5/30/2025
Last update
5/30/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 14 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1 g (1,000 mg)
1111%
Rose Hips Powder (Rosa canina) (fruit)
25 mg
†
Top Medical Research Studies
8
We aimed to understand how Vitamin C could help with the toxicity caused by omeprazole, a common treatment for conditions like gastroesophageal reflux disease (GERD) and gastritis. During our study, we examined gastric cells from rabbits to see how Vitamin C, alongside other antioxidants, could protect these cells from damage caused by omeprazole.
We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.
This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.
We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.
This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.
Read More
7
Antioxidants may reduce cancer risk
We studied how antioxidants, particularly vitamin C, relate to reflux esophagitis and esophageal adenocarcinoma, aiming to uncover potential protective effects. Through a case-control approach involving groups with reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma, we assessed the dietary intake of antioxidants and their relationship with these conditions.
Our findings revealed that a higher overall antioxidant intake was linked to a reduced risk of esophageal adenocarcinoma. Specifically, individuals with the highest vitamin C intake had a significantly lower risk of developing this type of cancer. However, while vitamin C also appeared to reduce the risk of reflux esophagitis, we found no strong connection between vitamin C and Barrett's esophagus, nor with other antioxidants such as vitamin E, carotenoids, zinc, copper, or selenium.
This suggests that while antioxidants could play a role in lowering the risk of esophageal adenocarcinoma, they might be more influential in terms of progression rather than initiating reflux conditions. Overall, our study highlights the potential significance of dietary vitamin C in addressing reflux issues but points out limitations when it comes to other forms of esophageal disorders.
Our findings revealed that a higher overall antioxidant intake was linked to a reduced risk of esophageal adenocarcinoma. Specifically, individuals with the highest vitamin C intake had a significantly lower risk of developing this type of cancer. However, while vitamin C also appeared to reduce the risk of reflux esophagitis, we found no strong connection between vitamin C and Barrett's esophagus, nor with other antioxidants such as vitamin E, carotenoids, zinc, copper, or selenium.
This suggests that while antioxidants could play a role in lowering the risk of esophageal adenocarcinoma, they might be more influential in terms of progression rather than initiating reflux conditions. Overall, our study highlights the potential significance of dietary vitamin C in addressing reflux issues but points out limitations when it comes to other forms of esophageal disorders.
Read More
Most Useful Reviews
9
No heartburn issues
86 people found this helpful
NOW brand doesn’t trigger heartburn or acid reflux in my wife. We’ve tried other vitamin C brands that caused her awful heartburn. We've been using NOW vitamin C for a while now (on our second bottle) and she hasn’t experienced any heartburn or acid reflux issues. The pills are not particularly small but are manageable. I can’t recall the last time I was sick, and I genuinely believe that taking vitamin C contributes to that. I typically take two tablets a day (2000 mg total), one with breakfast and another with dinner, and I increase to four when in crowded situations.
Read More
9
Amazing stomach tolerance
This product has been easy on my stomach! I suffer from acid reflux, and regular Vitamin C often upset my stomach. To my surprise, I had no trouble with these 1000mg tablets, even on an empty stomach. One a day is sufficient, but I might increase the dosage to two if I feel a cold coming on.
Read More
9
Safe for severe reflux
I started taking Vitamin C daily in 2016 primarily due to my skin condition. I chose this brand after researching, as it is highly rated. It doesn’t make my urine yellow like others and is not acidic, making it suitable for my severe acid reflux. After six years, it remains my go-to for Vitamin C.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We aimed to understand how Vitamin C could help with the toxicity caused by omeprazole, a common treatment for conditions like gastroesophageal reflux disease (GERD) and gastritis. During our study, we examined gastric cells from rabbits to see how Vitamin C, alongside other antioxidants, could protect these cells from damage caused by omeprazole.
We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.
This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.
We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.
This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.
Read More
7
Antioxidants may reduce cancer risk
We studied how antioxidants, particularly vitamin C, relate to reflux esophagitis and esophageal adenocarcinoma, aiming to uncover potential protective effects. Through a case-control approach involving groups with reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma, we assessed the dietary intake of antioxidants and their relationship with these conditions.
Our findings revealed that a higher overall antioxidant intake was linked to a reduced risk of esophageal adenocarcinoma. Specifically, individuals with the highest vitamin C intake had a significantly lower risk of developing this type of cancer. However, while vitamin C also appeared to reduce the risk of reflux esophagitis, we found no strong connection between vitamin C and Barrett's esophagus, nor with other antioxidants such as vitamin E, carotenoids, zinc, copper, or selenium.
This suggests that while antioxidants could play a role in lowering the risk of esophageal adenocarcinoma, they might be more influential in terms of progression rather than initiating reflux conditions. Overall, our study highlights the potential significance of dietary vitamin C in addressing reflux issues but points out limitations when it comes to other forms of esophageal disorders.
Our findings revealed that a higher overall antioxidant intake was linked to a reduced risk of esophageal adenocarcinoma. Specifically, individuals with the highest vitamin C intake had a significantly lower risk of developing this type of cancer. However, while vitamin C also appeared to reduce the risk of reflux esophagitis, we found no strong connection between vitamin C and Barrett's esophagus, nor with other antioxidants such as vitamin E, carotenoids, zinc, copper, or selenium.
This suggests that while antioxidants could play a role in lowering the risk of esophageal adenocarcinoma, they might be more influential in terms of progression rather than initiating reflux conditions. Overall, our study highlights the potential significance of dietary vitamin C in addressing reflux issues but points out limitations when it comes to other forms of esophageal disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
No heartburn issues
86 people found this helpful
NOW brand doesn’t trigger heartburn or acid reflux in my wife. We’ve tried other vitamin C brands that caused her awful heartburn. We've been using NOW vitamin C for a while now (on our second bottle) and she hasn’t experienced any heartburn or acid reflux issues. The pills are not particularly small but are manageable. I can’t recall the last time I was sick, and I genuinely believe that taking vitamin C contributes to that. I typically take two tablets a day (2000 mg total), one with breakfast and another with dinner, and I increase to four when in crowded situations.
Read More
9
Amazing stomach tolerance
This product has been easy on my stomach! I suffer from acid reflux, and regular Vitamin C often upset my stomach. To my surprise, I had no trouble with these 1000mg tablets, even on an empty stomach. One a day is sufficient, but I might increase the dosage to two if I feel a cold coming on.
Read More
9
Safe for severe reflux
I started taking Vitamin C daily in 2016 primarily due to my skin condition. I chose this brand after researching, as it is highly rated. It doesn’t make my urine yellow like others and is not acidic, making it suitable for my severe acid reflux. After six years, it remains my go-to for Vitamin C.
Read More
9
No negative effects
Although I have acid reflux, this vitamin does not have negative effects on me.
Read More
9
No reflux experienced
I take vitamin C, zinc, and other vitamins to support my immune system. I have stayed Covid-free by combining this with wearing a mask and frequent hand washing. The coated tablets are easier to swallow, and despite suffering from reflux, this tablet has not caused me any issues. I take the 1000mg tablet twice a day.
Read More
Frequently Asked Questions
9
No negative effects
Although I have acid reflux, this vitamin does not have negative effects on me.
9
Boosts immunity
I take Vitamin C daily, and this is my favourite brand from iHerb. The potency, quality, and efficacy of this product are outstanding! I've been using it since the pandemic began and it plays a significant role in boosting my immunity. The acidity is mild; I never experience any stomach or reflux issues. Excellent work, NOW!
2
Triggers reflux
1 people found this helpful
I usually take Vitamin C from Sports Research, but since it was out of stock, I decided to try this product for the first time. I’ve been taking it for a week, but I stopped because I frequently burped and experienced acid reflux.
9
Amazing stomach tolerance
This product has been easy on my stomach! I suffer from acid reflux, and regular Vitamin C often upset my stomach. To my surprise, I had no trouble with these 1000mg tablets, even on an empty stomach. One a day is sufficient, but I might increase the dosage to two if I feel a cold coming on.
9
Safe for severe reflux
I started taking Vitamin C daily in 2016 primarily due to my skin condition. I chose this brand after researching, as it is highly rated. It doesn’t make my urine yellow like others and is not acidic, making it suitable for my severe acid reflux. After six years, it remains my go-to for Vitamin C.
9
No reflux experienced
I take vitamin C, zinc, and other vitamins to support my immune system. I have stayed Covid-free by combining this with wearing a mask and frequent hand washing. The coated tablets are easier to swallow, and despite suffering from reflux, this tablet has not caused me any issues. I take the 1000mg tablet twice a day.
9
Blessing for reflux
I love NOW brand vitamins; they work wonderfully for me. The capsules are easy to swallow, and I have no discomfort in my stomach. Given my acid reflux, not all vitamins suit me, but NOW brand feels like a blessing.
6
Caused acid reflux
I would recommend a plain vitamin C instead. The sustained release gave me some acid reflux and heartburn, which occurs because it releases the ascorbic acid over several hours. I don't have this issue when I take a standard vitamin C supplement with food.
7
Antioxidants may reduce cancer risk
We studied how antioxidants, particularly vitamin C, relate to reflux esophagitis and esophageal adenocarcinoma, aiming to uncover potential protective effects. Through a case-control approach involving groups with reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma, we assessed the dietary intake of antioxidants and their relationship with these conditions.
Our findings revealed that a higher overall antioxidant intake was linked to a reduced risk of esophageal adenocarcinoma. Specifically, individuals with the highest vitamin C intake had a significantly lower risk of developing this type of cancer. However, while vitamin C also appeared to reduce the risk of reflux esophagitis, we found no strong connection between vitamin C and Barrett's esophagus, nor with other antioxidants such as vitamin E, carotenoids, zinc, copper, or selenium.
This suggests that while antioxidants could play a role in lowering the risk of esophageal adenocarcinoma, they might be more influential in terms of progression rather than initiating reflux conditions. Overall, our study highlights the potential significance of dietary vitamin C in addressing reflux issues but points out limitations when it comes to other forms of esophageal disorders.
Our findings revealed that a higher overall antioxidant intake was linked to a reduced risk of esophageal adenocarcinoma. Specifically, individuals with the highest vitamin C intake had a significantly lower risk of developing this type of cancer. However, while vitamin C also appeared to reduce the risk of reflux esophagitis, we found no strong connection between vitamin C and Barrett's esophagus, nor with other antioxidants such as vitamin E, carotenoids, zinc, copper, or selenium.
This suggests that while antioxidants could play a role in lowering the risk of esophageal adenocarcinoma, they might be more influential in terms of progression rather than initiating reflux conditions. Overall, our study highlights the potential significance of dietary vitamin C in addressing reflux issues but points out limitations when it comes to other forms of esophageal disorders.
8
We aimed to understand how Vitamin C could help with the toxicity caused by omeprazole, a common treatment for conditions like gastroesophageal reflux disease (GERD) and gastritis. During our study, we examined gastric cells from rabbits to see how Vitamin C, alongside other antioxidants, could protect these cells from damage caused by omeprazole.
We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.
This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.
We found that both omeprazole and another thiol-oxidant, monochloramine, significantly reduced cell viability. Interestingly, the toxicity from omeprazole occurred independently from monochloramine. However, we observed that using Vitamin C effectively protected the gastric cells from this injury, maintaining their function without interfering with omeprazole's intended effects.
This suggests that incorporating Vitamin C into treatment plans for people using proton pump inhibitors (PPIs) like omeprazole could be beneficial. Ultimately, our research highlights the potential of using antioxidants to mitigate the adverse effects often associated with medication for reflux and related conditions.
References
- Murphy SJ, Anderson LA, Ferguson HR, Johnston BT, Watson PR, et al. Dietary antioxidant and mineral intake in humans is associated with reduced risk of esophageal adenocarcinoma but not reflux esophagitis or Barrett's esophagus. J Nutr. 2010;140:1757. 10.3945/jn.110.124362
- Kohler JE, Blass AL, Liu J, Tai K, Soybel DI. Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis. Free Radic Biol Med. 2010;49:786. 10.1016/j.freeradbiomed.2010.05.034
