnosing osteoporosis in postmenopausal women, indicating its potential importance in bone health management. Overall, while our findings show an association, they emphasize further exploration into vitamin K's therapeutic role in osteoporosis treatment.
Our study with 200 participants found that MK-7 levels declined earlier than vitamin D in those with osteoporosis. Crucially, we observed that MK-7 could serve as a valuable biomarker for diagnosing osteoporosis in postmenopausal women, indicating its potential importance in bone health management. Overall, while our findings show an association, they emphasize further exploration into vitamin K's therapeutic role in osteoporosis treatment.
References
- Ding F, Zhang W, Liu T, Rong X, Cui Y, et al. MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells. Drug Des Devel Ther. 2025;19:2173. doi:10.2147/DDDT.S503930
- Wang Q, Yu H, Kong Y. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:69. doi:10.1186/s12891-024-07173-y
- Öz İ, Kochai A, Avan YL, Keskin D, Çınar BM, et al. The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis. Jt Dis Relat Surg. 2023;34:356. doi:10.52312/jdrs.2023.911
- Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, et al. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Arch Osteoporos. 2023;18:83. doi:10.1007/s11657-023-01288-w
- Li C, Liang C, Kong Z, Su Y, Ren W, et al. Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism. Ann Nutr Metab. 2023;79:334. doi:10.1159/000531065
- Giordani C, Matacchione G, Giuliani A, Valli D, Scarpa ES, et al. Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108820
- Lee AS, Sung MJ, Son SJ, Han AR, Hong SM, et al. Effect of Menaquinone-4 on Receptor Activator of Nuclear Factor B Ligand-Induced Osteoclast Differentiation and Ovariectomy-Induced Bone Loss. J Med Food. 2023;26:128. doi:10.1089/jmf.2022.K.0078
- Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
- Tao X, Xu T, Liu L, Lin X, Zhang Z, et al. Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia. Front Endocrinol (Lausanne). 2022;13:961322. doi:10.3389/fendo.2022.961322
- Ma ML, Ma ZJ, He YL, Sun H, Yang B, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649. doi:10.3389/fpubh.2022.979649
- Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6
- Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
- Mandatori D, Penolazzi L, Pelusi L, Lambertini E, Michelucci F, et al. Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2. Nutrients. 2021;13. doi:10.3390/nu13082823
- Wang H, Zhang N, Li L, Yang P, Ma Y. Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling. Nutrients. 2021;13. doi:10.3390/nu13082570
- Wang B, Tang J, Weng S, Chen L, Wu Z, et al. Is vitamin K a treatment choice for atypical femoral fractures in patients with secondary osteoporosis?. J Int Med Res. 2021;49:3000605211001643. doi:10.1177/03000605211001643
- Solmaz I, Ozdemir MA, Unal E, Abdurrezzak U, Muhtaroglu S, et al. Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study. J Pediatr Endocrinol Metab. 2021;34:441. doi:10.1515/jpem-2020-0637
- Zhang Z, Xia K, Gong W, Mai R, Liu P, et al. Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis. Horm Metab Res. 2025;57:33. doi:10.1055/a-2371-1642
- Hirashima S, Kiyooka Y, Kaetsu S, Nakagawa K. Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice. Biochem Biophys Res Commun. 2024;702:149635. doi:10.1016/j.bbrc.2024.149635
- Kong M, Gao C, Luan X, Fan C, Hao M, et al. Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis. BMC Musculoskelet Disord. 2024;25:109. doi:10.1186/s12891-024-07227-1
- Skalny AV, Aschner M, Tsatsakis A, Rocha JBT, Santamaria A, et al. Role of vitamins beyond vitamin D in bone health and osteoporosis (Review). Int J Mol Med. 2024;53. doi:10.3892/ijmm.2023.5333
- Cui Y, Zhang W, Yang P, Zhu S, Luo S, et al. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Free Radic Biol Med. 2023;206:33. doi:10.1016/j.freeradbiomed.2023.06.022
- Wang H, Li L, Zhang N, Ma Y. Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells. Nutrients. 2022;14. doi:10.3390/nu14142934
- Jadhav N, Ajgaonkar S, Saha P, Gurav P, Pandey A, et al. Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front Pharmacol. 2022;13:896920. doi:10.3389/fphar.2022.896920
- Hu L, Ji J, Li D, Meng J, Yu B. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:592. doi:10.1186/s13018-021-02728-4
