Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
We aimed to understand how Lycium barbarum glycopeptide could help reduce the harmful effects of iron overload in stroke-affected neurons. Through a controlled study involving rats, we examined the substance's ability to alleviate damage following a stroke induced by middle cerebral artery occlusion.
Over the course of seven days, beginning 24 hours after the stroke event, we treated these rats with Lycium barbarum glycopeptide. We observed significant improvements in brain health, including reduced infarct volume and neuronal death, which were verified through various medical imaging techniques.
More importantly, we noted improvements in sensory and motor functions, as well as reductions in anxiety and depression-like behaviors. The research also showed that this glycopeptide effectively decreased iron levels in the ischemic tissue while promoting protective proteins in the brain.
These findings suggest that Lycium barbarum glycopeptide could be a valuable neuroprotective agent for stroke patients by targeting iron overload and oxidation, ultimately enhancing recovery. The positive effects we found were compromised when a ferroptosis activator was introduced, highlighting the importance of the mechanisms that this treatment influences.
Over the course of seven days, beginning 24 hours after the stroke event, we treated these rats with Lycium barbarum glycopeptide. We observed significant improvements in brain health, including reduced infarct volume and neuronal death, which were verified through various medical imaging techniques.
More importantly, we noted improvements in sensory and motor functions, as well as reductions in anxiety and depression-like behaviors. The research also showed that this glycopeptide effectively decreased iron levels in the ischemic tissue while promoting protective proteins in the brain.
These findings suggest that Lycium barbarum glycopeptide could be a valuable neuroprotective agent for stroke patients by targeting iron overload and oxidation, ultimately enhancing recovery. The positive effects we found were compromised when a ferroptosis activator was introduced, highlighting the importance of the mechanisms that this treatment influences.
Read More
8
We investigated how iron affects brain injury following an intracerebral hemorrhage, a condition where bleeding occurs inside the brain. The study focused on the consequences of blood components and their breakdown products, especially free iron, on pericytes—cells that play a key role in the health of cerebral capillaries. Using human cell cultures and brain tissue slices, we observed that free iron significantly harmed pericyte function and survival, indicating its detrimental effect on the brain’s vascular system.
Our experiments revealed that while hemoglobin—another component of blood—did not contribute to this damage, free iron induced a form of cell death called ferroptosis. This was linked to oxidative stress and impacted the ability of pericytes to support cerebral capillaries. Interestingly, we found that this disruption could be partially reversed with a specific treatment, highlighting a potential pathway for reducing secondary brain injury after a stroke.
Ultimately, our findings suggest that addressing free iron levels could be important for stroke treatment strategies. However, we did not isolate the direct impacts of iron treatments specifically targeted at stroke patients, which limits the clarity of how these treatments could effectively mitigate stroke damage.
Our experiments revealed that while hemoglobin—another component of blood—did not contribute to this damage, free iron induced a form of cell death called ferroptosis. This was linked to oxidative stress and impacted the ability of pericytes to support cerebral capillaries. Interestingly, we found that this disruption could be partially reversed with a specific treatment, highlighting a potential pathway for reducing secondary brain injury after a stroke.
Ultimately, our findings suggest that addressing free iron levels could be important for stroke treatment strategies. However, we did not isolate the direct impacts of iron treatments specifically targeted at stroke patients, which limits the clarity of how these treatments could effectively mitigate stroke damage.
Read More
8
We explored the role of iron deficiency (ID) in influencing the recovery of patients who experienced an acute ischemic stroke. Our investigation, conducted through a multicentric cohort study, focused on patients admitted to stroke units across four centers from January to December 2023. By analyzing blood samples to assess iron status at admission, we sought to establish whether ID had a significant impact on functional recovery.
What we found is striking: ID was present in 65.6% of the patients. After evaluating various factors like age, stroke severity, and existing health conditions, we discovered that ID was strongly linked to poorer functional outcomes at 90 days post-stroke. Those with ID were about 2.3 times more likely to experience a severe decline in their recovery according to the modified Rankin Scale.
Although our study highlighted the association between ID and negative outcomes, it is important to note that we did not specifically investigate the effects of iron treatment on stroke recovery. Consequently, we cannot make direct recommendations regarding iron supplementation as a therapeutic strategy just yet. Further research is necessary to determine if addressing iron deficiency could enhance patient recovery after a stroke.
What we found is striking: ID was present in 65.6% of the patients. After evaluating various factors like age, stroke severity, and existing health conditions, we discovered that ID was strongly linked to poorer functional outcomes at 90 days post-stroke. Those with ID were about 2.3 times more likely to experience a severe decline in their recovery according to the modified Rankin Scale.
Although our study highlighted the association between ID and negative outcomes, it is important to note that we did not specifically investigate the effects of iron treatment on stroke recovery. Consequently, we cannot make direct recommendations regarding iron supplementation as a therapeutic strategy just yet. Further research is necessary to determine if addressing iron deficiency could enhance patient recovery after a stroke.
Read More
Most Useful Reviews
8.8
Improved dizziness
I purchased this for my elderly mother, who was very dizzy following her stroke. The doctor mentioned she might require iron supplements, so I decided to get this one. I am pleased with the results; the quality is excellent, the size is convenient, and the benefits are significant. Many older adults suffer from iron deficiency, making this supplement essential. Dizziness is the primary symptom. The taste is reasonable, and I use it twice daily. The ingredients include iron.
Read More
9.5
Effective iron boost
I gave this to my father-in-law after his stroke, and his iron levels improved significantly. The quality is good.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
We aimed to understand how Lycium barbarum glycopeptide could help reduce the harmful effects of iron overload in stroke-affected neurons. Through a controlled study involving rats, we examined the substance's ability to alleviate damage following a stroke induced by middle cerebral artery occlusion.
Over the course of seven days, beginning 24 hours after the stroke event, we treated these rats with Lycium barbarum glycopeptide. We observed significant improvements in brain health, including reduced infarct volume and neuronal death, which were verified through various medical imaging techniques.
More importantly, we noted improvements in sensory and motor functions, as well as reductions in anxiety and depression-like behaviors. The research also showed that this glycopeptide effectively decreased iron levels in the ischemic tissue while promoting protective proteins in the brain.
These findings suggest that Lycium barbarum glycopeptide could be a valuable neuroprotective agent for stroke patients by targeting iron overload and oxidation, ultimately enhancing recovery. The positive effects we found were compromised when a ferroptosis activator was introduced, highlighting the importance of the mechanisms that this treatment influences.
Over the course of seven days, beginning 24 hours after the stroke event, we treated these rats with Lycium barbarum glycopeptide. We observed significant improvements in brain health, including reduced infarct volume and neuronal death, which were verified through various medical imaging techniques.
More importantly, we noted improvements in sensory and motor functions, as well as reductions in anxiety and depression-like behaviors. The research also showed that this glycopeptide effectively decreased iron levels in the ischemic tissue while promoting protective proteins in the brain.
These findings suggest that Lycium barbarum glycopeptide could be a valuable neuroprotective agent for stroke patients by targeting iron overload and oxidation, ultimately enhancing recovery. The positive effects we found were compromised when a ferroptosis activator was introduced, highlighting the importance of the mechanisms that this treatment influences.
Read More
8
We investigated how iron affects brain injury following an intracerebral hemorrhage, a condition where bleeding occurs inside the brain. The study focused on the consequences of blood components and their breakdown products, especially free iron, on pericytes—cells that play a key role in the health of cerebral capillaries. Using human cell cultures and brain tissue slices, we observed that free iron significantly harmed pericyte function and survival, indicating its detrimental effect on the brain’s vascular system.
Our experiments revealed that while hemoglobin—another component of blood—did not contribute to this damage, free iron induced a form of cell death called ferroptosis. This was linked to oxidative stress and impacted the ability of pericytes to support cerebral capillaries. Interestingly, we found that this disruption could be partially reversed with a specific treatment, highlighting a potential pathway for reducing secondary brain injury after a stroke.
Ultimately, our findings suggest that addressing free iron levels could be important for stroke treatment strategies. However, we did not isolate the direct impacts of iron treatments specifically targeted at stroke patients, which limits the clarity of how these treatments could effectively mitigate stroke damage.
Our experiments revealed that while hemoglobin—another component of blood—did not contribute to this damage, free iron induced a form of cell death called ferroptosis. This was linked to oxidative stress and impacted the ability of pericytes to support cerebral capillaries. Interestingly, we found that this disruption could be partially reversed with a specific treatment, highlighting a potential pathway for reducing secondary brain injury after a stroke.
Ultimately, our findings suggest that addressing free iron levels could be important for stroke treatment strategies. However, we did not isolate the direct impacts of iron treatments specifically targeted at stroke patients, which limits the clarity of how these treatments could effectively mitigate stroke damage.
Read More
8
We explored the role of iron deficiency (ID) in influencing the recovery of patients who experienced an acute ischemic stroke. Our investigation, conducted through a multicentric cohort study, focused on patients admitted to stroke units across four centers from January to December 2023. By analyzing blood samples to assess iron status at admission, we sought to establish whether ID had a significant impact on functional recovery.
What we found is striking: ID was present in 65.6% of the patients. After evaluating various factors like age, stroke severity, and existing health conditions, we discovered that ID was strongly linked to poorer functional outcomes at 90 days post-stroke. Those with ID were about 2.3 times more likely to experience a severe decline in their recovery according to the modified Rankin Scale.
Although our study highlighted the association between ID and negative outcomes, it is important to note that we did not specifically investigate the effects of iron treatment on stroke recovery. Consequently, we cannot make direct recommendations regarding iron supplementation as a therapeutic strategy just yet. Further research is necessary to determine if addressing iron deficiency could enhance patient recovery after a stroke.
What we found is striking: ID was present in 65.6% of the patients. After evaluating various factors like age, stroke severity, and existing health conditions, we discovered that ID was strongly linked to poorer functional outcomes at 90 days post-stroke. Those with ID were about 2.3 times more likely to experience a severe decline in their recovery according to the modified Rankin Scale.
Although our study highlighted the association between ID and negative outcomes, it is important to note that we did not specifically investigate the effects of iron treatment on stroke recovery. Consequently, we cannot make direct recommendations regarding iron supplementation as a therapeutic strategy just yet. Further research is necessary to determine if addressing iron deficiency could enhance patient recovery after a stroke.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved dizziness
I purchased this for my elderly mother, who was very dizzy following her stroke. The doctor mentioned she might require iron supplements, so I decided to get this one. I am pleased with the results; the quality is excellent, the size is convenient, and the benefits are significant. Many older adults suffer from iron deficiency, making this supplement essential. Dizziness is the primary symptom. The taste is reasonable, and I use it twice daily. The ingredients include iron.
Read More
9.5
Effective iron boost
I gave this to my father-in-law after his stroke, and his iron levels improved significantly. The quality is good.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Balk S, Panier F, Brandner S, Coras R, Blümcke I, et al. Intracerebral Hemorrhage-Associated Iron Release Leads to Pericyte-Dependent Cerebral Capillary Function Disruption. Biomolecules. 2025;15. doi:10.3390/biom15020164
- Zhang W, Tang M, Wang Y, Huang Y, Yu Z, et al. Lycium barbarum glycopeptide reduces brain damage following ischemic stroke by inhibiting ferroptosis and oxidation. Neural Regen Res. 2025. doi:10.4103/NRR.NRR-D-24-00747
- Ciacciarelli A, Falcou A, Nicolini E, Broccolini A, Frisullo G, et al. The prognostic role of iron deficiency in acute ischemic stroke patients: A prospective multicentric cohort study. J Neurol Sci. 2025;469:123371. doi:10.1016/j.jns.2024.123371
