Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Read More
8
We aimed to understand the link between vitamin D levels and blood pressure in elderly patients who are experiencing both hypertension and osteoporosis. Our investigation was conducted as a single-center observational study at Zhongshan Hospital, where we gathered data on blood pressure, bone density, and vitamin D levels from newly diagnosed patients.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
Read More
8
Vitamin D3 improves blood pressure
We evaluated how high doses of vitamin D3, specifically cholecalciferol, affect blood pressure in patients diagnosed with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). Our study included 67 participants, divided into two groups: those with CAN and those without.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
Read More
Most Useful Reviews
9
Vital for hypertension
13 people found this helpful
Good composition of lanolin. Vitamin D (D3) is vital for health, possibly preventing serious ailments. Studies show that optimal vitamin D levels can lower the risk of heart attacks and hypertension. I took 2000 units during the pandemic with food.
Read More
4
Reduces hypertension risk
2 people found this helpful
The best manufacturer of vitamin D3. I take this regularly as vitamin D deficiency raises the risk of various diseases, including hypertension.
Read More
2
Prevents hypertension complications
Be sure to take vitamin D3! It impacts immunity, mood, calcium absorption, and can affect conditions like hypertension and diabetes. A deficiency can lead to various health issues, including chronic fatigue and hypertension.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
- All Researches
9
We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Read More
8
We investigated the effects of vitamin D3, also known as cholecalciferol, on blood pressure among overweight elderly individuals. In a well-structured study, 221 participants took part in a year-long trial that was double-blind and randomized. They received vitamin D3 along with calcium at two different doses—600 IU/day or 3750 IU/day—to see how it impacted their systolic and diastolic blood pressure.
Our findings revealed that both the low and high doses of vitamin D3 alongside calcium resulted in significant reductions in blood pressure for participants who were overweight, particularly those with a body mass index (BMI) over 30 and those with hypertension. Notably, while the high dose showed a more pronounced effect, the results suggest that higher doses may not necessarily lead to better outcomes. In those with high blood pressure, we found decreases in systolic and diastolic readings that were consistent regardless of the dose.
Overall, it appears that vitamin D3 and calcium could be beneficial in managing blood pressure for certain groups, particularly older adults who are overweight. However, more is not always better, as we observed that the effectiveness was relatively independent of the dosage administered.
Our findings revealed that both the low and high doses of vitamin D3 alongside calcium resulted in significant reductions in blood pressure for participants who were overweight, particularly those with a body mass index (BMI) over 30 and those with hypertension. Notably, while the high dose showed a more pronounced effect, the results suggest that higher doses may not necessarily lead to better outcomes. In those with high blood pressure, we found decreases in systolic and diastolic readings that were consistent regardless of the dose.
Overall, it appears that vitamin D3 and calcium could be beneficial in managing blood pressure for certain groups, particularly older adults who are overweight. However, more is not always better, as we observed that the effectiveness was relatively independent of the dosage administered.
Read More
8
We embarked on a study to evaluate how vitamin D3 supplementation might influence hypertension, particularly among patients coping with COVID-19 and cardiovascular diseases. By involving 50 adult participants, we effectively organized them into two groups: one receiving daily doses of 10,000 IU of vitamin D3 and the other receiving a placebo.
Our findings revealed promising results for those taking vitamin D3. We observed an increase in the Ang-(1-7)/Ang II ratio, which suggests enhanced ACE2 activity, an important factor in heart and blood vessel function. Notably, patients treated with vitamin D3 experienced a significant decline in inflammatory markers, which often exacerbate hypertension.
Moreover, we noted a trend towards reductions in blood pressure levels among hypertensive patients in the vitamin D3 group. This suggests that vitamin D3 could play a role in better managing blood pressure, alongside potentially influencing overall recovery from COVID-19.
Overall, our research indicates that vitamin D3 supplementation may hold therapeutic promise for individuals with hypertension, especially during challenging times such as the COVID-19 pandemic.
Our findings revealed promising results for those taking vitamin D3. We observed an increase in the Ang-(1-7)/Ang II ratio, which suggests enhanced ACE2 activity, an important factor in heart and blood vessel function. Notably, patients treated with vitamin D3 experienced a significant decline in inflammatory markers, which often exacerbate hypertension.
Moreover, we noted a trend towards reductions in blood pressure levels among hypertensive patients in the vitamin D3 group. This suggests that vitamin D3 could play a role in better managing blood pressure, alongside potentially influencing overall recovery from COVID-19.
Overall, our research indicates that vitamin D3 supplementation may hold therapeutic promise for individuals with hypertension, especially during challenging times such as the COVID-19 pandemic.
Read More
8
We aimed to understand the link between vitamin D levels and blood pressure in elderly patients who are experiencing both hypertension and osteoporosis. Our investigation was conducted as a single-center observational study at Zhongshan Hospital, where we gathered data on blood pressure, bone density, and vitamin D levels from newly diagnosed patients.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
Read More
8
Vitamin D3 improves blood pressure
We evaluated how high doses of vitamin D3, specifically cholecalciferol, affect blood pressure in patients diagnosed with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). Our study included 67 participants, divided into two groups: those with CAN and those without.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
At the start, we noticed that those with CAN had higher systolic blood pressure during sleep and a less significant nocturnal dip in blood pressure compared to those without CAN. However, after a 12-week period of high-dose vitamin D supplementation, we observed positive changes—especially in the CAN group.
Notably, the patients with CAN showed improvements in their CAN measurements and a decrease in their morning systolic blood pressure. This suggests that vitamin D3 could offer benefits, particularly for individuals with cardiovascular autonomic neuropathy related to diabetes.
Overall, our findings provide encouraging evidence for vitamin D3 as a potential aid in managing hypertension among patients with specific diabetes-related complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vital for hypertension
13 people found this helpful
Good composition of lanolin. Vitamin D (D3) is vital for health, possibly preventing serious ailments. Studies show that optimal vitamin D levels can lower the risk of heart attacks and hypertension. I took 2000 units during the pandemic with food.
Read More
4
Reduces hypertension risk
2 people found this helpful
The best manufacturer of vitamin D3. I take this regularly as vitamin D deficiency raises the risk of various diseases, including hypertension.
Read More
2
Prevents hypertension complications
Be sure to take vitamin D3! It impacts immunity, mood, calcium absorption, and can affect conditions like hypertension and diabetes. A deficiency can lead to various health issues, including chronic fatigue and hypertension.
Read More
Frequently Asked Questions
9
Vital for hypertension
13 people found this helpful
Good composition of lanolin. Vitamin D (D3) is vital for health, possibly preventing serious ailments. Studies show that optimal vitamin D levels can lower the risk of heart attacks and hypertension. I took 2000 units during the pandemic with food.
4
Reduces hypertension risk
2 people found this helpful
The best manufacturer of vitamin D3. I take this regularly as vitamin D deficiency raises the risk of various diseases, including hypertension.
2
Prevents hypertension complications
Be sure to take vitamin D3! It impacts immunity, mood, calcium absorption, and can affect conditions like hypertension and diabetes. A deficiency can lead to various health issues, including chronic fatigue and hypertension.
8
We investigated the effects of vitamin D3, also known as cholecalciferol, on blood pressure among overweight elderly individuals. In a well-structured study, 221 participants took part in a year-long trial that was double-blind and randomized. They received vitamin D3 along with calcium at two different doses—600 IU/day or 3750 IU/day—to see how it impacted their systolic and diastolic blood pressure.
Our findings revealed that both the low and high doses of vitamin D3 alongside calcium resulted in significant reductions in blood pressure for participants who were overweight, particularly those with a body mass index (BMI) over 30 and those with hypertension. Notably, while the high dose showed a more pronounced effect, the results suggest that higher doses may not necessarily lead to better outcomes. In those with high blood pressure, we found decreases in systolic and diastolic readings that were consistent regardless of the dose.
Overall, it appears that vitamin D3 and calcium could be beneficial in managing blood pressure for certain groups, particularly older adults who are overweight. However, more is not always better, as we observed that the effectiveness was relatively independent of the dosage administered.
Our findings revealed that both the low and high doses of vitamin D3 alongside calcium resulted in significant reductions in blood pressure for participants who were overweight, particularly those with a body mass index (BMI) over 30 and those with hypertension. Notably, while the high dose showed a more pronounced effect, the results suggest that higher doses may not necessarily lead to better outcomes. In those with high blood pressure, we found decreases in systolic and diastolic readings that were consistent regardless of the dose.
Overall, it appears that vitamin D3 and calcium could be beneficial in managing blood pressure for certain groups, particularly older adults who are overweight. However, more is not always better, as we observed that the effectiveness was relatively independent of the dosage administered.
8
We embarked on a study to evaluate how vitamin D3 supplementation might influence hypertension, particularly among patients coping with COVID-19 and cardiovascular diseases. By involving 50 adult participants, we effectively organized them into two groups: one receiving daily doses of 10,000 IU of vitamin D3 and the other receiving a placebo.
Our findings revealed promising results for those taking vitamin D3. We observed an increase in the Ang-(1-7)/Ang II ratio, which suggests enhanced ACE2 activity, an important factor in heart and blood vessel function. Notably, patients treated with vitamin D3 experienced a significant decline in inflammatory markers, which often exacerbate hypertension.
Moreover, we noted a trend towards reductions in blood pressure levels among hypertensive patients in the vitamin D3 group. This suggests that vitamin D3 could play a role in better managing blood pressure, alongside potentially influencing overall recovery from COVID-19.
Overall, our research indicates that vitamin D3 supplementation may hold therapeutic promise for individuals with hypertension, especially during challenging times such as the COVID-19 pandemic.
Our findings revealed promising results for those taking vitamin D3. We observed an increase in the Ang-(1-7)/Ang II ratio, which suggests enhanced ACE2 activity, an important factor in heart and blood vessel function. Notably, patients treated with vitamin D3 experienced a significant decline in inflammatory markers, which often exacerbate hypertension.
Moreover, we noted a trend towards reductions in blood pressure levels among hypertensive patients in the vitamin D3 group. This suggests that vitamin D3 could play a role in better managing blood pressure, alongside potentially influencing overall recovery from COVID-19.
Overall, our research indicates that vitamin D3 supplementation may hold therapeutic promise for individuals with hypertension, especially during challenging times such as the COVID-19 pandemic.
8
We aimed to understand the link between vitamin D levels and blood pressure in elderly patients who are experiencing both hypertension and osteoporosis. Our investigation was conducted as a single-center observational study at Zhongshan Hospital, where we gathered data on blood pressure, bone density, and vitamin D levels from newly diagnosed patients.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
The results revealed a noteworthy negative correlation between vitamin D, specifically 25-hydroxyvitamin D3 (25-(OH)D3), and various measures of blood pressure such as mean systolic blood pressure (mSBP). We found that when 25-(OH)D3 levels were below 42 nmol/L, they were significantly linked to higher blood pressure readings. However, for those whose vitamin D levels exceeded this threshold, there was no significant relationship with blood pressure.
Overall, our findings suggest that vitamin D deficiency may contribute to elevated blood pressure in older adults contending with these health issues. This indicates the potential importance of monitoring vitamin D levels in managing hypertension within this demographic.
7
We aimed to understand how cholecalciferol, or vitamin D3, affects hypertension, particularly in adults who are obese and have low vitamin D levels. In a well-structured trial lasting 24 weeks, we evaluated the metabolic changes in 36 participants with obesity-related hypertension after they received cholecalciferol, alongside their regular medication.
Throughout the study, we discovered that hypertensive patients initially had lower levels of several amino acids compared to normotensive individuals. After supplementation with cholecalciferol, we observed significant increases in glutamine and histidine. Additionally, levels of glucose and acetate decreased after 24 weeks, suggesting that vitamin D3 may play a role in managing glucose metabolism, which could have further implications for metabolic health.
Despite these interesting findings in metabolic changes, it's important to note that the study used routine medication alongside vitamin D3, which makes it difficult to determine the isolated effects of vitamin D3 on hypertension alone. However, we can say that the changes in metabolite levels provide insight into how vitamin D3 may contribute to a healthier metabolic state in individuals with obesity-related hypertension.
Throughout the study, we discovered that hypertensive patients initially had lower levels of several amino acids compared to normotensive individuals. After supplementation with cholecalciferol, we observed significant increases in glutamine and histidine. Additionally, levels of glucose and acetate decreased after 24 weeks, suggesting that vitamin D3 may play a role in managing glucose metabolism, which could have further implications for metabolic health.
Despite these interesting findings in metabolic changes, it's important to note that the study used routine medication alongside vitamin D3, which makes it difficult to determine the isolated effects of vitamin D3 on hypertension alone. However, we can say that the changes in metabolite levels provide insight into how vitamin D3 may contribute to a healthier metabolic state in individuals with obesity-related hypertension.
References
- Rahme M, Al-Shaar L, Tamim H, El-Hajj Fuleihan G. Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial. J Endocr Soc. 2024;8:bvae168. 10.1210/jendso/bvae168
- Sanz RL, García F, Gutierrez A, García Menendez S, Inserra F, et al. Vitamin D3 supplementation in COVID-19 patients with cardiovascular disease and gut dysbiosis. Hipertens Riesgo Vasc. 2024;41:145. 10.1016/j.hipert.2024.04.002
- Wu T, Lin Z, Wang C, Liu X. Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis. Front Med (Lausanne). 2024;11:1396254. 10.3389/fmed.2024.1396254
- Santos C, Carvalho R, Fonseca AM, Castelo Branco M, Alves M, et al. Standard Doses of Cholecalciferol Reduce Glucose and Increase Glutamine in Obesity-Related Hypertension: Results of a Randomized Trial. Int J Mol Sci. 2024;25. 10.3390/ijms25063416
- Felício J, Moraes L, Lemos G, Souza Í, Vieira G, et al. High dose cholecalciferol supplementation causing morning blood pressure reduction in patients with type 1 diabetes mellitus and cardiovascular autonomic neuropathy. Sci Rep. 2024;14:6374. 10.1038/s41598-024-56934-1
- Hua R, Liu B, He W, Zhang H, Liu Y, et al. Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function. Clin Exp Hypertens. 2023;45:2277653. 10.1080/10641963.2023.2277653
