We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
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Lactobacillus improves vaginal healthEffect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors.
Study relevant to postmenopausal women
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
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L. acidophilus inhibits C. albicansLactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella.
Relevant support for probiotics
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
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Lactobacillus rhamnosus shows promiseAnticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation.
High relevance for Candida treatment.
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
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Probiotic shows potential against fungusLactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights.
Relevant for antifungal strategies
We investigated the effectiveness of Lactobacillus rhamnosus Lcr35® against Candida albicans using lab models. The study showed that this probiotic significantly reduced fungal growth and adhesion in cell cultures.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
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