' 
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
6.7
USERS' SCORE
Very Good
Based on 11 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
8
Vitamin D analogs reduce acne effectively
Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.
Focused study on acne treatment
We explored the effects of vitamin D and its analogs on acne, primarily focusing on their ability to reduce the size of comedones (or acne lesions) in a rhino mouse model. This study evaluated the active form of vitamin D, known as 1,25-dihydroxyvitamin D(3), along with several modified analogs.
All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.
Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.
Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.
All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.
Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.
Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.
Read More
8
Vitamin D's potential in acne treatment
Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial.
Direct application for acne treatment
We explored the relationship between vitamin D levels and acne by comparing 80 acne patients with 80 healthy individuals. Through our analysis, we found that vitamin D deficiency was noticeably more common among those with acne, highlighting a potential avenue for treatment. Almost 49% of the acne group was found to have low vitamin D levels, compared to just 22.5% in the control group.
Moreover, we observed a clear connection between the severity of acne and vitamin D levels. Specifically, lower vitamin D levels seemed to correlate with more severe inflammatory acne lesions. This prompted us to examine whether supplementing with vitamin D could lead to improvement. We treated participants with a vitamin D supplement for two months, and many reported a positive change in their skin condition.
However, it's important to note that our study had limitations, such as a small sample size for the supplementation group and the natural variability of acne. Overall, while there appears to be a link between vitamin D deficiency and acne severity, and some positive effects from supplementation, further research is needed to better understand and confirm these findings.
Moreover, we observed a clear connection between the severity of acne and vitamin D levels. Specifically, lower vitamin D levels seemed to correlate with more severe inflammatory acne lesions. This prompted us to examine whether supplementing with vitamin D could lead to improvement. We treated participants with a vitamin D supplement for two months, and many reported a positive change in their skin condition.
However, it's important to note that our study had limitations, such as a small sample size for the supplementation group and the natural variability of acne. Overall, while there appears to be a link between vitamin D deficiency and acne severity, and some positive effects from supplementation, further research is needed to better understand and confirm these findings.
Read More
8
Vitamin D3 effective against acne
Comedolytic effect of topically applied active vitamin D3 analogue on pseudocomedones in the rhino mouse.
Study highlights vitamin D3 benefits
We examined the potential of maxacalcitol, a form of active vitamin D3, in reducing acne through a study involving rhino mice, known for developing comedones. Our goal was to see if this vitamin D3 analogue could help clear these skin blemishes, as retinoids like tretinoin have been shown to be effective.
Over a treatment period, we applied both maxacalcitol and tretinoin topically. The results were promising—within just one week, both treatments significantly reduced the size of the comedones, suggesting that maxacalcitol has a notable comedolytic effect. However, while tretinoin also affected the density of these comedones, maxacalcitol did not show this same level of impact.
We noted some differences in how each treatment worked at a microscopic level. Both treatments led to increased skin cell growth, but maxacalcitol seemed to do so with fewer inflammatory responses compared to tretinoin.
In summary, our findings indicate that maxacalcitol is effective in combating comedones and may operate through mechanisms distinct from traditional retinoids, offering a promising option for those dealing with acne.
Over a treatment period, we applied both maxacalcitol and tretinoin topically. The results were promising—within just one week, both treatments significantly reduced the size of the comedones, suggesting that maxacalcitol has a notable comedolytic effect. However, while tretinoin also affected the density of these comedones, maxacalcitol did not show this same level of impact.
We noted some differences in how each treatment worked at a microscopic level. Both treatments led to increased skin cell growth, but maxacalcitol seemed to do so with fewer inflammatory responses compared to tretinoin.
In summary, our findings indicate that maxacalcitol is effective in combating comedones and may operate through mechanisms distinct from traditional retinoids, offering a promising option for those dealing with acne.
Read More
Most Useful Reviews
9.5
Cleared acne
Great for acne! I started taking this for my health, but it significantly improved my acne. After about two weeks, my facial acne had completely disappeared. If you struggle with rough skin, I highly recommend this.
Read More
9.5
Better skin
We've taken this vitamin for nearly a year, and my skin has improved greatly—my acne is almost gone, even at 36. My parents also noticed benefits, like reduced leg cramps.
Read More
9.5
No more acne
This works wonders for prevention; my skin is noticeably smoother, acne has vanished, and my nails no longer peel.
Read More
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9
Tracnil™ effective for PCOS acne
Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study.
Combined effects of study ingredients
We investigated the effectiveness of Tracnil™, which combines myo-inositol, folic acid, and vitamin D3, on acne and other dermatological issues in overweight women with conditions related to Polycystic Ovary Syndrome (PCOS). Our findings showed that participants experienced a significant reduction in both inflammatory and non-inflammatory acne lesions within just eight weeks.
Notably, alongside improvements in acne, we observed positive changes in hirsutism—excess hair growth—and menstrual irregularities. Throughout the study, participants' safety was closely monitored, showing minimal adverse effects, while hormone levels remained stable despite our subjects initially having normal readings.
This leads us to believe that Tracnil™ may help regulate the body's response to sex hormones or perform other essential functions in managing PCOS symptoms, even when hormonal levels are not significantly abnormal. Therefore, we suggest that Tracnil™ could be an effective first-line treatment option for addressing dermatological concerns related to PCOS, simplifying treatment for those affected.
Notably, alongside improvements in acne, we observed positive changes in hirsutism—excess hair growth—and menstrual irregularities. Throughout the study, participants' safety was closely monitored, showing minimal adverse effects, while hormone levels remained stable despite our subjects initially having normal readings.
This leads us to believe that Tracnil™ may help regulate the body's response to sex hormones or perform other essential functions in managing PCOS symptoms, even when hormonal levels are not significantly abnormal. Therefore, we suggest that Tracnil™ could be an effective first-line treatment option for addressing dermatological concerns related to PCOS, simplifying treatment for those affected.
Read More
8
Vitamin D3 positively affects acne
Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial.
Moderate relevance in combined treatment
We set out to investigate the effectiveness of topical vitamin D3 in treating acne vulgaris, particularly focusing on its anti-inflammatory effects. To do this, we conducted a well-structured double-blind, randomized, placebo-controlled trial over eight weeks. Participants were divided into two groups—one receiving topical vitamin D3 and the other a placebo—both alongside a common acne treatment known as adapalene.
Throughout the study, we closely monitored the levels of interleukin-1 beta (IL-1β), a pro-inflammatory cytokine often elevated in acne lesions. By using advanced assays, we were able to quantify the decrease in IL-1β alongside observing the reduction in inflammatory lesions over time. What we discovered was promising; the topical application of vitamin D3 not only helped lower IL-1β levels in acne lesions but also contributed to a noticeable decrease in acne severity.
These results suggest that vitamin D3 might play a valuable role in managing acne through its ability to modulate inflammation and improve skin conditions. Therefore, incorporating vitamin D3 into acne treatment regimens could be beneficial for those struggling with this common skin issue.
Throughout the study, we closely monitored the levels of interleukin-1 beta (IL-1β), a pro-inflammatory cytokine often elevated in acne lesions. By using advanced assays, we were able to quantify the decrease in IL-1β alongside observing the reduction in inflammatory lesions over time. What we discovered was promising; the topical application of vitamin D3 not only helped lower IL-1β levels in acne lesions but also contributed to a noticeable decrease in acne severity.
These results suggest that vitamin D3 might play a valuable role in managing acne through its ability to modulate inflammation and improve skin conditions. Therefore, incorporating vitamin D3 into acne treatment regimens could be beneficial for those struggling with this common skin issue.
Read More
8
Vitamin D's potential in acne treatment
Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial.
Direct application for acne treatment
We explored the relationship between vitamin D levels and acne by comparing 80 acne patients with 80 healthy individuals. Through our analysis, we found that vitamin D deficiency was noticeably more common among those with acne, highlighting a potential avenue for treatment. Almost 49% of the acne group was found to have low vitamin D levels, compared to just 22.5% in the control group.
Moreover, we observed a clear connection between the severity of acne and vitamin D levels. Specifically, lower vitamin D levels seemed to correlate with more severe inflammatory acne lesions. This prompted us to examine whether supplementing with vitamin D could lead to improvement. We treated participants with a vitamin D supplement for two months, and many reported a positive change in their skin condition.
However, it's important to note that our study had limitations, such as a small sample size for the supplementation group and the natural variability of acne. Overall, while there appears to be a link between vitamin D deficiency and acne severity, and some positive effects from supplementation, further research is needed to better understand and confirm these findings.
Moreover, we observed a clear connection between the severity of acne and vitamin D levels. Specifically, lower vitamin D levels seemed to correlate with more severe inflammatory acne lesions. This prompted us to examine whether supplementing with vitamin D could lead to improvement. We treated participants with a vitamin D supplement for two months, and many reported a positive change in their skin condition.
However, it's important to note that our study had limitations, such as a small sample size for the supplementation group and the natural variability of acne. Overall, while there appears to be a link between vitamin D deficiency and acne severity, and some positive effects from supplementation, further research is needed to better understand and confirm these findings.
Read More
8
Vitamin D analogs reduce acne effectively
Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.
Focused study on acne treatment
We explored the effects of vitamin D and its analogs on acne, primarily focusing on their ability to reduce the size of comedones (or acne lesions) in a rhino mouse model. This study evaluated the active form of vitamin D, known as 1,25-dihydroxyvitamin D(3), along with several modified analogs.
All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.
Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.
Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.
All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.
Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.
Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.
Read More
8
Vitamin D3 effective against acne
Comedolytic effect of topically applied active vitamin D3 analogue on pseudocomedones in the rhino mouse.
Study highlights vitamin D3 benefits
We examined the potential of maxacalcitol, a form of active vitamin D3, in reducing acne through a study involving rhino mice, known for developing comedones. Our goal was to see if this vitamin D3 analogue could help clear these skin blemishes, as retinoids like tretinoin have been shown to be effective.
Over a treatment period, we applied both maxacalcitol and tretinoin topically. The results were promising—within just one week, both treatments significantly reduced the size of the comedones, suggesting that maxacalcitol has a notable comedolytic effect. However, while tretinoin also affected the density of these comedones, maxacalcitol did not show this same level of impact.
We noted some differences in how each treatment worked at a microscopic level. Both treatments led to increased skin cell growth, but maxacalcitol seemed to do so with fewer inflammatory responses compared to tretinoin.
In summary, our findings indicate that maxacalcitol is effective in combating comedones and may operate through mechanisms distinct from traditional retinoids, offering a promising option for those dealing with acne.
Over a treatment period, we applied both maxacalcitol and tretinoin topically. The results were promising—within just one week, both treatments significantly reduced the size of the comedones, suggesting that maxacalcitol has a notable comedolytic effect. However, while tretinoin also affected the density of these comedones, maxacalcitol did not show this same level of impact.
We noted some differences in how each treatment worked at a microscopic level. Both treatments led to increased skin cell growth, but maxacalcitol seemed to do so with fewer inflammatory responses compared to tretinoin.
In summary, our findings indicate that maxacalcitol is effective in combating comedones and may operate through mechanisms distinct from traditional retinoids, offering a promising option for those dealing with acne.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 11 Reviews
7.9
9.5
Cleared acne
Great for acne! I started taking this for my health, but it significantly improved my acne. After about two weeks, my facial acne had completely disappeared. If you struggle with rough skin, I highly recommend this.
9.5
Better skin
We've taken this vitamin for nearly a year, and my skin has improved greatly—my acne is almost gone, even at 36. My parents also noticed benefits, like reduced leg cramps.
9.5
No more acne
This works wonders for prevention; my skin is noticeably smoother, acne has vanished, and my nails no longer peel.
9.5
Collagen boost
Vitamin D3 aids collagen production, decreasing with age, and reduces inflammation—great for acne and hair loss. It supports various bodily systems, promoting overall health.
8.8
Stable skin
This gel-type supplement is small, tasteless, and easy to drink. I've suffered from skin problems for years, but since starting this, my acne has stabilised.
