Reviewed By
Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Good
Based on 23 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
2
Vitamin D3 shows no diabetes benefit
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Read More
8
We conducted a well-structured double-blind, randomized, placebo-controlled trial to explore the effects of cholecalciferol, a form of vitamin D3, on depressive symptoms among individuals with type 2 diabetes mellitus (T2DM). Our primary goal was to determine how this supplementation could influence both mood and specific markers related to diabetes, such as C-peptide, serotonin, and neurotrophin-3 levels.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Read More
8
We aimed to understand how high doses of vitamin D3 could affect individuals with type 2 diabetes (T2DM). Our analysis included data from 20 studies, comprising 612 patients receiving vitamin D3 and 592 in the control group. This research focused on vitamin D3 doses exceeding 4000 IU and their potential impact on various metabolic parameters like blood glucose levels, hemoglobin A1c, and blood pressure.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
Read More
Most Useful Reviews
9
Vitamin D recommendation
513 people found this helpful
It appears that vitamin D deficiency occurs even in sunny countries like Italy and Mexico. The optimal level of vitamin D is between 60-100 ng/ml, ideally measured by mass spectrometry. Many labs use ELISA, which underestimates levels. Vitamin D, being a steroid hormone, when deficient can lead to conditions including diabetes. After taking 10,000 IU of vitamin D daily, my levels rose from 18 to 111 ng/ml. I believe everyone should consider having it in their home remedies.
Read More
9
Supports children’s health
199 people found this helpful
Vitamin D3 is crucial for overall health, especially in children, where deficiency is linked to diabetes, obesity, and autoimmune diseases. I recommend vitamin D3 for the entire family as it supports growth and immunity.
Read More
9
Prevents diseases
15 people found this helpful
Vitamin D3 is vital for immune function and may reduce the risk of viral and respiratory infections, critical for diabetes management. I recommend taking it with magnesium and K2 for better absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
- All Researches
9
Vitamin D3 combined benefits in diabetes
We examined how vitamin D3 works alongside empagliflozin, a medication often used for diabetes, to tackle a condition called metabolic dysfunction-associated steatohepatitis (MASH) in diabetic mice. In this study, we grouped the mice into several categories, including control groups and those receiving treatments, all while feeding them a high-fructose and high-fat diet.
The results showed that while empagliflozin alone helped improve conditions like high blood sugar and fatty liver, when combined with vitamin D3, the benefits were even more pronounced. We observed significant reductions in symptoms such as hyperglycemia and fat buildup in the liver.
Interestingly, this dual therapy demonstrated enhanced control over metabolic processes, oxidative stress, and inflammation markers in the liver. These findings suggest that vitamin D3, when paired with empagliflozin, has potential benefits in managing diabetes-related liver issues. However, as the study primarily focused on the combination effect, isolating the specific impact of vitamin D alone would require further investigation.
The results showed that while empagliflozin alone helped improve conditions like high blood sugar and fatty liver, when combined with vitamin D3, the benefits were even more pronounced. We observed significant reductions in symptoms such as hyperglycemia and fat buildup in the liver.
Interestingly, this dual therapy demonstrated enhanced control over metabolic processes, oxidative stress, and inflammation markers in the liver. These findings suggest that vitamin D3, when paired with empagliflozin, has potential benefits in managing diabetes-related liver issues. However, as the study primarily focused on the combination effect, isolating the specific impact of vitamin D alone would require further investigation.
Read More
9
Vitamin D3 aids diabetes management
We investigated the impact of vitamin D3, in combination with high-intensity interval training (HIIT), on specific markers related to diabetes, namely Chemokine Ligand 5 (CCL-5) and Chemokine Receptor 5 (CCR5). Our study focused on male rats with type 2 diabetes, examining how these interventions could influence conditions exacerbated by a high-fat diet.
Over eight weeks, we divided our 40 rats into five groups: a healthy control group, a diabetic control group, a group undergoing HIIT, one receiving vitamin D3, and a group combining both HIIT and vitamin D3. The findings were quite revealing. While both vitamin D3 and HIIT showed some benefits, the combination of the two had the most significant impact in lowering CCL-5 and CCR5 levels in white adipose tissue.
Notably, vitamin D3 alone reduced the CCR5 levels effectively, demonstrating its potential role in diabetes management. We also noticed that the combined treatment had a notably stronger effect than either intervention alone, highlighting the importance of a multi-faceted approach to manage diabetes. Our study suggests that incorporating both vitamin D3 and exercise may help in lowering certain inflammatory markers in diabetic conditions.
Over eight weeks, we divided our 40 rats into five groups: a healthy control group, a diabetic control group, a group undergoing HIIT, one receiving vitamin D3, and a group combining both HIIT and vitamin D3. The findings were quite revealing. While both vitamin D3 and HIIT showed some benefits, the combination of the two had the most significant impact in lowering CCL-5 and CCR5 levels in white adipose tissue.
Notably, vitamin D3 alone reduced the CCR5 levels effectively, demonstrating its potential role in diabetes management. We also noticed that the combined treatment had a notably stronger effect than either intervention alone, highlighting the importance of a multi-faceted approach to manage diabetes. Our study suggests that incorporating both vitamin D3 and exercise may help in lowering certain inflammatory markers in diabetic conditions.
Read More
8
We sought to explore the effects of vitamin D on diabetes by fortifying jamun juice with this essential nutrient. Our approach involved creating a nanoemulsion of vitamin D using a low-temperature sonication method, which allowed us to enhance its presence in the juice.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
Read More
8
We explored the possibility of using vitamin D3, or cholecalciferol, as part of a combination therapy to enhance diabetes treatment, particularly for type 2 diabetes mellitus (T2DM). Recent research by Attia investigated this approach using a rat model, where they combined metformin, vitamin D3, and taurine.
The findings from this study suggest that this treatment combination can lead to better blood sugar control and also reduce oxidative stress, inflammation, and lipid issues, which are common in diabetes patients. However, it’s essential to note that the study does not provide a detailed safety profile or explore the underlying biological mechanisms that explain these benefits.
While the idea of incorporating vitamin D3 in diabetes therapy is promising, the lack of comprehensive safety data means we should approach this combination with caution. There’s a clear need for further research to fully understand how vitamin D3 works in this context and to ensure that it is safe for broader use among diabetes patients.
The findings from this study suggest that this treatment combination can lead to better blood sugar control and also reduce oxidative stress, inflammation, and lipid issues, which are common in diabetes patients. However, it’s essential to note that the study does not provide a detailed safety profile or explore the underlying biological mechanisms that explain these benefits.
While the idea of incorporating vitamin D3 in diabetes therapy is promising, the lack of comprehensive safety data means we should approach this combination with caution. There’s a clear need for further research to fully understand how vitamin D3 works in this context and to ensure that it is safe for broader use among diabetes patients.
Read More
8
We conducted a well-structured double-blind, randomized, placebo-controlled trial to explore the effects of cholecalciferol, a form of vitamin D3, on depressive symptoms among individuals with type 2 diabetes mellitus (T2DM). Our primary goal was to determine how this supplementation could influence both mood and specific markers related to diabetes, such as C-peptide, serotonin, and neurotrophin-3 levels.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vitamin D recommendation
513 people found this helpful
It appears that vitamin D deficiency occurs even in sunny countries like Italy and Mexico. The optimal level of vitamin D is between 60-100 ng/ml, ideally measured by mass spectrometry. Many labs use ELISA, which underestimates levels. Vitamin D, being a steroid hormone, when deficient can lead to conditions including diabetes. After taking 10,000 IU of vitamin D daily, my levels rose from 18 to 111 ng/ml. I believe everyone should consider having it in their home remedies.
Read More
9
Supports children’s health
199 people found this helpful
Vitamin D3 is crucial for overall health, especially in children, where deficiency is linked to diabetes, obesity, and autoimmune diseases. I recommend vitamin D3 for the entire family as it supports growth and immunity.
Read More
9
Prevents diseases
15 people found this helpful
Vitamin D3 is vital for immune function and may reduce the risk of viral and respiratory infections, critical for diabetes management. I recommend taking it with magnesium and K2 for better absorption.
Read More
9
Critical for diabetes
13 people found this helpful
The composition of lanolin in vitamin D3 is notable. Research shows it may prevent respiratory infections and related complications, with optimised levels reducing risks for diabetes and other serious diseases. I took 2000 units regularly during the pandemic.
Read More
9
High diabetes risk
13 people found this helpful
Vitamin D3 is essential for health, playing a vital role in preventing severe diseases, including diabetes. Regular intake is critical for those with limited sun exposure, especially during the pandemic when I took 2000 units daily.
Read More
Frequently Asked Questions
7.5
Supports diabetes management
1 people found this helpful
D3 is crucial for enhancing calcium absorption and preventing diabetes. It also aids in controlling cell growth and division, which may prevent cancer cells. Having taken it for a year, I've seen positive developments in my osteoporosis and diabetes management.
7.5
Reduces disease risk
5 people found this helpful
Daily supplementation of 2,000 IU of vitamin D is crucial. It's linked to reducing risks of various conditions, including diabetes and heart disease, proving essential for maintaining good health.
6
Essential for diabetes
37 people found this helpful
I bought 2000 IU of vitamin D and found it quite worthwhile for managing diabetes. Safe doses range from 2000 to 5000 IU daily for diabetics. However, be cautious not to exceed this, as it may lead to health issues.
9
Vitamin D recommendation
513 people found this helpful
It appears that vitamin D deficiency occurs even in sunny countries like Italy and Mexico. The optimal level of vitamin D is between 60-100 ng/ml, ideally measured by mass spectrometry. Many labs use ELISA, which underestimates levels. Vitamin D, being a steroid hormone, when deficient can lead to conditions including diabetes. After taking 10,000 IU of vitamin D daily, my levels rose from 18 to 111 ng/ml. I believe everyone should consider having it in their home remedies.
7.5
Supports metabolic health
8 people found this helpful
Vitamin D3 enhances immune function and is necessary for overall metabolism, including sugar regulation, essential for preventing diabetes. Due to insufficient sunlight, supplementation is advisable, and I recommend NOW Vitamin D3.
7.5
Low energy levels
211 people found this helpful
Vitamin D deficiency leads to varied symptoms, notably low energy and weakened immunity. Chronic deficiency can cause severe issues, including diabetes, muscle weakness, and poor wound healing. It's essential to monitor vitamin D levels, and I recommend taking 100 mg of K2 with doses over 5000 IU to enhance the benefits.
9
Prevents diseases
15 people found this helpful
Vitamin D3 is vital for immune function and may reduce the risk of viral and respiratory infections, critical for diabetes management. I recommend taking it with magnesium and K2 for better absorption.
7.5
Tonic for diabetes
2 people found this helpful
Vitamin D3 is an excellent tonic for immunity and strengthens bones. It regulates heart issues and blood vessel health and promotes cell growth while reducing the impact of many diseases such as diabetes. Consultation with a doctor is advised.
9
High diabetes risk
13 people found this helpful
Vitamin D3 is essential for health, playing a vital role in preventing severe diseases, including diabetes. Regular intake is critical for those with limited sun exposure, especially during the pandemic when I took 2000 units daily.
7.5
Diabetes link
Vitamin D is vital for healthy bone growth and is linked to a lower risk of diabetes. Its deficiency may lead to immune disorders and infections, highlighting the need for sufficient intake, especially in regions with limited sun exposure.
8
We sought to explore the effects of vitamin D on diabetes by fortifying jamun juice with this essential nutrient. Our approach involved creating a nanoemulsion of vitamin D using a low-temperature sonication method, which allowed us to enhance its presence in the juice.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
8
We set out to investigate how vitamin D3, specifically in the form of 1,25(OH)2D3, influences diabetes and its associated complications like inflammation and pancreatic damage. Our study utilized both laboratory models and real-life scenarios where we introduced this treatment to those with diabetes.
We found that 1,25(OH)2D3 seems to have an intriguing impact on insulin secretion levels and could play a role in reducing inflammation in pancreatic β-cells. This suggests that vitamin D3 not only aids in insulin production but also helps protect these cells from damage caused by diabetes.
Through our experiments, we observed that this form of vitamin D3 appears to lower the expression of certain proteins linked to a type of cell death called pyroptosis, which is particularly damaging in diabetes. By inhibiting these processes, 1,25(OH)2D3 might help preserve the function of pancreatic cells and alleviate some symptoms of diabetes.
While further research is needed, our findings hint at the potential benefits of 1,25(OH)2D3 for those dealing with diabetes, creating a strong case for considering vitamin D3 as an adjuvant treatment in managing this chronic condition.
We found that 1,25(OH)2D3 seems to have an intriguing impact on insulin secretion levels and could play a role in reducing inflammation in pancreatic β-cells. This suggests that vitamin D3 not only aids in insulin production but also helps protect these cells from damage caused by diabetes.
Through our experiments, we observed that this form of vitamin D3 appears to lower the expression of certain proteins linked to a type of cell death called pyroptosis, which is particularly damaging in diabetes. By inhibiting these processes, 1,25(OH)2D3 might help preserve the function of pancreatic cells and alleviate some symptoms of diabetes.
While further research is needed, our findings hint at the potential benefits of 1,25(OH)2D3 for those dealing with diabetes, creating a strong case for considering vitamin D3 as an adjuvant treatment in managing this chronic condition.
2
Vitamin D3 shows no diabetes benefit
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
8
We aimed to understand how high doses of vitamin D3 could affect individuals with type 2 diabetes (T2DM). Our analysis included data from 20 studies, comprising 612 patients receiving vitamin D3 and 592 in the control group. This research focused on vitamin D3 doses exceeding 4000 IU and their potential impact on various metabolic parameters like blood glucose levels, hemoglobin A1c, and blood pressure.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
References
- Jan Y, Binsuwaidan R, Malik M, Yaseen M, Ahmad S, et al. Characterization of jamun () juice fortified with nanoemulsified vitamin D: and assessment of its nutraceutical value and anti-diabetic potential. Food Chem X. 2025;25:102133. 10.1016/j.fochx.2024.102133
- Dawi J, Misakyan Y, Affa S, Kades S, Narasimhan A, et al. Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions. Biomedicines. 2024;13. 10.3390/biomedicines13010018
- El-Akabawy G, Eid N. Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy: Potential and limitations. World J Diabetes. 2025;16:100066. 10.4239/wjd.v16.i1.100066
- Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. 10.52225/narra.v4i3.1342
- Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04476-y
- Zheng Y, Wu Z, Wei X, Zhang L, Hu Y, et al. 1,25(OH)2D3 promotes insulin secretion through the classical pyroptosis pathway in vitro and vivo. Biochem Biophys Res Commun. 2025;742:151058. 10.1016/j.bbrc.2024.151058
- Virtanen JK, Hantunen S, Kallio N, Lamberg-Allardt C, Manson JE, et al. The effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial. Diabetologia. 2024. 10.1007/s00125-024-06336-9
- Max F, Gažová A, Smaha J, Jankovský M, Tesař T, et al. High Doses of Vitamin D and Specific Metabolic Parameters in Type 2 Diabetes Patients: Systematic Review. Nutrients. 2024;16. 10.3390/nu16223903
- Shokri B, Mohebbi H, Mehrabani J. Amelioration of fructose-induced hepatic lipid accumulation by vitamin D supplementation and high-intensity interval training in male Sprague‒Dawley rats. Lipids Health Dis. 2024;23:362. 10.1186/s12944-024-02347-y
- Farrash WF, Idris S, Elzubier ME, Khidir EBA, Aslam A, et al. Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways. Int J Exp Pathol. 2024;105:219. 10.1111/iep.12519
- Fallahi F, Tahmasebi W, Rahimi MR, Azizi M. High-Intensity Interval Training and Vitamin D3 Supplementation Decrease CCL-5 and CCR5 Expression In White Adipose Tissue of Diabetic Rats Fed with A High-Fat Diet and Streptozotocin. Cell J. 2024;26:465. 10.22074/cellj.2024.2027582.1560
