Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 21 Reviews
8.8
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Read More
8
Iron and vitamin D impact depression
We explored whether maternal iron and vitamin D levels during pregnancy could impact depression symptoms later on. By measuring various iron biomarkers and vitamin D metabolites, we assessed the mental health of nearly 2,000 pregnant participants in their third trimester. Our findings showed that higher levels of both iron and vitamin D were associated with significantly fewer depression symptoms. Interestingly, many women experienced lower vitamin D levels postpartum, suggesting the need for continued monitoring beyond pregnancy.
Read More
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Read More
Most Useful Reviews
9.3
Improved mood
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
Read More
9.5
Fatigue relief
I take this iron due to very low ferritin levels which caused fatigue and depression. After using it with probiotics at night, I've noticed cold hands and feet, mood swings, and constant tiredness are a thing of the past!
Read More
9.5
Anemia recovery
After my father's death, I became depressed and anaemic. Despite taking prescribed iron supplements, my condition worsened until I found a regimen that worked for me. Combining iron with Vitamin C, I experienced a significant rise in ferritin levels in just a month, so I continue to take it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
We evaluated how brain iron levels affect depression and cognitive function in unmedicated individuals with major depressive disorder (MDD) undergoing mindfulness-based cognitive therapy (MBCT).
Using advanced imaging techniques, we noticed participants with MDD had lower brain iron levels in specific regions compared to healthy controls.
Participants who started with lower iron levels experienced greater improvements in their depression after receiving MBCT. Our findings suggest that brain iron might play a role in MDD symptoms and treatment response.
Using advanced imaging techniques, we noticed participants with MDD had lower brain iron levels in specific regions compared to healthy controls.
Participants who started with lower iron levels experienced greater improvements in their depression after receiving MBCT. Our findings suggest that brain iron might play a role in MDD symptoms and treatment response.
Read More
8
We examined how Kaixinsan (KXS), a traditional Chinese medicine, affects depression-like behaviors in mice undergoing adriamycin treatment for breast cancer. By dividing forty mice into groups, we observed their responses through various tests.
The results showed that KXS significantly improved the depression-related behaviors linked to chemotherapy. It appeared to work by reducing ferroptosis—a type of cell death—in the prefrontal cortex, suggesting a protective role against these adverse effects.
The results showed that KXS significantly improved the depression-related behaviors linked to chemotherapy. It appeared to work by reducing ferroptosis—a type of cell death—in the prefrontal cortex, suggesting a protective role against these adverse effects.
Read More
8
Iron and vitamin D impact depression
We explored whether maternal iron and vitamin D levels during pregnancy could impact depression symptoms later on. By measuring various iron biomarkers and vitamin D metabolites, we assessed the mental health of nearly 2,000 pregnant participants in their third trimester. Our findings showed that higher levels of both iron and vitamin D were associated with significantly fewer depression symptoms. Interestingly, many women experienced lower vitamin D levels postpartum, suggesting the need for continued monitoring beyond pregnancy.
Read More
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Read More
8
We investigated how dietary iron intake affects depressive symptoms among adults using data from the National Health and Nutrition Examination Survey. Our analysis revealed that higher iron intake is linked to lower rates of depression.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Interestingly, we discovered that this relationship varies with body mass index (BMI). For individuals with a BMI under 25, the connection was U-shaped, indicating that too little or too much iron can impact mood.
However, it’s important to note that the study was cross-sectional and relied on self-reported data, making firm conclusions challenging.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.3
Improved mood
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
Read More
9.5
Fatigue relief
I take this iron due to very low ferritin levels which caused fatigue and depression. After using it with probiotics at night, I've noticed cold hands and feet, mood swings, and constant tiredness are a thing of the past!
Read More
9.5
Anemia recovery
After my father's death, I became depressed and anaemic. Despite taking prescribed iron supplements, my condition worsened until I found a regimen that worked for me. Combining iron with Vitamin C, I experienced a significant rise in ferritin levels in just a month, so I continue to take it.
Read More
9.5
Mood improvement
Taking iron supplements has significantly helped my mood and motivation amidst my struggles with prenatal and postnatal depression due to iron deficiency. I continue to take iron regularly, and it makes a notable difference in my general well-being.
Read More
8.5
Enhanced vitality
I take four tablets daily, noticing my complexion improves. Many Japanese face iron deficiency, leading to tiredness and issues. Although not anaemic, I experienced fatigue and shortness of breath on stairs, which has since improved. The supplement has no stomach discomfort, making it easy to take.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
- Pobee RA, Setorglo J, Klevor M, Murray-Kolb LE. Associations between iron status and psychosocial wellbeing among pregnant women in Cape Coast, Ghana: a longitudinal study. Public Health Nutr. 2024. doi:10.1017/S1368980024002088
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Ouyang M, Cui J, Wang H, Liang Z, Pi D, et al. [ alleviates adriamycin-induced depression-like behaviors in mice by reducing ferroptosis in the prefrontal cortex]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:1441. doi:10.12122/j.issn.1673-4254.2024.08.02
- Evanchuk JL, Kozyrskyj A, Vaghef-Mehrabani E, Lamers Y, Giesbrecht GF, et al. Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort. J Nutr. 2024;154:174. doi:10.1016/j.tjnut.2023.10.029
- Ciulei MA, Ahluwalia N, McCormick BJJ, Teti DM, Murray-Kolb LE. Iron Deficiency is Related to Depressive Symptoms in United States Nonpregnant Women of Reproductive Age: A Cross-Sectional Analysis of NHANES 2005-2010. J Nutr. 2023;153:3521. doi:10.1016/j.tjnut.2023.09.023
- Zeng T, Li J, Xie L, Dong Z, Chen Q, et al. Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression. J Neuroinflammation. 2023;20:212. doi:10.1186/s12974-023-02875-x
- Tian S, Wu L, Zheng H, Zhong X, Yu X, et al. Body mass index modifies the relationship between dietary iron intake and depressive symptoms among adults: A national population-based cohort. J Affect Disord. 2023;340:907. doi:10.1016/j.jad.2023.08.105
- Jakary A, Lupo JM, Mackin S, Yin A, Murray D, et al. Evaluation of major depressive disorder using 7 Tesla phase sensitive neuroimaging before and after mindfulness-based cognitive therapy. J Affect Disord. 2023;335:383. doi:10.1016/j.jad.2023.05.038
