Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
7
Vitamin E (as dl-Alpha tocopheryl acetate)
68 mg
453%
Coenzyme Q10
100 mg
**
Top Medical Research Studies
8
Q10 alleviates post-stroke depression
We explored the effects of Coenzyme Q10 (Q10) on depression and cognitive deficits following global cerebral ischemia/reperfusion (I/R) injury in rats. In this study, we induced brain injury by blocking blood flow to both carotid arteries for 20 minutes. The rats then received Q10 at a dose of 200 mg/kg for six weeks.
The results illustrated that the I/R injury led to increased anxiety and depressive behaviors in the animals, alongside a noticeable decline in cognitive performance. Moreover, we found that the levels of brain-derived neurotrophic factor (BDNF) and the activity of superoxide dismutase (SOD) were reduced after the stroke.
Upon treating with Q10, we observed significant improvements. The treatment not only decreased brain swelling but also lessened anxiety and depressive-like symptoms. Cognitive impairments improved as well, with increased BDNF levels and SOD activity in the brain tissues of the animals receiving Q10.
Ultimately, this study points to the potential benefits of Q10 supplementation in mitigating symptoms of depression and cognitive issues after a stroke.
The results illustrated that the I/R injury led to increased anxiety and depressive behaviors in the animals, alongside a noticeable decline in cognitive performance. Moreover, we found that the levels of brain-derived neurotrophic factor (BDNF) and the activity of superoxide dismutase (SOD) were reduced after the stroke.
Upon treating with Q10, we observed significant improvements. The treatment not only decreased brain swelling but also lessened anxiety and depressive-like symptoms. Cognitive impairments improved as well, with increased BDNF levels and SOD activity in the brain tissues of the animals receiving Q10.
Ultimately, this study points to the potential benefits of Q10 supplementation in mitigating symptoms of depression and cognitive issues after a stroke.
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8
We conducted a clinical trial to investigate how coenzyme Q10 (CoQ10) supplementation affects depression in women diagnosed with polycystic ovary syndrome (PCOS). This study involved 55 women aged 18 to 40, divided into two groups—one received 100 mg of CoQ10 daily, while the other was given a placebo, all over a period of 12 weeks.
Our findings revealed that CoQ10 led to significant improvements in mental health. Specifically, we noted a reduction in depression and anxiety symptoms, as measured by the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Additionally, markers of inflammation and oxidative stress also improved among those taking CoQ10, with notable decreases in high-sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) levels.
Beyond just mood enhancements, CoQ10 supplementation resulted in hormonal changes as well, including lower levels of total testosterone and dehydroepiandrosterone sulfate (DHEAS), alongside a rise in sex hormone-binding globulin (SHBG) and overall antioxidant capacity. These findings suggest that CoQ10 could play a crucial role in managing depression symptoms in women with PCOS.
Our findings revealed that CoQ10 led to significant improvements in mental health. Specifically, we noted a reduction in depression and anxiety symptoms, as measured by the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Additionally, markers of inflammation and oxidative stress also improved among those taking CoQ10, with notable decreases in high-sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) levels.
Beyond just mood enhancements, CoQ10 supplementation resulted in hormonal changes as well, including lower levels of total testosterone and dehydroepiandrosterone sulfate (DHEAS), alongside a rise in sex hormone-binding globulin (SHBG) and overall antioxidant capacity. These findings suggest that CoQ10 could play a crucial role in managing depression symptoms in women with PCOS.
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8
Chronic stress is known to impact neuronal health and energy levels, leading to depressive symptoms. In this study, we explored how the protein dynamin-related protein 1 (Drp1) affects mitochondrial function and how coenzyme Q10 (CoQ10) may help combat the resulting stress-induced depression.
We found that chronic stress triggers an increase in mitochondrial fission, disrupting energy production in the brain's medial prefrontal cortex. This disruption in energy metabolism is linked to reduced excitatory synaptic transmission, which can lead to depressive-like behaviors in male mice. However, when we inhibited Drp1 through pharmacological methods or genetic reduction, we observed improved synaptic function and a decrease in depressive behaviors.
Interestingly, enhancing mitochondrial fission by activating Drp1 increased susceptibility to stress, but this adverse effect was significantly offset by treatment with CoQ10—a substance known to boost ATP production in mitochondria. This suggests that CoQ10 can play a beneficial role in managing stress-related depression by improving overall brain energy function.
Our findings highlight the potential of CoQ10 as a therapeutic option for those struggling with metabolic-related emotional disorders.
We found that chronic stress triggers an increase in mitochondrial fission, disrupting energy production in the brain's medial prefrontal cortex. This disruption in energy metabolism is linked to reduced excitatory synaptic transmission, which can lead to depressive-like behaviors in male mice. However, when we inhibited Drp1 through pharmacological methods or genetic reduction, we observed improved synaptic function and a decrease in depressive behaviors.
Interestingly, enhancing mitochondrial fission by activating Drp1 increased susceptibility to stress, but this adverse effect was significantly offset by treatment with CoQ10—a substance known to boost ATP production in mitochondria. This suggests that CoQ10 can play a beneficial role in managing stress-related depression by improving overall brain energy function.
Our findings highlight the potential of CoQ10 as a therapeutic option for those struggling with metabolic-related emotional disorders.
Read More
Most Useful Reviews
9
Improved mood
9 people found this helpful
Joy to life! I ordered this medication for my grandfather, who had been experiencing depression and lacked the desire to communicate with his family while his appetite diminished. After two weeks of taking one capsule daily in the morning, along with alpha-lipoic acid, his mood significantly improved, and he rediscovered joy in life. He also shared the medication with his wife, who has Alzheimer's disease, and she noticed an improvement too. He expresses nothing but gratitude for these medications! Previously, he had tried various remedies like purification and spirulina, but they were ineffective. I will definitely order more, especially as the price and dosage are very economical. Highly recommend for boosting energy and reducing fatigue!
Read More
9
Boosted energy
4 people found this helpful
I reached out to my mother because she was feeling utterly drained, lacking strength and motivation, and wanted to sleep all the time. Once she began taking Ubiquinol, her strength returned, and her depression lifted. Her friends were so impressed that they asked me to get them this medication too. I do advise caution, however, for those with high blood pressure, as I experienced tachycardia.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
- All Researches
9
We explored the potential of coenzyme Q10 (Q10) in tackling mental and memory issues often faced by patients with Alzheimer's disease (AD). The study took a closer look at whether low-intensity pulsed ultrasound (LIPUS) could help in delivering a specially prepared 30 nm form of Q10 across the blood-brain barrier more effectively.
Through this research, we administered 30 nm Q10 to both wild-type mice and genetically modified APP/PS1 mice that model familial AD. We examined the effects of Q10 alone and in combination with LIPUS at two different intensities (50 and 100 mW/cm). What we discovered was intriguing: combining the higher intensity of LIPUS with 30 nm Q10 not only improved mood and reduced anxiety and depressive behaviors but also led to an increase in essential brain chemicals like serotonin and dopamine, while lowering harmful substances like formaldehyde.
However, it's important to note that even with these promising results, LIPUS alone did not completely eliminate symptoms of anxiety, depression, or memory deficits. While the combination therapy showed effectiveness in enhancing Q10 delivery and boosting some mood-related markers, further research is needed to refine these treatments for better overall outcomes in Alzheimer’s.
Through this research, we administered 30 nm Q10 to both wild-type mice and genetically modified APP/PS1 mice that model familial AD. We examined the effects of Q10 alone and in combination with LIPUS at two different intensities (50 and 100 mW/cm). What we discovered was intriguing: combining the higher intensity of LIPUS with 30 nm Q10 not only improved mood and reduced anxiety and depressive behaviors but also led to an increase in essential brain chemicals like serotonin and dopamine, while lowering harmful substances like formaldehyde.
However, it's important to note that even with these promising results, LIPUS alone did not completely eliminate symptoms of anxiety, depression, or memory deficits. While the combination therapy showed effectiveness in enhancing Q10 delivery and boosting some mood-related markers, further research is needed to refine these treatments for better overall outcomes in Alzheimer’s.
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9
We explored the impact of coenzyme Q10 (Q10) on depression, particularly in relation to its use with phototherapy. The study examined how formaldehyde (FA) produced in the brain may connect to depression—specifically after exposure to lipopolysaccharide (LPS), a component that provokes inflammation.
We found that elevated levels of FA in the midbrain can stimulate various inflammatory cytokines, leading to depressive-like behaviors. The research highlighted that using FA scavengers, like Q10, along with phototherapy, significantly reduced both FA accumulation and neuroinflammation.
Importantly, the combination of Q10 and phototherapy showed a greater effect in easing depressive symptoms compared to each treatment on its own. While this suggests a promising avenue for treating depression through FA management, we also recognize that the findings might leave some questions unanswered regarding the precise role of Q10 without combined therapies.
We found that elevated levels of FA in the midbrain can stimulate various inflammatory cytokines, leading to depressive-like behaviors. The research highlighted that using FA scavengers, like Q10, along with phototherapy, significantly reduced both FA accumulation and neuroinflammation.
Importantly, the combination of Q10 and phototherapy showed a greater effect in easing depressive symptoms compared to each treatment on its own. While this suggests a promising avenue for treating depression through FA management, we also recognize that the findings might leave some questions unanswered regarding the precise role of Q10 without combined therapies.
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We explored how coenzyme Q10 (Q10) and vitamin E (Vit E) can impact depression and anxiety in response to heat stress in male mice. Our study involved five groups: a control group, a group exposed to heat stress, and three treatment groups using either Q10, Vit E, or a combination of both. The mice experienced heat stress for 14 days, where temperatures reached 43°C, followed by treatments for two more weeks.
The results were promising. We noticed that both Q10 and Vit E treatments, alone or together, led to significant improvements in mood. The mice showed fewer signs of anxiety and depression as assessed through various behavioral tests. Additionally, serum tests revealed that these treatments notably lowered stress hormone levels, suggesting a calming effect.
On a cellular level, we also observed a reduction in markers of inflammation in the prefrontal cortex, which is crucial for mood regulation. This suggests that Q10 and Vit E might help counteract the negative effects of heat stress by modulating inflammatory responses and the overall stress response system.
Overall, our findings indicate that coenzyme Q10, especially in combination with vitamin E, holds promise as a potential treatment for mood disturbances related to heat stress.
The results were promising. We noticed that both Q10 and Vit E treatments, alone or together, led to significant improvements in mood. The mice showed fewer signs of anxiety and depression as assessed through various behavioral tests. Additionally, serum tests revealed that these treatments notably lowered stress hormone levels, suggesting a calming effect.
On a cellular level, we also observed a reduction in markers of inflammation in the prefrontal cortex, which is crucial for mood regulation. This suggests that Q10 and Vit E might help counteract the negative effects of heat stress by modulating inflammatory responses and the overall stress response system.
Overall, our findings indicate that coenzyme Q10, especially in combination with vitamin E, holds promise as a potential treatment for mood disturbances related to heat stress.
Read More
8
We aimed to understand the potential benefits of coenzyme Q10 (CoQ10) as an added treatment for patients dealing with depression. In our study, we had 69 participants who were experiencing moderate to severe depression. They were divided into two groups: one received CoQ10 supplements at a dosage of 200 mg daily for 8 weeks, while the other group was given a placebo along with standard depression treatments.
After 8 weeks, we found that those taking CoQ10 reported a notable reduction in their depression symptoms, which was statistically significant compared to their emotional state at the beginning. In contrast, the placebo group did not show any meaningful changes in their symptoms over the same period. Furthermore, our blood tests indicated positive shifts in certain biological markers, suggesting that CoQ10 might help improve oxidative stress levels and inflammation associated with depression.
This suggests that incorporating 200 mg of CoQ10 daily over 8 weeks can significantly enhance the well-being of individuals with depression, leading to decreased fatigue and improved quality of life.
After 8 weeks, we found that those taking CoQ10 reported a notable reduction in their depression symptoms, which was statistically significant compared to their emotional state at the beginning. In contrast, the placebo group did not show any meaningful changes in their symptoms over the same period. Furthermore, our blood tests indicated positive shifts in certain biological markers, suggesting that CoQ10 might help improve oxidative stress levels and inflammation associated with depression.
This suggests that incorporating 200 mg of CoQ10 daily over 8 weeks can significantly enhance the well-being of individuals with depression, leading to decreased fatigue and improved quality of life.
Read More
8
Chronic stress is known to impact neuronal health and energy levels, leading to depressive symptoms. In this study, we explored how the protein dynamin-related protein 1 (Drp1) affects mitochondrial function and how coenzyme Q10 (CoQ10) may help combat the resulting stress-induced depression.
We found that chronic stress triggers an increase in mitochondrial fission, disrupting energy production in the brain's medial prefrontal cortex. This disruption in energy metabolism is linked to reduced excitatory synaptic transmission, which can lead to depressive-like behaviors in male mice. However, when we inhibited Drp1 through pharmacological methods or genetic reduction, we observed improved synaptic function and a decrease in depressive behaviors.
Interestingly, enhancing mitochondrial fission by activating Drp1 increased susceptibility to stress, but this adverse effect was significantly offset by treatment with CoQ10—a substance known to boost ATP production in mitochondria. This suggests that CoQ10 can play a beneficial role in managing stress-related depression by improving overall brain energy function.
Our findings highlight the potential of CoQ10 as a therapeutic option for those struggling with metabolic-related emotional disorders.
We found that chronic stress triggers an increase in mitochondrial fission, disrupting energy production in the brain's medial prefrontal cortex. This disruption in energy metabolism is linked to reduced excitatory synaptic transmission, which can lead to depressive-like behaviors in male mice. However, when we inhibited Drp1 through pharmacological methods or genetic reduction, we observed improved synaptic function and a decrease in depressive behaviors.
Interestingly, enhancing mitochondrial fission by activating Drp1 increased susceptibility to stress, but this adverse effect was significantly offset by treatment with CoQ10—a substance known to boost ATP production in mitochondria. This suggests that CoQ10 can play a beneficial role in managing stress-related depression by improving overall brain energy function.
Our findings highlight the potential of CoQ10 as a therapeutic option for those struggling with metabolic-related emotional disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mood
9 people found this helpful
Joy to life! I ordered this medication for my grandfather, who had been experiencing depression and lacked the desire to communicate with his family while his appetite diminished. After two weeks of taking one capsule daily in the morning, along with alpha-lipoic acid, his mood significantly improved, and he rediscovered joy in life. He also shared the medication with his wife, who has Alzheimer's disease, and she noticed an improvement too. He expresses nothing but gratitude for these medications! Previously, he had tried various remedies like purification and spirulina, but they were ineffective. I will definitely order more, especially as the price and dosage are very economical. Highly recommend for boosting energy and reducing fatigue!
Read More
9
Boosted energy
4 people found this helpful
I reached out to my mother because she was feeling utterly drained, lacking strength and motivation, and wanted to sleep all the time. Once she began taking Ubiquinol, her strength returned, and her depression lifted. Her friends were so impressed that they asked me to get them this medication too. I do advise caution, however, for those with high blood pressure, as I experienced tachycardia.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Luo Q, Ye X, Xu J, Sun Z, Wang P, et al. Low-intensity pulsed ultrasound enhances delivery of 30 nm Q10 for improving mental and memory disorder in APP/PS1 mice. Drug Deliv Transl Res. 2025. doi:10.1007/s13346-025-01814-y
- Mahmoudi J, Kazmi S, Vatandoust S, Athari SZ, Sadigh-Eteghad S, et al. Coenzyme Q10 and vitamin E alleviate heat stress-induced mood disturbances in male mice: Modulation of inflammatory pathways and the HPA axis. Behav Brain Res. 2025;476:115259. doi:10.1016/j.bbr.2024.115259
- Majmasanaye M, Mehrpooya M, Amiri H, Eshraghi A. Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression. J Clin Psychopharmacol. 2024;44:232. doi:10.1097/JCP.0000000000001845
- Zhao D, Wu Y, Zhao H, Zhang F, Wang J, et al. Midbrain FA initiates neuroinflammation and depression onset in both acute and chronic LPS-induced depressive model mice. Brain Behav Immun. 2024;117:356. doi:10.1016/j.bbi.2024.02.004
- Dong WT, Long LH, Deng Q, Liu D, Wang JL, et al. Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice. Nat Metab. 2023;5:2220. doi:10.1038/s42255-023-00924-6
- Al Namat R, Al Namat D, Ciocoiu M, Hînganu MV, Șorodoc L, et al. H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation. J Cardiovasc Dev Dis. 2022;9. doi:10.3390/jcdd9080242
- Fatemi I, Saeed Askari P, Hakimizadeh E, Kaeidi A, Esmaeil Moghaddam S, et al. Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats. Iran J Basic Med Sci. 2022;25:39. doi:10.22038/IJBMS.2022.57630.12865
- Gabriel FC, Oliveira M, Berk M, Brietzke E, Jacka FN, et al. Nutrition and bipolar disorder: a systematic review. Nutr Neurosci. 2023;26:637. doi:10.1080/1028415X.2022.2077031
- Maiti R, Mishra A, Mishra BR, Jena M. Comparative efficacy of mitochondrial agents for bipolar disorder during depressive episodes: a network meta-analysis using frequentist and Bayesian approaches. Psychopharmacology (Berl). 2021;238:3347. doi:10.1007/s00213-021-06019-y
- Karamali M, Gholizadeh M. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome. Gynecol Endocrinol. 2022;38:45. doi:10.1080/09513590.2021.1991910
- Hoepner CT, McIntyre RS, Papakostas GI. Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence. Nutrients. 2021;13. doi:10.3390/nu13030767
- Ashton MM, Kavanagh BE, Marx W, Berk M, Sarris J, et al. A Systematic Review of Nutraceuticals for the Treatment of Bipolar Disorder. Can J Psychiatry. 2021;66:262. doi:10.1177/0706743720961734
- Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, et al. Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. Mol Neurobiol. 2020;57:4202. doi:10.1007/s12035-020-01996-1
