Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Zinc (elemental) (from 271 mg Zinc Picolinate)
50 mg
455%
Top Medical Research Studies
9
We set out to understand how zinc impacts vaginal candidiasis, a common condition affecting millions. The research highlighted that the fungus responsible for this infection responds to low zinc levels by producing a protein called Pra1. This protein is linked to inflammation and worsens symptoms of the infection.
Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.
Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.
Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.
Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.
9
We explored how dietary supplements of green-synthesized zinc oxide nanoparticles (ZnO-NPs) could help in controlling candidiasis in Nile tilapia (Oreochromis niloticus). Our study involved 252 healthy tilapia, which we divided into six different groups. This included tilapia on diets contaminated with the fungus Candida albicans and those supplemented with different amounts of ZnO-NPs to assess their effectiveness.
Over eight weeks, we observed that the fish receiving diets with green-synthesized ZnO-NPs showed significant improvements in growth, survival rates, and various immune responses, especially with a supplementation of 40 mg/kg. Notably, these fish had enhanced immune functions, demonstrated by increased serum lysozyme activity and other measures of immune response. Additionally, the presence of ZnO-NPs appeared to have direct antifungal effects on the C. albicans cells, indicating their potential role in aquaculture treatments.
We concluded that supplementing diets with 40 mg/kg of these phyco-synthesized ZnO-NPs could be a promising strategy for managing candidiasis in Nile tilapia, offering a safer and possibly more effective alternative to conventional antifungal agents. This research highlights the benefits of using natural materials in aquaculture for both fish health and disease management.
Over eight weeks, we observed that the fish receiving diets with green-synthesized ZnO-NPs showed significant improvements in growth, survival rates, and various immune responses, especially with a supplementation of 40 mg/kg. Notably, these fish had enhanced immune functions, demonstrated by increased serum lysozyme activity and other measures of immune response. Additionally, the presence of ZnO-NPs appeared to have direct antifungal effects on the C. albicans cells, indicating their potential role in aquaculture treatments.
We concluded that supplementing diets with 40 mg/kg of these phyco-synthesized ZnO-NPs could be a promising strategy for managing candidiasis in Nile tilapia, offering a safer and possibly more effective alternative to conventional antifungal agents. This research highlights the benefits of using natural materials in aquaculture for both fish health and disease management.
9
We explored how a new treatment known as hexyl-aminolevulinate ethosomes, or HAL-ES, affects candidiasis, particularly focusing on its impact on biofilms formed by Candida albicans. Biofilms are tough protective layers created by these fungi, making them resistant to conventional antifungal treatments. Our study found that HAL-ES can effectively weaken these biofilms at different stages, from early formation to maturity, even with just a short exposure time.
One of the most interesting findings from our research is how HAL-ES appears to disrupt zinc homeostasis in the Candida cells. By altering the balance of zinc, HAL-ES seems to hinder the process of protein synthesis in these fungi, impacting their growth and ability to form biofilms. As a result, we observed that not only did HAL-ES enhance the effectiveness of fluconazole, a common antifungal, but it also reduced the expression of certain multidrug resistance genes.
In addition to laboratory tests, we also demonstrated that HAL-ES has therapeutic benefits in real-world scenarios, such as in skin infections caused by Candida. This suggests that using HAL-ES could offer a promising new strategy to tackle the challenges posed by biofilm-related infections through the lens of zinc’s role.
Overall, our study unveils an innovative treatment pathway by targeting zinc homeostasis in Candida albicans, providing hope for better management of these stubborn infections.
One of the most interesting findings from our research is how HAL-ES appears to disrupt zinc homeostasis in the Candida cells. By altering the balance of zinc, HAL-ES seems to hinder the process of protein synthesis in these fungi, impacting their growth and ability to form biofilms. As a result, we observed that not only did HAL-ES enhance the effectiveness of fluconazole, a common antifungal, but it also reduced the expression of certain multidrug resistance genes.
In addition to laboratory tests, we also demonstrated that HAL-ES has therapeutic benefits in real-world scenarios, such as in skin infections caused by Candida. This suggests that using HAL-ES could offer a promising new strategy to tackle the challenges posed by biofilm-related infections through the lens of zinc’s role.
Overall, our study unveils an innovative treatment pathway by targeting zinc homeostasis in Candida albicans, providing hope for better management of these stubborn infections.
Most Useful Reviews
9
Essential for immune support
1 people found this helpful
I adore this zinc due to its large dosage of 50 mg (that's the maximum per day). The picolinate form is ideal for quick and effective absorption. Its price is reasonable as not everything is affordable. Many amino acids and substances like zinc are inexpensive to produce. Zinc from Nau performs exceptionally well. Before I drink alcohol, I take NAC, zinc, vitamin C, and B vitamins since alcohol metabolism relies on zinc-dependent enzyme alcohol dehydrogenase. Zinc is crucial during "anti" courses (anti-parasitic, anti-Candidiasis, etc.), as most immune reactions depend on it. I consistently give zinc to my child during illness, and it is vital for men's health. The appearance of white spots on nails indicates a zinc deficiency.
9
Enhanced sleep quality
I discovered that zinc helps me sleep better. I take one capsule just before bed, and I experience much improved sleep quality. I struggle with adrenal fatigue and Candidiasis, and this product truly makes a difference. When combined with the Pancreas supplement, Adrenal (both from Nutroligy), NAC, and Adrenal Health from Gaia Herbs, I feel a significant enhancement. When I forget to take it, my sleep suffers.
7.5
Improved skin condition
19 people found this helpful
My skin is in excellent condition since I started drinking this after the intestinal environmental improvement programme. I was previously concerned about hair loss, but now I hardly think about it. With the improvement of my intestinal environment, the Candidiasis did not block the absorption of zinc, leading to better nutrient uptake. I've read about this on international sites, and it genuinely feels that way.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
- All Researches
9
We set out to understand how zinc impacts vaginal candidiasis, a common condition affecting millions. The research highlighted that the fungus responsible for this infection responds to low zinc levels by producing a protein called Pra1. This protein is linked to inflammation and worsens symptoms of the infection.
Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.
Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.
Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.
Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.
9
We investigated the potential of zinc oxide nanoparticles (ZnO-NPs) to enhance antifungal treatments against candidiasis—a persistent fungal infection. By using an environmentally friendly approach to synthesize these nanoparticles from plant extracts, we set out to understand their effectiveness on common candidal pathogens, particularly focusing on how they work alongside established antifungal medications.
Our experiments involved testing the antifungal activity of the ZnO-NPs through a method known as disk diffusion. We discovered that one particular strain of Candida was highly susceptible to the zinc nanoparticles, showing impressive inhibition zones at both tested concentrations. The minimum inhibitory concentration (MIC) against this strain was found to be 40 µg/mL, with the minimum fungicidal concentration (MFC) at 80 µg/mL.
Moreover, we observed a remarkable synergy between ZnO-NPs and antifungal drugs like terbinafine and fluconazole, which led to significantly increased effectiveness against certain strains. Scanning electron microscopy revealed that the zinc nanoparticles caused noticeable changes in the candidal cells, such as abnormal cell membrane structures, which likely contribute to their antifungal action.
In conclusion, our findings highlight the potential of using biogenic zinc oxide nanoparticles in combination with traditional antifungals, showcasing their promising role in developing more effective treatments for candidiasis.
Our experiments involved testing the antifungal activity of the ZnO-NPs through a method known as disk diffusion. We discovered that one particular strain of Candida was highly susceptible to the zinc nanoparticles, showing impressive inhibition zones at both tested concentrations. The minimum inhibitory concentration (MIC) against this strain was found to be 40 µg/mL, with the minimum fungicidal concentration (MFC) at 80 µg/mL.
Moreover, we observed a remarkable synergy between ZnO-NPs and antifungal drugs like terbinafine and fluconazole, which led to significantly increased effectiveness against certain strains. Scanning electron microscopy revealed that the zinc nanoparticles caused noticeable changes in the candidal cells, such as abnormal cell membrane structures, which likely contribute to their antifungal action.
In conclusion, our findings highlight the potential of using biogenic zinc oxide nanoparticles in combination with traditional antifungals, showcasing their promising role in developing more effective treatments for candidiasis.
9
We explored how a new treatment known as hexyl-aminolevulinate ethosomes, or HAL-ES, affects candidiasis, particularly focusing on its impact on biofilms formed by Candida albicans. Biofilms are tough protective layers created by these fungi, making them resistant to conventional antifungal treatments. Our study found that HAL-ES can effectively weaken these biofilms at different stages, from early formation to maturity, even with just a short exposure time.
One of the most interesting findings from our research is how HAL-ES appears to disrupt zinc homeostasis in the Candida cells. By altering the balance of zinc, HAL-ES seems to hinder the process of protein synthesis in these fungi, impacting their growth and ability to form biofilms. As a result, we observed that not only did HAL-ES enhance the effectiveness of fluconazole, a common antifungal, but it also reduced the expression of certain multidrug resistance genes.
In addition to laboratory tests, we also demonstrated that HAL-ES has therapeutic benefits in real-world scenarios, such as in skin infections caused by Candida. This suggests that using HAL-ES could offer a promising new strategy to tackle the challenges posed by biofilm-related infections through the lens of zinc’s role.
Overall, our study unveils an innovative treatment pathway by targeting zinc homeostasis in Candida albicans, providing hope for better management of these stubborn infections.
One of the most interesting findings from our research is how HAL-ES appears to disrupt zinc homeostasis in the Candida cells. By altering the balance of zinc, HAL-ES seems to hinder the process of protein synthesis in these fungi, impacting their growth and ability to form biofilms. As a result, we observed that not only did HAL-ES enhance the effectiveness of fluconazole, a common antifungal, but it also reduced the expression of certain multidrug resistance genes.
In addition to laboratory tests, we also demonstrated that HAL-ES has therapeutic benefits in real-world scenarios, such as in skin infections caused by Candida. This suggests that using HAL-ES could offer a promising new strategy to tackle the challenges posed by biofilm-related infections through the lens of zinc’s role.
Overall, our study unveils an innovative treatment pathway by targeting zinc homeostasis in Candida albicans, providing hope for better management of these stubborn infections.
9
We explored how dietary supplements of green-synthesized zinc oxide nanoparticles (ZnO-NPs) could help in controlling candidiasis in Nile tilapia (Oreochromis niloticus). Our study involved 252 healthy tilapia, which we divided into six different groups. This included tilapia on diets contaminated with the fungus Candida albicans and those supplemented with different amounts of ZnO-NPs to assess their effectiveness.
Over eight weeks, we observed that the fish receiving diets with green-synthesized ZnO-NPs showed significant improvements in growth, survival rates, and various immune responses, especially with a supplementation of 40 mg/kg. Notably, these fish had enhanced immune functions, demonstrated by increased serum lysozyme activity and other measures of immune response. Additionally, the presence of ZnO-NPs appeared to have direct antifungal effects on the C. albicans cells, indicating their potential role in aquaculture treatments.
We concluded that supplementing diets with 40 mg/kg of these phyco-synthesized ZnO-NPs could be a promising strategy for managing candidiasis in Nile tilapia, offering a safer and possibly more effective alternative to conventional antifungal agents. This research highlights the benefits of using natural materials in aquaculture for both fish health and disease management.
Over eight weeks, we observed that the fish receiving diets with green-synthesized ZnO-NPs showed significant improvements in growth, survival rates, and various immune responses, especially with a supplementation of 40 mg/kg. Notably, these fish had enhanced immune functions, demonstrated by increased serum lysozyme activity and other measures of immune response. Additionally, the presence of ZnO-NPs appeared to have direct antifungal effects on the C. albicans cells, indicating their potential role in aquaculture treatments.
We concluded that supplementing diets with 40 mg/kg of these phyco-synthesized ZnO-NPs could be a promising strategy for managing candidiasis in Nile tilapia, offering a safer and possibly more effective alternative to conventional antifungal agents. This research highlights the benefits of using natural materials in aquaculture for both fish health and disease management.
8
We explored the effectiveness of a novel zinc-chelating compound characterized as an alkyl polyamine compound (APC), discovering its potential as an antifungal agent against various species of Candida. The study highlights the innovative approach of depriving fungi of essential metals like zinc—a strategy that could significantly impact treatment options for drug-resistant candidiasis, especially in vulnerable populations.
By examining the compound's antifungal activity using methods like transcriptomics and intracellular zinc quantification, we confirmed the ability of this specific compound, APC6, to effectively capture zinc within fungal cells. Not only was APC6 able to work well on its own, but it also boosted the effectiveness of existing antifungal drugs, specifically voriconazole, enhancing treatment outcomes when used together.
Additionally, we found that APC6 could disrupt the biofilms that Candida species form, which are often resistant to treatment. This dual action indicates that regulating zinc levels within these fungi could be a promising new method for tackling persistent cases of candidiasis that don't respond to conventional medications.
By examining the compound's antifungal activity using methods like transcriptomics and intracellular zinc quantification, we confirmed the ability of this specific compound, APC6, to effectively capture zinc within fungal cells. Not only was APC6 able to work well on its own, but it also boosted the effectiveness of existing antifungal drugs, specifically voriconazole, enhancing treatment outcomes when used together.
Additionally, we found that APC6 could disrupt the biofilms that Candida species form, which are often resistant to treatment. This dual action indicates that regulating zinc levels within these fungi could be a promising new method for tackling persistent cases of candidiasis that don't respond to conventional medications.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for immune support
1 people found this helpful
I adore this zinc due to its large dosage of 50 mg (that's the maximum per day). The picolinate form is ideal for quick and effective absorption. Its price is reasonable as not everything is affordable. Many amino acids and substances like zinc are inexpensive to produce. Zinc from Nau performs exceptionally well. Before I drink alcohol, I take NAC, zinc, vitamin C, and B vitamins since alcohol metabolism relies on zinc-dependent enzyme alcohol dehydrogenase. Zinc is crucial during "anti" courses (anti-parasitic, anti-Candidiasis, etc.), as most immune reactions depend on it. I consistently give zinc to my child during illness, and it is vital for men's health. The appearance of white spots on nails indicates a zinc deficiency.
9
Enhanced sleep quality
I discovered that zinc helps me sleep better. I take one capsule just before bed, and I experience much improved sleep quality. I struggle with adrenal fatigue and Candidiasis, and this product truly makes a difference. When combined with the Pancreas supplement, Adrenal (both from Nutroligy), NAC, and Adrenal Health from Gaia Herbs, I feel a significant enhancement. When I forget to take it, my sleep suffers.
7.5
Improved skin condition
19 people found this helpful
My skin is in excellent condition since I started drinking this after the intestinal environmental improvement programme. I was previously concerned about hair loss, but now I hardly think about it. With the improvement of my intestinal environment, the Candidiasis did not block the absorption of zinc, leading to better nutrient uptake. I've read about this on international sites, and it genuinely feels that way.
Frequently Asked Questions
9
Enhanced sleep quality
I discovered that zinc helps me sleep better. I take one capsule just before bed, and I experience much improved sleep quality. I struggle with adrenal fatigue and Candidiasis, and this product truly makes a difference. When combined with the Pancreas supplement, Adrenal (both from Nutroligy), NAC, and Adrenal Health from Gaia Herbs, I feel a significant enhancement. When I forget to take it, my sleep suffers.
7.5
Improved skin condition
19 people found this helpful
My skin is in excellent condition since I started drinking this after the intestinal environmental improvement programme. I was previously concerned about hair loss, but now I hardly think about it. With the improvement of my intestinal environment, the Candidiasis did not block the absorption of zinc, leading to better nutrient uptake. I've read about this on international sites, and it genuinely feels that way.
9
Essential for immune support
1 people found this helpful
I adore this zinc due to its large dosage of 50 mg (that's the maximum per day). The picolinate form is ideal for quick and effective absorption. Its price is reasonable as not everything is affordable. Many amino acids and substances like zinc are inexpensive to produce. Zinc from Nau performs exceptionally well. Before I drink alcohol, I take NAC, zinc, vitamin C, and B vitamins since alcohol metabolism relies on zinc-dependent enzyme alcohol dehydrogenase. Zinc is crucial during "anti" courses (anti-parasitic, anti-Candidiasis, etc.), as most immune reactions depend on it. I consistently give zinc to my child during illness, and it is vital for men's health. The appearance of white spots on nails indicates a zinc deficiency.
9
We investigated the potential of zinc oxide nanoparticles (ZnO-NPs) to enhance antifungal treatments against candidiasis—a persistent fungal infection. By using an environmentally friendly approach to synthesize these nanoparticles from plant extracts, we set out to understand their effectiveness on common candidal pathogens, particularly focusing on how they work alongside established antifungal medications.
Our experiments involved testing the antifungal activity of the ZnO-NPs through a method known as disk diffusion. We discovered that one particular strain of Candida was highly susceptible to the zinc nanoparticles, showing impressive inhibition zones at both tested concentrations. The minimum inhibitory concentration (MIC) against this strain was found to be 40 µg/mL, with the minimum fungicidal concentration (MFC) at 80 µg/mL.
Moreover, we observed a remarkable synergy between ZnO-NPs and antifungal drugs like terbinafine and fluconazole, which led to significantly increased effectiveness against certain strains. Scanning electron microscopy revealed that the zinc nanoparticles caused noticeable changes in the candidal cells, such as abnormal cell membrane structures, which likely contribute to their antifungal action.
In conclusion, our findings highlight the potential of using biogenic zinc oxide nanoparticles in combination with traditional antifungals, showcasing their promising role in developing more effective treatments for candidiasis.
Our experiments involved testing the antifungal activity of the ZnO-NPs through a method known as disk diffusion. We discovered that one particular strain of Candida was highly susceptible to the zinc nanoparticles, showing impressive inhibition zones at both tested concentrations. The minimum inhibitory concentration (MIC) against this strain was found to be 40 µg/mL, with the minimum fungicidal concentration (MFC) at 80 µg/mL.
Moreover, we observed a remarkable synergy between ZnO-NPs and antifungal drugs like terbinafine and fluconazole, which led to significantly increased effectiveness against certain strains. Scanning electron microscopy revealed that the zinc nanoparticles caused noticeable changes in the candidal cells, such as abnormal cell membrane structures, which likely contribute to their antifungal action.
In conclusion, our findings highlight the potential of using biogenic zinc oxide nanoparticles in combination with traditional antifungals, showcasing their promising role in developing more effective treatments for candidiasis.
9
We set out to understand how zinc impacts vaginal candidiasis, a common condition affecting millions. The research highlighted that the fungus responsible for this infection responds to low zinc levels by producing a protein called Pra1. This protein is linked to inflammation and worsens symptoms of the infection.
Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.
Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.
Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.
Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.
References
- Shinohara T, Wada A, Abe M, Nakayama N, Nagi M, et al. A novel zinc-chelating compound has antifungal activity against a wide range of species, including multidrug-resistant . JAC Antimicrob Resist. 2024;6:dlad155. doi:10.1093/jacamr/dlad155
- Roselletti E, Pericolini E, Nore A, Takacs P, Kozma B, et al. Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein. Sci Transl Med. 2023;15:eadi3363. doi:10.1126/scitranslmed.adi3363
- Yassin MT, Al-Otibi FO, Al-Askar AA, Elmaghrabi MM. Synergistic Anticandidal Effectiveness of Greenly Synthesized Zinc Oxide Nanoparticles with Antifungal Agents against Nosocomial Candidal Pathogens. Microorganisms. 2023;11. doi:10.3390/microorganisms11081957
- Wang Y, Long W, Zhang F, Zhang M, Zeng K, et al. Hexyl-Aminolevulinate Ethosomes: a Novel Antibiofilm Agent Targeting Zinc Homeostasis in Candida albicans. Microbiol Spectr. 2022;10:e0243822. doi:10.1128/spectrum.02438-22
- Diab AM, Shokr BT, Shukry M, Farrag FA, Mohamed RA. Effects of Dietary Supplementation with Green-Synthesized Zinc Oxide Nanoparticles for Candidiasis Control in Oreochromis niloticus. Biol Trace Elem Res. 2022;200:4126. doi:10.1007/s12011-021-02985-8
- Hosseini SS, Joshaghani H, Shokohi T, Ahmadi A, Mehrbakhsh Z. Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1-3 Genes Expression in Fluconazole-Resistant Isolates from Vulvovaginal Candidiasis. Infect Drug Resist. 2020;13:385. doi:10.2147/IDR.S226154
