5/21/2025
Last update
5/21/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Proprietary Probiotic BlendProviding 1 billion CFUBifidobacterium longum BB536, HOWARU® Lactobacillus acidophilus NCFM®
11 mg
**
Top Medical Research Studies
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
8
Probiotics inhibit Candida biofilm growth
We investigated how probiotics, particularly Lactobacillus acidophilus and its relatives, affect the development of Candida albicans biofilms. Our findings revealed that these probiotics notably decreased biofilm growth and altered the yeast's growth behavior.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
Read More
8
Lactobacilli may reduce Candida virulence
We examined how cell-free supernatants from lactobacilli, specifically L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri, affect the virulence traits of Candida parapsilosis in the context of vulvovaginal candidiasis. Our findings indicated that these lactobacilli can reduce the growth and harmful effects of C. parapsilosis, helping to enhance the vaginal lining's resistance to infection. This suggests that incorporating these lactobacilli could be beneficial in preventing yeast infections caused by non-albicans species like C. parapsilosis, although more research is needed to fully understand their effectiveness.
Read More
Most Useful Reviews
10
Life-changing impact
22 people found this helpful
Buy this TODAY if you have a yeast infection. I discovered this product while desperately seeking a cure for recurrent yeast infections that my doctor attributes to hormonal changes. This product, along with acidophilus pills, has transformed my life. I had monthly yeast infections for six years, despite various treatments. Since using this product daily, I've been yeast-infection free for four months! This has also helped with bowel irregularities. Honestly, GET THIS TODAY; it's the best deal I've found!
Read More
9
Effective treatment for husband
8 people found this helpful
My husband struggled with systemic yeast infections for years. Despite various treatments, he eventually accepted it wouldn't go away until I tried yeast cleanses. I first introduced Garden of Life Fungal Defense, followed by Renew Life CandiGONE. His rashes cleared, and after trying Enzymatic Therapy Acidophilus Pearls daily, he has been yeast-free for about a year now. He swears by these Pearls!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
- All Researches
9
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
We aimed to understand whether the use of probiotics could lower yeast infections in children receiving broad-spectrum antibiotics.
In a study comparing antibiotic-treated kids, we enrolled 344 who took probiotics and 376 who did not.
The results were promising, showing a significant drop in both bloodstream and urinary Candida infections among those taking probiotics.
This suggests that probiotics, including Bifidobacterium longum, can effectively help reduce yeast infections in these vulnerable patients.
In a study comparing antibiotic-treated kids, we enrolled 344 who took probiotics and 376 who did not.
The results were promising, showing a significant drop in both bloodstream and urinary Candida infections among those taking probiotics.
This suggests that probiotics, including Bifidobacterium longum, can effectively help reduce yeast infections in these vulnerable patients.
Read More
9
We evaluated the effectiveness and safety of probiotics for treating Candida-associated stomatitis in a controlled trial.
A total of 65 patients were assigned to receive either antifungal treatments alone or antifungals plus a probiotic mix containing Bifidobacterium longum.
While both groups showed a reduction in pain and hyperaemia, the probiotic group had a significantly lower Candida presence after treatment, highlighting a potential benefit in using probiotics along with conventional therapies.
However, changes in other oral bacteria were inconsistent, suggesting that more research is needed in this area.
A total of 65 patients were assigned to receive either antifungal treatments alone or antifungals plus a probiotic mix containing Bifidobacterium longum.
While both groups showed a reduction in pain and hyperaemia, the probiotic group had a significantly lower Candida presence after treatment, highlighting a potential benefit in using probiotics along with conventional therapies.
However, changes in other oral bacteria were inconsistent, suggesting that more research is needed in this area.
Read More
8
Lactobacilli may reduce Candida virulence
We examined how cell-free supernatants from lactobacilli, specifically L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri, affect the virulence traits of Candida parapsilosis in the context of vulvovaginal candidiasis. Our findings indicated that these lactobacilli can reduce the growth and harmful effects of C. parapsilosis, helping to enhance the vaginal lining's resistance to infection. This suggests that incorporating these lactobacilli could be beneficial in preventing yeast infections caused by non-albicans species like C. parapsilosis, although more research is needed to fully understand their effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing impact
22 people found this helpful
Buy this TODAY if you have a yeast infection. I discovered this product while desperately seeking a cure for recurrent yeast infections that my doctor attributes to hormonal changes. This product, along with acidophilus pills, has transformed my life. I had monthly yeast infections for six years, despite various treatments. Since using this product daily, I've been yeast-infection free for four months! This has also helped with bowel irregularities. Honestly, GET THIS TODAY; it's the best deal I've found!
Read More
9
Effective treatment for husband
8 people found this helpful
My husband struggled with systemic yeast infections for years. Despite various treatments, he eventually accepted it wouldn't go away until I tried yeast cleanses. I first introduced Garden of Life Fungal Defense, followed by Renew Life CandiGONE. His rashes cleared, and after trying Enzymatic Therapy Acidophilus Pearls daily, he has been yeast-free for about a year now. He swears by these Pearls!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. 10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. 10.1128/spectrum.02696-21
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. 10.3906/sag-1709-143
- Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. 10.1007/s00404-016-4235-2
- Matsubara VH, Wang Y, Bandara HMHN, Mayer MPA, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100:6415. 10.1007/s00253-016-7527-3
- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. 10.1007/s10096-015-2447-1
- Vilela SF, Barbosa JO, Rossoni RD, Santos JD, Prata MC, et al. Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella. Virulence. 2015;6:29. 10.4161/21505594.2014.981486
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7:38. 10.1007/s12602-014-9176-0
- Ishikawa KH, Mayer MP, Miyazima TY, Matsubara VH, Silva EG, et al. A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015;24:194. 10.1111/jopr.12198
- Kumar S, Singhi S, Chakrabarti A, Bansal A, Jayashree M. Probiotic use and prevalence of candidemia and candiduria in a PICU. Pediatr Crit Care Med. 2013;14:e409. 10.1097/PCC.0b013e31829f5d88
- Li D, Li Q, Liu C, Lin M, Li X, et al. Efficacy and safety of probiotics in the treatment of Candida-associated stomatitis. Mycoses. 2014;57:141. 10.1111/myc.12116
- Kumar S, Bansal A, Chakrabarti A, Singhi S. Evaluation of efficacy of probiotics in prevention of candida colonization in a PICU-a randomized controlled trial. Crit Care Med. 2013;41:565. 10.1097/CCM.0b013e31826a409c
