Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.2
USERS' SCORE
Good
Based on 82 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Women's Care Probiotic Blend
50 Billion CFU 222 mg
***
Bifido Probiotic BlendBifidobacterium lactis BI-04®, Bifidobacterium lactis DSM 15954, Bifidobacterium infantis Bi-26™
26 Billion CFU
Lacto Probiotic BlendLactobacillus reuteri RC-14®, Lactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactobacillus rhamnosus GR-1®, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus brevis Lbr-35™
24 Billion CFU
Top Medical Research Studies
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
This study examined how Lactobacillus rhamnosus could impact the development of yeast infections, specifically candidiasis. By using immunosuppressed mice, we created various groups to see if taking this probiotic before or during Candida exposure made a difference.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
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9
We looked into how Lactobacillus reuteri 29A can combat yeast infections, specifically vulvovaginal candidiasis. The study examined its cell-free supernatant (CFS) for its ability to disrupt and inhibit biofilms formed by Candida species in both lab settings and in mice.
What we found was promising—the CFS effectively weakened established fungal biofilms and showed no harm to healthy tissues in mice. This suggests that L. reuteri could be a beneficial addition to treating or preventing vaginal yeast infections.
What we found was promising—the CFS effectively weakened established fungal biofilms and showed no harm to healthy tissues in mice. This suggests that L. reuteri could be a beneficial addition to treating or preventing vaginal yeast infections.
Read More
Most Useful Reviews
10
No yeast infection.
60 people found this helpful
Life changing! I hardly ever write reviews, but I had to for this one. I was a current bv and yeast infection sufferer. I kept returning to my gyno, trying various pills. They suggested a six-month treatment with metronidazole gel twice a week. Unfortunately, treating the bv led to a yeast infection, which returned after treatment. Desperate, I found this product. After three weeks, I'm thrilled to report that I have no yeast infection or bv. I'm a whole new woman and enjoying life again. Try it; you won't regret it.
Read More
9
Life-changing product
51 people found this helpful
Life Saver, Game Changer! I never write reviews, but this product prompted me to do so. I've dealt with BV and yeast infections after nearly every period for the last two years. Despite trying various remedies, nothing worked for me. I purchased this probiotic a month ago and now feel like I've found a solution! After taking antibiotics for a tooth extraction, I was worried about irritation, but to my surprise, there was none. After my period, I can happily say my vagina is thriving! I'm relieved to find something that works so well.
Read More
9
Restored normalcy
37 people found this helpful
Finally, I started feeling normal within three days of taking these probiotics! After five years of chronic yeast infections, I sought various treatments with little success. I noticed significant improvement after only a week, and my discomfort during sex improved by 80%. I carefully monitor my vaginal pH and saw it drop from 7 to 5 in a week, indicating better health. Though people say these are pricey, they offer a two-month supply, making them worth every penny for those with persistent issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.2
- All Researches
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Read More
9
Probiotic shows potential against fungus
We investigated the effectiveness of Lactobacillus rhamnosus Lcr35® against Candida albicans using lab models. The study showed that this probiotic significantly reduced fungal growth and adhesion in cell cultures.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 82 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
No yeast infection.
60 people found this helpful
Life changing! I hardly ever write reviews, but I had to for this one. I was a current bv and yeast infection sufferer. I kept returning to my gyno, trying various pills. They suggested a six-month treatment with metronidazole gel twice a week. Unfortunately, treating the bv led to a yeast infection, which returned after treatment. Desperate, I found this product. After three weeks, I'm thrilled to report that I have no yeast infection or bv. I'm a whole new woman and enjoying life again. Try it; you won't regret it.
Read More
9
Life-changing product
51 people found this helpful
Life Saver, Game Changer! I never write reviews, but this product prompted me to do so. I've dealt with BV and yeast infections after nearly every period for the last two years. Despite trying various remedies, nothing worked for me. I purchased this probiotic a month ago and now feel like I've found a solution! After taking antibiotics for a tooth extraction, I was worried about irritation, but to my surprise, there was none. After my period, I can happily say my vagina is thriving! I'm relieved to find something that works so well.
Read More
9
Restored normalcy
37 people found this helpful
Finally, I started feeling normal within three days of taking these probiotics! After five years of chronic yeast infections, I sought various treatments with little success. I noticed significant improvement after only a week, and my discomfort during sex improved by 80%. I carefully monitor my vaginal pH and saw it drop from 7 to 5 in a week, indicating better health. Though people say these are pricey, they offer a two-month supply, making them worth every penny for those with persistent issues.
Read More
9
Balanced gut bacteria
30 people found this helpful
Say goodbye to worries while on antibiotics regarding gut bacteria and yeast infections! This is my second purchase and I highly recommend it. As a med student, I researched probiotics that help maintain gut bacteria balance and prevent recurring yeast infections during antibiotic use. With long-term antibiotics, infections are common for me, but thankfully, I have yet to encounter a yeast infection while on my current antibiotic. I sought a probiotic effective throughout the digestive tract, and this fits perfectly.
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9
Best on the market
24 people found this helpful
AMAZING. For anyone battling chronic yeast infections due to hormonal imbalances, this is, without a doubt, the best product available. After suffering my first yeast infection, I tried over-the-counter treatments—none were effective. My doctor repeatedly prescribed me Diflucan with little advice on preventing infections. After researching, I discovered probiotics could provide relief. Although slightly pricey, this probiotic works wonders for me, and I recommend it to other women struggling with similar issues.
Read More
Frequently Asked Questions
7.5
Excellent relief
8 people found this helpful
My doctor recommended this after I experienced recurring infections post-childbirth. After a month, I can say it’s been excellent for me, relieving the burning sensation in my bladder and ensuring I feel much better now.
9
No yeast infections
11 people found this helpful
I used to suffer from frequent yeast infections every month, likely due to pH issues. After taking this daily for a month, I’ve had no problems at all. I feel great with no stomach irritation or side effects. Definitely worth the price.
9
Effective control
5 people found this helpful
I was concerned about my recurring yeast infections before my period. After trying this, I've noticed significant improvement after two bottles. It seems to help control the yeast much better. Patience is key, and it heals from within.
9
Long-term relief
2 people found this helpful
I was struggling with recurring yeast infections until a doctor recommended this product. It has been a great help, and I haven’t had an infection for about four months now.
10
Quick relief
1 people found this helpful
Great product! I have tried many probiotics for my ongoing yeast infection issue, and this made a difference within three days. I am very pleased I discovered it.
9
Yeast infection relief
5 people found this helpful
In conjunction with Udo's Probiotic, this product has kept my chronic yeast infections at bay for an impressive length of time.
10
Quick relief
2 people found this helpful
After suffering from a severe yeast infection, I found that applying kefir and two Ultimate Flora capsules helped me recover within days, without any chemicals.
10
Amazing results
5 people found this helpful
This product works a charm! I previously suffered from monthly yeast infections and tried several probiotics without success. Taking this daily in the mornings, while reducing sugar, has resulted in no more infections. It's an absolute godsend!
8
We examined the impacts of combining standard azole therapy with a local probiotic treatment to combat recurrent yeast infections. Involving 436 women, we divided participants into two groups: one receiving standard azole treatment alone and the other receiving the same treatment along with Lactobacillus acidophilus probiotics.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
7
We examined a series of studies focusing on the effects of Lactobacillus probiotics against Candida species, which cause yeast infections affecting many adult women. Reviewing 15 articles from 2015 to 2020, we noticed that particular strains like L. acidophilus can inhibit Candida growth.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
8
Lactobacilli may reduce Candida virulence
We examined how cell-free supernatants from lactobacilli, specifically L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri, affect the virulence traits of Candida parapsilosis in the context of vulvovaginal candidiasis. Our findings indicated that these lactobacilli can reduce the growth and harmful effects of C. parapsilosis, helping to enhance the vaginal lining's resistance to infection. This suggests that incorporating these lactobacilli could be beneficial in preventing yeast infections caused by non-albicans species like C. parapsilosis, although more research is needed to fully understand their effectiveness.
9
Probiotics combat Candida glabrata
We explored how probiotic strains Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 can combat a specific yeast infection caused by Candida glabrata. Using various methods, we demonstrated that these lactobacilli not only inhibited the growth of C. glabrata but also induced cell death in the yeast. Their ability to aggregate may help prevent colonization, offering insights into new treatment options for vulvovaginal candidiasis.
7
Probiotics showed increased effectiveness
We examined the effectiveness of oral probiotics containing Lactobacillus acidophilus among 60 pre-menopausal women to see if they could prevent vaginal infections.
In this double-blind study, participants received different probiotic mixtures for 14 days or a placebo.
Results showed that the probiotics F_1 and F_2 increased antimicrobial activity and enhanced the detection of beneficial bacteria in the vagina.
This study lays the groundwork for future research into these probiotics’ potential for treating or preventing uro-genital infections.
In this double-blind study, participants received different probiotic mixtures for 14 days or a placebo.
Results showed that the probiotics F_1 and F_2 increased antimicrobial activity and enhanced the detection of beneficial bacteria in the vagina.
This study lays the groundwork for future research into these probiotics’ potential for treating or preventing uro-genital infections.
References
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. 10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. 10.1128/spectrum.02696-21
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. 10.3906/sag-1709-143
- Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. 10.1007/s00404-016-4235-2
- Matsubara VH, Wang Y, Bandara HMHN, Mayer MPA, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100:6415. 10.1007/s00253-016-7527-3
- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. 10.1007/s10096-015-2447-1
- Vilela SF, Barbosa JO, Rossoni RD, Santos JD, Prata MC, et al. Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella. Virulence. 2015;6:29. 10.4161/21505594.2014.981486
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7:38. 10.1007/s12602-014-9176-0
- Ishikawa KH, Mayer MP, Miyazima TY, Matsubara VH, Silva EG, et al. A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015;24:194. 10.1111/jopr.12198
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. 10.1007/s00284-024-03800-y
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. 10.1038/s41598-020-74027-7
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. 10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. 10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. 10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. 10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. 10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. 10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. 10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. 10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. 10.1016/j.micpath.2017.08.006
- Boahen A, Chew SY, Neela VK, Than LTL. Limosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis. Probiotics Antimicrob Proteins. 2023;15:1681. 10.1007/s12602-023-10050-0
- Kraft-Bodi E, Jørgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015;94:181S. 10.1177/0022034515595950
- Chew SY, Cheah YK, Seow HF, Sandai D, Than LT. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118:1180. 10.1111/jam.12772
- Oncel MY, Arayici S, Sari FN, Simsek GK, Yurttutan S, et al. Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants. J Matern Fetal Neonatal Med. 2015;28:1790. 10.3109/14767058.2014.968842
- Wagner RD, Johnson SJ. Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans. J Biomed Sci. 2012;19:58. 10.1186/1423-0127-19-58
- Martinez RC, Seney SL, Summers KL, Nomizo A, De Martinis EC, et al. Effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the ability of Candida albicans to infect cells and induce inflammation. Microbiol Immunol. 2009;53:487. 10.1111/j.1348-0421.2009.00154.x
- Martinez RC, Franceschini SA, Patta MC, Quintana SM, Candido RC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl Microbiol. 2009;48:269. 10.1111/j.1472-765X.2008.02477.x
