Last update
4/6/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Zinc (elemental) (from 271 mg Zinc Picolinate)
50 mg
455%
Top Medical Research Studies
9
We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
Read More
Most Useful Reviews
8
Supports wound healing
1 people found this helpful
A must for wound healing. After extensive research, I chose picolinate and have no regrets. It alleviates heartburn and is essential for those with a compromised immune system, alongside vitamin C like sodium ascorbate powder.
Read More
9
No heartburn
I always took it for immunity, but switching from zinc citrate to picolinate eliminated heartburn for me.
Read More
9
Heartburn-free option
My favourite zinc form is picolinate; there’s no heartburn, it's convenient, and I find this cheaper option just as good as Thorne's.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
8
Supports wound healing
1 people found this helpful
A must for wound healing. After extensive research, I chose picolinate and have no regrets. It alleviates heartburn and is essential for those with a compromised immune system, alongside vitamin C like sodium ascorbate powder.
Read More
9
No heartburn
I always took it for immunity, but switching from zinc citrate to picolinate eliminated heartburn for me.
Read More
9
Heartburn-free option
My favourite zinc form is picolinate; there’s no heartburn, it's convenient, and I find this cheaper option just as good as Thorne's.
Read More
1
Caused heartburn
One of the best zinc forms, but after 10 days of taking it, I developed heartburn, which is unusual for me.
Read More
0
Caused discomfort
I usually respect this manufacturer, but alas, zinc didn’t suit me. I experienced heartburn and gastrointestinal heaviness, leading me to stop taking it. Be cautious if your gut isn't in order.
Read More
Frequently Asked Questions
9
No heartburn
I always took it for immunity, but switching from zinc citrate to picolinate eliminated heartburn for me.
1
Caused heartburn
One of the best zinc forms, but after 10 days of taking it, I developed heartburn, which is unusual for me.
0
Caused discomfort
I usually respect this manufacturer, but alas, zinc didn’t suit me. I experienced heartburn and gastrointestinal heaviness, leading me to stop taking it. Be cautious if your gut isn't in order.
9
Heartburn-free option
My favourite zinc form is picolinate; there’s no heartburn, it's convenient, and I find this cheaper option just as good as Thorne's.
8
Supports wound healing
1 people found this helpful
A must for wound healing. After extensive research, I chose picolinate and have no regrets. It alleviates heartburn and is essential for those with a compromised immune system, alongside vitamin C like sodium ascorbate powder.
7.5
Pre-meal advice
Zinc, magnesium, and vitamin D are essential, but should be taken before meals to avoid heartburn.
9
We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
References
- Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. 10.1016/j.nut.2023.111999
