Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine hydrochloride)
10 mg
588%
Magnesium (as magnesium aspartate, magnesium oxide)
435 mg
104%
Zinc (as zinc aspartate, zinc monomethionine, zinc oxide)
28 mg
255%
Top Medical Research Studies
8
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Read More
7
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Read More
9.5
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.
We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.
The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.
The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
Read More
Most Useful Reviews
9
Easier bathroom visits
Excellent, it assisted me with sleeping and made going to the bathroom easier, as I suffer from irritable bowel syndrome.
Read More
6
Improved bowel movements
Taking magnesium enhances bowel movements and is beneficial for dieting.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.3
- All Researches
9.5
In our exploration of how vitamin B6 influences irritable bowel syndrome (IBS), we conducted a controlled, double-blind study involving 25 IBS patients who met the Rome IV criteria. These individuals were randomly assigned to receive either a novel formulation combining Bifidobacterium longum BB536, Lactobacillus rhamnosus HN001, and vitamin B6, or a placebo for one month before switching treatments.
We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.
The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
We observed significant improvements in several IBS symptoms when patients were treated with the vitamin B6 probiotic combination compared to the placebo. Specifically, abdominal pain showed a notable decrease of nearly 49%, and bloating symptoms dropped by over 36%. Furthermore, the overall severity of the disease lessened substantially, suggesting that vitamin B6 in conjunction with these probiotics may play an essential role in managing IBS.
The trial also revealed improvements in intestinal permeability, which is a key factor in gut health. We noted an increase in beneficial gut bacteria, which indicates a revitalization of the intestinal microbiota during treatment. While the study's findings support the benefits of the B6 probiotic blend in alleviating IBS symptoms, it is important to recognize that these symptoms could be related to the probiotics themselves rather than the vitamin B6 alone.
Read More
8
We conducted a study to assess the effectiveness of a dry jelly concentrate containing vitamin B6, along with inulin and curcumin, on patients with irritable bowel syndrome (IBS) with constipation (IBS-C). Fifty patients who met the criteria for IBS-C were divided into two groups. One group received the jelly drinks alongside a standard diet for two weeks, while the control group followed the standard diet only.
Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.
It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.
Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
Throughout the study, we carefully monitored changes in abdominal pain, bloating, stool frequency, and overall quality of life. The results showed that those who consumed the jelly concentrate experienced significant improvements in several gastrointestinal parameters. For instance, stool frequency increased, abdominal pain decreased, and there was a notable enhancement in quality of life ratings.
It's worth mentioning that while vitamin B6 was part of the jelly formulation, the specific benefits attributed solely to vitamin B6 are difficult to isolate. The improvements in the jelly group indicate that the combination of ingredients worked well together to alleviate symptoms of IBS-C. However, the control group did show some improvement in pain and bloating, which suggests that dietary factors alone can also play a role.
Overall, the inclusion of this jelly concentrate could be a beneficial addition for patients suffering from IBS-C, particularly due to its positive effects on stool parameters and quality of life. The study did not report any significant adverse effects, making this product a potentially safe option for those looking to manage their symptoms.
Read More
8
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Read More
7
We explored the relationship between vitamin B6 intake and the severity of symptoms in individuals with irritable bowel syndrome (IBS). Through a study involving 17 participants diagnosed with IBS according to the Rome II criteria, we gathered daily symptom reports and food intake logs over a week.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Our findings indicated that the only significant dietary component linked to symptom severity was vitamin B6. Participants generally consumed less than the recommended daily intake of vitamin B6, averaging just 0.9 mg per day, compared to the suggested amounts of 1.6 mg for men and 1.2 mg for women. Notably, a higher symptom score correlated with lower vitamin B6 consumption.
This suggests that individuals with IBS may benefit from increasing their vitamin B6 intake. Although this study has limitations—being small in scale and cross-sectional—it highlights a potential dietary factor that may impact the management of IBS symptoms.
Read More
4
We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Easier bathroom visits
Excellent, it assisted me with sleeping and made going to the bathroom easier, as I suffer from irritable bowel syndrome.
Read More
6
Improved bowel movements
Taking magnesium enhances bowel movements and is beneficial for dieting.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. doi:10.1111/eci.13201
- Pilipenko VI, Teplyuk DA, Shakhovskaya AK, Isakov VA, Vorobyova VM, et al. [Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled study]. Vopr Pitan. 2015;84:83.
- Ligaarden SC, Farup PG. Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms. Nutr Res. 2011;31:356. doi:10.1016/j.nutres.2011.04.001
- Harvey RF, Read AE. Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome. Gut. 1973;14:983.
- Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412
