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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Zinc (from 150 mg Zinc Bisglycinate) (TRAACS™)
30 mg
273%
Pumpkin Seed Oil (Cold Pressed)
250 mg
†
Top Medical Research Studies
8
Zinc improves prostate health in obesity
Zinc Attenuates Prostate Hyperplasia and Inflammatory Injury in Obese Rats by Regulating Zinc Homeostasis and Inhibiting the JAK1/STAT3 Pathway.
Highly relevant to prostate research
We explored how zinc supplementation affects prostate health in obese rats, particularly in terms of prostate inflammation and cell proliferation. The study involved a well-structured experiment with control and treatment groups over eight weeks. Obese rats were given either zinc sulfate or a saline solution, allowing us to compare the effects of zinc directly.
Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.
We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.
Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.
Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.
We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.
Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.
Read More
8
Zinc's role in obesity explored
Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients.
Strong relevance to obesity research
We examined the relationship between zinc levels and obesity by conducting a thorough case-control study involving 104 university students, including 51 individuals with obesity and 53 healthy controls. This research used biochemical tests to measure zinc and copper levels and employed advanced genetic analysis to explore the MTHFR gene.
Our findings revealed that serum zinc levels were notably higher in the obese group compared to their non-obese counterparts. The average zinc level for the individuals with obesity was around 145.1 μg/dl, while for the controls, it was significantly lower at 114.8 μg/dl. Additionally, we uncovered that a specific genetic polymorphism in the MTHFR gene, known as rs1801133, appeared more frequently in those who were obese, suggesting a possible link between this genetic factor and obesity.
In summary, both zinc and the rs1801133 genetic variant seem to be related to obesity risk, with the A allele of rs1801133 being particularly prevalent among obese individuals. These findings point towards the potential for using this genetic marker to identify individuals at a higher risk for developing obesity, adding a layer of complexity to our understanding of obesity and its causes.
Our findings revealed that serum zinc levels were notably higher in the obese group compared to their non-obese counterparts. The average zinc level for the individuals with obesity was around 145.1 μg/dl, while for the controls, it was significantly lower at 114.8 μg/dl. Additionally, we uncovered that a specific genetic polymorphism in the MTHFR gene, known as rs1801133, appeared more frequently in those who were obese, suggesting a possible link between this genetic factor and obesity.
In summary, both zinc and the rs1801133 genetic variant seem to be related to obesity risk, with the A allele of rs1801133 being particularly prevalent among obese individuals. These findings point towards the potential for using this genetic marker to identify individuals at a higher risk for developing obesity, adding a layer of complexity to our understanding of obesity and its causes.
Read More
7
Zinc levels linked to obesity
A pilot study on the relationship between zinc deficiency and anthropometric and metabolic parameters in obese adults in Serbia.
Highly relevant obesity-study insights
We conducted a case-control study to understand how zinc deficiency affects obesity, particularly among Serbian adults. Our research involved 31 obese individuals and 31 controls, focusing on their body measurements, lipid levels, and inflammation markers.
We found that those with obesity had notably lower levels of zinc in their blood compared to those without obesity. In fact, we observed significant negative correlations between zinc levels and factors such as body weight, body mass index, body fat percentage, and triglycerides. This suggests that lower zinc levels might be linked to higher obesity markers.
Additionally, we also saw a positive correlation between zinc and high-density lipoproteins, which are often referred to as "good cholesterol." We discovered relationships between zinc levels and atherosclerotic markers as well, which are important for understanding cardiovascular health.
Our findings indicate that monitoring zinc levels in obese adults could be beneficial in identifying those at higher risk for heart-related issues. While zinc may not be a standalone treatment for obesity, understanding its role helps highlight the broader impact of micronutrients on health.
We found that those with obesity had notably lower levels of zinc in their blood compared to those without obesity. In fact, we observed significant negative correlations between zinc levels and factors such as body weight, body mass index, body fat percentage, and triglycerides. This suggests that lower zinc levels might be linked to higher obesity markers.
Additionally, we also saw a positive correlation between zinc and high-density lipoproteins, which are often referred to as "good cholesterol." We discovered relationships between zinc levels and atherosclerotic markers as well, which are important for understanding cardiovascular health.
Our findings indicate that monitoring zinc levels in obese adults could be beneficial in identifying those at higher risk for heart-related issues. While zinc may not be a standalone treatment for obesity, understanding its role helps highlight the broader impact of micronutrients on health.
Read More
Most Useful Reviews
8
Reduced cravings
I noticed from my first visit that I no longer feel an uncontrollable urge to sweep everything off the table, which is a significant benefit. I have struggled with metabolic disorders, hypothyroidism, and obesity, and I hope that zinc will aid in maintaining my immunity during this second wave. I believe it can help!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.4
9
Zinc's Role in Obesity Management
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.
Significant findings on zinc and obesity
We explored the link between zinc and obesity, particularly its role in managing liver function and blood sugar. Our focus was on a specific zinc efflux transporter gene, known as SLC39A5, which has shown potential in reducing diabetes risk.
In our investigation, we found that specific variants in this gene impacted zinc levels in the body. Mice engineered to lack this transporter exhibited notable improvements when faced with obesity, whether it was genetic or diet-induced. Their liver health improved, and they experienced reductions in high blood sugar levels.
The enhanced liver function seemed to stem from increased zinc levels, which triggered beneficial pathways in the liver. We also noted that these mice demonstrated lower levels of inflammation and fibrosis, especially in a condition mimicking non-alcoholic fatty liver disease. This suggests that targeting the SLC39A5 transporter could be a promising strategy for managing metabolic issues linked to obesity.
In our investigation, we found that specific variants in this gene impacted zinc levels in the body. Mice engineered to lack this transporter exhibited notable improvements when faced with obesity, whether it was genetic or diet-induced. Their liver health improved, and they experienced reductions in high blood sugar levels.
The enhanced liver function seemed to stem from increased zinc levels, which triggered beneficial pathways in the liver. We also noted that these mice demonstrated lower levels of inflammation and fibrosis, especially in a condition mimicking non-alcoholic fatty liver disease. This suggests that targeting the SLC39A5 transporter could be a promising strategy for managing metabolic issues linked to obesity.
Read More
8
Zinc improves prostate health in obesity
Zinc Attenuates Prostate Hyperplasia and Inflammatory Injury in Obese Rats by Regulating Zinc Homeostasis and Inhibiting the JAK1/STAT3 Pathway.
Highly relevant to prostate research
We explored how zinc supplementation affects prostate health in obese rats, particularly in terms of prostate inflammation and cell proliferation. The study involved a well-structured experiment with control and treatment groups over eight weeks. Obese rats were given either zinc sulfate or a saline solution, allowing us to compare the effects of zinc directly.
Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.
We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.
Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.
Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.
We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.
Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.
Read More
8
Zinc's role in obesity explored
Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients.
Strong relevance to obesity research
We examined the relationship between zinc levels and obesity by conducting a thorough case-control study involving 104 university students, including 51 individuals with obesity and 53 healthy controls. This research used biochemical tests to measure zinc and copper levels and employed advanced genetic analysis to explore the MTHFR gene.
Our findings revealed that serum zinc levels were notably higher in the obese group compared to their non-obese counterparts. The average zinc level for the individuals with obesity was around 145.1 μg/dl, while for the controls, it was significantly lower at 114.8 μg/dl. Additionally, we uncovered that a specific genetic polymorphism in the MTHFR gene, known as rs1801133, appeared more frequently in those who were obese, suggesting a possible link between this genetic factor and obesity.
In summary, both zinc and the rs1801133 genetic variant seem to be related to obesity risk, with the A allele of rs1801133 being particularly prevalent among obese individuals. These findings point towards the potential for using this genetic marker to identify individuals at a higher risk for developing obesity, adding a layer of complexity to our understanding of obesity and its causes.
Our findings revealed that serum zinc levels were notably higher in the obese group compared to their non-obese counterparts. The average zinc level for the individuals with obesity was around 145.1 μg/dl, while for the controls, it was significantly lower at 114.8 μg/dl. Additionally, we uncovered that a specific genetic polymorphism in the MTHFR gene, known as rs1801133, appeared more frequently in those who were obese, suggesting a possible link between this genetic factor and obesity.
In summary, both zinc and the rs1801133 genetic variant seem to be related to obesity risk, with the A allele of rs1801133 being particularly prevalent among obese individuals. These findings point towards the potential for using this genetic marker to identify individuals at a higher risk for developing obesity, adding a layer of complexity to our understanding of obesity and its causes.
Read More
8
Zinc helps combat obesity effects
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.
Significant relevance to obesity research
We explored how zinc supplementation affects obesity-related heart issues in a study involving mice. The research focused on understanding the negative changes to the heart caused by a high-fat diet (HFD), which can lead to conditions like insulin resistance and heart inflammation.
Our findings revealed that when zinc was added, it helped counteract some of these health problems by boosting levels of metallothionein, a protein that plays a protective role in the body. In mice that had this protective gene deleted, we observed worsened obesity and heart damage, highlighting the importance of metallothionein in managing metabolic health.
By seeing how these factors interact, we learned that zinc could be beneficial for those struggling with obesity. It seems to work by preventing harmful changes in the heart caused by excessive fat in the diet. Overall, zinc supplementation presents an interesting avenue for enhancing heart health in obese individuals, specifically by stabilizing metal levels and reducing oxidative stress.
Our findings revealed that when zinc was added, it helped counteract some of these health problems by boosting levels of metallothionein, a protein that plays a protective role in the body. In mice that had this protective gene deleted, we observed worsened obesity and heart damage, highlighting the importance of metallothionein in managing metabolic health.
By seeing how these factors interact, we learned that zinc could be beneficial for those struggling with obesity. It seems to work by preventing harmful changes in the heart caused by excessive fat in the diet. Overall, zinc supplementation presents an interesting avenue for enhancing heart health in obese individuals, specifically by stabilizing metal levels and reducing oxidative stress.
Read More
8
Zinc may improve obesity-related sperm issues
Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS).
Zinc treatment effects complex
We explored the effects of zinc on obesity-related issues affecting sperm health using a mouse model. The study involved feeding mice a high-fat diet to induce obesity and then assessing sperm viability and epididymal tissue damage after introducing zinc and other treatments like salubrinal, an inhibitor of endoplasmic reticulum stress.
Our findings revealed that obesity significantly reduces sperm motility and damages the epididymal tissue. Specifically, this condition was accompanied by lower levels of the ZnT9 protein and increased markers of stress and cell death. However, when we introduced zinc supplementation, either alone or in combination with salubrinal, we observed notable improvements.
The treatment helped restore sperm viability, reduced tissue damage, and improved overall markers of health in the epididymal tissue. Importantly, zinc seemed to work by enhancing the ZnT9 protein levels and lessening stress in the cells. This points to zinc's potential in combating sperm-related problems linked to obesity, while also highlighting the complexity of its interactions when combined with other treatments.
Overall, our study suggests encouraging implications for zinc as a viable option in alleviating obesity-related reproductive issues, even though we had to consider the influences of the other treatments involved.
Our findings revealed that obesity significantly reduces sperm motility and damages the epididymal tissue. Specifically, this condition was accompanied by lower levels of the ZnT9 protein and increased markers of stress and cell death. However, when we introduced zinc supplementation, either alone or in combination with salubrinal, we observed notable improvements.
The treatment helped restore sperm viability, reduced tissue damage, and improved overall markers of health in the epididymal tissue. Importantly, zinc seemed to work by enhancing the ZnT9 protein levels and lessening stress in the cells. This points to zinc's potential in combating sperm-related problems linked to obesity, while also highlighting the complexity of its interactions when combined with other treatments.
Overall, our study suggests encouraging implications for zinc as a viable option in alleviating obesity-related reproductive issues, even though we had to consider the influences of the other treatments involved.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8
Reduced cravings
I noticed from my first visit that I no longer feel an uncontrollable urge to sweep everything off the table, which is a significant benefit. I have struggled with metabolic disorders, hypothyroidism, and obesity, and I hope that zinc will aid in maintaining my immunity during this second wave. I believe it can help!
Read More
