Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.9
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Women's Care Probiotic Blend
50 Billion CFU 222 mg
***
Bifido Probiotic BlendBifidobacterium lactis BI-04®, Bifidobacterium lactis DSM 15954, Bifidobacterium infantis Bi-26™
26 Billion CFU
Lacto Probiotic BlendLactobacillus reuteri RC-14®, Lactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactobacillus rhamnosus GR-1®, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus brevis Lbr-35™
24 Billion CFU
Top Medical Research Studies
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
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9
We studied the effects of BD400 in a collagen-induced arthritis rat model, aiming to understand if it could delay rheumatoid arthritis (RA). Through monitoring arthritis signs, measuring gut health, and assessing immune responses, we found that BD400 significantly reduced swelling and clinical scores in the rats.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
Most Useful Reviews
9
Miracle for vaginosis
106 people found this helpful
After five years of battling bacterial vaginosis with countless treatments, I found this miraculous product. Initially sceptical, I was astonished at its effectiveness. I highly recommend it to anyone struggling with similar issues or autoimmune disorders.
Read More
9
Improves yeast issues
1 people found this helpful
Having tried many probiotics for digestion, I noticed improvements in my yeast infection after using this product. I'm satisfied and have reordered it from iHerb.
Read More
9
Supports bowel health
1 people found this helpful
Previously struggling with autoimmune disorder, I noticed significant improvements in my bowel movements after taking this product. I hope it is effective for my vaginitis, the original aim of my intake.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.9
- All Researches
9
We studied the effects of BD400 in a collagen-induced arthritis rat model, aiming to understand if it could delay rheumatoid arthritis (RA). Through monitoring arthritis signs, measuring gut health, and assessing immune responses, we found that BD400 significantly reduced swelling and clinical scores in the rats.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Additionally, it positively impacted the gut microbiota and metabolite levels, particularly through histidine metabolism. This led to a decrease in inflammation and improved intestinal barrier function, hinting at BD400's potential as a preventive treatment for RA.
Read More
9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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9
Synbiotics improve rheumatoid arthritis symptoms
We investigated how synbiotic supplementation affects patients with rheumatoid arthritis (RA). In an 8-week, randomized, double-blind trial involving 54 participants, we compared the outcomes of those taking synbiotic capsules with a placebo group.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
After the trial, those who received synbiotics showed a significant drop in inflammation markers and pain levels. Additionally, improvements were observed in insulin resistance and overall metabolic responses.
These findings suggest that synbiotics might benefit individuals managing RA by reducing inflammation and enhancing metabolic health.
Read More
9
Lactobacillus acidophilus shows promise in autoimmune management
We explored how specific Lactobacillus acidophilus strains can impact autoimmune disorders by reducing leptin production in mice. In our study, we compared the effects of CBA4P and other lactobacilli on adipocytes from mice sensitive to Th1 immune diseases.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Results showed that CBA4P significantly lowered leptin levels and inhibited the activation of immune lymphocytes in the SJL mouse strain. This suggests that CBA4P might help manage Th1-related inflammatory conditions, representing a potentially valuable probiotic option for autoimmune control.
Read More
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Miracle for vaginosis
106 people found this helpful
After five years of battling bacterial vaginosis with countless treatments, I found this miraculous product. Initially sceptical, I was astonished at its effectiveness. I highly recommend it to anyone struggling with similar issues or autoimmune disorders.
Read More
9
Improves yeast issues
1 people found this helpful
Having tried many probiotics for digestion, I noticed improvements in my yeast infection after using this product. I'm satisfied and have reordered it from iHerb.
Read More
9
Supports bowel health
1 people found this helpful
Previously struggling with autoimmune disorder, I noticed significant improvements in my bowel movements after taking this product. I hope it is effective for my vaginitis, the original aim of my intake.
Read More
6
Effective for thrush
261 people found this helpful
This probiotic has effectively eliminated my thrush temporarily; however, my main aim was to improve my gastrointestinal tract. It seems to be a good supplement for normalising microflora, and I believe it may combat thrush effectively.
Read More
7.5
Good for infections
3 people found this helpful
I utilised this probiotic to help with recurring yeast infections and experienced no negative reactions. I believe it is beneficial for my vaginal health alongside other treatments.
Read More
Frequently Asked Questions
9
Supports bowel health
1 people found this helpful
Previously struggling with autoimmune disorder, I noticed significant improvements in my bowel movements after taking this product. I hope it is effective for my vaginitis, the original aim of my intake.
9
Miracle for vaginosis
106 people found this helpful
After five years of battling bacterial vaginosis with countless treatments, I found this miraculous product. Initially sceptical, I was astonished at its effectiveness. I highly recommend it to anyone struggling with similar issues or autoimmune disorders.
9
Improves yeast issues
1 people found this helpful
Having tried many probiotics for digestion, I noticed improvements in my yeast infection after using this product. I'm satisfied and have reordered it from iHerb.
6
Effective for thrush
261 people found this helpful
This probiotic has effectively eliminated my thrush temporarily; however, my main aim was to improve my gastrointestinal tract. It seems to be a good supplement for normalising microflora, and I believe it may combat thrush effectively.
2
Not effective for UTI
Unfortunately, this product did not work well for my frequent UTIs, so I won't reorder. However, it might still be worth trying for those needing probiotics focused on women's health.
7.5
Good for infections
3 people found this helpful
I utilised this probiotic to help with recurring yeast infections and experienced no negative reactions. I believe it is beneficial for my vaginal health alongside other treatments.
8
We explored the role of synbiotics, including Bifidobacterium lactis, in managing systemic lupus erythematosus (SLE), an autoimmune disease known for causing widespread inflammation. In a randomized, double-blind, placebo-controlled trial with 50 SLE patients, we compared those receiving standard therapy plus synbiotics against those on standard therapy alone for two months.
The results revealed that those in the synbiotics group had lower levels of the inflammatory cytokine IL-17A and improved disease activity scores. In contrast, the placebo group showed no significant changes. While these findings suggest that synbiotics could be a helpful addition to SLE treatment, further studies are necessary to uncover the mechanisms behind these effects.
The results revealed that those in the synbiotics group had lower levels of the inflammatory cytokine IL-17A and improved disease activity scores. In contrast, the placebo group showed no significant changes. While these findings suggest that synbiotics could be a helpful addition to SLE treatment, further studies are necessary to uncover the mechanisms behind these effects.
7
Probiotics reduce inflammation in RA
We carried out a double-blind, placebo-controlled study with 42 rheumatoid arthritis (RA) patients to see how a blend of probiotics affected inflammation. The results were promising!
After 60 days, the group taking probiotics had lower white blood cell counts and decreased levels of harmful inflammatory proteins, like tumor necrosis factor-α. Additionally, they showed improvements in oxidative stress markers.
However, we didn’t find significant differences in some other measures of inflammation and disease activity between the two groups.
After 60 days, the group taking probiotics had lower white blood cell counts and decreased levels of harmful inflammatory proteins, like tumor necrosis factor-α. Additionally, they showed improvements in oxidative stress markers.
However, we didn’t find significant differences in some other measures of inflammation and disease activity between the two groups.
8
Probiotics reduce neuroinflammation effectively
We explored the impact of two probiotic strains, Bifidobacterium animalis and Lactobacillus plantarum, on an animal model of Multiple Sclerosis (MS). Over 22 days, we observed that these probiotics significantly reduced harmful cytokines while boosting anti-inflammatory responses.
Our findings indicated that the treatment encouraged the growth of beneficial Treg cells, which help manage the immune response. By promoting a balance between immune cell subsets, these probiotics showed promise in mitigating the effects of neuroinflammation associated with MS.
Our findings indicated that the treatment encouraged the growth of beneficial Treg cells, which help manage the immune response. By promoting a balance between immune cell subsets, these probiotics showed promise in mitigating the effects of neuroinflammation associated with MS.
References
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Wang CH, Yen HR, Lu WL, Ho HH, Lin WY, et al. Adjuvant Probiotics of subsp. AP-32, MH-68, and subsp. CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:754401. 10.3389/fendo.2022.754401
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. 10.1016/j.nut.2021.111282
- Zhang H, Liu M, Liu X, Zhong W, Li Y, et al. ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells. Front Immunol. 2020;11:569104. 10.3389/fimmu.2020.569104
- Cardoso RS, Messora MR, Silva PHF, Oliveira LF, Leite-Panissi C, et al. Effects of subsp. HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis. Benef Microbes. 2020;11:33. 10.3920/BM2019.0038
- Salehipour Z, Haghmorad D, Sankian M, Rastin M, Nosratabadi R, et al. Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance. Biomed Pharmacother. 2017;95:1535. 10.1016/j.biopha.2017.08.117
- Ezendam J, de Klerk A, Gremmer ER, van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154:424. 10.1111/j.1365-2249.2008.03788.x
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. 10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. 10.3389/fimmu.2021.696074
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. 10.3389/fimmu.2020.01832
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. 10.1007/s00296-020-04558-9
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. 10.3390/nu9111166
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. 10.1080/07315724.2017.1347074
- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. 10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. 10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. 10.1002/fsn3.70068
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. 10.1039/d4fo03966a
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. 10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. 10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. 10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. 10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. 10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. 10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. 10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. 10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. 10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. 10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. 10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. 10.1002/jcp.26819
