' 
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Teaspoons (10 ml)
Serving Per Container: 12
Amount Per Serving
%DV
Calories
25
Total Carbohydrate
7 g
3%†
Total Sugars
7 g
**
Includes 3.1 g Added Sugars
6.2%
Vitamin C (ascorbic acid)
110 mg
122%
Zinc (as zinc gluconate)
2.6 mg
24%
Black Elderberry Extract
3.8 g
**
Top Medical Research Studies
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
Insightful effects of zinc demonstrated
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
Directly investigates zinc for allergies
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
Partially relevant to zinc allergies
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9.5
Amazingly effective
Absolutely amazing! This herb is exceptionally beneficial, especially during flu and cold season, as it strengthens the immune system. Personally, I rely on it to manage my seasonal allergy flare-ups. It is astonishing how effective this product is at controlling my allergies. I will never be without it!
Read More
8.8
Helps with allergies
Helps with allergies. Although liquid, it appears to contain more elderberry than the chewable version. It seems to assist my other allergy medications effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
Study directly addresses allergic rhinitis
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
Insightful effects of zinc demonstrated
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
Directly investigates zinc for allergies
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
Partially relevant to zinc allergies
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Pleuran and Vitamin C aid asthma
Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.
Vitamin C's effect is unclear
We conducted a thorough evaluation of how vitamin C, when combined with pleuran, impacts asthma control and respiratory issues in children suffering from perennial asthma. The study was meticulously designed as a double-blind, placebo-controlled trial involving 230 children aged 7 to 17 years. This means that neither the participants nor the researchers knew who was receiving the active treatment or the placebo, ensuring the findings were reliable.
The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.
While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
The results were promising, especially for children under 12 years. They showed significant improvements in asthma control compared to those receiving only the placebo treatment. Meanwhile, older children (12 years and above) experienced fewer respiratory infections with the combination treatment. Overall, by the end of the 48 weeks, a majority of children on the pleuran and vitamin C treatment reported better asthma control compared to those on the placebo.
While the combination of pleuran and vitamin C was indeed beneficial for managing asthma, we must note that the study did not specifically isolate the effect of vitamin C alone on allergies or asthma. Thus, it is hard to draw definitive conclusions about vitamin C's effectiveness independently from pleuran. However, the approach suggested that using these supplements together could offer a helpful boost in managing asthma symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Amazingly effective
Absolutely amazing! This herb is exceptionally beneficial, especially during flu and cold season, as it strengthens the immune system. Personally, I rely on it to manage my seasonal allergy flare-ups. It is astonishing how effective this product is at controlling my allergies. I will never be without it!
Read More
8.8
Helps with allergies
Helps with allergies. Although liquid, it appears to contain more elderberry than the chewable version. It seems to assist my other allergy medications effectively.
