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However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
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Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
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Frequently Asked Questions
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Vitamin C is often touted as a remedy for the common cold and flu, but the scientific evidence supporting its effectiveness is mixed. Some studies suggest that taking Vitamin C may reduce the duration and severity of flu-like symptoms, particularly in people who are under physical stress, such as athletes. However, for the average person, the benefits of high-dose Vitamin C in preventing or treating the flu are not conclusively supported by research. It's generally recommended to maintain an adequate intake of Vitamin C as part of a balanced diet, but relying solely on supplements is not a guaranteed method for preventing the flu.
Incorporating Vitamin C-rich foods, such as citrus fruits, strawberries, and bell peppers, can support your immune system and overall health. It's important to note that while Vitamin C can contribute to your well-being, it should not replace conventional flu prevention measures, like vaccination and good hygiene practices. If you're already experiencing flu symptoms, it's advisable to consult with a healthcare professional for appropriate treatment options.
Based on the user reviews, individuals taking this Vitamin C supplement for flu often report results within a few days to a couple of weeks. For instance, one user noted that after taking a large dose for a whole month during the flu, they experienced significant benefits ((Read Review)). Another user mentioned feeling better after just three to four days of use during an illness ((Read Review)). Furthermore, some users claim it helps speed up recovery from flu symptoms, indicating that the supplement might start working relatively quickly in reducing discomfort and enhancing immunity.
Overall, while many users report they have not experienced the flu at all after using this supplement regularly for years ((Read Review)), it seems that acute benefits can be felt in as little as two to four days for those who are already feeling unwell. Therefore, if you're dealing with flu symptoms, you might expect to see noticeable improvements shortly after starting the supplement.
Vitamin C has garnered attention in the context of flu management due to several studies suggesting its potential benefits. Research indicates that vitamin C supplementation can reduce the risk of acute respiratory infections, such as the flu, by about 4% and may shorten the duration of flu symptoms by approximately 9%—an effect particularly pronounced in certain demographics [1]. Furthermore, studies have also revealed that vitamin C works synergistically with other compounds, like red ginseng, to boost immune response and decrease lung inflammation, enhancing the body's ability to combat viral infections [3].
Additionally, vitamin C has shown potential in modulating the immune response at the gene level, which could further aid in preventing severe outcomes from influenza infections [5]. Some findings even suggest that vitamin C may inhibit the activity of influenza neuraminidase, although its effects in this context are moderate when compared to established antiviral medications [2]. While all these studies highlight a promising role for vitamin C in flu management, it is important to note that it is not a standalone solution and should be part of a larger strategy for flu prevention and treatment.
Many users report significant improvements in their immune response and a reduction in the frequency of colds and flu after taking this Vitamin C supplement. For instance, one user noted they haven't experienced any cold or flu for a decade, attributing this to consistent use of Solaray Super Bio Vitamin C ((Read Review)). Others mention feeling less susceptible to illnesses, with one user feeling they get sick less often and recover quicker when they do, especially during the cold and flu season ((Read Review)).
Several reviewers highlight anecdotal evidence of rapid recovery, stating that they feel better within a few days of starting the supplement ((Read Review); (Read Review)). Users have also reported joint benefits, with some feeling enhanced immunity not just against flu but also against other pathogens, saying they feel more robust and energized overall ((Read Review)). Overall, while individual results may vary, the common thread in these reviews suggests that many experience meaningful health benefits after incorporating this Vitamin C supplement into their daily routines.
Many users have reported successfully combining this Vitamin C supplement with other supplements to enhance their immune response and tackle flu symptoms. One user shared their regimen of using Vitamin C along with Oregano, Elderberry, Quercetin, and NAC, claiming that this combination allowed them to recover from flu symptoms in under three days ((Read Review)). Additionally, other reviewers noted that pairing Vitamin C with supplements like D3 and K2 or collagen has contributed to their overall health, leading to extended periods without experiencing colds or flu ((Read Review); (Read Review)).
Overall, many users emphasize the importance of strategic combinations of supplements to boost immune protection and recovery speeds. For instance, pairing this Vitamin C with Oregano and an Immune Formula is noted to effectively curb flu symptoms and enhance recovery rates ((Read Review); (Read Review)). This anecdotal evidence suggests that users find benefits from thoughtful supplement stacking and may advise others to explore similar combinations based on their individual health needs.
The research indicates that vitamin C can be beneficial in managing flu symptoms, particularly by reducing the duration of illness. A study observed that vitamin C supplementation could shorten the time flu symptoms last by approximately 9% [1]. Additionally, high doses have shown promise in decreasing severity and mortality related to influenza, especially when administered in a targeted manner. For instance, in trials involving stressed mice, doses around 125 to 250 mg/kg were linked to a significant reduction in severe symptoms from the H1N1 virus [5].
While the exact "optimal" dose for vitamin C when it comes to flu treatment remains somewhat elusive, these studies suggest that higher doses could be more effective, particularly in specific contexts such as stress-induced situations or with certain population demographics. However, it's important to note that while vitamin C can be a helpful adjunct in managing flu symptoms, it is not a standalone solution and should be considered part of a broader treatment strategy [1].
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
References
- Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. doi:10.1136/bmjgh-2020-003176
- Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. doi:10.3390/molecules25184248
- Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. doi:10.1111/jphp.12529
- Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. doi:10.1016/j.ejmech.2016.01.005
- Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. doi:10.1155/2015/675149
