Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine hydrochloride)
10 mg
588%
Magnesium (as magnesium aspartate, magnesium oxide)
435 mg
104%
Zinc (as zinc aspartate, zinc monomethionine, zinc oxide)
28 mg
255%
Top Medical Research Studies
9.5
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Read More
9
We investigated whether supplementation with alkaline minerals could ease chronic low back pain. In a study with 82 participants, those who took a lactose-based alkaline multimineral supplement for four weeks reported a significant 49% reduction in pain scores.
We also noted an increase in blood buffering capacity and pH, indicating an improved acid-base balance. Although intracellular magnesium levels increased, plasma magnesium slightly decreased, suggesting that while the supplementation helped alleviate pain, it didn't significantly impact magnesium levels overall.
This study highlights the potential benefits of correcting acid-base balance to reduce low back pain symptoms.
We also noted an increase in blood buffering capacity and pH, indicating an improved acid-base balance. Although intracellular magnesium levels increased, plasma magnesium slightly decreased, suggesting that while the supplementation helped alleviate pain, it didn't significantly impact magnesium levels overall.
This study highlights the potential benefits of correcting acid-base balance to reduce low back pain symptoms.
Read More
7
We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.
Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.
Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.
Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.
Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.
Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.
Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.
Read More
Most Useful Reviews
9
Chronic pain diminished
1 people found this helpful
For the past year, using a specific recipe has significantly crushed my fibromyalgia and plantar fasciitis. Taking three capsules each night has led to a complete disappearance of chronic pain. If I substitute any ingredient, the pain returns. This concoction has been transformational for me.
Read More
7.5
Pain relief noted
5 people found this helpful
I need surgery – that’s how severe my condition is. However, I noticed relief from my tennis elbow pain after only two days of using this product. I usually wear a brace but forgot it the second day, and the pain was significantly less. I have ongoing issues like degenerative disk disease and back pain. Surprisingly, this product hasn’t triggered any adverse effects for me, making it worthwhile to continue.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
- All Researches
9.5
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Read More
9
We examined a randomized double-blind study that explored the impact of adding B vitamins, specifically B1, B6, and B12, to the treatment regimen of diclofenac for patients suffering from lower back pain due to degenerative spinal conditions.
During the study, 256 individuals participated, with some receiving diclofenac alone while others were given diclofenac alongside B vitamins for a maximum of two weeks. Interestingly, those in the group taking the B vitamins reported significantly better pain relief, allowing more patients to stop treatment early due to decreased symptoms.
While we documented some side effects, they were not significantly different between the two groups. Overall, the results indicated that incorporating B vitamins can enhance the effectiveness of diclofenac therapy, potentially allowing for less reliance on this medication for pain relief.
However, it’s important to note that the specific benefits of vitamin B6 alone on back pain cannot be definitively determined from this study, as it focused on a combination of B vitamins.
During the study, 256 individuals participated, with some receiving diclofenac alone while others were given diclofenac alongside B vitamins for a maximum of two weeks. Interestingly, those in the group taking the B vitamins reported significantly better pain relief, allowing more patients to stop treatment early due to decreased symptoms.
While we documented some side effects, they were not significantly different between the two groups. Overall, the results indicated that incorporating B vitamins can enhance the effectiveness of diclofenac therapy, potentially allowing for less reliance on this medication for pain relief.
However, it’s important to note that the specific benefits of vitamin B6 alone on back pain cannot be definitively determined from this study, as it focused on a combination of B vitamins.
Read More
9
Dolo-Neurobion's effectiveness in pain
We explored the use of Dolo-Neurobion for managing acute pain in the lumbosacral area, particularly when linked to problems in the surrounding pelvic organs. This treatment combines neurotropic vitamins B1, B6, and B12 with the analgesic metamizole, forming an interesting approach to dealing with this kind of pain.
In our evaluation involving 53 patients, we found that the overall effectiveness of Dolo-Neurobion was quite promising. The treatment initially began with injections, followed by oral doses, which showed good to excellent results in 77.4% of the patients and moderate effects in 15.1%.
While vitamin B6 plays a role as part of this combination therapy, it’s complex to isolate its specific contribution to alleviating back pain due to the presence of other active ingredients. No major side effects or intolerance were reported, making it a fairly safe option for those suffering from lumbosacral discomfort.
In our evaluation involving 53 patients, we found that the overall effectiveness of Dolo-Neurobion was quite promising. The treatment initially began with injections, followed by oral doses, which showed good to excellent results in 77.4% of the patients and moderate effects in 15.1%.
While vitamin B6 plays a role as part of this combination therapy, it’s complex to isolate its specific contribution to alleviating back pain due to the presence of other active ingredients. No major side effects or intolerance were reported, making it a fairly safe option for those suffering from lumbosacral discomfort.
Read More
9
We conducted a double-blind study to evaluate the effectiveness of magnesium therapy for chronic low back pain that has a neuropathic component. Our research involved 80 patients, all of whom were already engaged in physical therapy and taking medications like anticonvulsants and antidepressants.
Among the participants, we divided them into two groups: one group received a placebo for six weeks, while the other group was treated with a two-week intravenous magnesium infusion followed by four weeks of oral magnesium supplements.
The results were promising for those in the magnesium group. By the end of the study, their pain intensity decreased significantly, with scores dropping from an average of 7.5 to 4.7 over six months. Additionally, we observed notable improvements in their lumbar spine mobility, suggesting that magnesium therapy could be beneficial for those suffering from this type of chronic pain.
Overall, our findings indicate that sequential intravenous and oral magnesium treatment can effectively ease pain and enhance mobility in individuals with refractory low back pain featuring a neuropathic aspect.
Among the participants, we divided them into two groups: one group received a placebo for six weeks, while the other group was treated with a two-week intravenous magnesium infusion followed by four weeks of oral magnesium supplements.
The results were promising for those in the magnesium group. By the end of the study, their pain intensity decreased significantly, with scores dropping from an average of 7.5 to 4.7 over six months. Additionally, we observed notable improvements in their lumbar spine mobility, suggesting that magnesium therapy could be beneficial for those suffering from this type of chronic pain.
Overall, our findings indicate that sequential intravenous and oral magnesium treatment can effectively ease pain and enhance mobility in individuals with refractory low back pain featuring a neuropathic aspect.
Read More
9
We investigated whether supplementation with alkaline minerals could ease chronic low back pain. In a study with 82 participants, those who took a lactose-based alkaline multimineral supplement for four weeks reported a significant 49% reduction in pain scores.
We also noted an increase in blood buffering capacity and pH, indicating an improved acid-base balance. Although intracellular magnesium levels increased, plasma magnesium slightly decreased, suggesting that while the supplementation helped alleviate pain, it didn't significantly impact magnesium levels overall.
This study highlights the potential benefits of correcting acid-base balance to reduce low back pain symptoms.
We also noted an increase in blood buffering capacity and pH, indicating an improved acid-base balance. Although intracellular magnesium levels increased, plasma magnesium slightly decreased, suggesting that while the supplementation helped alleviate pain, it didn't significantly impact magnesium levels overall.
This study highlights the potential benefits of correcting acid-base balance to reduce low back pain symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Chronic pain diminished
1 people found this helpful
For the past year, using a specific recipe has significantly crushed my fibromyalgia and plantar fasciitis. Taking three capsules each night has led to a complete disappearance of chronic pain. If I substitute any ingredient, the pain returns. This concoction has been transformational for me.
Read More
7.5
Pain relief noted
5 people found this helpful
I need surgery – that’s how severe my condition is. However, I noticed relief from my tennis elbow pain after only two days of using this product. I usually wear a brace but forgot it the second day, and the pain was significantly less. I have ongoing issues like degenerative disk disease and back pain. Surprisingly, this product hasn’t triggered any adverse effects for me, making it worthwhile to continue.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25:2589. doi:10.3111/13696990903246911
- Jurna I. [Analgesic and analgesia-potentiating action of B vitamins]. Schmerz. 1998;12:136.
- Brüggemann G, Koehler CO, Koch EM. [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr. 1990;68:116.
- Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, et al. [Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes]. Z Rheumatol. 1988;47:351.
- Kunt T. [Complaints in the lumbosacral region and their management with Dolo-Neurobion]. Fortschr Med. 1978;96:299.
- Dadkhah P, Hashemi M, Taheri M, Alizadeh Ojoor A, Jaffari M, et al. A Comparison of Analgesic Efficacy of Triamcinolone vs Magnesium Sulfate as Adjuvants in Caudal Block in Patients with Low Back Pain: A Double-Blind Randomized Controlled Trial. Anesth Pain Med. 2024;14:e145718. doi:10.5812/aapm-145718
- Zhang T, Wang Y, Li R, Xin J, Zheng Z, et al. ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration. Acta Biomater. 2023;158:475. doi:10.1016/j.actbio.2023.01.020
- Celenlioglu AE, Sir E, Ors-Yildirim N, Yildirim AK, Ince ME, et al. Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting. J Vasc Surg Venous Lymphat Disord. 2023;11:517. doi:10.1016/j.jvsv.2022.09.008
- Marchesi N, Govoni S, Allegri M. Non-drug pain relievers active on non-opioid pain mechanisms. Pain Pract. 2022;22:255. doi:10.1111/papr.13073
- Huber D, Grafetstätter C, Proßegger J, Pichler C, Wöll E, et al. Green exercise and mg-ca-SO thermal balneotherapy for the treatment of non-specific chronic low back pain: a randomized controlled clinical trial. BMC Musculoskelet Disord. 2019;20:221. doi:10.1186/s12891-019-2582-4
- Yousef AA, Al-deeb AE. A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia. 2013;68:260. doi:10.1111/anae.12107
- Vormann J, Worlitschek M, Goedecke T, Silver B. Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain. J Trace Elem Med Biol. 2001;15:179.
- Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3
- Bhardwaj A, Swe KM, Sinha NK, Osunkwo I. Treatment for osteoporosis in people with ß-thalassaemia. Cochrane Database Syst Rev. 2016;3:CD010429. doi:10.1002/14651858.CD010429.pub2
