Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
Most Useful Reviews
8.3
Effective alternative treatment
I was recently informed that Vitamin D is preferable to Vitamin C. Since I occasionally suffer from reflux, Vitamin D has been a remarkable alternative for me.
Read More
8.8
Reduced reflux symptoms
Excellent for bodily health! I take one softgel daily, which suffices for me. I’ve noticed an improvement in my gastric reflux issues and find I'm less prone to colds, particularly as I live in a city with limited sunlight.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
8
We investigated how Vitamin D3 affects inflammation caused by reflux esophagitis—a condition where stomach acid irritates the esophagus. In our study, we used 70 male rats, dividing them into groups to examine the impact of Vitamin D3 at different doses on inflammation levels.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Our findings revealed that the levels of pro-inflammatory cytokines like IL-1β, IL-6, and IL-8 were significantly elevated in cases of acute reflux esophagitis. However, when we treated these rats with Vitamin D3, we observed that the inflammation markers decreased notably in the acute cases, while there wasn’t any significant change in the chronic cases.
Despite some improvements in cytokine levels with Vitamin D3, we noted that the overall morphological damage to the esophagus remained unchanged. Interestingly, while Vitamin D3 did raise serum calcium levels, it didn’t seem to help repair esophageal damage in the longer-term chronic setting.
These results suggest that while Vitamin D3 has the potential to mitigate inflammation in early stages of reflux esophagitis, it does not offer a complete solution regarding the physical damage caused by the condition over time.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Effective alternative treatment
I was recently informed that Vitamin D is preferable to Vitamin C. Since I occasionally suffer from reflux, Vitamin D has been a remarkable alternative for me.
Read More
8.8
Reduced reflux symptoms
Excellent for bodily health! I take one softgel daily, which suffices for me. I’ve noticed an improvement in my gastric reflux issues and find I'm less prone to colds, particularly as I live in a city with limited sunlight.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. doi:10.21873/invivo.13056
