Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
USERS' SCORE
Good
Based on 33 Reviews
8.3
Supplement Facts
Serving Size: 2 VegCaps
Serving Per Container: 125
Amount Per Serving
%DV
Vitamin C (As ascorbic Acid, Rose Hips, Acerola Cherry)
1,000 mg
1,111%
Bioflavonoid Concentrate (From Lemon)
500 mg
*
Rutin Concentrate
100 mg
*
Hesperidin Concentrate
100 mg
*
Citrus Pectin
30 mg
*

Top Medical Research Studies

8
Vitamin C mitigates flu pneumonia
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.

However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.

Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.

Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
8
Vitamin C triterpene flu inhibitors
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.

Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.

We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.

In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.

Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.

Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More

Most Useful Reviews

9
Well absorbed
2 people found this helpful
Excellent during cold and flu season, and well absorbed.
Read More
9
Regular vitamin intake
2 people found this helpful
It works! I regularly take Solray buffered vitamin C and attribute not getting colds or flu to this great supplement.
Read More
10
No colds
Great value! The biggest upside of taking Solaray Super Bio Vitamin C with Biflavonoids is that I haven't experienced a cold or the flu for 10 years.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.2
  • All Researches
9
Immune booster for flu treatment
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.

Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.

In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Read More
8
Vitamin C triterpene flu inhibitors
We recently explored the potential of novel compounds that are combinations of L-ascorbic acid, commonly known as vitamin C, and pentacyclic triterpenes in battling the flu. The study focused on compounds we created and tested against the influenza virus in MDCK cells, particularly looking at their effectiveness and any possible side effects.

Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.

We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
Read More
8
Vitamin C mitigates flu pneumonia
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.

However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.

Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.

Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Read More
7
Vitamin C's promise against flu
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).

Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.

Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Read More
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.

In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.

Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.

Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
Read More

User Reviews

USERS' SCORE
Good
Based on 33 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Well absorbed
2 people found this helpful
Excellent during cold and flu season, and well absorbed.
Read More
9
Regular vitamin intake
2 people found this helpful
It works! I regularly take Solray buffered vitamin C and attribute not getting colds or flu to this great supplement.
Read More
10
No colds
Great value! The biggest upside of taking Solaray Super Bio Vitamin C with Biflavonoids is that I haven't experienced a cold or the flu for 10 years.
Read More
9
Outstanding effect
The effect is outstanding! I take six or more tablets a day, and it significantly boosts my immunity. It is also effective against coronavirus and influenza.
Read More
9
Improves sleep
Excellent vitamin C! A friend asked me to order this for her; she said it has improved her sleep and made her more resistant to colds and flu.
Read More

Frequently Asked Questions

9
Highly effective during flu
Very good and I highly recommend it. I took it for a whole month. Note that I took a large dose of 5000 during the flu, which is wonderful.
7.5
Improves well-being
Good quality and effective; I've taken it for 3 or 4 days when feeling ill (flu, cold, etc.), and I feel better afterwards.
9
Aids recovery
It really helps with my flu and speeds up my recovery from being unwell.
10
No colds
Great value! The biggest upside of taking Solaray Super Bio Vitamin C with Biflavonoids is that I haven't experienced a cold or the flu for 10 years.
9
Great vitamin choice
I started taking Solaray Super Bio Vitamin C Buffered months ago, and it's the best vitamin C I've tried! It's buffered, making it gentle on my stomach. Each capsule contains 500 mg of vitamin C, which supports my immune system during cold and flu season. I feel I get sick less often and recover faster.
7.5
Speeds recovery
I'm taking Vitamin C + Oregano + Elderberry + Quercetin + NAC + Immune Formula to tackle flu at the first sign. It speeds up my recovery in under 3 days.
7.5
Supports immunity
1 people found this helpful
I recently started taking Solaray Buffered Super Bio Vitamin C and wanted to share my thoughts. The packaging is convenient, and the 100 vegetarian capsules offer a great long-term supply. I appreciate that this vitamin C is buffered, which makes it gentle on the stomach. After taking it, I experienced no discomfort. The small capsules are easy to swallow. I take them daily, and I've noticed an increase in my energy levels and overall well-being. This vitamin C supports the immune system, making me feel more protected during cold and flu season. Importantly, the product is gluten-free and free of artificial additives, catering to various dietary restrictions. I'm very pleased with Solaray Buffered Super Bio Vitamin C and recommend it to anyone seeking a quality vitamin.
9
Cold issues resolved
Vitamin C is vital for my immune system. I’ve been using this product with D3 and K2 for two years, and flu and colds are no longer issues for me.
9
No colds experienced
I took vitamin C along with collagen for a year and haven’t had any colds or the flu since.
9
Effective against flu
It is an excellent immune booster, especially when taken with Oregano, Immune Formula, Vitamin C, and NAC, effectively curbing the flu while speeding up recovery.
9
Good booster
Good. It is an excellent immune booster, taken alongside Oregano, Immune Formula, Vitamin C, and NAC, effectively curbing the flu and enhancing recovery speed.
7
Vitamin C's promise against flu
We examined how vitamin C supplementation can impact flu incidence and symptom duration. Our analysis of clinical studies indicated that vitamin C does show promise in reducing the risk of acute respiratory infections, including flu. Specifically, vitamin C reduced the likelihood of catching an acute respiratory infection by approximately 4% (risk ratio of 0.96).

Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.

Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
9
Immune booster for flu treatment
We set out to discover how red ginseng and vitamin C work together to enhance immune cell function and fight off viral infections like the flu. In our investigation, we treated human immune cells and specific types of mice unable to produce vitamin C, looking closely at their reaction to influenza A virus/H1N1.

Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.

In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
8
Vitamin C mitigates flu pneumonia
We examined the effects of vitamin C on pneumonia caused by the influenza virus, specifically the H1N1 strain, in mice under stress. The study found that when exposed to restraint stress, the mice experienced increased mortality and more severe pneumonia symptoms.

However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.

Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.

Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
We investigated the effects of various compounds, including vitamin C, on the neuraminidase (NA) activity of influenza viruses, specifically H1N1 and H5N2. Neuraminidase is crucial for the virus as it helps release new viral particles from infected cells, making it a key target for antiviral treatments.

In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.

Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.

Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.

References

  1. Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
  2. Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. 10.3390/molecules25184248
  3. Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. 10.1111/jphp.12529
  4. Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. 10.1016/j.ejmech.2016.01.005
  5. Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. 10.1155/2015/675149
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