Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend
5 Billion CFU**
< 1 g†
Maltodextrin, Microcrystalline cellulose, L. reuteri (RC-14®), L. rhamnosus (GR-1®), Magnesium Stearate
Top Medical Research Studies
9
This study examined how Lactobacillus rhamnosus could impact the development of yeast infections, specifically candidiasis. By using immunosuppressed mice, we created various groups to see if taking this probiotic before or during Candida exposure made a difference.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
Read More
9
We looked into how Lactobacillus reuteri 29A can combat yeast infections, specifically vulvovaginal candidiasis. The study examined its cell-free supernatant (CFS) for its ability to disrupt and inhibit biofilms formed by Candida species in both lab settings and in mice.
What we found was promising—the CFS effectively weakened established fungal biofilms and showed no harm to healthy tissues in mice. This suggests that L. reuteri could be a beneficial addition to treating or preventing vaginal yeast infections.
What we found was promising—the CFS effectively weakened established fungal biofilms and showed no harm to healthy tissues in mice. This suggests that L. reuteri could be a beneficial addition to treating or preventing vaginal yeast infections.
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8
We examined how lactobacilli, particularly Lactobacillus rhamnosus, impact the battle against yeast infections like vulvovaginal candidiasis (VVC). In our study, thirty strains were tested in the lab, revealing that some were effective at inhibiting Candida growth, mainly through organic acids.
In a murine model, the preventive-therapeutic use of L. rhamnosus showed significant promise, reducing fungal presence and associated inflammation. However, we found mixed results, as some testing methods showed no anti-Candida activity. Overall, lactobacilli could be beneficial, but more research is needed.
In a murine model, the preventive-therapeutic use of L. rhamnosus showed significant promise, reducing fungal presence and associated inflammation. However, we found mixed results, as some testing methods showed no anti-Candida activity. Overall, lactobacilli could be beneficial, but more research is needed.
Read More
Most Useful Reviews
10
Life changer
8 people found this helpful
I was plagued with yeast infections in my younger years. Since finding this product, everything has improved. I've spent a lot on medical consultations, and numerous experts emphasised "probiotics". I’m glad I researched and incorporated this into my routine, as I have not experienced any of my old issues since using RepHresh capsules.
Read More
10
Problem solved
7 people found this helpful
I suffer from chronic yeast infections due to imbalanced yeast and pH. Despite various prescriptions not completely resolving the issue, once I started using this product, my problem is SOLVED! I no longer have infections, and I feel fantastic. Please keep this item on the market!
Read More
10
Effective remedy
3 people found this helpful
This female probiotic works wonderfully! I used to struggle with vaginal infections every year, but since using this product over the past few years, I’ve not had any infections at all.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.3
- All Researches
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Read More
9
Probiotic shows potential against fungus
We investigated the effectiveness of Lactobacillus rhamnosus Lcr35® against Candida albicans using lab models. The study showed that this probiotic significantly reduced fungal growth and adhesion in cell cultures.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
Read More
9
This study examined how Lactobacillus rhamnosus could impact the development of yeast infections, specifically candidiasis. By using immunosuppressed mice, we created various groups to see if taking this probiotic before or during Candida exposure made a difference.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
Read More
9
Potential ally against Candida infections
We explored how Lactobacillus rhamnosus (LR) can aid in fighting Candida infections. The study tested LR and other lactobacilli in both mouse macrophages and Galleria mellonella larvae.
Results showed that LR significantly boosted immune responses and enhanced larvae survival against Candida. In particular, it reduced yeast counts, showcasing its potential as an adjunct treatment for managing yeast infections.
Ultimately, LR stood out for its anti-Candida effects, making it a promising ally against these tough fungal threats.
Results showed that LR significantly boosted immune responses and enhanced larvae survival against Candida. In particular, it reduced yeast counts, showcasing its potential as an adjunct treatment for managing yeast infections.
Ultimately, LR stood out for its anti-Candida effects, making it a promising ally against these tough fungal threats.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life changer
8 people found this helpful
I was plagued with yeast infections in my younger years. Since finding this product, everything has improved. I've spent a lot on medical consultations, and numerous experts emphasised "probiotics". I’m glad I researched and incorporated this into my routine, as I have not experienced any of my old issues since using RepHresh capsules.
Read More
10
Problem solved
7 people found this helpful
I suffer from chronic yeast infections due to imbalanced yeast and pH. Despite various prescriptions not completely resolving the issue, once I started using this product, my problem is SOLVED! I no longer have infections, and I feel fantastic. Please keep this item on the market!
Read More
10
Effective remedy
3 people found this helpful
This female probiotic works wonderfully! I used to struggle with vaginal infections every year, but since using this product over the past few years, I’ve not had any infections at all.
Read More
9
Drastic reduction
3 people found this helpful
I experience frequent yeast infections, likely due to being a type 1 diabetic, yet my blood sugar levels are perfect. No one suggested a probiotic until I decided to try one specifically for gynecological needs, and my yeast infections have decreased by nearly 90%. I can now take antibiotics and manage my cycle without issues. These are fantastic and I highly recommend them.
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10
No issues experienced
1 people found this helpful
I have seen results with this supplement. Honestly, since I began taking it two years ago, I haven't experienced any yeast infection issues.
Read More
Frequently Asked Questions
8
We examined 15 recent articles on various Lactobacillus strains and their effects on Candida species. Our exploration revealed that certain strains, including Lactobacillus rhamnosus, could inhibit Candida growth and reduce the chance of recurrent yeast infections.
We also learned that using these probiotics for a longer duration tends to yield better results, especially when combined with standard treatments. Though the probiotics showed potential, it's essential to consider the specific strain and usage time for effective results.
We also learned that using these probiotics for a longer duration tends to yield better results, especially when combined with standard treatments. Though the probiotics showed potential, it's essential to consider the specific strain and usage time for effective results.
8
Lactobacillus rhamnosus aids in yeast infection
We examined the effects of lactobacilli on Candida parapsilosis, a fungus causing vulvovaginal candidiasis (VVC) that is increasingly prevalent. Using cell-free supernatants from Lactobacillus rhamnosus and others, we observed significant reductions in the fungus's virulence and improved vaginal cell resistance. This suggests that incorporating these beneficial bacteria into treatment strategies could help prevent VVC caused by non-albicans species. The findings highlight the potential of lactobacilli in enhancing vaginal health and tackling persistent yeast infections.
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
8
We investigated how Lactobacillus rhamnosus can help treat yeast infections. From 50 vaginal swabs, we isolated various lactobacilli and noted their functional properties, including antimicrobial activity. Notably, L. rhamnosus showed strong anti-Candida effects, alongside good antibacterial activity.
The findings suggest that L. rhamnosus, especially when combined with other strains, holds promise for creating effective probiotic treatments for vulvovaginal infections in both pregnant and non-pregnant women. While we found potential benefits, further research is still needed to confirm its effectiveness in clinical settings.
The findings suggest that L. rhamnosus, especially when combined with other strains, holds promise for creating effective probiotic treatments for vulvovaginal infections in both pregnant and non-pregnant women. While we found potential benefits, further research is still needed to confirm its effectiveness in clinical settings.
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
References
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. 10.1007/s00284-024-03800-y
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. 10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. 10.1128/spectrum.02696-21
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. 10.1038/s41598-020-74027-7
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. 10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. 10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. 10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. 10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. 10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. 10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. 10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. 10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. 10.1016/j.micpath.2017.08.006
- Boahen A, Chew SY, Neela VK, Than LTL. Limosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis. Probiotics Antimicrob Proteins. 2023;15:1681. 10.1007/s12602-023-10050-0
- Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. 10.1007/s00404-016-4235-2
- Kraft-Bodi E, Jørgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015;94:181S. 10.1177/0022034515595950
- Chew SY, Cheah YK, Seow HF, Sandai D, Than LT. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118:1180. 10.1111/jam.12772
- Oncel MY, Arayici S, Sari FN, Simsek GK, Yurttutan S, et al. Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants. J Matern Fetal Neonatal Med. 2015;28:1790. 10.3109/14767058.2014.968842
- Wagner RD, Johnson SJ. Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans. J Biomed Sci. 2012;19:58. 10.1186/1423-0127-19-58
- Martinez RC, Seney SL, Summers KL, Nomizo A, De Martinis EC, et al. Effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the ability of Candida albicans to infect cells and induce inflammation. Microbiol Immunol. 2009;53:487. 10.1111/j.1348-0421.2009.00154.x
- Martinez RC, Franceschini SA, Patta MC, Quintana SM, Candido RC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl Microbiol. 2009;48:269. 10.1111/j.1472-765X.2008.02477.x
