Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 25 Reviews
8.2
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
We investigated how onion peel extract, packed with quercetin, affects high cholesterol levels in mice. Divided into four groups, the mice were fed different diets for 12 weeks.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Read More
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Read More
8
Quercetin shows promise for cholesterol
We explored how quercetin affects heart health in rats with high cholesterol. The study found that quercetin significantly improved lipid profiles and reduced oxidative stress linked to high-cholesterol diets.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
Read More
Most Useful Reviews
9
Supports immunity
34 people found this helpful
I found this supplement effective for my weak immunity and blood vessel issues. After using it, I had a significant improvement in health. Quercetin is a strong antioxidant that helps prevent allergies and strengthens blood vessels, making it an excellent choice. I highly recommend it for anyone needing similar support!
Read More
8
Cholesterol reduction
33 people found this helpful
I take quercetin for hyperlipidemia and to lower inflammation. Since I started, my bad cholesterol fell from 250 to 170. I avoided medicinal products but I'm thrilled with these results. I advise others with similar concerns to consider trying it as it has truly helped me.
Read More
7.5
Blood pressure regulation
29 people found this helpful
Older age brought high blood pressure, but I didn't want to rely on strong medications. After a week of quercetin, my upper pressure dropped by 20, which is fantastic. I also noticed my son’s stubborn cough disappeared after he took it. I'm pleased with the results!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
We examined the effects of a berry extract from Lonicera caerulea, rich in polyphenols, on high cholesterol levels. In laboratory tests with Caco-2 cells and rats, the extract proved effective in reducing cholesterol levels and boosting antioxidant capacity.
In rats fed a high cholesterol diet, supplementation with this berry extract significantly lowered total cholesterol and harmful LDL levels while raising beneficial HDL levels. We observed measurable improvements in cholesterol metabolism and antioxidant activity. Overall, Lonicera caerulea berry extract holds promise as a functional food for cholesterol management.
In rats fed a high cholesterol diet, supplementation with this berry extract significantly lowered total cholesterol and harmful LDL levels while raising beneficial HDL levels. We observed measurable improvements in cholesterol metabolism and antioxidant activity. Overall, Lonicera caerulea berry extract holds promise as a functional food for cholesterol management.
Read More
9
We investigated how onion peel extract, packed with quercetin, affects high cholesterol levels in mice. Divided into four groups, the mice were fed different diets for 12 weeks.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Read More
8
We examined the effects of quercetin nanoemulsion (QT+NE) on cholesterol levels and muscle function in mice on a high-fat diet. Over 11 weeks, QT+NE showed a notable reduction in body weight gain and improved fat distribution when compared to a high-fat diet alone.
Interestingly, QT+NE significantly boosted the activation of SIRT1, a gene linked to mitochondrial health, and maintained mitochondrial DNA levels. However, traditional quercetin failed to show these benefits. Our findings suggest that QT+NE could be a promising option for enhancing muscle health and managing cholesterol in high-fat dietary contexts.
Interestingly, QT+NE significantly boosted the activation of SIRT1, a gene linked to mitochondrial health, and maintained mitochondrial DNA levels. However, traditional quercetin failed to show these benefits. Our findings suggest that QT+NE could be a promising option for enhancing muscle health and managing cholesterol in high-fat dietary contexts.
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8
We investigated how Massa Medicata Fermentata (MMF), which contains quercetin, impacts cholesterol and overall metabolic health. In our study, zebrafish were fed a high-cholesterol diet while receiving MMF for three weeks.
The results showed that MMF helped reduce cholesterol accumulation and body mass index, indicating positive metabolic changes. Additionally, MMF demonstrated strong antioxidant effects, effectively inhibiting LDL oxidation and decreasing inflammation markers.
While we observed beneficial effects on cholesterol and inflammation, further research is needed to fully understand quercetin's role in these outcomes.
The results showed that MMF helped reduce cholesterol accumulation and body mass index, indicating positive metabolic changes. Additionally, MMF demonstrated strong antioxidant effects, effectively inhibiting LDL oxidation and decreasing inflammation markers.
While we observed beneficial effects on cholesterol and inflammation, further research is needed to fully understand quercetin's role in these outcomes.
Read More
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports immunity
34 people found this helpful
I found this supplement effective for my weak immunity and blood vessel issues. After using it, I had a significant improvement in health. Quercetin is a strong antioxidant that helps prevent allergies and strengthens blood vessels, making it an excellent choice. I highly recommend it for anyone needing similar support!
Read More
8
Cholesterol reduction
33 people found this helpful
I take quercetin for hyperlipidemia and to lower inflammation. Since I started, my bad cholesterol fell from 250 to 170. I avoided medicinal products but I'm thrilled with these results. I advise others with similar concerns to consider trying it as it has truly helped me.
Read More
7.5
Blood pressure regulation
29 people found this helpful
Older age brought high blood pressure, but I didn't want to rely on strong medications. After a week of quercetin, my upper pressure dropped by 20, which is fantastic. I also noticed my son’s stubborn cough disappeared after he took it. I'm pleased with the results!
Read More
9
Hay fever relief
16 people found this helpful
This product is fantastic for hay fever and sinus issues. As a long-term sufferer, I can genuinely recommend it. The service from iHerb is also excellent.
Read More
7.5
Improved sinusitis
10 people found this helpful
I found many positive reviews on Doctor Best products. The quercetin content is higher than bromelain. Initially, I had a headache, but now I feel well. I have sinusitis, and after consuming it, my nasal condition improved by 30-40%.
Read More
Frequently Asked Questions
8
Cholesterol reduction
33 people found this helpful
I take quercetin for hyperlipidemia and to lower inflammation. Since I started, my bad cholesterol fell from 250 to 170. I avoided medicinal products but I'm thrilled with these results. I advise others with similar concerns to consider trying it as it has truly helped me.
7.5
Cholesterol moderate
8 people found this helpful
I faced high cholesterol levels and found quercetin helpful in bringing it down. The addition of bromelain means I can take it without stomach issues. I’ve been using it daily, noticing an improvement in my cholesterol levels, and it helps with inflammation too.
6
Cholesterol control
2 people found this helpful
The slightly larger capsules seem effective for improving blood flow, lowering cholesterol levels, and relieving joint pain. Since starting this product, I’ve been feeling quite good.
7.5
Cost-effective
18 people found this helpful
Quercetin from NOW Foods offers 400mg per capsule, unlike many brands that provide less, making it effective for immune support. My son only needs half a capsule. It's a preventive supplement rather than a cure for infections, but it's definitely useful in maintaining health.
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
8
Quercetin potentially aids cholesterol management
We explored the impact of quercetin-3-glucoside on mice with high cholesterol diets. Over 12 weeks, mice were given either low or high cholesterol diets, some supplemented with quercetin.
While there was no noticeable effect in those on a low cholesterol diet, quercetin did help reduce cholesterol and insulin levels in high cholesterol-diet mice. It increased important proteins that assist in cholesterol clearance but also seemed to promote insulin secretion in pancreatic cells.
Overall, quercetin may hold potential for managing cholesterol levels.
While there was no noticeable effect in those on a low cholesterol diet, quercetin did help reduce cholesterol and insulin levels in high cholesterol-diet mice. It increased important proteins that assist in cholesterol clearance but also seemed to promote insulin secretion in pancreatic cells.
Overall, quercetin may hold potential for managing cholesterol levels.
8
We explored whether quercetin can help control high cholesterol by examining its effects on specific liver enzymes in hypercholesterolemic rats. Using a controlled study, we treated these rats with varying doses of quercetin.
The results were promising: quercetin significantly reduced levels of plasma cholesterol, triglycerides, and LDL cholesterol, while boosting HDL levels and promoting beneficial liver function. Quercetin also inhibited the harmful enzyme HMG-CoA reductase and improved related gene expressions.
This suggests that quercetin could be a promising candidate for future cholesterol-lowering therapies.
The results were promising: quercetin significantly reduced levels of plasma cholesterol, triglycerides, and LDL cholesterol, while boosting HDL levels and promoting beneficial liver function. Quercetin also inhibited the harmful enzyme HMG-CoA reductase and improved related gene expressions.
This suggests that quercetin could be a promising candidate for future cholesterol-lowering therapies.
4
We investigated the effects of quercetin and rutin on cholesterol levels. In laboratory settings using liver cells, we found that both compounds significantly lowered cholesterol levels. They achieved this by boosting the expression of proteins involved in cholesterol metabolism.
However, when tested in hamsters with high cholesterol, neither quercetin nor rutin led to significant reductions in plasma cholesterol after eight weeks. This suggests that while they might work well in cells, their benefits may not extend effectively to living organisms due to issues with how well they are absorbed.
However, when tested in hamsters with high cholesterol, neither quercetin nor rutin led to significant reductions in plasma cholesterol after eight weeks. This suggests that while they might work well in cells, their benefits may not extend effectively to living organisms due to issues with how well they are absorbed.
References
- Lee MS, Doo M, Kim Y. Effects of quercetin nanoemulsion on SIRT1 activation and mitochondrial biogenesis in the skeletal muscle of high-fat diet-fed mice. Nutr Res Pract. 2024;18:806. doi:10.4162/nrp.2024.18.6.806
- Jung KM, Yu GR, Kim DH, Lim DW, Park WH. Massa Medicata Fermentata, a Functional Food for Improving the Metabolic Profile via Prominent Anti-Oxidative and Anti-Inflammatory Effects. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13101271
- Lee MS, Kim Y. Effects of Quercetin Nanoemulsion on Cholesterol Efflux and MicroRNA-33/34a Expression in the Liver of Mice Fed with a High-Cholesterol Diet. Prev Nutr Food Sci. 2023;28:271. doi:10.3746/pnf.2023.28.3.271
- Yammine A, Auezova L, Lizard G, Greige-Gerges H. Activity of Na/K- and Ca-ATPases in human erythrocyte membranes: Protocol improvement, relation to cholesterol content, and effects of polyphenols. Biochimie. 2023;212:95. doi:10.1016/j.biochi.2023.04.010
- Liang N, Li YM, He Z, Hao W, Zhao Y, et al. Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration. Molecules. 2021;26. doi:10.3390/molecules26123766
- Oyetayo FL, Akomolafe SF, Ogundumi OA. Anti-hypercholesterolemic potential of diet supplemented with and tubers in high cholesterol fed rats. J Diabetes Metab Disord. 2020;19:1139. doi:10.1007/s40200-020-00615-z
- Donaldson J, Ngema M, Nkomozepi P, Erlwanger K. Quercetin administration post-weaning attenuates high-fructose, high-cholesterol diet-induced hepatic steatosis in growing, female, Sprague Dawley rat pups. J Sci Food Agric. 2019;99:6954. doi:10.1002/jsfa.9984
- Son HY, Lee MS, Chang E, Kim SY, Kang B, et al. Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats. Nutrients. 2019;11. doi:10.3390/nu11020244
- Liu S, You L, Zhao Y, Chang X. Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo. Food Res Int. 2018;107:73. doi:10.1016/j.foodres.2018.02.016
- Castillo RL, Herrera EA, Gonzalez-Candia A, Reyes-Farias M, de la Jara N, et al. Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. Oxid Med Cell Longev. 2018;2018:7239123. doi:10.1155/2018/7239123
- Mbikay M, Mayne J, Sirois F, Fedoryak O, Raymond A, et al. Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas. Mol Nutr Food Res. 2018;62:e1700729. doi:10.1002/mnfr.201700729
- Woo M, Kim M, Noh JS, Park CH, Song YO. Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis. Nutr Res Pract. 2017;11:445. doi:10.4162/nrp.2017.11.6.445
- Khamis AA, Salama AF, Kenawy ME, Mohamed TM. Regulation of hepatic hydroxy methyl glutarate - CoA reductase for controlling hypercholesterolemia in rats. Biomed Pharmacother. 2017;95:1242. doi:10.1016/j.biopha.2017.09.071
- Bhaskar S, Helen A. Quercetin modulates toll-like receptor-mediated protein kinase signaling pathways in oxLDL-challenged human PBMCs and regulates TLR-activated atherosclerotic inflammation in hypercholesterolemic rats. Mol Cell Biochem. 2016;423:53.
- Carrasco-Pozo C, Tan KN, Reyes-Farias M, De La Jara N, Ngo ST, et al. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biol. 2016;9:229. doi:10.1016/j.redox.2016.08.007
- Kang HJ, Pichiah PBT, Abinaya RV, Sohn HS, Cha YS. Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet. Food Sci Biotechnol. 2016;25:855. doi:10.1007/s10068-016-0141-4
