Last update
5/10/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Proprietary Probiotic BlendProviding 1 billion CFUBifidobacterium longum BB536, HOWARU® Lactobacillus acidophilus NCFM®
11 mg
**
Top Medical Research Studies
8
We explored the effects of Lactobacillus species on bile-induced DNA damage in esophageal cells, which occurs during gastroesophageal reflux disease (GERD). By exposing these bacteria to a bile-rich environment, we found they could survive and interact beneficially with injured cells.
Notably, adding Lactobacillus after bile injury boosted the repair of DNA damage and lessened inflammation. This suggests that these probiotics could play a role in protecting against long-term complications of GERD, like Barrett's esophagus and esophageal cancer.
Notably, adding Lactobacillus after bile injury boosted the repair of DNA damage and lessened inflammation. This suggests that these probiotics could play a role in protecting against long-term complications of GERD, like Barrett's esophagus and esophageal cancer.
Read More
9
Probiotic supplement alleviates GERD symptoms
We investigated the impact of a dietary supplement containing lactobacillus acidophilus, bioactive peptides, and vitamins on individuals with mild-to-moderate gastroesophageal reflux disease (GERD). Conducted as a randomized, double-blind, placebo-controlled study, we followed fifty-six adults over 28 days.
Participants reported a significant reduction in heartburn frequency and severity with the active supplement compared to the placebo. They also noted a decreased reliance on over-the-counter medications and improved quality of life. Overall, this supplement appears to bring meaningful relief to those struggling with GERD symptoms.
Participants reported a significant reduction in heartburn frequency and severity with the active supplement compared to the placebo. They also noted a decreased reliance on over-the-counter medications and improved quality of life. Overall, this supplement appears to bring meaningful relief to those struggling with GERD symptoms.
Read More
5
Lactobacillus acidophilus shows minimal effect
We investigated whether the probiotic Lactobacillus acidophilus could help infants with primary vesicoureteral reflux (VUR) and recurrent urinary tract infections (UTIs). In this study, 128 infants were split into two groups: one received probiotics while the other received antibiotics.
While the probiotic group experienced slightly fewer UTIs compared to the antibiotic group, the results were not statistically significant. Overall, both groups had similar outcomes for UTI causes, resolution of VUR, and renal scarring. However, probiotic treatment showed a reduced rate of antibiotic resistance among the infections.
While the probiotic group experienced slightly fewer UTIs compared to the antibiotic group, the results were not statistically significant. Overall, both groups had similar outcomes for UTI causes, resolution of VUR, and renal scarring. However, probiotic treatment showed a reduced rate of antibiotic resistance among the infections.
Read More
Most Useful Reviews
7.5
Probiotics improved reflux
141 people found this helpful
I wish I had tried probiotics years ago. I had many digestive issues, including reflux and bloating. After trying Pearls following an endoscopy that showed acid burns, I experienced significant improvement within days. My nausea and bloating disappeared, and my reflux remains much better. I used to take Zantac frequently, but now I only take it occasionally, thanks to Pearls.
Read More
9
Effective daily relief
4 people found this helpful
I used to take Zantac or Tagamet almost every day for my acid stomach. Since starting this product every morning, I haven't needed anything else. I recommend it for anyone suffering ongoing discomfort without requiring a doctor's visit. Reflux can lead to serious issues, but this isn't a pain killer; it's effective without masking any serious problems.
Read More
9
No more meds needed
1 people found this helpful
After years of acid reflux meds, a friend recommended Pearls. I no longer experience digestive issues and don’t need any medication. I highly recommend this product!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
- All Researches
9
Probiotic supplement alleviates GERD symptoms
We investigated the impact of a dietary supplement containing lactobacillus acidophilus, bioactive peptides, and vitamins on individuals with mild-to-moderate gastroesophageal reflux disease (GERD). Conducted as a randomized, double-blind, placebo-controlled study, we followed fifty-six adults over 28 days.
Participants reported a significant reduction in heartburn frequency and severity with the active supplement compared to the placebo. They also noted a decreased reliance on over-the-counter medications and improved quality of life. Overall, this supplement appears to bring meaningful relief to those struggling with GERD symptoms.
Participants reported a significant reduction in heartburn frequency and severity with the active supplement compared to the placebo. They also noted a decreased reliance on over-the-counter medications and improved quality of life. Overall, this supplement appears to bring meaningful relief to those struggling with GERD symptoms.
Read More
8
We explored the effects of Lactobacillus species on bile-induced DNA damage in esophageal cells, which occurs during gastroesophageal reflux disease (GERD). By exposing these bacteria to a bile-rich environment, we found they could survive and interact beneficially with injured cells.
Notably, adding Lactobacillus after bile injury boosted the repair of DNA damage and lessened inflammation. This suggests that these probiotics could play a role in protecting against long-term complications of GERD, like Barrett's esophagus and esophageal cancer.
Notably, adding Lactobacillus after bile injury boosted the repair of DNA damage and lessened inflammation. This suggests that these probiotics could play a role in protecting against long-term complications of GERD, like Barrett's esophagus and esophageal cancer.
Read More
5
Lactobacillus acidophilus shows minimal effect
We investigated whether the probiotic Lactobacillus acidophilus could help infants with primary vesicoureteral reflux (VUR) and recurrent urinary tract infections (UTIs). In this study, 128 infants were split into two groups: one received probiotics while the other received antibiotics.
While the probiotic group experienced slightly fewer UTIs compared to the antibiotic group, the results were not statistically significant. Overall, both groups had similar outcomes for UTI causes, resolution of VUR, and renal scarring. However, probiotic treatment showed a reduced rate of antibiotic resistance among the infections.
While the probiotic group experienced slightly fewer UTIs compared to the antibiotic group, the results were not statistically significant. Overall, both groups had similar outcomes for UTI causes, resolution of VUR, and renal scarring. However, probiotic treatment showed a reduced rate of antibiotic resistance among the infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Probiotics improved reflux
141 people found this helpful
I wish I had tried probiotics years ago. I had many digestive issues, including reflux and bloating. After trying Pearls following an endoscopy that showed acid burns, I experienced significant improvement within days. My nausea and bloating disappeared, and my reflux remains much better. I used to take Zantac frequently, but now I only take it occasionally, thanks to Pearls.
Read More
9
Effective daily relief
4 people found this helpful
I used to take Zantac or Tagamet almost every day for my acid stomach. Since starting this product every morning, I haven't needed anything else. I recommend it for anyone suffering ongoing discomfort without requiring a doctor's visit. Reflux can lead to serious issues, but this isn't a pain killer; it's effective without masking any serious problems.
Read More
9
No more meds needed
1 people found this helpful
After years of acid reflux meds, a friend recommended Pearls. I no longer experience digestive issues and don’t need any medication. I highly recommend this product!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Tursi F, Benedetto E, Spina A, De Ponti I, Amone F, et al. Efficacy of a Food Supplement Containing LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease. Nutrients. 2024;16. 10.3390/nu16111759
- Bernard JN, Chinnaiyan V, Almeda J, Catala-Valentin A, Andl CD. sp. Facilitate the Repair of DNA Damage Caused by Bile-Induced Reactive Oxygen Species in Experimental Models of Gastroesophageal Reflux Disease. Antioxidants (Basel). 2023;12. 10.3390/antiox12071314
- Lee SJ, Lee JW. Probiotics prophylaxis in infants with primary vesicoureteral reflux. Pediatr Nephrol. 2015;30:609. 10.1007/s00467-014-2988-z
