Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1 g (1,000 mg)
1111%
Rose Hips Powder (Rosa canina) (fruit)
25 mg
†
Top Medical Research Studies
9
We explored the effect of vitamin C on tendon cell degeneration, aiming to find out if it could be an effective treatment for tendinitis. The study involved human-derived tendon cells exposed to oxidative stress, simulating the conditions of tendinopathy. By applying various doses of ascorbic acid, we observed a significant reduction in cell death and oxidative stress in the groups that received vitamin C treatment.
Interestingly, we noted that while both lower and higher vitamin C doses helped with cell survival, the higher dose of 30 mM proved especially effective. It not only preserved the cytoskeletal structure of the tendon cells but also inhibited the expression of a marker linked to aging and degeneration. This suggests that high-dose vitamin C could play a vital role in supporting tendon health and recovery from damage.
In summary, our findings indicate that high-dose vitamin C is a promising option for mitigating tendon cell degeneration. This could provide a new avenue for those suffering from tendinopathy, offering hope for recovery and improved tendon function.
Interestingly, we noted that while both lower and higher vitamin C doses helped with cell survival, the higher dose of 30 mM proved especially effective. It not only preserved the cytoskeletal structure of the tendon cells but also inhibited the expression of a marker linked to aging and degeneration. This suggests that high-dose vitamin C could play a vital role in supporting tendon health and recovery from damage.
In summary, our findings indicate that high-dose vitamin C is a promising option for mitigating tendon cell degeneration. This could provide a new avenue for those suffering from tendinopathy, offering hope for recovery and improved tendon function.
Read More
8
We explored the effects of local treatment with ascorbic acid, commonly known as vitamin C, on the recovery from Achilles tendon injuries. In our study, we used male Wistar rats that underwent Achilles tendon rupture followed by surgical repair. The rats were divided into two groups: one received a saline injection while the other was treated with a 30 mM solution of ascorbic acid.
Over the course of 21 days, we closely monitored both the histological changes in the tendon tissue and the overall functionality of the tendon. What we discovered was quite striking. The group treated with vitamin C showed improved organization of tendon tissue and collagen network, indicating a more effective healing process compared to the control group.
Our findings provide clear evidence that local applications of vitamin C can significantly accelerate recovery in cases of tendon injury. This research brings promising insights for athletes and individuals prone to tendon-related injuries, suggesting that vitamin C treatment might be a valuable addition to recovery protocols.
Over the course of 21 days, we closely monitored both the histological changes in the tendon tissue and the overall functionality of the tendon. What we discovered was quite striking. The group treated with vitamin C showed improved organization of tendon tissue and collagen network, indicating a more effective healing process compared to the control group.
Our findings provide clear evidence that local applications of vitamin C can significantly accelerate recovery in cases of tendon injury. This research brings promising insights for athletes and individuals prone to tendon-related injuries, suggesting that vitamin C treatment might be a valuable addition to recovery protocols.
Read More
8
We examined the role of vitamin C as an antioxidant treatment for rotator cuff degeneration, building on previous findings that showed how a lack of superoxide dismutase 1 can lead to tendon damage in mice. The study involved giving vitamin C or a control solution to both mice with the antioxidant deficiency and wild-type mice over an 8-week period.
When the mice reached 20 weeks of age, we analyzed the rotator cuff tissues. Our results demonstrated that vitamin C significantly reduced harmful changes typically seen in tendon degeneration. For instance, we observed improvements in the structure of the supraspinatus tendon entheses and reductions in histological damage when comparing those treated with vitamin C to those that received the control solution.
These findings suggest that vitamin C can effectively counteract degeneration of the rotator cuff due to oxidative stress, highlighting its potential use in preventing this common injury. By showing improvements in tendon health, we contribute valuable knowledge that could lead to better treatments for conditions like tendonitis.
When the mice reached 20 weeks of age, we analyzed the rotator cuff tissues. Our results demonstrated that vitamin C significantly reduced harmful changes typically seen in tendon degeneration. For instance, we observed improvements in the structure of the supraspinatus tendon entheses and reductions in histological damage when comparing those treated with vitamin C to those that received the control solution.
These findings suggest that vitamin C can effectively counteract degeneration of the rotator cuff due to oxidative stress, highlighting its potential use in preventing this common injury. By showing improvements in tendon health, we contribute valuable knowledge that could lead to better treatments for conditions like tendonitis.
Read More
Most Useful Reviews
9
Enhances immune response
Wonderful! Vitamin C with bioflavonoids for better absorption! A generous dosage of 1000 mg! It acts as an antioxidant, providing protection against free radicals, and supports collagen synthesis for critical tissues including blood vessels and tendons. It enhances the immune system's ability to combat inflammatory diseases, stimulates white blood cell production, and promotes quicker wound healing. Additionally, it aids iron absorption and supports cardiovascular health.
Read More
7.5
Boosts healing process
Great! Vitamin C positively impacts gums, teeth, bone tissue, and regulates blood vessel health. It plays a crucial role in hastening the healing of wounds, improving immunity, and alleviating flu and cold symptoms. In our bodies, vitamin C helps in collagen synthesis, essential for the stability of blood vessels, bones, and tendons. The quality is superb! It contains natural ingredients!
Read More
9
Increases energy levels
The primary role of vitamin C is to aid collagen synthesis, which is vital for the structure of skin, tendons, cartilage, and ligaments. It also supports muscles, teeth, and blood vessel health. Healthy collagen production protects these tissues from premature ageing. I intend to compare the results with other brands, and so far, I have experienced no side effects, feeling a surge of energy despite taking a higher dosage than recommended.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
- All Researches
9.5
We explored whether a nutritional supplement consisting of glucosamine, type II collagen, and vitamin C could effectively relieve pain associated with tendinopathy. Our study involved a randomized control trial at the Konaseema Institute of Medical Sciences from 2017 to 2019, which included 80 patients diagnosed with tendinopathy.
We divided the patients into two groups: 60 received the supplement while 20 were given a placebo. Throughout the study, we conducted regular follow-ups at intervals of two weeks, two months, and six months to gauge pain relief and improvement in symptoms.
The results were promising; nearly 90% of the patients reported complete pain relief after six months. However, while vitamin C was part of the treatment mix, it’s important to note we can’t separate its specific effects from those of glucosamine and collagen. Thus, while the combination appears effective, we can't precisely determine how much, if any, vitamin C contributed to this success.
We also noticed that tendinopathy tends to affect non-athletes more than athletes, a finding that might inform treatment strategies going forward.
We divided the patients into two groups: 60 received the supplement while 20 were given a placebo. Throughout the study, we conducted regular follow-ups at intervals of two weeks, two months, and six months to gauge pain relief and improvement in symptoms.
The results were promising; nearly 90% of the patients reported complete pain relief after six months. However, while vitamin C was part of the treatment mix, it’s important to note we can’t separate its specific effects from those of glucosamine and collagen. Thus, while the combination appears effective, we can't precisely determine how much, if any, vitamin C contributed to this success.
We also noticed that tendinopathy tends to affect non-athletes more than athletes, a finding that might inform treatment strategies going forward.
Read More
9
We explored the effect of vitamin C on tendon cell degeneration, aiming to find out if it could be an effective treatment for tendinitis. The study involved human-derived tendon cells exposed to oxidative stress, simulating the conditions of tendinopathy. By applying various doses of ascorbic acid, we observed a significant reduction in cell death and oxidative stress in the groups that received vitamin C treatment.
Interestingly, we noted that while both lower and higher vitamin C doses helped with cell survival, the higher dose of 30 mM proved especially effective. It not only preserved the cytoskeletal structure of the tendon cells but also inhibited the expression of a marker linked to aging and degeneration. This suggests that high-dose vitamin C could play a vital role in supporting tendon health and recovery from damage.
In summary, our findings indicate that high-dose vitamin C is a promising option for mitigating tendon cell degeneration. This could provide a new avenue for those suffering from tendinopathy, offering hope for recovery and improved tendon function.
Interestingly, we noted that while both lower and higher vitamin C doses helped with cell survival, the higher dose of 30 mM proved especially effective. It not only preserved the cytoskeletal structure of the tendon cells but also inhibited the expression of a marker linked to aging and degeneration. This suggests that high-dose vitamin C could play a vital role in supporting tendon health and recovery from damage.
In summary, our findings indicate that high-dose vitamin C is a promising option for mitigating tendon cell degeneration. This could provide a new avenue for those suffering from tendinopathy, offering hope for recovery and improved tendon function.
Read More
9
We sought to understand how vitamin C, specifically L-ascorbic acid, combined with reduced serum levels, affects the tenogenic differentiation of human adipose-derived mesenchymal stromal cells (ASCs) relevant to tendonitis treatment. In our study, we used cells from three healthy donors and tested various conditions, one of which included 0.5 mM ascorbic acid 2-phosphate alongside a reduced serum concentration of 2% FBS.
Among the conditions tested, we found that the combination of ascorbic acid and lower serum levels significantly boosted the expression of key genes involved in tendon formation. Not only did this treatment enhance the genetic markers related to tenogenesis, but it also increased the production of important collagen proteins that contribute to tendon health, which we measured using Western blot analysis.
Further examination through immunocytochemical staining revealed that vitamin C notably enhanced the deposition of collagen types, indicating better extracellular matrix formation. Importantly, we confirmed through careful analysis that the vitamin C treatment did not induce any harmful reactions that might adversely affect cells in culture.
Our findings affirm the beneficial role of incorporating vitamin C into tendon-focused treatments, especially when paired with lower serum levels. This suggests a promising approach for improving recovery practices for tendon injuries.
Among the conditions tested, we found that the combination of ascorbic acid and lower serum levels significantly boosted the expression of key genes involved in tendon formation. Not only did this treatment enhance the genetic markers related to tenogenesis, but it also increased the production of important collagen proteins that contribute to tendon health, which we measured using Western blot analysis.
Further examination through immunocytochemical staining revealed that vitamin C notably enhanced the deposition of collagen types, indicating better extracellular matrix formation. Importantly, we confirmed through careful analysis that the vitamin C treatment did not induce any harmful reactions that might adversely affect cells in culture.
Our findings affirm the beneficial role of incorporating vitamin C into tendon-focused treatments, especially when paired with lower serum levels. This suggests a promising approach for improving recovery practices for tendon injuries.
Read More
8
Vitamin C shows potential in tendonitis
We aimed to understand how vitamin C, when combined with other natural compounds, could help with tendonitis, a condition marked by pain and inflammation in the tendons. In our study, we evaluated a mix of vitamin C, collagen peptides, resveratrol, and astaxanthin to see how it influenced pro-inflammatory and pro-oxidative factors in human tendon cells, known as tenocytes.
What we found was promising. This mixture significantly reduced the secretion of pro-inflammatory molecules and decreased oxidative stress in the cells. We noted a particular synergy in how these compounds worked together, enhancing overall effectiveness compared to each one used alone.
However, since we didn't focus solely on the effects of vitamin C, we can't specifically pinpoint its isolated benefits for tendonitis. While our results are encouraging about the mixture’s ability to tackle inflammation and oxidative stress, more research is needed to establish the specific role of vitamin C in treating tendonitis.
What we found was promising. This mixture significantly reduced the secretion of pro-inflammatory molecules and decreased oxidative stress in the cells. We noted a particular synergy in how these compounds worked together, enhancing overall effectiveness compared to each one used alone.
However, since we didn't focus solely on the effects of vitamin C, we can't specifically pinpoint its isolated benefits for tendonitis. While our results are encouraging about the mixture’s ability to tackle inflammation and oxidative stress, more research is needed to establish the specific role of vitamin C in treating tendonitis.
Read More
8
We investigated whether vitamin C supplementation could improve tendon healing, focusing specifically on equine superficial digital flexor tendon (SDFT). To do this, we created tendon constructs using cells from the tendon proper and peritenon, and then supplemented these constructs with varying doses of vitamin C.
The results were promising. We observed that vitamin C had anti-inflammatory properties and helped reduce the degenerative processes associated with tendon injuries. Additionally, we noted an increase in collagen content, which is essential for making tendons strong and durable.
When we introduced dexamethasone—a steroid that can inhibit tendon cell function—we found that vitamin C offered some protection, especially for tendon proper cells. However, it did not show the same protective effects for peritenon cells.
While this research indicates that vitamin C may enhance the repair processes in equine tendons, further studies are needed. We plan to explore the effects of vitamin C during times of inflammation and within the natural environment of the tendon in live horses.
The results were promising. We observed that vitamin C had anti-inflammatory properties and helped reduce the degenerative processes associated with tendon injuries. Additionally, we noted an increase in collagen content, which is essential for making tendons strong and durable.
When we introduced dexamethasone—a steroid that can inhibit tendon cell function—we found that vitamin C offered some protection, especially for tendon proper cells. However, it did not show the same protective effects for peritenon cells.
While this research indicates that vitamin C may enhance the repair processes in equine tendons, further studies are needed. We plan to explore the effects of vitamin C during times of inflammation and within the natural environment of the tendon in live horses.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhances immune response
Wonderful! Vitamin C with bioflavonoids for better absorption! A generous dosage of 1000 mg! It acts as an antioxidant, providing protection against free radicals, and supports collagen synthesis for critical tissues including blood vessels and tendons. It enhances the immune system's ability to combat inflammatory diseases, stimulates white blood cell production, and promotes quicker wound healing. Additionally, it aids iron absorption and supports cardiovascular health.
Read More
7.5
Boosts healing process
Great! Vitamin C positively impacts gums, teeth, bone tissue, and regulates blood vessel health. It plays a crucial role in hastening the healing of wounds, improving immunity, and alleviating flu and cold symptoms. In our bodies, vitamin C helps in collagen synthesis, essential for the stability of blood vessels, bones, and tendons. The quality is superb! It contains natural ingredients!
Read More
9
Increases energy levels
The primary role of vitamin C is to aid collagen synthesis, which is vital for the structure of skin, tendons, cartilage, and ligaments. It also supports muscles, teeth, and blood vessel health. Healthy collagen production protects these tissues from premature ageing. I intend to compare the results with other brands, and so far, I have experienced no side effects, feeling a surge of energy despite taking a higher dosage than recommended.
Read More
7.5
Helps remove toxins
Perfectly, Vitamin C slows down the body’s ageing process. It is vital for tendons, ligaments, blood cells, skin, bones, and teeth. It boosts the immune system and accelerates recovery. It also helps cleanse the body of toxins.
Read More
6
Reduces inflammation
Great antioxidant. I trust this brand as they are lab-tested and offer excellent deals for this dosage. It assists in combating colds by boosting my immune system and aids my fitness goals by minimising inflammation of my tendons and muscles.
Read More
Frequently Asked Questions
9
Increases energy levels
The primary role of vitamin C is to aid collagen synthesis, which is vital for the structure of skin, tendons, cartilage, and ligaments. It also supports muscles, teeth, and blood vessel health. Healthy collagen production protects these tissues from premature ageing. I intend to compare the results with other brands, and so far, I have experienced no side effects, feeling a surge of energy despite taking a higher dosage than recommended.
7.5
Boosts healing process
Great! Vitamin C positively impacts gums, teeth, bone tissue, and regulates blood vessel health. It plays a crucial role in hastening the healing of wounds, improving immunity, and alleviating flu and cold symptoms. In our bodies, vitamin C helps in collagen synthesis, essential for the stability of blood vessels, bones, and tendons. The quality is superb! It contains natural ingredients!
6
Reduces inflammation
Great antioxidant. I trust this brand as they are lab-tested and offer excellent deals for this dosage. It assists in combating colds by boosting my immune system and aids my fitness goals by minimising inflammation of my tendons and muscles.
9
Enhances immune response
Wonderful! Vitamin C with bioflavonoids for better absorption! A generous dosage of 1000 mg! It acts as an antioxidant, providing protection against free radicals, and supports collagen synthesis for critical tissues including blood vessels and tendons. It enhances the immune system's ability to combat inflammatory diseases, stimulates white blood cell production, and promotes quicker wound healing. Additionally, it aids iron absorption and supports cardiovascular health.
9
We explored the effect of vitamin C on tendon cell degeneration, aiming to find out if it could be an effective treatment for tendinitis. The study involved human-derived tendon cells exposed to oxidative stress, simulating the conditions of tendinopathy. By applying various doses of ascorbic acid, we observed a significant reduction in cell death and oxidative stress in the groups that received vitamin C treatment.
Interestingly, we noted that while both lower and higher vitamin C doses helped with cell survival, the higher dose of 30 mM proved especially effective. It not only preserved the cytoskeletal structure of the tendon cells but also inhibited the expression of a marker linked to aging and degeneration. This suggests that high-dose vitamin C could play a vital role in supporting tendon health and recovery from damage.
In summary, our findings indicate that high-dose vitamin C is a promising option for mitigating tendon cell degeneration. This could provide a new avenue for those suffering from tendinopathy, offering hope for recovery and improved tendon function.
Interestingly, we noted that while both lower and higher vitamin C doses helped with cell survival, the higher dose of 30 mM proved especially effective. It not only preserved the cytoskeletal structure of the tendon cells but also inhibited the expression of a marker linked to aging and degeneration. This suggests that high-dose vitamin C could play a vital role in supporting tendon health and recovery from damage.
In summary, our findings indicate that high-dose vitamin C is a promising option for mitigating tendon cell degeneration. This could provide a new avenue for those suffering from tendinopathy, offering hope for recovery and improved tendon function.
8
Vitamin C shows potential in tendonitis
We aimed to understand how vitamin C, when combined with other natural compounds, could help with tendonitis, a condition marked by pain and inflammation in the tendons. In our study, we evaluated a mix of vitamin C, collagen peptides, resveratrol, and astaxanthin to see how it influenced pro-inflammatory and pro-oxidative factors in human tendon cells, known as tenocytes.
What we found was promising. This mixture significantly reduced the secretion of pro-inflammatory molecules and decreased oxidative stress in the cells. We noted a particular synergy in how these compounds worked together, enhancing overall effectiveness compared to each one used alone.
However, since we didn't focus solely on the effects of vitamin C, we can't specifically pinpoint its isolated benefits for tendonitis. While our results are encouraging about the mixture’s ability to tackle inflammation and oxidative stress, more research is needed to establish the specific role of vitamin C in treating tendonitis.
What we found was promising. This mixture significantly reduced the secretion of pro-inflammatory molecules and decreased oxidative stress in the cells. We noted a particular synergy in how these compounds worked together, enhancing overall effectiveness compared to each one used alone.
However, since we didn't focus solely on the effects of vitamin C, we can't specifically pinpoint its isolated benefits for tendonitis. While our results are encouraging about the mixture’s ability to tackle inflammation and oxidative stress, more research is needed to establish the specific role of vitamin C in treating tendonitis.
8
We set out to evaluate how vitamin C supplementation could aid in the recovery from tendinopathy, a common issue affecting athletes and active individuals. Our research focused on analyzing studies that looked at vitamin C both on its own and when combined with other treatments.
The findings suggest that vitamin C plays a potentially beneficial role in tendon recovery, mainly by boosting collagen synthesis, which is crucial for tendon health. In cases of vitamin C deficiency, we noted that there is a significant drop in procollagen synthesis and reduced ability to properly process essential amino acids. This can hamper the healing process of tendons and lead to prolonged discomfort.
Our review pointed towards optimal dosages and timing for vitamin C supplementation; however, further research is required to fully understand the best practices. Overall, we believe there is promise in using vitamin C as a therapeutic option to improve recovery from tendinopathy, although more targeted studies are necessary to solidify its role.
The findings suggest that vitamin C plays a potentially beneficial role in tendon recovery, mainly by boosting collagen synthesis, which is crucial for tendon health. In cases of vitamin C deficiency, we noted that there is a significant drop in procollagen synthesis and reduced ability to properly process essential amino acids. This can hamper the healing process of tendons and lead to prolonged discomfort.
Our review pointed towards optimal dosages and timing for vitamin C supplementation; however, further research is required to fully understand the best practices. Overall, we believe there is promise in using vitamin C as a therapeutic option to improve recovery from tendinopathy, although more targeted studies are necessary to solidify its role.
7
Vitamin C's ambiguous tendonitis role
We conducted a study to evaluate how vitamin C works alongside hydrolyzed collagen to help athletes recover from patellar tendinopathy, commonly known as jumper's knee. Our double-blinded, randomized controlled trial involved 76 athletes aged 16 to 40 who had been experiencing symptoms for at least 12 weeks.
Participants were divided into two groups. One group received a daily dose of hydrolyzed collagen and vitamin C, while the other group received a placebo. Both groups engaged in progressive tendon loading exercises designed to alleviate their pain and improve their function. Over the course of 24 weeks, we carefully measured their progress using a specialized scale called the VISA-P, which assesses pain, function, and sports participation.
While we were hopeful about the benefits of vitamin C, the study’s design made it difficult to isolate its specific effect from that of hydrolyzed collagen. Although we collected a wealth of data regarding pain levels and functional improvements, we found that the results would not showcase the vitamin C's effectiveness alone in treating tendonitis. This indicates a need for further research to better understand vitamin C's role in tendon health.
Participants were divided into two groups. One group received a daily dose of hydrolyzed collagen and vitamin C, while the other group received a placebo. Both groups engaged in progressive tendon loading exercises designed to alleviate their pain and improve their function. Over the course of 24 weeks, we carefully measured their progress using a specialized scale called the VISA-P, which assesses pain, function, and sports participation.
While we were hopeful about the benefits of vitamin C, the study’s design made it difficult to isolate its specific effect from that of hydrolyzed collagen. Although we collected a wealth of data regarding pain levels and functional improvements, we found that the results would not showcase the vitamin C's effectiveness alone in treating tendonitis. This indicates a need for further research to better understand vitamin C's role in tendon health.
References
- Ueda S, Ichiseki T, Shimasaki M, Soma D, Sakurai M, et al. Effect of High-Dose Vitamin C on Tendon Cell Degeneration-An In Vitro Study. Int J Mol Sci. 2024;25. doi:10.3390/ijms252413358
- Marzagalli M, Battaglia S, Raimondi M, Fontana F, Cozzi M, et al. Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies. Mediators Inflamm. 2024;2024:5273198. doi:10.1155/2024/5273198
- Mienaltowski MJ, Callahan M, Gonzales NL, Wong A. Examining the Potential of Vitamin C Supplementation in Tissue-Engineered Equine Superficial Digital Flexor Tendon Constructs. Int J Mol Sci. 2023;24. doi:10.3390/ijms242317098
- van Dam L, Terink R, Mensink M, de Vos RJ, Zwerver J. The JUMPFOOD study: additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper's knee) in athletes-study protocol for a double-blind randomized controlled trial. Trials. 2023;24:768. doi:10.1186/s13063-023-07783-2
- Balaji M, Ranganath KV, Pugazhendhi G, Mayasa V, Barathiraja K, et al. Management of tendinopathies among south Indians using collagen II peptide, glucosamine and vitamin C. Bioinformation. 2022;18:558. doi:10.6026/97320630018558
- Uehara H, Itoigawa Y, Morikawa D, Koga A, Tsurukami H, et al. The Effect of Vitamin C and -Acetylcysteine on Tendon-to-Bone Healing in a Rodent Model of Rotator Cuff Repair. Am J Sports Med. 2023;51:1596. doi:10.1177/03635465231160772
- Noriega-González DC, Drobnic F, Caballero-García A, Roche E, Perez-Valdecantos D, et al. Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review. Nutrients. 2022;14. doi:10.3390/nu14132663
- Choudhary A, Sahu S, Vasudeva A, Sheikh NA, Venkataraman S, et al. Comparing Effectiveness of Combination of Collagen Peptide Type-1, Low Molecular Weight Chondroitin Sulphate, Sodium Hyaluronate, and Vitamin-C Versus Oral Diclofenac Sodium in Achilles Tendinopathy: A Prospective Randomized Control Trial. Cureus. 2021;13:e19737. doi:10.7759/cureus.19737
- Martel M, Laumonerie P, Girard M, Dauzere F, Mansat P, et al. Does vitamin C supplementation improve rotator cuff healing? A preliminary study. Eur J Orthop Surg Traumatol. 2022;32:63. doi:10.1007/s00590-021-02926-0
- Bochon K, Zielniok K, Gawlak M, Zawada K, Zarychta-Wiśniewska W, et al. The Effect of L-Ascorbic Acid and Serum Reduction on Tenogenic Differentiation of Human Mesenchymal Stromal Cells. Int J Stem Cells. 2021;14:33. doi:10.15283/ijsc20023
- Souza M, Moraes SAS, de Paula DR, Maciel AA, Batista EJO, et al. Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats. Braz J Med Biol Res. 2019;52:e8290. doi:10.1590/1414-431X20198290
- Chiu CH, Chen P, Chen AC, Chan YS, Hsu KY, et al. Real-Time Monitoring of Ascorbic Acid-Mediated Reduction of Cytotoxic Effects of Analgesics and NSAIDs on Tenocytes Proliferation. Dose Response. 2019;17:1559325819832143. doi:10.1177/1559325819832143
- Oliva F, Maffulli N, Gissi C, Veronesi F, Calciano L, et al. Combined ascorbic acid and T produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study. J Orthop Surg Res. 2019;14:54. doi:10.1186/s13018-019-1098-9
- Morikawa D, Nojiri H, Itoigawa Y, Ozawa Y, Kaneko K, et al. Antioxidant treatment with vitamin C attenuated rotator cuff degeneration caused by oxidative stress in -deficient mice. JSES Open Access. 2018;2:91. doi:10.1016/j.jses.2017.11.003
- Dincel YM, Adanir O, Arikan Y, Caglar AK, Dogru SC, et al. EFFECTS OF HIGH-DOSE VITAMIN C AND HYALURONIC ACID ON TENDON HEALING. Acta Ortop Bras. 2018;26:82. doi:10.1590/1413-785220182602182353
