5/1/2025
Last update
5/1/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 68 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Advanced 40+ Acidophilus 1.5 billion CFUproviding:Lactobacillus. acidophilus, (LA-5®)300 million CFULactobacillus rhamnosus GG (LGG®)300 million CFULactobacillus paracasei (L. CASEI 431®)300 million CFU Bifidobacterium lactis (BB-12®)300 million CFUStreptococcus thermophilus, (TH-4®)300 million CFU
2.4 mg
**
Top Medical Research Studies
8
We investigated the impact of a probiotic ice cream containing engineered bacteria on pollen allergies in mice. After sensitizing the mice, we treated them with this unique ice cream for four weeks. The results were promising! The ice cream significantly lowered serum IgE levels, which are linked to allergic reactions. Additionally, beneficial cytokines increased while the levels of a harmful cytokine decreased. Overall, our findings suggest that this probiotic ice cream could improve allergy responses, particularly with Th1 and Treg involvement.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
Most Useful Reviews
9
Good allergy improvement
Recommended purchase. I have observed a good improvement in my allergies.
Read More
7.5
Improved skin allergies
The quality of the ingredients is good, the packaging is effective, and the probiotics are plentiful. The presence of LGG bacteria can aid in improving skin allergies, and I’ve certainly noticed an improvement.
Read More
4
No improvement yet
I selected this probiotic hoping it would address some suspected rhinitis and skin allergies within my family. However, after using one box, I haven't noticed any specific improvement thus far. Perhaps it requires a longer duration to take effect.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 68 Researches
8.2
- All Researches
9.5
We sought to understand if Bifiform Kids, a probiotic, could help prevent respiratory infections in children with recurrent infections and gastrointestinal allergy symptoms. In our controlled trial with 92 children aged 4 to 5, those taking the probiotic showed a significant 3-fold reduction in respiratory infections compared to the control group.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
Read More
9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We investigated the effects of Lactobacillus acidophilus on allergies, particularly its peptidoglycan derived from dairy. In a mouse model of β-lactoglobulin allergy, we discovered that this peptidoglycan helped lower IgE production and promoted a healthier immune response. It also appeared to influence specific immune signaling pathways that help manage allergic reactions.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
Read More
9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
9
Lactobacillus acidophilus may reduce allergies
Our study assessed how Lactobacillus acidophilus in probiotic Dahi affects allergies, particularly cow milk allergy in mice. Mice were given two types of probiotic Dahi before being exposed to whey proteins.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Good allergy improvement
Recommended purchase. I have observed a good improvement in my allergies.
Read More
7.5
Improved skin allergies
The quality of the ingredients is good, the packaging is effective, and the probiotics are plentiful. The presence of LGG bacteria can aid in improving skin allergies, and I’ve certainly noticed an improvement.
Read More
4
No improvement yet
I selected this probiotic hoping it would address some suspected rhinitis and skin allergies within my family. However, after using one box, I haven't noticed any specific improvement thus far. Perhaps it requires a longer duration to take effect.
Read More
Frequently Asked Questions
9
Good allergy improvement
Recommended purchase. I have observed a good improvement in my allergies.
7.5
Improved skin allergies
The quality of the ingredients is good, the packaging is effective, and the probiotics are plentiful. The presence of LGG bacteria can aid in improving skin allergies, and I’ve certainly noticed an improvement.
4
No improvement yet
I selected this probiotic hoping it would address some suspected rhinitis and skin allergies within my family. However, after using one box, I haven't noticed any specific improvement thus far. Perhaps it requires a longer duration to take effect.
8
We investigated the potential of Lactobacillus acidophilus KLDS 1.0738 to alleviate allergic inflammation, focusing on its ability to influence a specific inflammatory pathway in macrophages. By treating β-lactoglobulin-induced macrophages with viable L. acidophilus, we found that it effectively reduced inflammation by inhibiting the TLR4/NF-κB signaling pathway. This strain outperformed other probiotics in its effectiveness. Additionally, it was linked to increased levels of miR-146a, a molecule that regulates inflammation. These findings suggest that probiotics could play a significant role in managing milk allergies, particularly in infants.
8
We aimed to assess how probiotic supplementation, particularly using Lactobacillus acidophilus, can help treat adult atopic dermatitis (AD). After analyzing nine studies, we found that specific probiotics, including L. acidophilus, provided some benefits, especially for those with moderate to severe AD.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
8
We investigated the use of a symbiotic food supplement, combining probiotics and prebiotics, in combatting birch pollen allergies. Conducted in a controlled allergen exposure chamber, our research monitored patients' symptoms over four months.
The results showed noticeable improvements in allergy symptoms and overall well-being after regular use of the supplement. This suggests such supplements can be a helpful addition to managing allergic rhinitis, with a strong safety record.
The results showed noticeable improvements in allergy symptoms and overall well-being after regular use of the supplement. This suggests such supplements can be a helpful addition to managing allergic rhinitis, with a strong safety record.
8
Probiotics beneficial for eczema treatment
We examined the use of probiotics in alleviating symptoms of atopic dermatitis in children. Through a thorough review of multiple studies, we found that certain probiotic strains, particularly Mix1 and Mix6, significantly improved allergic symptoms compared to a placebo.
Although evidence was strongest for Mix1 among the strains assessed, Mix6 showed promising potential as well. Conversely, while Lactobacillus casei DN-114001 indicated some benefit, the certainty of this effect was lower.
Overall, specific probiotic preparations do seem to help in managing allergies associated with pediatric atopic dermatitis.
Although evidence was strongest for Mix1 among the strains assessed, Mix6 showed promising potential as well. Conversely, while Lactobacillus casei DN-114001 indicated some benefit, the certainty of this effect was lower.
Overall, specific probiotic preparations do seem to help in managing allergies associated with pediatric atopic dermatitis.
References
- Kim WK, Jang YJ, Park S, Min SG, Kwon H, et al. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. J Microbiol. 2024;62:91. 10.1007/s12275-024-00104-5
- Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49:46. 10.1093/ced/llad318
- Li A, Yang J, Zhang C, Chi H, Zhang C, et al. Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a. J Food Biochem. 2021;45:e13662. 10.1111/jfbc.13662
- Bergmann KC, Krause L, Hiller J, Becker S, Kugler S, et al. First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients. World Allergy Organ J. 2021;14:100494. 10.1016/j.waojou.2020.100494
- Tan-Lim CSC, Esteban-Ipac NAR, Mantaring JBV, Chan Shih Yen E, Recto MST, et al. Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:124. 10.1111/pai.13305
- Ni WW, Zhang QM, Zhang X, Li Y, Yu SS, et al. Modulation effect of Lactobacillus acidophilus KLDS 1.0738 on gut microbiota and TLR4 expression in β-lactoglobulin-induced allergic mice model. Allergol Immunopathol (Madr). 2020;48:149. 10.1016/j.aller.2019.06.002
- Wang JJ, Zhang QM, Ni WW, Zhang X, Li Y, et al. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice. Microbiol Immunol. 2019;63:303. 10.1111/1348-0421.12723
- Nakata J, Hirota T, Umemura H, Nakagawa T, Kando N, et al. Additive effect of L-92 on children with atopic dermatitis concomitant with food allergy. Asia Pac Allergy. 2019;9:e18. 10.5415/apallergy.2019.9.e18
- Wang JJ, Li SH, Li AL, Zhang QM, Ni WW, et al. Effect of Lactobacillus acidophilus KLDS 1.0738 on miRNA expression in in vitro and in vivo models of β-lactoglobulin allergy. Biosci Biotechnol Biochem. 2018;82:1955. 10.1080/09168451.2018.1495551
- Li AL, Sun YQ, Du P, Meng XC, Guo L, et al. The Effect of Lactobacillus actobacillus Peptidoglycan on Bovine β-Lactoglobulin-Sensitized Mice via TLR2/NF-κB Pathway. Iran J Allergy Asthma Immunol. 2017;16:147.
- Rø ADB, Simpson MR, Rø TB, Storrø O, Johnsen R, et al. Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. Clin Exp Allergy. 2017;47:1014. 10.1111/cea.12930
- Gelardi M, De Luca C, Taliente S, Fiorella ML, Quaranta N, et al. Adjuvant treatment with a symbiotic in patients with inflammatory non-allergic rhinitis. J Biol Regul Homeost Agents. 2017;31:201.
- Shen X, Li M, Shi L, Ling N, He M, et al. [The Immunomodulatory and Anti-allergy Effects of Lactobacilli]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2016;47:192.
- Yamamoto K, Yokoyama K, Matsukawa T, Kato S, Kato S, et al. Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis. J Dairy Sci. 2016;99:5039. 10.3168/jds.2015-10605
- Shandilya UK, Sharma A, Kapila R, Kansal VK. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice. J Sci Food Agric. 2016;96:3180. 10.1002/jsfa.7497
- Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 2015;15:13. 10.1186/s12895-015-0030-1
- Xu H, Duan X, Wang Y, Geng W. Amelioration Effect of ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB/c Mice. Foods. 2024;14. 10.3390/foods14010016
- Lungaro L, Malfa P, Manza F, Costanzini A, Valentini G, et al. Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16234173
- Song S, Zhang H, Liu L, Li M, Wang X, et al. Probiotic DNA regulates intestinal Th2 polarization by inducing epithelial cells to produce PD-L1. Apoptosis. 2025;30:239. 10.1007/s10495-024-02043-3
- Mennini M, Piccirillo M, Furio S, Valitutti F, Ferretti A, et al. Probiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review. Front Allergy. 2024;5:1473352. 10.3389/falgy.2024.1473352
- Malekiantaghi A, Ghanaati F, Shabani-Mirzaee H, Shariat M, Mojtahedi SY, et al. Helps to Reduce the Duration of Bleeding in Breastfed Infants with Allergic Proctocolitis. Breastfeed Med. 2025;20:59. 10.1089/bfm.2024.0185
- Xue J, Liu Z, Xie B, Dong R, Wu J, et al. Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy. Inflamm Res. 2024;73:1919. 10.1007/s00011-024-01940-2
- Puisto R, Gómez-Gallego C, Collado MC, Turta O, Isolauri E, et al. The Role of Infant Gut Microbiota Modulation by Perinatal Maternal Probiotic Intervention in Atopic Eczema Risk Reduction. Neonatology. 2025;122:84. 10.1159/000540075
- Uberos J, Garcia-Cuesta A, Carrasco-Solis M, Ruiz-López A, Fernandez-Marı N E, et al. Lacticaseibacillus rhamnosus and breastmilk are associated with a decreased risk of atopic dermatitis in very low birth weight premature infants. Benef Microbes. 2023;14:433. 10.1163/18762891-20220144
- Shi J, Dong P, Liu C, Xu Y, Zheng M, et al. Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism. Food Funct. 2023;14:10784. 10.1039/d3fo03321j
- Li L, Wen X, Gong Y, Chen Y, Xu J, et al. HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis. Front Microbiol. 2023;14:1202858. 10.3389/fmicb.2023.1202858
- Vasconcelos JA, Mota AS, Olímpio F, Rosa PC, Damaceno-Rodrigues N, et al. Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome. Probiotics Antimicrob Proteins. 2025;17:588. 10.1007/s12602-023-10167-2
- Tan Lim CSC, Sajo MEJV, Orteza KEMP, Fernandez PBA, Vila MJC. Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis. Pediatr Allergy Immunol. 2023;34:e14022. 10.1111/pai.14022
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. 10.1111/pai.14004
- Hou Y, Zheng S, Zou F, Wang D, Da H, et al. Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway. Immunobiology. 2023;228:152712. 10.1016/j.imbio.2023.152712
- Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. ВB-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. 10.33029/0042-8833-2023-92-3-79-86
- Lee JY, Park JY, Jeong Y, Kang CH. Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474. J Microbiol Biotechnol. 2023;33:1039. 10.4014/jmb.2301.01028
- Wang H, He Y, Dang D, Feng L, Huang L, et al. subsp. CCFM1274 relieved allergic asthma symptoms by modifying intestinal tryptophan metabolism in mice. Food Funct. 2024;15:8810. 10.1039/d4fo01079e
- Adjibade M, Vigneron L, Delvert R, Adel-Patient K, Divaret-Chauveau A, et al. Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother-child cohort. Matern Child Nutr. 2024;20:e13673. 10.1111/mcn.13673
- Tian X, Liang X, He H, Cui Q, Liu Q, et al. Probiotics Alleviate Food Protein Allergy in Mice by Activating TLR4 Signaling Pathway. Mol Nutr Food Res. 2023;67:e2200579. 10.1002/mnfr.202200579
- Bezruk VV, Godovanets OS, Buriak OH, Voytkevich NI, Makarova OV, et al. The use of hydrolyzed formulas as a method of correction of feeding and clinical rehabilitation of infants with atopy signs. J Med Life. 2022;15:1536. 10.25122/jml-2022-0254
- Feíto-Rodríguez M, Ramírez-Boscà A, Vidal-Asensi S, Fernández-Nieto D, Ros-Cervera G, et al. Randomized double-blind placebo-controlled clinical trial to evaluate the effect of a mixture of probiotic strains on symptom severity and use of corticosteroids in children and adolescents with atopic dermatitis. Clin Exp Dermatol. 2023;48:495. 10.1093/ced/llad007
- Shikh EV, Drozdov VN, Vorobieva OA, Zhukova OV, Ermolaeva AS, et al. [The effectiveness of BIFIFORM KIDS in the prevention of the incidence of acute respiratory infections in children]. Vopr Pitan. 2022;91:97. 10.33029/0042-8833-2022-91-4-97-106
- Uwaezuoke SN, Ayuk AC, Eze JN, Odimegwu CL, Ndiokwelu CO, et al. Postnatal probiotic supplementation can prevent and optimize treatment of childhood asthma and atopic disorders: A systematic review of randomized controlled trials. Front Pediatr. 2022;10:956141. 10.3389/fped.2022.956141
- Anania C, Di Marino VP, Olivero F, De Canditiis D, Brindisi G, et al. Treatment with a Probiotic Mixture Containing Subsp. BB12 and L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial. Nutrients. 2021;13. 10.3390/nu13041315
- Tan-Lim CSC, Esteban-Ipac NAR, Recto MST, Castor MAR, Casis-Hao RJ, et al. Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:1255. 10.1111/pai.13514
- Schmidt RM, Pilmann Laursen R, Bruun S, Larnkjaer A, Mølgaard C, et al. Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial. Pediatr Allergy Immunol. 2019;30:335. 10.1111/pai.13018
- Liu Q, Jing W, Wang W. Ameliorates the Risk of Food Allergy in Chinese Children by Affecting Relative Percentage of Treg and Th17 Cells. Can J Infect Dis Med Microbiol. 2018;2018:4561038. 10.1155/2018/4561038
- Baars T, van Esch B, van Ooijen L, Zhang Z, Dekker P, et al. Raw milk kefir: microbiota, bioactive peptides, and immune modulation. Food Funct. 2023;14:1648. 10.1039/d2fo03248a
- Zhang Q, Ai C, Wang G, Liu X, Tian F, et al. Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation. J Appl Microbiol. 2015;119:809. 10.1111/jam.12885
- Petrarca C, Clemente E, Toto V, Iezzi M, Rossi C, et al. rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant. Hum Vaccin Immunother. 2014;10:1228. 10.4161/hv.28155
- Ivakhnenko ES, Nian'kovskiĭ SL. [Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants]. Georgian Med News. 2013.
- Ivakhnenko O, Niankovskyy S. [Clinical effectiveness of probiotics in complex treatment of infants with cow's milk allergy]. Georgian Med News. 2013.
- Morisset M, Aubert-Jacquin C, Soulaines P, Moneret-Vautrin DA, Dupont C. A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy. Eur J Clin Nutr. 2011;65:175. 10.1038/ejcn.2010.250
- Bu G, Luo Y, Zhang Y, Chen F. Effects of fermentation by lactic acid bacteria on the antigenicity of bovine whey proteins. J Sci Food Agric. 2010;90:2015. 10.1002/jsfa.4046
- Ongol MP, Iguchi T, Tanaka M, Sone T, Ikeda H, et al. Potential of selected strains of lactic acid bacteria to induce a Th1 immune profile. Biosci Biotechnol Biochem. 2008;72:2847.
- Peng S, Lin JY, Lin MY. Antiallergic effect of milk fermented with lactic acid bacteria in a murine animal model. J Agric Food Chem. 2007;55:5092.
- Mastrandrea F, Coradduzza G, Serio G, Minardi A, Manelli M, et al. Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects. Eur Ann Allergy Clin Immunol. 2004;36:118.
- Di Marzio L, Centi C, Cinque B, Masci S, Giuliani M, et al. Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. Exp Dermatol. 2003;12:615.
- Lee MF, Chen YH, Chiang CH, Wu CS, Li MH, et al. Oral Administration of Expressing Mite and Cockroach Major Allergens Alleviates Progression of Atopic March in a Mouse Model. Allergy Asthma Immunol Res. 2024;16:520. 10.4168/aair.2024.16.5.520
- Nakagawa R, Gu W, Mizobuchi H, Kodera S, Takano T, et al. subsp. YRC3780 modifies function of mesenteric lymph node dendritic cells to modulate the balance of T cell differentiation inducing regulatory T cells. Front Immunol. 2024;15:1395380. 10.3389/fimmu.2024.1395380
- Lee MF, Wang NM, Chen YH, Wu CS, Lee MH, et al. An atopic dermatitis-like murine model by skin-brushed cockroach Per a 2 and oral tolerance induction by Lactococcus lactis-derived Per a 2. PLoS One. 2023;18:e0291162. 10.1371/journal.pone.0291162
- Baek J, Kim JH, Kim W. Potential Anti-Allergy and Immunomodulatory Properties of LB 1022 Observed In Vitro and in an Atopic Dermatitis Mouse Model. J Microbiol Biotechnol. 2023;33:823. 10.4014/jmb.2301.01019
- Lee DH, Park HK, Lee HR, Sohn H, Sim S, et al. Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma. Clin Transl Allergy. 2022;12:e12138. 10.1002/clt2.12138
- Lee MF, Chiang CH, Lin SJ, Wu CS, Chen YH. Effectiveness and safety of oral lactococci-based vaccine encoding triple common allergens to prevent airway allergy in mice. PLoS One. 2021;16:e0261333. 10.1371/journal.pone.0261333
- El Mecherfi KE, Lupi R, Cherkaoui M, Albuquerque MAC, Todorov SD, et al. Fermentation of Gluten by Lactococcus lactis LLGKC18 Reduces its Antigenicity and Allergenicity. Probiotics Antimicrob Proteins. 2022;14:779. 10.1007/s12602-021-09808-1
- Zhang K, Mirza WA, Ni P, Yu M, Wang C, et al. Recombination Lactococcus lactis expressing Helicobacter pylori neutrophil-activating protein A attenuates food allergy symptoms in mice. FEMS Microbiol Lett. 2021;368. 10.1093/femsle/fnab034
- Cervantes-García D, Jiménez M, Rivas-Santiago CE, Gallegos-Alcalá P, Hernández-Mercado A, et al. Lactococcus lactis NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production. Int Arch Allergy Immunol. 2021;182:277. 10.1159/000511146
- de Lacerda LB, Rios WM, Masson AP, Brandão IT, Milani TM, et al. Oral administration of Hsp65-producing Lactococcus lactis attenuates allergic asthma in a murine model. J Appl Microbiol. 2021;130:2075. 10.1111/jam.14913
- Vasiee A, Falah F, Sankian M, Tabatabaei-Yazdi F, Mortazavi SA. Oral Immunotherapy Using Probiotic Ice Cream Containing Recombinant Food-Grade Which Inhibited Allergic Responses in a BALB/c Mouse Model. J Immunol Res. 2020;2020:2635230. 10.1155/2020/2635230
- Suzuki T, Nishiyama K, Kawata K, Sugimoto K, Isome M, et al. Effect of the 11/19-B1 Strain on Atopic Dermatitis in a Clinical Test and Mouse Model. Nutrients. 2020;12. 10.3390/nu12030763
- Chan CJ, Yong YS, Song AAL, Abdul Rahim R, In LLA, et al. Lactococcus lactis harbouring Ara h 2.02 alleviates allergen-specific Th2-associated responses in sensitized mice. J Appl Microbiol. 2020;128:862. 10.1111/jam.14524
- Jin M, Lee S, Choi YA, Jang HJ, Lee SW, et al. Lactococcus lactis KR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation. J Appl Microbiol. 2019;126:230. 10.1111/jam.14116
